1 Amino 1

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The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform

Steven G Withers - One of the best experts on this subject based on the ideXlab platform.

Viresh H Rawal - One of the best experts on this subject based on the ideXlab platform.

Andrzej Pilc - One of the best experts on this subject based on the ideXlab platform.

  • trans 1 Amino 1 3 cyclopentanedicarboxylate trans acpd stimulates camp accumulation in rat cerebral cortical slices but not in glial or neuronal cell cultures
    Neuroscience Letters, 1994
    Co-Authors: Andrzej Pilc, Beata Legutko, Tadeusz Frankiewicz, A Czyrak
    Abstract:

    Abstract Recent cloning experiments indicate that multiple metabotropic receptors for excitatory Amino acids (EAAs) exist, which are coupled to adenylate cyclase. Trans-(±)-1-Amino-1, 3-cyclopentanedicarboxylate (trans-ACPD) is a selective agonist of metabotropic receptors for EAAs. One of the effects of trans-ACPD is stimulation of cAMP accumulation. In the present experiments, cAMP accumulation was measured using a [3H]adenine-prelabelling technique. It has been found that trans-ACPD was able to induce significant stimulation of cAMP accumulation in rat cerebral cortical slices, with ED50 of 47.8 μM, which value is similar to that described earlier for hippocampal slices. However, trans-ACPD had no effect on cAMP accumulation either in primary neuronal or glial cell cultures. The reason for the lack of effects of trans-ACPD on cAMP accumulation in primary cultures from glial cells and neurons is discussed.

Tanja M Wrodnigg - One of the best experts on this subject based on the ideXlab platform.

A Czyrak - One of the best experts on this subject based on the ideXlab platform.

  • trans 1 Amino 1 3 cyclopentanedicarboxylate trans acpd stimulates camp accumulation in rat cerebral cortical slices but not in glial or neuronal cell cultures
    Neuroscience Letters, 1994
    Co-Authors: Andrzej Pilc, Beata Legutko, Tadeusz Frankiewicz, A Czyrak
    Abstract:

    Abstract Recent cloning experiments indicate that multiple metabotropic receptors for excitatory Amino acids (EAAs) exist, which are coupled to adenylate cyclase. Trans-(±)-1-Amino-1, 3-cyclopentanedicarboxylate (trans-ACPD) is a selective agonist of metabotropic receptors for EAAs. One of the effects of trans-ACPD is stimulation of cAMP accumulation. In the present experiments, cAMP accumulation was measured using a [3H]adenine-prelabelling technique. It has been found that trans-ACPD was able to induce significant stimulation of cAMP accumulation in rat cerebral cortical slices, with ED50 of 47.8 μM, which value is similar to that described earlier for hippocampal slices. However, trans-ACPD had no effect on cAMP accumulation either in primary neuronal or glial cell cultures. The reason for the lack of effects of trans-ACPD on cAMP accumulation in primary cultures from glial cells and neurons is discussed.