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Chengjian Zheng - One of the best experts on this subject based on the ideXlab platform.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
Khalid Rahman - One of the best experts on this subject based on the ideXlab platform.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
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authentication and quantitative analysis on the chemical profile of Xanthium fruit cang er zi by high performance liquid chromatography diode array detection tandem mass spectrometry method
Analytica Chimica Acta, 2009Co-Authors: Qiaoyan Zhang, Khalid Rahman, Hong Zhang, Yang Wang, Baokang Huang, Hanchen ZhengAbstract:Abstract A high-performance liquid chromatographic method using diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD–ESI-MS/MS) was developed for the qualitative and quantitative analysis on Xanthium fruit, a commonly used traditional Chinese medicine. In this study, 7 characteristic components, 1-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, chlorogenic acid, 1,5-O-di-caffeoylquinic acid, 1,3-O-di-caffeoylquinic acid, 4,5-O-di-caffeoylquinic acid and 1,3,5-O-tri-caffeoylquinic acid were identified and quantified by a validated HPLC-DAD method, and a fingerprint comprised of 12 markers was established under the same operating conditions. Furthermore, HPLC–ESI-MS/MS method was successfully used to deduce the structure of three main constituents. On the basis of the established chromatographic profiles, 30 populations of cocklebur samples including 3 related species and 1 unknown species were divided into 3 chemotypes, indicated that place of origin significantly influences the kinds and content of components in cocklebur, and hence affects their quality. The simultaneous determination of 7 caffeoylquinic acids in the 30 samples showed a great variety in the amounts of caffeoylquinic acids present. The study indicated that some species such as Xanthium mongolicum of the genus Xanthium might be suitable for development as new alternative sources of caffeoylquinic acids to supplement the officially listed Xanthium species, and the abundant constituents such as chlorogenic acid perhaps should be recorded in some authorized publications and applied to the quality control or quality evaluation for Xanthium in China. The entire analytical procedure is reproducible and suitable for the authentication and quantification of Xanthium fruits.
Yong Zhao - One of the best experts on this subject based on the ideXlab platform.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
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anti arthritic activity of Xanthium strumarium l extract on complete freund s adjuvant induced arthritis in rats
Journal of Ethnopharmacology, 2014Co-Authors: Yong Zhao, Khalid Rahman, Chengjian ZhengAbstract:Abstract Ethnopharmacological relevance Xanthium strumarium L. fruit (Xanthiu fruit) has been traditionally used as a medicinal herb in China for the treatment of many ailments including rheumatoid arthritis. However, the anti-arthritic activity of Xanthium strumarium fruit has still not been demonstrated. In the present study, we confirmed that the extract of Xanthium strumarium (EXS) prevents rheumatoid arthritis induced by Complete Freund׳s Adjuvant (CFA) in rats. Materials and methods Male Wistar rats (160±10 g) were immunized by intradermal injection of 0.1 mL of CFA into the left hind metatarsal footpad. EXS was administered orally at a dose of 300 and 75 mg/kg once a day after the induction of adjuvant arthritis. Methotrexate (3 mg/kg, twice a week) was used as a positive control. Paw swelling, arthritic score, body weight loss, spleen index, thymus index, serum cytokines, inflammatory mediators and histological change were measured. The chemical profile of EXS was analyzed by HPLC-DAD. Results We found that the EXS significantly suppressed paw swelling and arthritic score, increased body weight loss and decreased the thymus index. The overproduction of TNF-α and IL-1β were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. The level of COX-2 and 5-LOX was also decreased with EXS treatment. Ten phenolic acid derivatives were identified from 14 detected peaks by HPLC-DAD with the reference substances and verified by LC–MS. Conclusions These results suggest the potential effect of EXS as an anti-arthritis agent towards CFA-induced arthritis in rats. Xanthium strumarium has the potential to be regarded as a candidate for use in general therapeutics and as an immune-modulatory medicine in rheumatoid arthritis.
Js Pasricha - One of the best experts on this subject based on the ideXlab platform.
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pattern of cross sensitivity between 4 compositae plants parthenium hysterophorus Xanthium strumarium helianthus annuus and chrysanthemum coronarium in indian patients
Contact Dermatitis, 1994Co-Authors: Th. Nandakishore, Js PasrichaAbstract:To assess the pattern of cross-sensitivity between 4 members of the Compositae family, namely Parthenium hysterophorus L., Xanthium strumarium L., Helianthus annuus L. and Chrysanthemum coronarium L., 63 patients clinically diagnosed to have airborne contact dermatitis, and 51 controls having well-defined patterns of contact dermatitis caused by agents other than plants, were patch tested with measured amounts of standardized aqueous extracts of these plants. Positive reactions were obtained in 62 patients and 13 controls with Parthenium hysterophorus, in 47 patients and 9 controls with Xanthium strumarium, in 7 patients and 2 controls with Helianthus annuus. and in 13 of the 57 patients and one out of 28 controls tested with Chrysanthemum coronarium. 2 patients were allergic to all 4 of the plants; 14 patients to 3 plants, namely Parthenium. Xanthium and Chrysanthemum in 9 cases and Parthenium. Xanthium and Helianthus in 5 cases; 32 patients to 2 plants, namely Parthenium and Xanthium in 30 cases, and Parthenium and Chrysanthemum, and Xanthium and Chrysanthemum in 1 case each; 15 patients were allergic to 1 plant only, that being Parthenium. All the 47 patients allergic to Xanthium. 13 patients allergic to Chrysanthemum and 7 patients allergic to Helianthus were positive with some other plant as well. There was 1 patient who was allergic to Xanthium and Chrysanthemum but not to Parthenium. The titre of contact hypersensitivity (TCH) determined in the patients allergic to Parthenium, Xanthium and Helianthus showed values that varied widely with each plant in different patients, and there was no parallelism between the TCH with various plants. In 36 patients, the TCH was highest with Parthenium and in 3 patients with Xanthium. In 7 patients the TCH was the same with Parthenium and Xanthium The TCH with Helianthus was lower than or equal to that with the other plants. Thus, it seems that most of the patients in this group were primarily sensitized to Parthenium, while in a few cases Xanthium was the primary sensitizer. Several of these cross-reacted with other Compositae plants. One patient from Srinagar, where Chrysanthemum is more prevalent while Parthenium has not yet infiltrated, showed the severest patch test reaction to Chrysanthemum, while the reactions to Parthenium and Xanthium were milder. He was possibly sensitized primarily to Chrysanthemum and cross-reacted with Parthenium and Xanthium.
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a high rate of cross sensitivity between parthenium hysterophorus and Xanthium strumarium in indian patients with contact dermatitis
Journal of The European Academy of Dermatology and Venereology, 1994Co-Authors: Js PasrichaAbstract:Parthenium hysterophorus is well known to produce contact dermatitis in India. Xanthium strumarium is another weed also belonging to the Compositae family present in India since much earlier times, but not recognised among the plants causing contact dermatitis. We have found a very high rate of cross-sensitivity between the two plants in patients presenting air-borne contact dermatitis. Of the 28 patients with air-borne contact dermatitis. 22 revealed positive patch tests with aqueous extracts of both plants, one patient showed a negative patch test with Parthenium hysterophorus and a positive test with Xanthium strumarium, while five patients were negative with both plants. In a control group of 15 patients with contact dermatitis due to other agents, only one patient showed a positive patch test with Xanthium strumarium, while the patch test with Parthenium hysterophorus was negative. Patch tests performed with serial 10-fold dilutions of standard extracts of both plants to determine the degree (titre) of contact hypersensitivity (TCH) revealed variable litres in different patients. Some patients had a much higher titre with Parthenium hysterophorus while others had a higher titre with Xanthium strumarium. The antigen in Xanthium strumarium, like that of Parthenium hysterophorus, could be extracted with water, acetone, ethanol, chloroform, benzene, ether and carbon tetrachloride. Infra-red spectrophotometry of extracts in ether revealed similar spectra in the two plants. The antigens in the two plants seem lo be very similar.
Hai Jiang - One of the best experts on this subject based on the ideXlab platform.
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two new monoterpene glucosides from Xanthium strumarium subsp sibiricum with their anti inflammatory activity
Natural Product Research, 2019Co-Authors: Hai Jiang, Xudong Xing, Lin Yang, Liu YangAbstract:AbstractTwo new monoterpene glucosides: xanmonoter A (1) and xanmonoter B (2) were isolated from Xanthium strumarium. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analy...
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Two new monoterpene glucosides from Xanthium strumarium subsp. sibiricum with their anti-inflammatory activity
2019Co-Authors: Hai Jiang, Xudong Xing, Lin Yang, Meiling Yan, Xinyue Guo, Liu YangAbstract:Two new monoterpene glucosides: xanmonoter A (1) and xanmonoter B (2) were isolated from Xanthium strumarium. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested for their anti-inflammatory activity with IC50 values of 17.4, 22.1 μM, respectively.
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new phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti inflammatory activity
Fitoterapia, 2017Co-Authors: Hai Jiang, Xudong Xing, Qiuhong Wang, Liu Yang, Yanyan Zhang, Meiling Yan, Bingyou Yang, Haixue KuangAbstract:Abstract The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as Xanthiumnolics A–E (1–5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC50 value of 8.73 μM.
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rearranged ent kauranoid glycosides from the fruits of Xanthium strumarium and their antiproliferative activity
Phytochemistry Letters, 2016Co-Authors: Xudong Xing, Qiuhong Wang, Haixue Kuang, Liu Yang, Hai Jiang, Yanyan Zhang, Xudong XuAbstract:Abstract Three new ent-kauranoid glycosides, fructusnoids A-C (1-3) were isolated from the fruits of Xanthium strumarium. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and HRESIMS data. Compounds 1-2 are novel examples of rearranged ent-kauranoid diterpenes with missing C-18/19 carbons. All the compounds were evaluated for their antiproliferative activity in vitro against three human cancer cell lines, and compound 3 showed selective cytotoxic activity against the AGS cancer cell line with an IC50 value of 7.6 μM.
