The Experts below are selected from a list of 48861 Experts worldwide ranked by ideXlab platform
Rui Tang - One of the best experts on this subject based on the ideXlab platform.
-
reconstruction of Abdominal Wall musculofascial defects with small intestinal submucosa scaffolds seeded with tenocytes in rats
2013Co-Authors: Zhicheng Song, Zhiyou Peng, Zhengni Liu, Jianjun Yang, Rui TangAbstract:The repair of Abdominal Wall defects following surgery remains a difficult challenge. Although multiple methods have been described to restore the integrity of the Abdominal Wall, there is no clear consensus on the ideal material for reconstruction. This study explored the feasibility of in vivo reconstruction of a rat model of an Abdominal Wall defect with a composite scaffold of tenocytes and porcine small intestinal submucosa (SIS). In the current study, we created a 2×1.5 cm Abdominal Wall defect in the anterolateral Abdominal Wall of Sprague-Dawley rats, which were assigned into three groups: the cell-SIS construct group, the cell-free SIS scaffold group, and the Abdominal Wall defect group. Tenocytes were obtained from the tendons of rat limbs. After isolation and expansion, cells (2×107/mL) were seeded onto the three-layer SIS scaffolds and cultured in vitro for 5 days. Cell-SIS constructs or cell-free constructs were implanted to repair the Abdominal Wall defects. The results showed that the tenoc...
-
erratum to immediate repair of major Abdominal Wall defect after extensive tumor excision in patients with Abdominal Wall neoplasm a retrospective review of 27 cases
2009Co-Authors: Rui Tang, Dingquan Gong, Yunliang QianAbstract:The treatment of Abdominal Wall neoplasm continues to present a challenging problem because it is not easy to repair the giant defect which is resulted from extensive tumor excision. Some techniques and materials have been reported, but most report a certain technique or material for Abdominal Wall reconstruction. Therefore, we retrospectively reviewed the treatment of such patients in our department and assessed the reconstruction algorithm in such a situation. We studied 27 patients undergoing immediate Abdominal Wall reconstruction between 1999 and 2008 who sought care for major defects after extensive tumor excision of malignancy. We categorized the defects into three types: type I, defects involving only the loss of skin (15 cases); type II, myofascial defects with intact skin coverage (6 cases); and type III, myofascial defects without skin coverage (6 cases). Different techniques and materials were used. Postoperative morbidities, sign of herniation, and other follow-up data were recorded. The immediate Abdominal Wall reconstruction was successful in all patients. There was no severe morbidity after the operation. Only one patient developed hernia. Most type I defects can be corrected with primary suture. For type II defects, a prosthetic or biological mesh, or alternatively an autologous fascial substitute, may be used. For type III defects, the resulting full-thickness defect will require a myocutaneous flap, such as the tensor fascia lata flap, with or without a mesh for Abdominal Wall reconstruction. Human acellular dermal matrix, a biological mesh, is an ideal alternative for synthetic mesh, especially in situations of infection or contamination.
-
erratum to immediate repair of major Abdominal Wall defect after extensive tumor excision in patients with Abdominal Wall neoplasm a retrospective review of 27 cases
2009Co-Authors: Rui Tang, Dingquan Gong, Yunliang QianAbstract:Background The treatment of Abdominal Wall neoplasm continues to present a challenging problem because it is not easy to repair the giant defect which is resulted from extensive tumor excision. Some techniques and materials have been reported, but most report a certain technique or material for Abdominal Wall reconstruction. Therefore, we retrospectively reviewed the treatment of such patients in our department and assessed the reconstruction algorithm in such a situation.
Yunliang Qian - One of the best experts on this subject based on the ideXlab platform.
-
erratum to immediate repair of major Abdominal Wall defect after extensive tumor excision in patients with Abdominal Wall neoplasm a retrospective review of 27 cases
2009Co-Authors: Rui Tang, Dingquan Gong, Yunliang QianAbstract:The treatment of Abdominal Wall neoplasm continues to present a challenging problem because it is not easy to repair the giant defect which is resulted from extensive tumor excision. Some techniques and materials have been reported, but most report a certain technique or material for Abdominal Wall reconstruction. Therefore, we retrospectively reviewed the treatment of such patients in our department and assessed the reconstruction algorithm in such a situation. We studied 27 patients undergoing immediate Abdominal Wall reconstruction between 1999 and 2008 who sought care for major defects after extensive tumor excision of malignancy. We categorized the defects into three types: type I, defects involving only the loss of skin (15 cases); type II, myofascial defects with intact skin coverage (6 cases); and type III, myofascial defects without skin coverage (6 cases). Different techniques and materials were used. Postoperative morbidities, sign of herniation, and other follow-up data were recorded. The immediate Abdominal Wall reconstruction was successful in all patients. There was no severe morbidity after the operation. Only one patient developed hernia. Most type I defects can be corrected with primary suture. For type II defects, a prosthetic or biological mesh, or alternatively an autologous fascial substitute, may be used. For type III defects, the resulting full-thickness defect will require a myocutaneous flap, such as the tensor fascia lata flap, with or without a mesh for Abdominal Wall reconstruction. Human acellular dermal matrix, a biological mesh, is an ideal alternative for synthetic mesh, especially in situations of infection or contamination.
-
erratum to immediate repair of major Abdominal Wall defect after extensive tumor excision in patients with Abdominal Wall neoplasm a retrospective review of 27 cases
2009Co-Authors: Rui Tang, Dingquan Gong, Yunliang QianAbstract:Background The treatment of Abdominal Wall neoplasm continues to present a challenging problem because it is not easy to repair the giant defect which is resulted from extensive tumor excision. Some techniques and materials have been reported, but most report a certain technique or material for Abdominal Wall reconstruction. Therefore, we retrospectively reviewed the treatment of such patients in our department and assessed the reconstruction algorithm in such a situation.
Jacob C Langer - One of the best experts on this subject based on the ideXlab platform.
-
Neonatal Abdominal Wall defects
2011Co-Authors: Emily R. Christison-lagay, Cassandra M. Kelleher, Jacob C LangerAbstract:Gastroschisis and omphalocele are the two most common congenital Abdominal Wall defects. Both are frequently detected prenatally due to routine maternal serum screening and fetal ultrasound. Prenatal diagnosis may influence timing, mode and location of delivery. Prognosis for gastroschisis is primarily determined by the degree of bowel injury, whereas prognosis for omphalocele is related to the number and severity of associated anomalies. The surgical management of both conditions consists of closure of the Abdominal Wall defect, while minimizing the risk of injury to the Abdominal viscera either through direct trauma or due to increased intra-Abdominal pressure. Options include primary closure or a variety of staged approaches. Long-term outcome is favorable in most cases; however, significant associated anomalies (in the case of omphalocele) or intestinal dysfunction (in the case of gastroschisis) may result in morbidity and mortality. © 2011.
Seth R. Thaller - One of the best experts on this subject based on the ideXlab platform.
-
Abdominal Wall closure after intestinal transplantation
2000Co-Authors: Ioannis J Alexandrides, Deirdra M Marshall, John R Nery, Andreas G. Tzakis, Seth R. ThallerAbstract:Successful surgical closure of the Abdominal Wall after either combined or isolated intestinal transplantation may present a challenging dilemma for the plastic and reconstructive surgeon because of the following factors: restricted volume of the recipient Abdominal cavity; donor-recipient size discrepancies as expressed by the donor to recipient weight ratio; and significant intraoperative edema. The purpose of this investigation is to present clinical experience with 51 consecutive patients who underwent a total of 57 sequential intestinal transplantations at the University of Miami-Jackson Memorial Hospital. A retrospective chart review of 36 pediatric (63 percent) and 21 adult (37 percent) transplantations was performed. Age of the pediatric population ranged from 1 month to 13 years (mean, 2.4 years) and of the adult population from 22 to 55 years (mean, 33.5 years). Several diagnostic classifications necessitated organ transplantation. Because of insufficient donor graft size for the recipient Abdominal cavity in 19 transplantations (33 percent), several technical modifications were used to achieve anatomic and functional Abdominal Wall closure in all patients. In summary, the plastic and reconstructive surgeon should have a significant role in the comprehensive planning and management of Abdominal Wall closure in this challenging group of patients.
Andreas G. Tzakis - One of the best experts on this subject based on the ideXlab platform.
-
Abdominal Wall transplantation surgical and immunologic aspects
2009Co-Authors: Gennaro Selvaggi, D. Levi, R Cipriani, R Sgarzani, Antonio Daniele Pinna, Andreas G. TzakisAbstract:Abdominal Wall transplantation is a type of composite tissue allograft that can be utilized to reconstitute the Abdominal domain of patients undergoing intestinal transplantation. We have presented herein combined experience and long-term follow-up results of a series of Abdominal Wall transplants performed at 2 institutions. A total of 15 Abdominal Wall transplants from cadaveric donors were performed in 14 patients at the end of intestinal transplant surgery or, in 2 cases, a few days after the primary intestinal transplant. The vascular supply was through the inferior epigastric vessels, from the iliac vessels in 12 cases and via a microsurgical technique in 3 cases. Immunosuppression consisted of induction with alemtuzumab and maintenance treatment with tacrolimus monotherapy. Two grafts lost to vascular thrombosis were removed. Five patients are still alive, although all deaths were unrelated to the Abdominal Wall transplant. There were 3 episodes of Abdominal Wall graft rejection, treated with steroids; the Abdominal Wall graft and the intestinal grafts experienced rejection independent from each other. In summary, Abdominal Wall transplantation is a feasible technique for recipients of intestinal or multivisceral transplants, when the closure of the Abdominal cavity by primary intention is technically impossible.
-
expanded use of transplantation techniques Abdominal Wall transplantation and intestinal autotransplantation
2004Co-Authors: Gennaro Selvaggi, Tomoaki Kato, J. Moon, Juan Madariaga, Seigo Nishida, D. Levi, Andreas G. TzakisAbstract:Surgical principles and techniques derived from organ transplantation surgery can provide novel applications in general surgery. We present an update on our 5-year experience with intestinal autotransplantation and Abdominal Wall transplantation. Nine patients underwent intestinal or multivisceral transplantation with the addition of 10 Abdominal Wall grafts to cover the large open areas from previous surgeries. Seven patients underwent near-total Abdominal evisceration, ex vivo resection of masses at the base of the mesentery, followed by intestinal autotransplantation; 44% of the Abdominal Wall graft recipients are alive, but none of the fatalities were related to the graft itself. In two cases the graft had to be removed due to venous thrombosis. Of patients with intestinal autotransplants, 71% are alive with two mortalities due to recurrent metastatic malignancy. In only one case, the intestinal autograft had to be removed because of venous thrombosis. All surviving patients but one are on a regular diet; two are on supplemental enteral feeds. These results show that anastomotic and resection techniques derived from the experience in solid organ transplant can be utilized in complex wound closure, as is the case of Abdominal Wall transplantation, or resection of large retroperitoneal tumors with intestinal autotransplantation.
-
transplantation of the Abdominal Wall
2003Co-Authors: D. Levi, Tomoaki Kato, Juan Madariaga, Andreas G. Tzakis, Seigo Nishida, Naveen K Mittal, J Nery, Phillip RuizAbstract:Summary Background Closure of the abdomen in patients undergoing intestinal transplantation can be extremely difficult, if not impossible. We describe our initial experience with Abdominal Wall allotransplantation to facilitate Abdominal closure. Methods We undertook nine cadaveric Abdominal Wall composite allograft transplants in eight patients. The graft's blood supply was based on the inferior epigastric vessels left in continuity with the donor femoral and iliac vessels. Skin biopsies were undertaken randomly and when rejection was suspected. Vessel patency was monitored by doppler ultrasound. Findings Six patients have survived, five of whom have intact, viable Abdominal Wall grafts. Two patients have had a clinically mild episode of acute rejection of the skin of the Abdominal Wall that resolved with corticosteroid therapy. No clinically apparent graft-versus-host disease has been noted. Interpretation Transplantation of an Abdominal Wall composite allograft can facilitate reconstruction and closure of the Abdominal compartment in intestinal transplant recipients with complex Abdominal Wall defects.
-
Abdominal Wall closure after intestinal transplantation
2000Co-Authors: Ioannis J Alexandrides, Deirdra M Marshall, John R Nery, Andreas G. Tzakis, Seth R. ThallerAbstract:Successful surgical closure of the Abdominal Wall after either combined or isolated intestinal transplantation may present a challenging dilemma for the plastic and reconstructive surgeon because of the following factors: restricted volume of the recipient Abdominal cavity; donor-recipient size discrepancies as expressed by the donor to recipient weight ratio; and significant intraoperative edema. The purpose of this investigation is to present clinical experience with 51 consecutive patients who underwent a total of 57 sequential intestinal transplantations at the University of Miami-Jackson Memorial Hospital. A retrospective chart review of 36 pediatric (63 percent) and 21 adult (37 percent) transplantations was performed. Age of the pediatric population ranged from 1 month to 13 years (mean, 2.4 years) and of the adult population from 22 to 55 years (mean, 33.5 years). Several diagnostic classifications necessitated organ transplantation. Because of insufficient donor graft size for the recipient Abdominal cavity in 19 transplantations (33 percent), several technical modifications were used to achieve anatomic and functional Abdominal Wall closure in all patients. In summary, the plastic and reconstructive surgeon should have a significant role in the comprehensive planning and management of Abdominal Wall closure in this challenging group of patients.
