The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Edgar Selvaag - One of the best experts on this subject based on the ideXlab platform.
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Photohemolysis Due to Diuretic Drugs
Journal of Toxicology-cutaneous and Ocular Toxicology, 2008Co-Authors: Edgar SelvaagAbstract:AbstractThe diuretics acetazolamide, bemetizide, bendroflumethiazide, benzthizide, benzylhydrochlorothiazide, bumetanide, butizide, chlorazanile, chlorothiazide, chlortalidone, clopamide, cyclopenthiazide, cyclothiazide, diazoxide, etozoline, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, mefruside, metolazone, piretanide, polythiazide, trichlormethiazide, and Xipamide were screened in vitro for phototoxic effects by the means of a photo- hemolysis test. Suspensions of red blood cells and test substances were irradiated with ultraviolet B (UVB) (TL 20W/12 light bulbs), ultraviolet A (UVA; UVASUN 5000 apparatus), visible light (prototype, VL lamp), or with solar-simulating radiation (SOL 3 lamp). In all, 19 of the 25 tested compounds exhibited phototoxic hemolysis in this model. Eight known photosensitizers described as inducing clinical photosensitivity in humans were identified in this model. In addition, 11 diuretics not previously described as exerting photosensitizing side effects in...
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Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: comparative in-vitro and in-vivo investigations
Photochemotherapy: Photodynamic Therapy and Other Modalities III, 1997Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:Seven oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide, and tolbutamide), and 14 diuretics (bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide, and Xipamide) were investigated for potential phototoxicity in vitro using a cell culture model and in vivo in hairless mice. After exposure to broad band UVA, the majority of the substances tested in vitro yielded phototoxic action leading to loss of culture forming ability. In vivo, all tested substances induced edema or ulceration, and lead to a significant increase in skin fold thickness of the mouse skin. In all a number of substances not described to induce clinical photosensitivity nor phototoxicity in vitro or in vivo were detected in our testing. In determining potential photosensitizers, it seems important to utilize different test methods, as not all substances will exhibit action in a given assay.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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Cell cultures in the investigation of thiazide phototoxicity.
Naunyn-schmiedebergs Archives of Pharmacology, 1997Co-Authors: Edgar SelvaagAbstract:The NHIK 3025 cell line (Norsk Hydro Institutt for Kreftforskning), a human in situ carcinoma of the cervix cell line, was used to investigate the thiazides bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and Xipamide for their potential phototoxic properties. Cell death following UVA irradiation and dependent on test substance concentration was observed in the presence of all the tested substances except chlortalidone, furosemide, indapamide and Xipamide. Bendroflumethiazide was phototoxic at concentrations of 0.05mM and higher; bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 0.25mM and higher and butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 0.5mM and higher.
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In Vitro Phototoxicity Due to Sulfonamide-Derived Oral Antidiabetic and Diuretic Drugs
Journal of Toxicology-cutaneous and Ocular Toxicology, 1997Co-Authors: Edgar SelvaagAbstract:AbstractThe sulfonamide-derived oral antidiabetic agents chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide, and tolbutamide, and the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, tubizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide, and Xipamide were investigated for phototoxicity in a cell culture model. Cell death dependent on ultraviolet A (UVA) fluence and test substance concentration was observed in the presence of the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, hydrochlorothiazide, hydroflumethiazide, piretanide, polythiazide, and trichlormethiazide. Bendroflumethiazide was phototoxic at concentrations of 5 × 10−5 M and higher; bemetizide, benzylhydrochlorothiazide, bumetanide, and hydroflumethiazide were phototoxic at concentrations of 2.5 × 10−4 ...
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Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations
in Vivo, 1997Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:The oral antidiabetics chlorpropamide, glibenclamide, glipizide, gliquiudone, glymidine, tolazamide and tolbutamide, and the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide, and Xipamide were investigated for potential phototoxicity in vitro using a cell culture model, and in vivo in hairless mice. After exposure to broad band UVA, the majority of the substances tested in vitro yielded a phototoxic action leading to loss of culture forming ability. In vivo, all tested substances induced edema or ulceration, and lead to a significantly increase in skin fold thickness of the mouse skin. In all, a number of substances not described to induce clinical photosensitivity nor phototoxicity in vitro or in vivo were detected in our testing. When determining potential photosensitizers, it seems important to utilize different test methods, as not all substances will exhibit action in a given assay.
Per Thune - One of the best experts on this subject based on the ideXlab platform.
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Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: comparative in-vitro and in-vivo investigations
Photochemotherapy: Photodynamic Therapy and Other Modalities III, 1997Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:Seven oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide, and tolbutamide), and 14 diuretics (bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide, and Xipamide) were investigated for potential phototoxicity in vitro using a cell culture model and in vivo in hairless mice. After exposure to broad band UVA, the majority of the substances tested in vitro yielded phototoxic action leading to loss of culture forming ability. In vivo, all tested substances induced edema or ulceration, and lead to a significant increase in skin fold thickness of the mouse skin. In all a number of substances not described to induce clinical photosensitivity nor phototoxicity in vitro or in vivo were detected in our testing. In determining potential photosensitizers, it seems important to utilize different test methods, as not all substances will exhibit action in a given assay.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations
in Vivo, 1997Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:The oral antidiabetics chlorpropamide, glibenclamide, glipizide, gliquiudone, glymidine, tolazamide and tolbutamide, and the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide, and Xipamide were investigated for potential phototoxicity in vitro using a cell culture model, and in vivo in hairless mice. After exposure to broad band UVA, the majority of the substances tested in vitro yielded a phototoxic action leading to loss of culture forming ability. In vivo, all tested substances induced edema or ulceration, and lead to a significantly increase in skin fold thickness of the mouse skin. In all, a number of substances not described to induce clinical photosensitivity nor phototoxicity in vitro or in vivo were detected in our testing. When determining potential photosensitizers, it seems important to utilize different test methods, as not all substances will exhibit action in a given assay.
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Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures Investigations with sulphonamide-derived oral antidiabetics and diuretics
Journal of Photochemistry and Photobiology B-biology, 1997Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:The sulphonamide-derived oral antidiabetics chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide, and the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and Xipamide were investigated for phototoxicity in a cell culture model. Cell death dependent on ultraviolet A (UVA) radiation fluence and test substance concentration was observed in the presence of the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, hydrochlorothiazide, hydroflumethiazide, piretanide, polythiazide and trichlormethiazide. Bendroflumethiazide was phototoxic at concentrations of 0.05 mM and above; bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at concentrations of 0.25 mM or more; the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at concentrations of 0.5 mM. To evaluate the effects of antioxidants, ascorbic acid, alpha-tocopherol, beta-carotene or ubiquinone was added to the tissue culture flasks before irradiation. The phototoxic inhibition of the colony-forming ability was largely reduced by the addition of ascorbic acid and alpha-tocopherole, indicating the involvement of reactive oxygen species in the phototoxic process.
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Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model
Photodermatology Photoimmunology and Photomedicine, 1996Co-Authors: Edgar Selvaag, Helle Anholt, Johan Emelian Moan, Per ThuneAbstract:A number of sulphonamide-derived oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide) and diuretics (bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and Xipamide) were investigated for phototoxicity in a cell culture model. Cell death dependent on ultraviolet A fluence and test substance concentration was observed in the presence of the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics bemetizide, bendroflumethiazide, benzyl-hydrochlorothiazide, bumetanide, butizide, hydrochlorothiazide, hydroflumethiazide, piretanide, polythiazide and trichlormethiazide. Bendroflumethiazide was phototoxic at 5times10−5 M and higher concentrations, bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 2.5times10−4 M and higher concentrations, and the oral antidiabetics glibenclamide and gliquidone as well as the diuretics butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 5−4 M and higher concentrations. Electron microscopic investigations showed swelling of mitochondria and endoplasmic reticulum as well as aggregation of euchromatin when the cells were irradiated in the presence of photosensitizers***
Bharti Jain - One of the best experts on this subject based on the ideXlab platform.
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Interaction of Schiff Base Derived from 4-chloro-5-sulfamoyl-2â,6â-salicyloxylidide with Ni(II), Co(II) and Cu(II)
2019Co-Authors: Suparna Ghosh, Suman Malik, Shweta Sharma, Ruchi Sharma, K Anita, Bharti JainAbstract:A new unsymmetrical bidentate Schiff base was synthesized using 4-chloro-5-sulfamoyl-2’,6’-salicyloxylidide (Xipamide) and salicylaldehyde. The Ni(II), Co(II) and Cu(II) complexes of this Schiff base of ML2 type have been synthesized and characterized by elemental analysis, conductivity, magnetic measurements, IR and electronic spectra studies. The conductivity data of the complexes suggests their non-electrolytic nature. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli and Bacillus subtilis and that the complexes have higher activity than that of the Schiff base.
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synthesis spectral and biological studies of some transition metal complexes derived from schiff base of Xipamide drug
Moroccan Journal of Chemistry, 2015Co-Authors: Suparna Ghosh, Suman Malik, Bharti JainAbstract:Transition metal complexes of Mn(II), Fe(II), Ni(II), Co(II) have been synthesized from Schiff base of Xipamide drug, that is, 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2- hydroxybenzamide. Elemental analyses suggest ML 2 stoichiometry for all metals. All the complexes are non-electrolytic in nature as suggested by conductivity data. The ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and phenolic oxygen. Magnetic susceptibility, electronic, IR, ESR spectral studies suggest that the complexes possess octahedral geometry. The ligand and some of the synthesized complexes were screened for their antibacterial and diuretic activity also.
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synthesis characterization and biological evaluation of some 3d metal complexes of schiff base derived from Xipamide drug
International Journal of Inorganic Chemistry, 2013Co-Authors: Suman Malik, Suparna Ghosh, Bharti Jain, Archana Singh, Mamta BhattacharyaAbstract:The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from Xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.
Suparna Ghosh - One of the best experts on this subject based on the ideXlab platform.
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Interaction of Schiff Base Derived from 4-chloro-5-sulfamoyl-2â,6â-salicyloxylidide with Ni(II), Co(II) and Cu(II)
2019Co-Authors: Suparna Ghosh, Suman Malik, Shweta Sharma, Ruchi Sharma, K Anita, Bharti JainAbstract:A new unsymmetrical bidentate Schiff base was synthesized using 4-chloro-5-sulfamoyl-2’,6’-salicyloxylidide (Xipamide) and salicylaldehyde. The Ni(II), Co(II) and Cu(II) complexes of this Schiff base of ML2 type have been synthesized and characterized by elemental analysis, conductivity, magnetic measurements, IR and electronic spectra studies. The conductivity data of the complexes suggests their non-electrolytic nature. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli and Bacillus subtilis and that the complexes have higher activity than that of the Schiff base.
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synthesis spectral and biological studies of some transition metal complexes derived from schiff base of Xipamide drug
Moroccan Journal of Chemistry, 2015Co-Authors: Suparna Ghosh, Suman Malik, Bharti JainAbstract:Transition metal complexes of Mn(II), Fe(II), Ni(II), Co(II) have been synthesized from Schiff base of Xipamide drug, that is, 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2- hydroxybenzamide. Elemental analyses suggest ML 2 stoichiometry for all metals. All the complexes are non-electrolytic in nature as suggested by conductivity data. The ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and phenolic oxygen. Magnetic susceptibility, electronic, IR, ESR spectral studies suggest that the complexes possess octahedral geometry. The ligand and some of the synthesized complexes were screened for their antibacterial and diuretic activity also.
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synthesis characterization and biological evaluation of some 3d metal complexes of schiff base derived from Xipamide drug
International Journal of Inorganic Chemistry, 2013Co-Authors: Suman Malik, Suparna Ghosh, Bharti Jain, Archana Singh, Mamta BhattacharyaAbstract:The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from Xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.
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synthesis and pharmacological studies of some bivalent metal complexes with schiff based ligand derived from Xipamide
Der Pharma Chemica, 2013Co-Authors: Suparna GhoshAbstract:The Zn(II) and Hg(II) complexes of Schiff base derived from Salicylaldehyde and Xipamide have been synthesized keeping in view that some metal complexes are found to be more potent than their parent drugs. The complexes of the type ML2 have been synthesized and characterized on the basis of elemental analysis, conductivity, magnetic measurements, IR and electronic spectral studies. The conductivity data of the complexes also suggests their nonelectrolytic nature. Comparative antimicrobial behavior and particle size analysis of Schiff base with their complexes has also been studied
Magda A Barary - One of the best experts on this subject based on the ideXlab platform.
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bioavailability study of triamterene and Xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination
Journal of Pharmaceutical and Biomedical Analysis, 2012Co-Authors: Hadir M Maher, Eman I Elkimary, Rasha M Youssef, Ekram M Hassan, Magda A BararyAbstract:Abstract An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and Xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array detector (HPLC–DAD) has been developed. The HPLC separation was performed on a RP stainless-steel C-18 analytical column (250 mm × 4.6 mm, 5 μm) with a gradient elution system of 0.05 M phosphate buffer adjusted to pH 4.0 and methanol as the mobile phase. The method was used to determine the urinary excretion profile and to calculate different urinary pharmacokinetic parameters following oral dose of their combination compared with single oral doses of each drug and hence comparing their bioavailability. Quantitation was performed using chlorthalidone as internal standard. The calibration graphs of each drug were rectilinear in the range of 0.2–40 μg/mL urine for TRI and 0.2–15 μg/mL urine for XIP. An HPLC–DAD method was also successfully developed for the simultaneous determination of the investigated drugs in pharmaceutical preparations. The methods were validated in terms of linearity, accuracy, precision, selectivity, limits of detection and quantitation and other aspects of analytical validation.
