The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Irfan Ahmad Ghazi - One of the best experts on this subject based on the ideXlab platform.
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antioxidant and antiproliferative activities of Abrus precatorius leaf extracts an in vitro study
BMC Complementary and Alternative Medicine, 2013Co-Authors: Farhan Jalees Ahmad, Anand K Kondapi, Insaf A Qureshi, Irfan Ahmad GhaziAbstract:Background The use of traditional medicine at the primary health care level is widespread and plant-based treatments are being recommended for curing various diseases by traditional medical practitioners all over the world. The phytochemicals present in the fruits, vegetables and medicinal plants are getting attention day-by-day for their active role in the prevention of several human diseases. Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties. Therefore in the present study, A. precatorius leaf extracts were examined for their antioxidant and cytotoxic properties in vitro in order to discover resources for new lead structures or to improve the traditional medicine.
Farhan Jalees Ahmad - One of the best experts on this subject based on the ideXlab platform.
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antioxidant and antiproliferative activities of Abrus precatorius leaf extracts an in vitro study
BMC Complementary and Alternative Medicine, 2013Co-Authors: Farhan Jalees Ahmad, Anand K Kondapi, Insaf A Qureshi, Irfan Ahmad GhaziAbstract:Background The use of traditional medicine at the primary health care level is widespread and plant-based treatments are being recommended for curing various diseases by traditional medical practitioners all over the world. The phytochemicals present in the fruits, vegetables and medicinal plants are getting attention day-by-day for their active role in the prevention of several human diseases. Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties. Therefore in the present study, A. precatorius leaf extracts were examined for their antioxidant and cytotoxic properties in vitro in order to discover resources for new lead structures or to improve the traditional medicine.
Shannon L Johnson - One of the best experts on this subject based on the ideXlab platform.
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detection of abrin like and prepropulchellin like toxin genes and transcripts using whole genome sequencing and full length transcript sequencing of Abrus precatorius
Toxins, 2019Co-Authors: Blake T Hovde, Hajnalka E Daligault, Erik R Hanschen, Yuliya A Kunde, Matthew B Johnson, Shawn R Starkenburg, Shannon L JohnsonAbstract:The sequenced genome and the leaf transcriptome of a near relative of Abrus pulchellus and Abrus precatorius was analyzed to characterize the genetic basis of toxin gene expression. From the high-quality genome assembly, a total of 26 potential coding regions were identified that contain genes with abrin-like, pulchellin-like, and agglutinin-like homology, with full-length transcripts detected in leaf tissue for 9 of the 26 coding regions. All of the toxin-like genes were identified within only five isolated regions of the genome, with each region containing 1 to 16 gene variants within each genomic region (<1 Mbp). The Abrus precatorius cultivar sequenced here contains genes which encode for proteins that are homologous to certain abrin and prepropulchellin genes previously identified, and we observed substantial diversity of genes and predicted gene products in Abrus precatorius and previously characterized toxins. This suggests diverse toxin repertoires within Abrus, potentially the results of rapid toxin evolution.
Rakesh Sinha - One of the best experts on this subject based on the ideXlab platform.
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post testicular antifertility effects of Abrus precatorius seed extract in albino rats
Journal of Ethnopharmacology, 1990Co-Authors: Rakesh SinhaAbstract:Abstract Oral administration of a 50% ethanol extract of Abrus precatorius seeds (250 mg/kg) in albino rats for 30 and 60 days induced an absolute infertility in males which was reversible. Suppression of sperm motility in the cauda epididymis was the most pronounced effect of the treatment. Such treatment may affect the oxidative/energy metabolism of the cauda epididymis. Histological and histocytometric observations in testis and parareproductive tissues appeared normal while the protein, sialic acid, acid phosphatase and succinic dehydrogenase levels were significantly depleted.
G A S Premakumara - One of the best experts on this subject based on the ideXlab platform.
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sperm antimotility properties of a seed extract of Abrus precatorius
Journal of Ethnopharmacology, 1991Co-Authors: W D Ratnasooriya, A S Amarasekera, N S D Perera, G A S PremakumaraAbstract:Abstract This study examined the inhibitory effects of a methanol extract of Abrus precatorius seeds on the motility of washed human spermatozoa. The extract caused a concentration-related impairment of percentage sperm motility; with the EC50 concentration being 2.29 mg ml . This effect on motility was essentially irreversible. With the highest concentration tested (20.0 mg ml ), the onset of the antimotility action was almost immediate. In addition, this concentration impaired the functional integrity of the plasma membrane (hypoosmotic swelling test) and viability (nigrosin-eosin stain) of spermatozoa. In contrast, with a lower concentration (5.0 mg ml ), such effects were not evident. It is concluded that at the lower concentrations the antimotility action may result from a rise in intracellular calcium (not via influx) and/or a decline in cAMP content and/or enhanced generation of a reactive oxygen species.
