The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Bruce R. Smoller - One of the best experts on this subject based on the ideXlab platform.
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Mycosis fungoides: classic Disease and variant presentations.
Seminars in Cutaneous Medicine and Surgery, 2000Co-Authors: Michael S. Howard, Bruce R. SmollerAbstract:: Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinicopathologic variants of mycosis fungoides have been delineated, including poikiloderma atrophicans vasculare (parapsoriasis variegata), Sezary syndrome, granulomatous mycosis fungoides, hypopigmented mycosis fungoides, folliculocentric mycosis fungoides, syringotropic mycosis fungoides, and Woringer Kolopp Disease. We will review the salient features of patch, plaque, and tumor stage mycosis fungoides in this article and follow with a discussion of these variant clinicopathologic presentations and of therapeutic modalities.
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pagetoid reticulosis Woringer Kolopp Disease an immunophenotypic molecular and clinicopathologic study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, Sabine KohlerAbstract:Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, S KohlerAbstract:Pagetoid reticulosis (PR), also known as Woringer-Kolopp Disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (γ and/or β) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of Disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow Disease course. The Disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile.
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Mycosis fungoides palmaris et plantaris.
Archives of Dermatology, 1996Co-Authors: Bruce R. SmollerAbstract:I read with interest the article by Resnick et al,1in which the authors attempt to group cases of limited acral cutaneous T-cell lymphoma into a single entity entitled "mycosis fungoides palmaris et plantaris." While this is certainly an admirable goal, I must object to the inclusion of several of their cases under such a designation, including a case report we published.2 Mycosis fungoidesis defined as a neoplastic proliferation of CD4+T-helper cells by most groups studying cutaneous T-cell lymphomas.3-5Our case was that of a cutaneous T-cell lymphoma limited to an extremity for longer than 30 years, which was characterized by CD8+, CD30+, CD4-lymphocytes. This is not an immunophenotype that would ordinarily be seen in mycosis fungoides. In addition, almost half of all reported cases of Woringer-Kolopp Disease (pagetoid reticulosis) are CD8+, CD4-T-cell lymphomas. These cases are neoplasms derived from a different population of
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a case of Woringer Kolopp Disease with ki 1 cd30 cytotoxic suppressor cells
Archives of Dermatology, 1992Co-Authors: Bruce R. Smoller, Margaret I Stewart, Roger A. WarnkeAbstract:• Background.— Woringer-Kolopp (W-K) Disease is a rare, localized, histologically malignant, but clinically indolent lymphoproliferative disorder. Most authors have regarded W-K Disease as a variant of mycosis fungoides. However, a recent case suggests that W-K Disease may represent a spectrum of lymphoproliferative disorders that may not be related to mycosis fungoides. Observations.— A patient with a 40-year history of a localized cutaneous eruption characterized by markedly atypical epidermotropic lymphocytes was seen at Stanford (Calif) University Hospital. The lymphocytes were predominantly CD30+cytotoxic/suppressor T cells, an immunophenotype not previously described in W-K Disease. Genotype analysis revealed a clonal rearrangement. Conclusions.— The findings in our patient, along with a review of all cases previously reported in the literature, suggest that W-K Disease may be an entity with a uniform clinical and histologic presentation, but one with marked immunophenotypic heterogeneity of the malignant-appearing atypical cells. Some cases showed immunophenotypic similarities to mycosis fungoides. However, in almost half of the reviewed cases, including the one presented here, the immunophenotypic differences exceeded the similarities. (Arch Dermatol.1992;128:526-529)
Roger A. Warnke - One of the best experts on this subject based on the ideXlab platform.
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pagetoid reticulosis Woringer Kolopp Disease an immunophenotypic molecular and clinicopathologic study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, Sabine KohlerAbstract:Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, S KohlerAbstract:Pagetoid reticulosis (PR), also known as Woringer-Kolopp Disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (γ and/or β) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of Disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow Disease course. The Disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile.
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a case of Woringer Kolopp Disease with ki 1 cd30 cytotoxic suppressor cells
Archives of Dermatology, 1992Co-Authors: Bruce R. Smoller, Margaret I Stewart, Roger A. WarnkeAbstract:• Background.— Woringer-Kolopp (W-K) Disease is a rare, localized, histologically malignant, but clinically indolent lymphoproliferative disorder. Most authors have regarded W-K Disease as a variant of mycosis fungoides. However, a recent case suggests that W-K Disease may represent a spectrum of lymphoproliferative disorders that may not be related to mycosis fungoides. Observations.— A patient with a 40-year history of a localized cutaneous eruption characterized by markedly atypical epidermotropic lymphocytes was seen at Stanford (Calif) University Hospital. The lymphocytes were predominantly CD30+cytotoxic/suppressor T cells, an immunophenotype not previously described in W-K Disease. Genotype analysis revealed a clonal rearrangement. Conclusions.— The findings in our patient, along with a review of all cases previously reported in the literature, suggest that W-K Disease may be an entity with a uniform clinical and histologic presentation, but one with marked immunophenotypic heterogeneity of the malignant-appearing atypical cells. Some cases showed immunophenotypic similarities to mycosis fungoides. However, in almost half of the reviewed cases, including the one presented here, the immunophenotypic differences exceeded the similarities. (Arch Dermatol.1992;128:526-529)
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A Case of Woringer-Kolopp Disease With Ki-1 (CD30)+ Cytotoxic/Suppressor Cells
Archives of Dermatology, 1992Co-Authors: Bruce R. Smoller, Margaret I Stewart, Roger A. WarnkeAbstract:• Background.— Woringer-Kolopp (W-K) Disease is a rare, localized, histologically malignant, but clinically indolent lymphoproliferative disorder. Most authors have regarded W-K Disease as a variant of mycosis fungoides. However, a recent case suggests that W-K Disease may represent a spectrum of lymphoproliferative disorders that may not be related to mycosis fungoides. Observations.— A patient with a 40-year history of a localized cutaneous eruption characterized by markedly atypical epidermotropic lymphocytes was seen at Stanford (Calif) University Hospital. The lymphocytes were predominantly CD30+cytotoxic/suppressor T cells, an immunophenotype not previously described in W-K Disease. Genotype analysis revealed a clonal rearrangement. Conclusions.— The findings in our patient, along with a review of all cases previously reported in the literature, suggest that W-K Disease may be an entity with a uniform clinical and histologic presentation, but one with marked immunophenotypic heterogeneity of the malignant-appearing atypical cells. Some cases showed immunophenotypic similarities to mycosis fungoides. However, in almost half of the reviewed cases, including the one presented here, the immunophenotypic differences exceeded the similarities. (Arch Dermatol.1992;128:526-529)
Sabine Kohler - One of the best experts on this subject based on the ideXlab platform.
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clinicopathologic features and treatment outcomes in Woringer Kolopp Disease
Journal of The American Academy of Dermatology, 2008Co-Authors: Natalie Viakhireva, Sabine Kohler, Christine Cesca, Richard T HoppeAbstract:Woringer-Kolopp Disease, also known as pagetoid reticulosis, is an exceedingly rare variant of mycosis fungoides. Accurate diagnosis and effective treatment is essential to prevent progression to debilitating Disease. We identified 7 patients with Woringer-Kolopp Disease treated at our institution. We review the major clinical and pathologic characteristics of this Disease, focusing on treatment strategies and patient outcomes. All of our patients were successfully treated with skin-directed therapies including topical steroids, topical nitrogen mustard, psoralen plus ultraviolet A, narrow-band ultraviolet B, and radiation therapy. Our observations confirm that Woringer-Kolopp Disease carries an excellent prognosis, and support that the most effective and appropriate treatment for recalcitrant or severe Woringer-Kolopp Disease is localized radiation therapy.
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pagetoid reticulosis Woringer Kolopp Disease an immunophenotypic molecular and clinicopathologic study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, Sabine KohlerAbstract:Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
Bijan Haghighi - One of the best experts on this subject based on the ideXlab platform.
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pagetoid reticulosis Woringer Kolopp Disease an immunophenotypic molecular and clinicopathologic study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, Sabine KohlerAbstract:Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Roger A. Warnke, Bruce R. Smoller, Christian A. Sander, Phillip E Leboit, S KohlerAbstract:Pagetoid reticulosis (PR), also known as Woringer-Kolopp Disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (γ and/or β) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of Disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow Disease course. The Disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile.
Martin Schaller - One of the best experts on this subject based on the ideXlab platform.
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pagetoid reticulosis Woringer Kolopp Disease
Journal Der Deutschen Dermatologischen Gesellschaft, 2009Co-Authors: V Lichte, Gisela Metzler, Annette Geyer, Kamran Ghoreschi, Martin Röcken, Mathias Mohrle, Martin SchallerAbstract:Summary Pagetoid reticulosis (Woringer-Kolopp Disease) is a rare subtype of cutaneous CD8-positive T-cell lymphoma. A 41-year-old man presented with a 7-year history with a slowly progressive erythematous plaque on his right buttocks. With the working diagnosis of psoriasis, he was treated with topical corticosteroids which produced no improvement. Histological examination showed an epidermotropic T-cell lymphoma with predominance of CD8- vs.CD4-positive lymphocytes. Based on the clinical picture and the histological findings, we diagnosed pagetoid reticulosis. Excision of the plaque and cream PUVA photo-chemotherapy produced long-term remission.
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Pagetoide Retikulose (Morbus Woringer-Kolopp)
Journal Der Deutschen Dermatologischen Gesellschaft, 2008Co-Authors: V Lichte, Gisela Metzler, Annette Geyer, Kamran Ghoreschi, Martin Röcken, Mathias Mohrle, Martin SchallerAbstract:Summary Pagetoid reticulosis (Woringer-Kolopp Disease) is a rare subtype of cutaneous CD8-positive T-cell lymphoma. A 41-year-old man presented with a 7-year history with a slowly progressive erythematous plaque on his right buttocks. With the working diagnosis of psoriasis, he was treated with topical corticosteroids which produced no improvement. Histological examination showed an epidermotropic T-cell lymphoma with predominance of CD8- vs.CD4-positive lymphocytes. Based on the clinical picture and the histological findings, we diagnosed pagetoid reticulosis. Excision of the plaque and cream PUVA photo-chemotherapy produced long-term remission.
