The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Soon Hyeok Hong - One of the best experts on this subject based on the ideXlab platform.
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highly regioselective and e z selective hydroalkylation of Ynone ynoate and ynamide via photoredox mediated ni ir dual catalysis
Organic Letters, 2018Co-Authors: Geun Seok Lee, Soon Hyeok HongAbstract:Exclusively α- and highly E/Z-selective hydroalkylation of Ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization.
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Highly Regioselective and E/Z‑Selective Hydroalkylation of Ynone, Ynoate, and Ynamide via Photoredox Mediated Ni/Ir Dual Catalysis
2018Co-Authors: Geun Seok Lee, Soon Hyeok HongAbstract:Exclusively α- and highly E/Z-selective hydroalkylation of Ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization
Joseph P A Harrity - One of the best experts on this subject based on the ideXlab platform.
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synthesis of bifunctional thiophenes via fiesselmann condensation of Ynone trifluoroborate salts
Organic Letters, 2018Co-Authors: Prisca Fricero, Laurent Bialy, Werngard Czechtizky, Maria Mendez, Joseph P A HarrityAbstract:Ynone trifluoroborate salts undergo a base-promoted condensation reaction with alkylthiols to generate thiophene boronates with complete regiocontrol. The products are isolated in high yield and can be further derivatized through conventional C-B bond functionalization reactions.
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synthesis of Ynone trifluoroborates toward functionalized pyrazoles
ChemInform, 2013Co-Authors: James D Kirkham, Steven J Edeson, Stephen Stokes, Joseph P A HarrityAbstract:Coupling of novel Ynone trifluoroborates like (III) with hydrazines provides a new, efficient, and regioselective approach to pyrazole trifluoroborates as precursors of diverse pyrazole derivatives.
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synthesis of Ynone trifluoroborates toward functionalized pyrazoles
Organic Letters, 2012Co-Authors: James D Kirkham, Steven J Edeson, Stephen Stokes, Joseph P A HarrityAbstract:The synthesis of a range of novel Ynone trifluoroborates has been achieved, in a two-pot process from propargylic alcohols. These alkynes have been subsequently used in the formation of a range of pyrazole trifluoroborate salts via cyclization with hydrazines. The products are generated with high levels of regiocontrol and in excellent yields and represent versatile synthetic intermediates.
Geun Seok Lee - One of the best experts on this subject based on the ideXlab platform.
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highly regioselective and e z selective hydroalkylation of Ynone ynoate and ynamide via photoredox mediated ni ir dual catalysis
Organic Letters, 2018Co-Authors: Geun Seok Lee, Soon Hyeok HongAbstract:Exclusively α- and highly E/Z-selective hydroalkylation of Ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization.
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Highly Regioselective and E/Z‑Selective Hydroalkylation of Ynone, Ynoate, and Ynamide via Photoredox Mediated Ni/Ir Dual Catalysis
2018Co-Authors: Geun Seok Lee, Soon Hyeok HongAbstract:Exclusively α- and highly E/Z-selective hydroalkylation of Ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization
Sayuri Sugiyama - One of the best experts on this subject based on the ideXlab platform.
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Conjugate addition of an Ynone containing azulene with a tertiary amine
Tetrahedron Letters, 2016Co-Authors: Jun-ichi Yamaguchi, Sayuri SugiyamaAbstract:Abstract Treatment of an Ynone-bearing azulene with tertiary amines resulted in transformation of the corresponding enaminone in high yield. The product ratio depended on the group at the structure of the amine. Investigation of the reaction mechanism indicated that treatment of the Ynone with a tertiary amine gave the corresponding ammonium salt, followed by removal of an alkyl group to form the enaminone as the final product. The color of the enaminone was different than that of the Ynone.
Michal Szostak - One of the best experts on this subject based on the ideXlab platform.
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cuii catalyzed coupling with two Ynone units by selective triple and sigma c c and c h bond cleavages
Organic Letters, 2021Co-Authors: Jiang Nan, Jiawen Zhang, Chao Wang, Tingting Wang, Weitao Wang, Michal SzostakAbstract:We report a new copper-catalyzed [2 + 2 + 1] annulation process through the selective cleavage of sigma and triple C-C and C-H bonds using two Ynone units. This new methodology involves breaking multiple chemical bonds in a single operation, including C≡C, C-C, C-H, and N-O. These high-value adducts lead to a diverse collection of synthetically challenging trisubstituted indolizines by the simultaneous engagement of different bond-breaking events and show excellent fluorescence in green aqueous solutions.