The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Steven G Withers - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 1 Amino 1 2 5 trideoxy 2 5 imino d mannitol a novel analogue of the powerful glucosidase inhibitor 2 5 dideoxy 2 5 imino d mannitol via an amadori rearrangement of 5 azido 5 deoxy d glucofuranose
Tetrahedron Letters, 1997Co-Authors: Tanja M Wrodnigg, Arnold E. Stütz, Steven G WithersAbstract:Abstract By an Amadori rearrangement of easily available 5-azido-5-deoxy- d -glucofuranose with dibenzylamine and subsequent catalytic hydrogenation of the resulting 5-azido-1-dibenzylAmino-1,5-dideoxy- d -fructopyranose, the new 1-Amino-1,2,5-trideoxy-2,5-imino- d -mannitol was obtained in only two steps and excellent overall yield. Likewise, other amines and/or other 5-modified hexofuranoses can be used to advantage. The reported rearrangement reaction is a high yielding, convenient and apparently general entry to 1-Aminodeoxyketopyranoses modified at C-5, facilitated by the ring enlargement of the aldofuranose to the ketopyranose as an additional driving force.
Viresh H Rawal - One of the best experts on this subject based on the ideXlab platform.
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diels alder reactions of 1 alkoxy 1 Amino 1 3 butadienes direct synthesis of 6 substituted and 6 6 disubstituted 2 cyclohexenones and 6 substituted 5 6 dihydropyran 2 ones
Organic Letters, 2021Co-Authors: Pavel K Elkin, Nathaniel D Durfee, Viresh H RawalAbstract:We report the cycloaddition reactions of 1-alkoxy-1-Amino-1,3-butadienes. These doubly activated dienes are prepared on a multigram scale from crotonic acid chloride and its derivatives. The dienes undergo Diels-Alder (DA) and hetero-Diels-Alder (HDA) reactions under mild reaction conditions with a variety of electron-deficient dienophiles to afford cycloadducts in good yields with excellent regioselectivities. The hydrolysis of the DA cycloadducts provides 6-substituted and 6,6-disubstituted 2-cylohexenones, which are versatile building blocks for complex molecule synthesis. The corresponding HDA cycloadducts afford 6-substituted 5,6-dihydropyran-2-ones.
Andrzej Pilc - One of the best experts on this subject based on the ideXlab platform.
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trans 1 Amino 1 3 cyclopentanedicarboxylate trans acpd stimulates camp accumulation in rat cerebral cortical slices but not in glial or neuronal cell cultures
Neuroscience Letters, 1994Co-Authors: Andrzej Pilc, Beata Legutko, Tadeusz Frankiewicz, A CzyrakAbstract:Abstract Recent cloning experiments indicate that multiple metabotropic receptors for excitatory Amino acids (EAAs) exist, which are coupled to adenylate cyclase. Trans-(±)-1-Amino-1, 3-cyclopentanedicarboxylate (trans-ACPD) is a selective agonist of metabotropic receptors for EAAs. One of the effects of trans-ACPD is stimulation of cAMP accumulation. In the present experiments, cAMP accumulation was measured using a [3H]adenine-prelabelling technique. It has been found that trans-ACPD was able to induce significant stimulation of cAMP accumulation in rat cerebral cortical slices, with ED50 of 47.8 μM, which value is similar to that described earlier for hippocampal slices. However, trans-ACPD had no effect on cAMP accumulation either in primary neuronal or glial cell cultures. The reason for the lack of effects of trans-ACPD on cAMP accumulation in primary cultures from glial cells and neurons is discussed.
Tanja M Wrodnigg - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 1 Amino 1 2 5 trideoxy 2 5 imino d mannitol a novel analogue of the powerful glucosidase inhibitor 2 5 dideoxy 2 5 imino d mannitol via an amadori rearrangement of 5 azido 5 deoxy d glucofuranose
Tetrahedron Letters, 1997Co-Authors: Tanja M Wrodnigg, Arnold E. Stütz, Steven G WithersAbstract:Abstract By an Amadori rearrangement of easily available 5-azido-5-deoxy- d -glucofuranose with dibenzylamine and subsequent catalytic hydrogenation of the resulting 5-azido-1-dibenzylAmino-1,5-dideoxy- d -fructopyranose, the new 1-Amino-1,2,5-trideoxy-2,5-imino- d -mannitol was obtained in only two steps and excellent overall yield. Likewise, other amines and/or other 5-modified hexofuranoses can be used to advantage. The reported rearrangement reaction is a high yielding, convenient and apparently general entry to 1-Aminodeoxyketopyranoses modified at C-5, facilitated by the ring enlargement of the aldofuranose to the ketopyranose as an additional driving force.
A Czyrak - One of the best experts on this subject based on the ideXlab platform.
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trans 1 Amino 1 3 cyclopentanedicarboxylate trans acpd stimulates camp accumulation in rat cerebral cortical slices but not in glial or neuronal cell cultures
Neuroscience Letters, 1994Co-Authors: Andrzej Pilc, Beata Legutko, Tadeusz Frankiewicz, A CzyrakAbstract:Abstract Recent cloning experiments indicate that multiple metabotropic receptors for excitatory Amino acids (EAAs) exist, which are coupled to adenylate cyclase. Trans-(±)-1-Amino-1, 3-cyclopentanedicarboxylate (trans-ACPD) is a selective agonist of metabotropic receptors for EAAs. One of the effects of trans-ACPD is stimulation of cAMP accumulation. In the present experiments, cAMP accumulation was measured using a [3H]adenine-prelabelling technique. It has been found that trans-ACPD was able to induce significant stimulation of cAMP accumulation in rat cerebral cortical slices, with ED50 of 47.8 μM, which value is similar to that described earlier for hippocampal slices. However, trans-ACPD had no effect on cAMP accumulation either in primary neuronal or glial cell cultures. The reason for the lack of effects of trans-ACPD on cAMP accumulation in primary cultures from glial cells and neurons is discussed.
