The Experts below are selected from a list of 287495121 Experts worldwide ranked by ideXlab platform
Donald D Phillips - One of the best experts on this subject based on the ideXlab platform.
-
9 10 dihydrophenanthrene
Organic Syntheses, 2003Co-Authors: Donald D PhillipsAbstract:9,10-Dihydrophenanthrene reactant: phenanthrene product: 9,10-dihydrophenanthrene Keywords: reduction, CC HCCH; catalysts, metal, copper chromite; phenanthrene; catalysts, metal, Raney nickel W-6; sodium; sodium, disposal
Quezia B. Cass - One of the best experts on this subject based on the ideXlab platform.
-
9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors.
Bioorganic & medicinal chemistry, 2015Co-Authors: Marili V.n. Rodrigues, Alexandre F. Barbosa, Júlia F. Da Silva, Deborah A. Dos Santos, Kenia L. Vanzolini, Marcela Cristina De Moraes, Arlene G. Corrêa, Quezia B. CassAbstract:A novel potent xanthine oxidase inhibitor, 3-nitrobenzoyl 9-deazaguanine (LSPN451), was selected from a series of 10 synthetic derivatives. The enzymatic assays were carried out using an on-flow bidimensional liquid chromatography (2D LC) system, which allowed the screening¸ the measurement of the kinetic inhibition constant and the characterization of the inhibition mode. This compound showed a non-competitive inhibition mechanism with more affinity for the enzyme-substrate complex than for the free enzyme, and inhibition constant of 55.1±9.80 nM, about thirty times more potent than allopurinol. Further details of synthesis and enzymatic studies are presented herein.
Heng-shan Wang - One of the best experts on this subject based on the ideXlab platform.
-
New inhibitors of matrix metalloproteinases 9 (MMP-9): Lignans from Selaginella moellendorffii.
Fitoterapia, 2018Co-Authors: Yuan Zhu, Ri-zhen Huang, Chun-gu Wang, Xi-lin Ouyang, Jing Xiaoteng, Dong Liang, Heng-shan WangAbstract:Matrix metalloproteinase 9 (MMP-9) is one of the structurally related zinc-dependent endopeptidases families and provides a new target for cancer therapy owing to its pivotal role in metastatic tumors. In this paper, fourteen lignans, including three novel lignans, named selamoellenin B-D (1-3), and eleven known lignan derivatives (4-14) were isolated from the plant of Selaginella moellendorffii. Among them, compound 3 is optically active, which was enantiomerically seperated to afford a pair of enantiomers, (-)-3 and (+)-3. Their structures were elucidated by extensive spectroscopic analyses. Their cytotoxic activities were evaluated against four human cancer cell lines. Among them, five compounds (4, 5, 6, 11 and 13) exhibited great potent cytotoxicity and their structure-activity relationships were also discussed. All compounds except for 3 lignan analogues with low cytotoxicity were selected for further in vitro enzyme inhibition, surface plasmon resonance (SPR), and molecular docking assays based on the MMPs target. The results shown that, compound 11 have the best inhibitory effect and can be considered as a potential drug candidate targeting at MMP-9 for cancer therapy.
D D C Bradley - One of the best experts on this subject based on the ideXlab platform.
-
temperature and field dependence of hole mobility in poly 9 9 dioctylfluorene
Physical Review B, 2006Co-Authors: T Kreouzis, D Poplavskyy, Sachetan M Tuladhar, Mariano Campoyquiles, Jenny Nelson, Alasdair J Campbell, D D C BradleyAbstract:Detailed studies of hole mobility in the electroluminescent conjugated polymer poly($9,{9}^{\ensuremath{'}}$-dioctylfluorene) by the time-of-flight technique are reported. The hole mobility is studied in a number of samples over a wide range of temperatures and electric field strengths. Significant sample-to-sample variations are observed in both hole mobility and the character of hole transport in as-spun films of different thicknesses. Hole mobility is found to improve irreversibly as a result of thermal annealing at elevated temperatures. Analysis of the experimental results is carried out within the Gaussian disorder model (GDM), the polaronic correlated disorder model (PCDM), and the geometry fluctuation model based on torsional interactions (known here as the Los Alamos model). The PCDM is found to be more successful than the GDM in explaining the experimental data. Moreover, the Los Alamos model succeeds in explaining the data when modified to include polaron hopping. Analysis with both PCDM and Los Alamos models leads to the conclusion that the improvement in hole mobility upon annealing is consistent with reduced energetic disorder and reduced polaron binding energy, both of which may result from crystallization of the material. Spectroscopic ellipsometry is used to confirm that crystallization occurs upon annealing.
-
ultrafast forster transfer dynamics in tetraphenylporphyrin doped poly 9 9 dioctylfluorene
Chemical Physics Letters, 2001Co-Authors: Giulio Cerullo, S Stagira, M Zavelanirossi, S De Silvestri, Tersilla Virgili, David G Lidzey, D D C BradleyAbstract:Abstract Femtosecond pump-probe spectroscopy was used to directly monitor, in the time domain, energy transfer from the blue-emitting poly(9,9-dioctylfluorene) conjugated polymer to the red-emitting tetraphenylporphyrin molecule. This system is under investigation for use as saturated red light-emitting component in an organic full-color display. The differential transmission spectrum of the system evolves, within a few picoseconds after photoexcitation, from that of the host polymer to that of the guest molecule. Experiments performed at different acceptor concentrations provide clear evidence for a Forster energy transfer mechanism and allow a determination of the interaction radius. A value of 4.2±0.2 nm was found.
Hao Huang - One of the best experts on this subject based on the ideXlab platform.
-
matrix metalloproteinase 9 mmp 9 as a cancer biomarker and mmp 9 biosensors recent advances
Sensors, 2018Co-Authors: Hao HuangAbstract:As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.
