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4-Aminobenzoic Acid

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Lida Khalafi – One of the best experts on this subject based on the ideXlab platform.

Qi Zhang – One of the best experts on this subject based on the ideXlab platform.

  • Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-Aminobenzoic Acid
    Crystals, 2016
    Co-Authors: Qiang Cai, Jiadan Xue, Qi Zhang
    Abstract:

    Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-Aminobenzoic Acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

  • Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-Aminobenzoic Acid
    , 2016
    Co-Authors: Qiang Cai, Jiadan Xue, Qi Zhang
    Abstract:

    Cocrystallizaiton could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-Aminobenzoic Acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

Stefano Mosca – One of the best experts on this subject based on the ideXlab platform.

Muammer Kiraz – One of the best experts on this subject based on the ideXlab platform.

  • synthesis and antimycobacterial activity of some coupling products from 4 aminobenzoic Acid hydrazones
    European Journal of Medicinal Chemistry, 1999
    Co-Authors: ş Guniz Kucukguzel, Sevim Rollas, Ilkay Kucukguzel, Muammer Kiraz
    Abstract:

    Abstract Various 2,3,4-pentanetrione-3-[4-[[(5-nitro-2-furyl/pyridyl/substituted phenyl)methylene]hydrazinocarbonyl]phenyl]hydrazones 3a–j were synthesized by the reactions of acetylacetone with the diazonium salts of 4-Aminobenzoic Acid-[(5-nitro-2-furyl/pyridyl/substituted phenyl)methylene]hydrazides 2a–j at 0–5 °C. The structures of these compounds were determined using spectral data. All the synthesized compounds were evaluated for their antimycobacterial activity against Mycobacterium fortuitum ATCC 6841 and Mycobacterium tuberculosis H37Rv. Of the compounds screened, 2e, 2i, 3e and 3g were found to be active against M. fortuitum at an MIC value of 32 μg/mL. Compound 3a, which exhibited > 90% inhibition in the primary screen at 12.5 μg/mL against M. tuberculosis H37Rv, was the most promising derivative for antituberculosis activity. Results obtained from the level II screening showed that the actual MIC and IC50 values of 3a were 3.13 and 0.32 μg/mL, respectively. The same compound was also tested against Mycobacterium avium, which was observed not to be susceptible to 3a.

Bo-tau Liu – One of the best experts on this subject based on the ideXlab platform.