The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Aleman Andre - One of the best experts on this subject based on the ideXlab platform.
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When Broca Goes Uninformed:Reduced Information Flow to Brocas Area in Schizophrenia Patients With Auditory Hallucinations
2013Co-Authors: Curcic-blake Branislava, Liemburg Edith, Vercammen Ans, Swart Marte, Knegtering Henderikus, Bruggeman Richard, Aleman AndreAbstract:Auditory-verbal hallucinations (AVHs) are frequently associated with activation of the left superior temporal gyrus (including Wernickes Area), left inferior frontal gyrus (including Brocas Area), and the right hemisphere homologs of both Areas. It has been hypothesized that disconnectivity of both interhemispheric transfer and frontal and temporal Areas may underlie hallucinations in schizophrenia. We investigated reduced information flow in this circuit for the first time using dynamic causal modeling, which allows for directional inference. A group of healthy subjects and 2 groups of schizophrenia patientsuwith and without AVHuperformed a task requiring inner speech processing during functional brain scanning. We employed connectivity models between left hemispheric speech-processing Areas and their right hemispheric homologs. Bayesian model averaging was used to estimate the connectivity strengths and evaluate group differences. Patients with AVH showed significantly reduced connectivity from Wernickes to Brocas Area (97% certainty) and a trend toward a reduction in connectivity from homologs of Brocas and Wernickes Areas to Brocas Area (93% and 94% certainty). The connectivity magnitude in patients without hallucinations was found to be intermediate. Our results point toward a reduced input from temporal to frontal language Areas in schizophrenia patients with AVH, suggesting that Brocas activity may be less constrained by perceptual information received from the temporal cortex. In addition, a lack of synchronization between Broca and its homolog may lead to the erroneous interpretation of emotional speech activity from the right hemisphere as coming from an external source.
Curcic-blake Branislava - One of the best experts on this subject based on the ideXlab platform.
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When Broca Goes Uninformed:Reduced Information Flow to Brocas Area in Schizophrenia Patients With Auditory Hallucinations
2013Co-Authors: Curcic-blake Branislava, Liemburg Edith, Vercammen Ans, Swart Marte, Knegtering Henderikus, Bruggeman Richard, Aleman AndreAbstract:Auditory-verbal hallucinations (AVHs) are frequently associated with activation of the left superior temporal gyrus (including Wernickes Area), left inferior frontal gyrus (including Brocas Area), and the right hemisphere homologs of both Areas. It has been hypothesized that disconnectivity of both interhemispheric transfer and frontal and temporal Areas may underlie hallucinations in schizophrenia. We investigated reduced information flow in this circuit for the first time using dynamic causal modeling, which allows for directional inference. A group of healthy subjects and 2 groups of schizophrenia patientsuwith and without AVHuperformed a task requiring inner speech processing during functional brain scanning. We employed connectivity models between left hemispheric speech-processing Areas and their right hemispheric homologs. Bayesian model averaging was used to estimate the connectivity strengths and evaluate group differences. Patients with AVH showed significantly reduced connectivity from Wernickes to Brocas Area (97% certainty) and a trend toward a reduction in connectivity from homologs of Brocas and Wernickes Areas to Brocas Area (93% and 94% certainty). The connectivity magnitude in patients without hallucinations was found to be intermediate. Our results point toward a reduced input from temporal to frontal language Areas in schizophrenia patients with AVH, suggesting that Brocas activity may be less constrained by perceptual information received from the temporal cortex. In addition, a lack of synchronization between Broca and its homolog may lead to the erroneous interpretation of emotional speech activity from the right hemisphere as coming from an external source.
Liemburg Edith - One of the best experts on this subject based on the ideXlab platform.
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When Broca Goes Uninformed:Reduced Information Flow to Brocas Area in Schizophrenia Patients With Auditory Hallucinations
2013Co-Authors: Curcic-blake Branislava, Liemburg Edith, Vercammen Ans, Swart Marte, Knegtering Henderikus, Bruggeman Richard, Aleman AndreAbstract:Auditory-verbal hallucinations (AVHs) are frequently associated with activation of the left superior temporal gyrus (including Wernickes Area), left inferior frontal gyrus (including Brocas Area), and the right hemisphere homologs of both Areas. It has been hypothesized that disconnectivity of both interhemispheric transfer and frontal and temporal Areas may underlie hallucinations in schizophrenia. We investigated reduced information flow in this circuit for the first time using dynamic causal modeling, which allows for directional inference. A group of healthy subjects and 2 groups of schizophrenia patientsuwith and without AVHuperformed a task requiring inner speech processing during functional brain scanning. We employed connectivity models between left hemispheric speech-processing Areas and their right hemispheric homologs. Bayesian model averaging was used to estimate the connectivity strengths and evaluate group differences. Patients with AVH showed significantly reduced connectivity from Wernickes to Brocas Area (97% certainty) and a trend toward a reduction in connectivity from homologs of Brocas and Wernickes Areas to Brocas Area (93% and 94% certainty). The connectivity magnitude in patients without hallucinations was found to be intermediate. Our results point toward a reduced input from temporal to frontal language Areas in schizophrenia patients with AVH, suggesting that Brocas activity may be less constrained by perceptual information received from the temporal cortex. In addition, a lack of synchronization between Broca and its homolog may lead to the erroneous interpretation of emotional speech activity from the right hemisphere as coming from an external source.
Vercammen Ans - One of the best experts on this subject based on the ideXlab platform.
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When Broca Goes Uninformed:Reduced Information Flow to Brocas Area in Schizophrenia Patients With Auditory Hallucinations
2013Co-Authors: Curcic-blake Branislava, Liemburg Edith, Vercammen Ans, Swart Marte, Knegtering Henderikus, Bruggeman Richard, Aleman AndreAbstract:Auditory-verbal hallucinations (AVHs) are frequently associated with activation of the left superior temporal gyrus (including Wernickes Area), left inferior frontal gyrus (including Brocas Area), and the right hemisphere homologs of both Areas. It has been hypothesized that disconnectivity of both interhemispheric transfer and frontal and temporal Areas may underlie hallucinations in schizophrenia. We investigated reduced information flow in this circuit for the first time using dynamic causal modeling, which allows for directional inference. A group of healthy subjects and 2 groups of schizophrenia patientsuwith and without AVHuperformed a task requiring inner speech processing during functional brain scanning. We employed connectivity models between left hemispheric speech-processing Areas and their right hemispheric homologs. Bayesian model averaging was used to estimate the connectivity strengths and evaluate group differences. Patients with AVH showed significantly reduced connectivity from Wernickes to Brocas Area (97% certainty) and a trend toward a reduction in connectivity from homologs of Brocas and Wernickes Areas to Brocas Area (93% and 94% certainty). The connectivity magnitude in patients without hallucinations was found to be intermediate. Our results point toward a reduced input from temporal to frontal language Areas in schizophrenia patients with AVH, suggesting that Brocas activity may be less constrained by perceptual information received from the temporal cortex. In addition, a lack of synchronization between Broca and its homolog may lead to the erroneous interpretation of emotional speech activity from the right hemisphere as coming from an external source.
Swart Marte - One of the best experts on this subject based on the ideXlab platform.
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When Broca Goes Uninformed:Reduced Information Flow to Brocas Area in Schizophrenia Patients With Auditory Hallucinations
2013Co-Authors: Curcic-blake Branislava, Liemburg Edith, Vercammen Ans, Swart Marte, Knegtering Henderikus, Bruggeman Richard, Aleman AndreAbstract:Auditory-verbal hallucinations (AVHs) are frequently associated with activation of the left superior temporal gyrus (including Wernickes Area), left inferior frontal gyrus (including Brocas Area), and the right hemisphere homologs of both Areas. It has been hypothesized that disconnectivity of both interhemispheric transfer and frontal and temporal Areas may underlie hallucinations in schizophrenia. We investigated reduced information flow in this circuit for the first time using dynamic causal modeling, which allows for directional inference. A group of healthy subjects and 2 groups of schizophrenia patientsuwith and without AVHuperformed a task requiring inner speech processing during functional brain scanning. We employed connectivity models between left hemispheric speech-processing Areas and their right hemispheric homologs. Bayesian model averaging was used to estimate the connectivity strengths and evaluate group differences. Patients with AVH showed significantly reduced connectivity from Wernickes to Brocas Area (97% certainty) and a trend toward a reduction in connectivity from homologs of Brocas and Wernickes Areas to Brocas Area (93% and 94% certainty). The connectivity magnitude in patients without hallucinations was found to be intermediate. Our results point toward a reduced input from temporal to frontal language Areas in schizophrenia patients with AVH, suggesting that Brocas activity may be less constrained by perceptual information received from the temporal cortex. In addition, a lack of synchronization between Broca and its homolog may lead to the erroneous interpretation of emotional speech activity from the right hemisphere as coming from an external source.
