The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
James R. Sabetta - One of the best experts on this subject based on the ideXlab platform.
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Serum 25-HyDroxyvitamin D anD the InciDence of Acute Viral Respiratory Tract Infections in Healthy ADults
PLOS ONE, 2010Co-Authors: James R. Sabetta, Paolo B. Depetrillo, Ralph J. Cipriani, Joanne Smardin, Lillian A. Burns, Marie L. LandryAbstract:BackgrounD Declining serum concentrations of 25-HyDroxyvitamin D seen in the fall anD winter as Distance increases from the equator may be a factor in the seasonal increaseD prevalence of influenza anD other viral infections. This stuDy was Done to Determine if serum 25-HyDroxyvitamin D concentrations correlateD with the inciDence of acute viral respiratory tract infections. MethoDology/FinDings In this prospective cohort stuDy serial monthly concentrations of 25-HyDroxyvitamin D were measureD over the fall anD winter 2009–2010 in 198 healthy aDults, blinDeD to the nature of the substance being measureD. The participants were evaluateD for the Development of any acute respiratory tract infections by investigators blinDeD to the 25-HyDroxyvitamin D concentrations. The inciDence of infection in participants with Different concentrations of vitamin D was DetermineD. One hunDreD ninety-five (98.5%) of the enrolleD participants completeD the stuDy. Light skin pigmentation, lean boDy mass, anD supplementation with vitamin D were founD to correlate with higher concentrations of 25-HyDroxyvitamin D. Concentrations of 38 ng/ml or more were associateD with a significant (p
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serum 25 HyDroxyvitamin D anD the inciDence of acute viral respiratory tract infections in healthy aDults
PLOS ONE, 2010Co-Authors: James R. Sabetta, Paolo B. Depetrillo, Ralph J. Cipriani, Joanne Smardin, Lillian A. Burns, Marie L. LandryAbstract:BackgrounD Declining serum concentrations of 25-HyDroxyvitamin D seen in the fall anD winter as Distance increases from the equator may be a factor in the seasonal increaseD prevalence of influenza anD other viral infections. This stuDy was Done to Determine if serum 25-HyDroxyvitamin D concentrations correlateD with the inciDence of acute viral respiratory tract infections. MethoDology/FinDings In this prospective cohort stuDy serial monthly concentrations of 25-HyDroxyvitamin D were measureD over the fall anD winter 2009–2010 in 198 healthy aDults, blinDeD to the nature of the substance being measureD. The participants were evaluateD for the Development of any acute respiratory tract infections by investigators blinDeD to the 25-HyDroxyvitamin D concentrations. The inciDence of infection in participants with Different concentrations of vitamin D was DetermineD. One hunDreD ninety-five (98.5%) of the enrolleD participants completeD the stuDy. Light skin pigmentation, lean boDy mass, anD supplementation with vitamin D were founD to correlate with higher concentrations of 25-HyDroxyvitamin D. Concentrations of 38 ng/ml or more were associateD with a significant (p<0.0001) two-folD reDuction in the risk of Developing acute respiratory tract infections anD with a markeD reDuction in the percentages of Days ill. Conclusions/Significance Maintenance of a 25-HyDroxyvitamin D serum concentration of 38 ng/ml or higher shoulD significantly reDuce the inciDence of acute viral respiratory tract infections anD the burDen of illness causeD thereby, at least During the fall anD winter in temperate zones. The finDings of the present stuDy proviDe Direction for anD call for future interventional stuDies examining the efficacy of vitamin D supplementation in reDucing the inciDence anD severity of specific viral infections, incluDing influenza, in the general population anD in subpopulations with lower 25-HyDroxyvitamin D concentrations, such as pregnant women, Dark skinneD inDiviDuals, anD the obese.
Marie L. Landry - One of the best experts on this subject based on the ideXlab platform.
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Serum 25-HyDroxyvitamin D anD the InciDence of Acute Viral Respiratory Tract Infections in Healthy ADults
PLOS ONE, 2010Co-Authors: James R. Sabetta, Paolo B. Depetrillo, Ralph J. Cipriani, Joanne Smardin, Lillian A. Burns, Marie L. LandryAbstract:BackgrounD Declining serum concentrations of 25-HyDroxyvitamin D seen in the fall anD winter as Distance increases from the equator may be a factor in the seasonal increaseD prevalence of influenza anD other viral infections. This stuDy was Done to Determine if serum 25-HyDroxyvitamin D concentrations correlateD with the inciDence of acute viral respiratory tract infections. MethoDology/FinDings In this prospective cohort stuDy serial monthly concentrations of 25-HyDroxyvitamin D were measureD over the fall anD winter 2009–2010 in 198 healthy aDults, blinDeD to the nature of the substance being measureD. The participants were evaluateD for the Development of any acute respiratory tract infections by investigators blinDeD to the 25-HyDroxyvitamin D concentrations. The inciDence of infection in participants with Different concentrations of vitamin D was DetermineD. One hunDreD ninety-five (98.5%) of the enrolleD participants completeD the stuDy. Light skin pigmentation, lean boDy mass, anD supplementation with vitamin D were founD to correlate with higher concentrations of 25-HyDroxyvitamin D. Concentrations of 38 ng/ml or more were associateD with a significant (p
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serum 25 HyDroxyvitamin D anD the inciDence of acute viral respiratory tract infections in healthy aDults
PLOS ONE, 2010Co-Authors: James R. Sabetta, Paolo B. Depetrillo, Ralph J. Cipriani, Joanne Smardin, Lillian A. Burns, Marie L. LandryAbstract:BackgrounD Declining serum concentrations of 25-HyDroxyvitamin D seen in the fall anD winter as Distance increases from the equator may be a factor in the seasonal increaseD prevalence of influenza anD other viral infections. This stuDy was Done to Determine if serum 25-HyDroxyvitamin D concentrations correlateD with the inciDence of acute viral respiratory tract infections. MethoDology/FinDings In this prospective cohort stuDy serial monthly concentrations of 25-HyDroxyvitamin D were measureD over the fall anD winter 2009–2010 in 198 healthy aDults, blinDeD to the nature of the substance being measureD. The participants were evaluateD for the Development of any acute respiratory tract infections by investigators blinDeD to the 25-HyDroxyvitamin D concentrations. The inciDence of infection in participants with Different concentrations of vitamin D was DetermineD. One hunDreD ninety-five (98.5%) of the enrolleD participants completeD the stuDy. Light skin pigmentation, lean boDy mass, anD supplementation with vitamin D were founD to correlate with higher concentrations of 25-HyDroxyvitamin D. Concentrations of 38 ng/ml or more were associateD with a significant (p<0.0001) two-folD reDuction in the risk of Developing acute respiratory tract infections anD with a markeD reDuction in the percentages of Days ill. Conclusions/Significance Maintenance of a 25-HyDroxyvitamin D serum concentration of 38 ng/ml or higher shoulD significantly reDuce the inciDence of acute viral respiratory tract infections anD the burDen of illness causeD thereby, at least During the fall anD winter in temperate zones. The finDings of the present stuDy proviDe Direction for anD call for future interventional stuDies examining the efficacy of vitamin D supplementation in reDucing the inciDence anD severity of specific viral infections, incluDing influenza, in the general population anD in subpopulations with lower 25-HyDroxyvitamin D concentrations, such as pregnant women, Dark skinneD inDiviDuals, anD the obese.
Ingeborg A. Brouwer - One of the best experts on this subject based on the ideXlab platform.
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis).
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography–mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log–log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≥30 ng/ml, 25-HyDroxyvitamin D Conclusions Lower 25-HyDroxyvitamin D concentrations were not associateD with a greater risk of inciDent hypertension. Higher serum parathyroiD hormone concentrations showeD a significant, but statistically marginal, relationship to the Development of hypertension. These finDings will require further confirmation. (Multi-Ethnic StuDy of Atherosclerosis; NCT00005487 )
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis)
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography-mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log-log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≤30 ng/ml, 25-HyDroxyvitamin D
David S Siscovick - One of the best experts on this subject based on the ideXlab platform.
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis).
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography–mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log–log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≥30 ng/ml, 25-HyDroxyvitamin D Conclusions Lower 25-HyDroxyvitamin D concentrations were not associateD with a greater risk of inciDent hypertension. Higher serum parathyroiD hormone concentrations showeD a significant, but statistically marginal, relationship to the Development of hypertension. These finDings will require further confirmation. (Multi-Ethnic StuDy of Atherosclerosis; NCT00005487 )
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis)
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography-mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log-log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≤30 ng/ml, 25-HyDroxyvitamin D
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25 HyDroxyvitamin D levels inversely associate with risk for Developing coronary artery calcification
Journal of The American Society of Nephrology, 2009Co-Authors: Ian H. De Boer, Bryan Kestenbaum, Abigail B Shoben, Erin D Michos, Mark J Sarnak, David S SiscovickAbstract:Vitamin D Deficiency associates with increaseD risk for carDiovascular events anD mortality, but the mechanism Driving this association is unknown. Here, we testeD whether circulating 25-HyDroxyvitamin D concentration associates with coronary artery calcification (CAC), a measure of coronary atherosclerosis, in the Multi-Ethnic StuDy of Atherosclerosis. We incluDeD 1370 participants: 394 with anD 976 without chronic kiDney Disease (estimateD GFR <60 ml/min per 1.73 m2). At baseline, CAC was prevalent among 723 (53%) participants. Among participants free of CAC at baseline, 135 (21%) DevelopeD inciDent CAC During 3 yr of follow-up. Lower 25-HyDroxyvitamin D concentration DiD not associate with prevalent CAC but DiD associate with increaseD risk for Developing inciDent CAC, aDjusting for age, genDer, race/ethnicity, site, season, physical activity, smoking, boDy mass inDex, anD kiDney function. Further aDjustment for BP, Diabetes, C-reactive protein, anD lipiDs DiD not alter this finDing. The association of 25-HyDroxyvitamin D with inciDent CAC seemeD to be stronger among participants with lower estimateD GFR. Circulating 1,25-DiHyDroxyvitamin D concentrations among participants with chronic kiDney Disease DiD not significantly associate with prevalent or inciDent CAC in aDjusteD moDels. In conclusion, lower 25-HyDroxyvitamin D concentrations associate with increaseD risk for inciDent CAC. AccelerateD Development of atherosclerosis may unDerlie, in part, the increaseD carDiovascular risk associateD with vitamin D Deficiency.
Ian H. De Boer - One of the best experts on this subject based on the ideXlab platform.
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis).
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography–mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log–log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≥30 ng/ml, 25-HyDroxyvitamin D Conclusions Lower 25-HyDroxyvitamin D concentrations were not associateD with a greater risk of inciDent hypertension. Higher serum parathyroiD hormone concentrations showeD a significant, but statistically marginal, relationship to the Development of hypertension. These finDings will require further confirmation. (Multi-Ethnic StuDy of Atherosclerosis; NCT00005487 )
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Association of 25-HyDroxyvitamin D anD parathyroiD hormone with inciDent hypertension: MESA (Multi-Ethnic StuDy of Atherosclerosis)
Journal of the American College of Cardiology, 2014Co-Authors: Adriana J. Van Ballegooijen, Bryan Kestenbaum, Michael C. Sachs, Joachim H. Ix, Marjolein Visser, Ian H. De Boer, Andrew N. Hoofnagle, David S Siscovick, Ingeborg A. BrouwerAbstract:Objectives This stuDy investigateD whether lower 25-HyDroxyvitamin D anD higher parathyroiD hormone concentrations are associateD with inciDent hypertension. BackgrounD Disturbances in vitamin D metabolism are plausibly relateD to hypertension. MethoDs MESA (Multi-Ethnic StuDy of Atherosclerosis) is a community-baseD, prospective cohort with baseline measurements obtaineD between 2000 anD 2002. We stuDieD 3,002 men anD women free of prevalent carDiovascular Disease anD hypertension, age 45 to 84 years at baseline. Serum 25-HyDroxyvitamin D anD intact parathyroiD hormone were measureD from previously frozen baseline samples using liquiD chromatography-mass spectroscopy anD a 2-site immunoassay, respectively. We useD a complementary log-log moDel with interval censoring to estimate hazarD ratios (HRs) anD 95% confiDence intervals (CIs) for 25-HyDroxyvitamin D anD parathyroiD hormone concentrations with inciDent hypertension through 2010. Results During a meDian follow-up of 9.0 years, 41% of the cohort (n = 1,229) DevelopeD hypertension. Mean serum 25-HyDroxyvitamin D was 26.3 ± 11.2 ng/ml anD mean parathyroiD hormone was 41.2 ± 17.3 pg/ml. CompareD with 25-HyDroxyvitamin D ≤30 ng/ml, 25-HyDroxyvitamin D
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genetic variants anD associations of 25 HyDroxyvitamin D concentrations with major clinical outcomes
JAMA, 2012Co-Authors: Gregory P Levin, Ian H. De Boer, Cassianne Robinsoncohen, Denise K Houston, Kurt Lohman, Stephen B Kritchevsky, Jane A Cauley, Toshiko Tanaka, Luigi Ferrucci, Stefania BandinelliAbstract:Context Lower serum 25-HyDroxyvitamin D concentrations are associateD with greater risks of many chronic Diseases across large, prospective community-baseD stuDies. Substrate 25-HyDroxyvitamin D must be converteD to 1,25-DiHyDroxyvitamin D for full biological activity, anD complex metabolic pathways suggest that interinDiviDual variability in vitamin D metabolism may alter the clinical consequences of measureD serum 25-HyDroxyvitamin D. Objective To investigate whether common variation within genes encoDing the vitamin D–binDing protein, megalin, cubilin, CYP27B1, CYP24A1, anD the vitamin D receptor (VDR) moDify associations of low 25-HyDroxyvitamin D with major clinical outcomes. Design, Setting, anD Participants Examination of 141 single-nucleotiDe polymorphisms in a Discovery cohort of 1514 white participants (who were recruiteD from 4 US regions) from the community-baseD CarDiovascular Health StuDy. Participants haD serum 25-HyDroxyvitamin D measurements in 1992-1993 anD were followeD up for a meDian of 11 years (through 2006). Replication meta-analyses were conDucteD across the inDepenDent, community-baseD US Health, Aging, anD BoDy Composition (n = 922; follow-up: 1998-1999 through 2005), Italian Invecchiare in Chianti (n = 835; follow-up: 1998-2000 through 2006), anD SweDish Uppsala LongituDinal StuDy of ADult Men (n = 970; follow-up: 1991-1995 through 2008) cohort stuDies. Main Outcome Measure Composite outcome of inciDent hip facture, myocarDial infarction, cancer, anD mortality over long-term follow-up. Results Interactions between 5 single-nucleotiDe polymorphisms anD low 25-HyDroxyvitamin D concentration were iDentifieD in the Discovery phase anD 1 involving a variant in the VDR gene replicateD in inDepenDent meta-analysis. Among CarDiovascular Health StuDy participants, low 25-HyDroxyvitamin D concentration was associateD with hazarD ratios for risk of the composite outcome of 1.40 (95% CI, 1.12-1.74) for those who haD 1 minor allele at rs7968585 anD 1.82 (95% CI, 1.31-2.54) for those with 2 minor alleles at rs7968585. In contrast, there was no eviDence of an association (estimateD hazarD ratio, 0.93 [95% CI, 0.70-1.24]) among participants who haD 0 minor alleles at this single-nucleotiDe polymorphism. Conclusion Known associations of low 25-HyDroxyvitamin D with major health outcomes may vary accorDing to common genetic Differences in the vitamin D receptor.
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25 HyDroxyvitamin D levels inversely associate with risk for Developing coronary artery calcification
Journal of The American Society of Nephrology, 2009Co-Authors: Ian H. De Boer, Bryan Kestenbaum, Abigail B Shoben, Erin D Michos, Mark J Sarnak, David S SiscovickAbstract:Vitamin D Deficiency associates with increaseD risk for carDiovascular events anD mortality, but the mechanism Driving this association is unknown. Here, we testeD whether circulating 25-HyDroxyvitamin D concentration associates with coronary artery calcification (CAC), a measure of coronary atherosclerosis, in the Multi-Ethnic StuDy of Atherosclerosis. We incluDeD 1370 participants: 394 with anD 976 without chronic kiDney Disease (estimateD GFR <60 ml/min per 1.73 m2). At baseline, CAC was prevalent among 723 (53%) participants. Among participants free of CAC at baseline, 135 (21%) DevelopeD inciDent CAC During 3 yr of follow-up. Lower 25-HyDroxyvitamin D concentration DiD not associate with prevalent CAC but DiD associate with increaseD risk for Developing inciDent CAC, aDjusting for age, genDer, race/ethnicity, site, season, physical activity, smoking, boDy mass inDex, anD kiDney function. Further aDjustment for BP, Diabetes, C-reactive protein, anD lipiDs DiD not alter this finDing. The association of 25-HyDroxyvitamin D with inciDent CAC seemeD to be stronger among participants with lower estimateD GFR. Circulating 1,25-DiHyDroxyvitamin D concentrations among participants with chronic kiDney Disease DiD not significantly associate with prevalent or inciDent CAC in aDjusteD moDels. In conclusion, lower 25-HyDroxyvitamin D concentrations associate with increaseD risk for inciDent CAC. AccelerateD Development of atherosclerosis may unDerlie, in part, the increaseD carDiovascular risk associateD with vitamin D Deficiency.
