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Jon M Arnemo - One of the best experts on this subject based on the ideXlab platform.
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a double blinded randomized comparison of medetomidine tiletamine Zolazepam and dexmedetomidine tiletamine Zolazepam anesthesia in free ranging brown bears ursus arctos
PLOS ONE, 2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:We compared anesthetic features, blood parameters, and physiological responses to either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam using a double-blinded, randomized experimental design during 40 anesthetic events of free-ranging brown bears (Ursus arctos) either captured by helicopter in Sweden or by culvert trap in Canada. Induction was smooth and predictable with both anesthetic protocols. Induction time, the need for supplemental drugs to sustain anesthesia, and capture-related stress were analyzed using generalized linear models, but anesthetic protocol did not differentially affect these variables. Arterial blood gases and acid-base status, and physiological responses were examined using linear mixed models. We documented acidemia (pH of arterial blood < 7.35), hypoxemia (partial pressure of arterial oxygen < 80 mmHg), and hypercapnia (partial pressure of arterial carbon dioxide ≥ 45 mmHg) with both protocols. Arterial pH and oxygen partial pressure were similar between groups with the latter improving markedly after oxygen supplementation (p < 0.001). We documented dose-dependent effects of both anesthetic protocols on induction time and arterial oxygen partial pressure. The partial pressure of arterial carbon dioxide increased as respiratory rate increased with medetomidine-tiletamine-Zolazepam, but not with dexmedetomidine-tiletamine-Zolazepam, demonstrating a differential drug effect. Differences in heart rate, respiratory rate, and rectal temperature among bears could not be attributed to the anesthetic protocol. Heart rate increased with increasing rectal temperature (p < 0.001) and ordinal day of capture (p = 0.002). Respiratory rate was significantly higher in bears captured by helicopter in Sweden than in bears captured by culvert trap in Canada (p < 0.001). Rectal temperature significantly decreased over time (p ≤ 0.05). Overall, we did not find any benefit of using dexmedetomidine-tiletamine-Zolazepam instead of medetomidine-tiletamine-Zolazepam in the anesthesia of brown bears. Both drug combinations appeared to be safe and reliable for the anesthesia of free-ranging brown bears captured by helicopter or by culvert trap.
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Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidin
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam in Sweden and Alberta, Canada in 2014–2015.
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Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 201
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 2014–2015.
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Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bear
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bears captured in Sweden and Alberta, Canada in 2014–2015.
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Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Swed
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Sweden (S, N = 34) and Alberta, Canada (A, N = 6) in 2014–2015.
Nuria Fandos Esteruelas - One of the best experts on this subject based on the ideXlab platform.
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a double blinded randomized comparison of medetomidine tiletamine Zolazepam and dexmedetomidine tiletamine Zolazepam anesthesia in free ranging brown bears ursus arctos
PLOS ONE, 2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:We compared anesthetic features, blood parameters, and physiological responses to either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam using a double-blinded, randomized experimental design during 40 anesthetic events of free-ranging brown bears (Ursus arctos) either captured by helicopter in Sweden or by culvert trap in Canada. Induction was smooth and predictable with both anesthetic protocols. Induction time, the need for supplemental drugs to sustain anesthesia, and capture-related stress were analyzed using generalized linear models, but anesthetic protocol did not differentially affect these variables. Arterial blood gases and acid-base status, and physiological responses were examined using linear mixed models. We documented acidemia (pH of arterial blood < 7.35), hypoxemia (partial pressure of arterial oxygen < 80 mmHg), and hypercapnia (partial pressure of arterial carbon dioxide ≥ 45 mmHg) with both protocols. Arterial pH and oxygen partial pressure were similar between groups with the latter improving markedly after oxygen supplementation (p < 0.001). We documented dose-dependent effects of both anesthetic protocols on induction time and arterial oxygen partial pressure. The partial pressure of arterial carbon dioxide increased as respiratory rate increased with medetomidine-tiletamine-Zolazepam, but not with dexmedetomidine-tiletamine-Zolazepam, demonstrating a differential drug effect. Differences in heart rate, respiratory rate, and rectal temperature among bears could not be attributed to the anesthetic protocol. Heart rate increased with increasing rectal temperature (p < 0.001) and ordinal day of capture (p = 0.002). Respiratory rate was significantly higher in bears captured by helicopter in Sweden than in bears captured by culvert trap in Canada (p < 0.001). Rectal temperature significantly decreased over time (p ≤ 0.05). Overall, we did not find any benefit of using dexmedetomidine-tiletamine-Zolazepam instead of medetomidine-tiletamine-Zolazepam in the anesthesia of brown bears. Both drug combinations appeared to be safe and reliable for the anesthesia of free-ranging brown bears captured by helicopter or by culvert trap.
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Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidin
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam in Sweden and Alberta, Canada in 2014–2015.
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Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 201
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 2014–2015.
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Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bear
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bears captured in Sweden and Alberta, Canada in 2014–2015.
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Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Swed
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Sweden (S, N = 34) and Alberta, Canada (A, N = 6) in 2014–2015.
Nicholas J Kenyon - One of the best experts on this subject based on the ideXlab platform.
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injectable anesthesia for mice combined effects of dexmedetomidine tiletamine Zolazepam and butorphanol
Anesthesiology Research and Practice, 2017Co-Authors: Leslie A Cagle, Steven E Epstein, Lisa M. Franzi, Philip H Kass, Nicholas J KenyonAbstract:Anesthetic protocols for murine models are varied within the literature and medetomidine has been implicated in the development of urethral plugs in male mice. Our objective was to evaluate the combination of butorphanol, dexmedetomidine, and tiletamine-Zolazepam. A secondary objective was to identify which class of agent was associated with urethral obstructions in male mice. BALB/c male () and female () mice were assigned to dexmedetomidine and tiletamine-Zolazepam with or without butorphanol or to single agent dexmedetomidine or tiletamine-Zolazepam. Anesthesia was achieved in 58% (14/24) of mice without butorphanol and in 100% (24/24) of mice with butorphanol. The combination of dexmedetomidine (0.2 mg/kg), tiletamine-Zolazepam (40 mg/kg), and butorphanol (3 mg/kg) resulted in an induction and anesthetic duration of 12 and 143 minutes, respectively. Urethral obstructions occurred in 66% (25/38) of trials in male mice that received dexmedetomidine with a mortality rate of 38% (5/13). Tiletamine-Zolazepam, when used alone, resulted in a 0% (0/21) incidence of urethral obstructions. Combination use of dexmedetomidine, tiletamine-Zolazepam, and butorphanol results in a longer and more reliable duration of anesthesia than the use of dexmedetomidine and tiletamine-Zolazepam alone. Dexmedetomidine is not recommended for use in nonterminal procedures in male mice due to the high incidence of urethral obstructions and resultant high mortality rate.
Alina L. Evans - One of the best experts on this subject based on the ideXlab platform.
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a double blinded randomized comparison of medetomidine tiletamine Zolazepam and dexmedetomidine tiletamine Zolazepam anesthesia in free ranging brown bears ursus arctos
PLOS ONE, 2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:We compared anesthetic features, blood parameters, and physiological responses to either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam using a double-blinded, randomized experimental design during 40 anesthetic events of free-ranging brown bears (Ursus arctos) either captured by helicopter in Sweden or by culvert trap in Canada. Induction was smooth and predictable with both anesthetic protocols. Induction time, the need for supplemental drugs to sustain anesthesia, and capture-related stress were analyzed using generalized linear models, but anesthetic protocol did not differentially affect these variables. Arterial blood gases and acid-base status, and physiological responses were examined using linear mixed models. We documented acidemia (pH of arterial blood < 7.35), hypoxemia (partial pressure of arterial oxygen < 80 mmHg), and hypercapnia (partial pressure of arterial carbon dioxide ≥ 45 mmHg) with both protocols. Arterial pH and oxygen partial pressure were similar between groups with the latter improving markedly after oxygen supplementation (p < 0.001). We documented dose-dependent effects of both anesthetic protocols on induction time and arterial oxygen partial pressure. The partial pressure of arterial carbon dioxide increased as respiratory rate increased with medetomidine-tiletamine-Zolazepam, but not with dexmedetomidine-tiletamine-Zolazepam, demonstrating a differential drug effect. Differences in heart rate, respiratory rate, and rectal temperature among bears could not be attributed to the anesthetic protocol. Heart rate increased with increasing rectal temperature (p < 0.001) and ordinal day of capture (p = 0.002). Respiratory rate was significantly higher in bears captured by helicopter in Sweden than in bears captured by culvert trap in Canada (p < 0.001). Rectal temperature significantly decreased over time (p ≤ 0.05). Overall, we did not find any benefit of using dexmedetomidine-tiletamine-Zolazepam instead of medetomidine-tiletamine-Zolazepam in the anesthesia of brown bears. Both drug combinations appeared to be safe and reliable for the anesthesia of free-ranging brown bears captured by helicopter or by culvert trap.
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Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidin
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam in Sweden and Alberta, Canada in 2014–2015.
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Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 201
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 2014–2015.
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Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bear
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bears captured in Sweden and Alberta, Canada in 2014–2015.
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Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Swed
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Sweden (S, N = 34) and Alberta, Canada (A, N = 6) in 2014–2015.
Andreas Zedrosser - One of the best experts on this subject based on the ideXlab platform.
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a double blinded randomized comparison of medetomidine tiletamine Zolazepam and dexmedetomidine tiletamine Zolazepam anesthesia in free ranging brown bears ursus arctos
PLOS ONE, 2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:We compared anesthetic features, blood parameters, and physiological responses to either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam using a double-blinded, randomized experimental design during 40 anesthetic events of free-ranging brown bears (Ursus arctos) either captured by helicopter in Sweden or by culvert trap in Canada. Induction was smooth and predictable with both anesthetic protocols. Induction time, the need for supplemental drugs to sustain anesthesia, and capture-related stress were analyzed using generalized linear models, but anesthetic protocol did not differentially affect these variables. Arterial blood gases and acid-base status, and physiological responses were examined using linear mixed models. We documented acidemia (pH of arterial blood < 7.35), hypoxemia (partial pressure of arterial oxygen < 80 mmHg), and hypercapnia (partial pressure of arterial carbon dioxide ≥ 45 mmHg) with both protocols. Arterial pH and oxygen partial pressure were similar between groups with the latter improving markedly after oxygen supplementation (p < 0.001). We documented dose-dependent effects of both anesthetic protocols on induction time and arterial oxygen partial pressure. The partial pressure of arterial carbon dioxide increased as respiratory rate increased with medetomidine-tiletamine-Zolazepam, but not with dexmedetomidine-tiletamine-Zolazepam, demonstrating a differential drug effect. Differences in heart rate, respiratory rate, and rectal temperature among bears could not be attributed to the anesthetic protocol. Heart rate increased with increasing rectal temperature (p < 0.001) and ordinal day of capture (p = 0.002). Respiratory rate was significantly higher in bears captured by helicopter in Sweden than in bears captured by culvert trap in Canada (p < 0.001). Rectal temperature significantly decreased over time (p ≤ 0.05). Overall, we did not find any benefit of using dexmedetomidine-tiletamine-Zolazepam instead of medetomidine-tiletamine-Zolazepam in the anesthesia of brown bears. Both drug combinations appeared to be safe and reliable for the anesthesia of free-ranging brown bears captured by helicopter or by culvert trap.
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Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidin
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Induction time (time interval from when a bear was darted to recumbency, in minutes) by tiletamine-Zolazepam dose level (in mg/kg body weight) and age class in 34 anesthetic events of free-ranging brown bears using a single dart of either medetomidine-tiletamine-Zolazepam or dexmedetomidine-tiletamine-Zolazepam in Sweden and Alberta, Canada in 2014–2015.
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Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 201
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Respiratory rate (breaths/minute) over time following administration by drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 34 anesthetic events of free-ranging brown bears captured in Sweden in 2014–2015.
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Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bear
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Partial pressure of arterial carbon dioxide (PaCO2, mmHg) by respiratory rate (breaths/minute) and drug combination (MTZ: medetomidine-tiletamine-Zolazepam; DTZ: dexmedetomidine-tiletamine-Zolazepam) in 40 anesthetic events of free-ranging brown bears captured in Sweden and Alberta, Canada in 2014–2015.
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Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Swed
2017Co-Authors: Nuria Fandos Esteruelas, Gordon B. Stenhouse, Marc Cattet, Susanne Küker, Alina L. Evans, Andreas Zedrosser, Jon M ArnemoAbstract:Response and predictor variables (interactions not shown), model types, and sample sizes (N) used to test hypotheses in brown bears anesthetized with either medetomidine-tiletamine-Zolazepam (MTZ) or dexmedetomidine-tiletamine-Zolazepam (DTZ) in Sweden (S, N = 34) and Alberta, Canada (A, N = 6) in 2014–2015.