Acanthamoeba Keratitis

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J Y Niederkorn - One of the best experts on this subject based on the ideXlab platform.

  • The immunobiology of Acanthamoeba Keratitis
    Microbes and infection, 2006
    Co-Authors: Daniel W. Clarke, J Y Niederkorn
    Abstract:

    Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba Keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.

  • Role of tear anti-Acanthamoeba IgA in Acanthamoeba Keratitis.
    Advances in experimental medicine and biology, 2002
    Co-Authors: J Y Niederkorn, H Alizadeh, Harrison D Cavanagh, Henry Leher, Sherine Apte, S. El Agha, L. Ling, Michael Hurt, Kevin Howard, J P Mcculley
    Abstract:

    Acanthamoeba Keratitis is a sight-threatening corneal disease caused by pathogenic free-living amoebae.1The organisms have been isolated from a wide variety of environments and from nasopharyngeal washes of asymptomatic individuals. 1Contact lens wear, practiced by over 25 million individuals in the United States, is the leading risk factor. Over 85% of the cases of Acanthamoeba Keratitis occurred in contact lens wearers.2 Antibodies against Acanthamoeba spp. were detected in 52-100% of normal subjects tested in two serological surveys.3,4 In spite of the ubiquity of Acanthamoeba spp., the large number of contact lens wearers, and the apparent frequency of exposure to Acanthamoeba antigens, Acanthamoeba Keratitis is rare. We hypothesized that frequent environmental exposure to Acanthamoeba antigens induces an immunity that protects against corneal infection in most contact lens wearers.

  • The diagnosis and management of Acanthamoeba Keratitis.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists Inc, 2000
    Co-Authors: J P Mcculley, H Alizadeh, J Y Niederkorn
    Abstract:

    Purpose: The purpose of this study was to evaluate the immunology, pathogenesis and therapy of Acanthamoeba Keratitis. Methods: The recent development of an animal model of Acanthamoeba Keratitis and its impact on the medical treatment and immunology of Acanthamoeba Keratitis was reviewed. Results: After initial reports, Acanthamoeba infection of the cornea remained a rare disease until an association with contact lens wear was first recognized. Although the disease is closely associated with contact lens wear, it appeared that the contaminated solutions that were coming into contact with the lenses caused the disease. All types of contact lenses can be associated with development of Acanthamoeba Keratitis. Therefore, the contact lens serves as a carrier of Acanthamoeba to the surface of the eye. The typical patient with Acanthamoeba Keratitis is a young healthy individual who is either a contact lens wearer or has had significant exposure to water contaminated with Acanthamoeba. There are several risk factors such as corneal trauma, contaminated solution and contact lenses that have been reported to be associated with Acanthamoeba Keratitis. In spite of significant improvement in the diagnosis of Acanthamoeba Keratitis, progress in developing and utilizing effective antimicrobial agents for treating this disease have been disappointing. A growing body of evidence suggests that the mammalian immune system, if properly activated, is capable of preventing and controlling ocular infections. Conclusions: In order to develop effective immunotherapeutic modalities, and to better understand the immune effector mechanisms that protect the cornea against Acanthamoeba infection, it is necessary to fully characterize and evaluate the immunobiology of Acanthamoeba Keratitis.

  • Acanthamoeba Keratitis.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists Inc, 1995
    Co-Authors: J P Mcculley, H Alizadeh, J Y Niederkorn
    Abstract:

    The incidence of Acanthamoeba Keratitis has decreased significantly, and it is no longer a reportable condition in the United States. Corneal abrasion and contact lenses play an important role in the development of Acanthamoeba Keratitis. One of the most important features of the disease is severe pain, which is atypical for herpes simplex. The pathognomonic sign for Acanthamoeba is radial neuritis or inflammation around the corneal nerve caused by the parasites. The most important step in prevention of Acanthamoeba Keratitis is effective education of patients about the care of contact lenses. A combination of Brolene and Neomycin is the best approach in treating Acanthamoeba Keratitis. However, if treatment with these drugs fails, clotrimazole is recommended.

  • A pig model of Acanthamoeba Keratitis: transmission via contaminated contact lenses.
    Investigative ophthalmology & visual science, 1992
    Co-Authors: J P Mcculley, H Alizadeh, M. Pidherney, Jessamee Mellon, John E. Ubelaker, George L. Stewart, Robert Silvany, J Y Niederkorn
    Abstract:

    A model of contact lens-induced Acanthamoeba Keratitis was developed in Yucatan micropigs. Pigs fitted with parasite-laden soft contact lenses developed corneal infections that clinically and histopathologically mimicked the human counterpart. Three distinct stages of disease became apparent and were categorized as: acute, condensed infiltrate, and resolution stages. Viable parasites were isolated from corneal scrapings and smears were taken during the acute and condensed infiltrate stages. In addition, cysts could be identified deep within the stroma of histological specimens taken during the resolution stages. The characteristic dense, white ring-like infiltrates, stroma edema, keratic precipitates, and the chronic nature of the infections were similar to those observed in human Acanthamoeba Keratitis. Histopathological examination of infected corneas revealed extensive neutrophilic infiltrates, stromal necrosis, and disorganization of the collagen lamellae. The strong correlation between the clinical and histopathologic features of contact lens-induced Acanthamoeba Keratitis in the pig as well as the anatomical similarity of the pig eye with the human eye make the porcine model a valuable tool for investigations of the immunology, cell biology, and therapy for Acanthamoeba Keratitis.

J P Mcculley - One of the best experts on this subject based on the ideXlab platform.

  • Updates in Acanthamoeba Keratitis
    Eye & contact lens, 2007
    Co-Authors: Shady T. Awwad, J P Mcculley, Walter M Petroll, Harrison D Cavanagh
    Abstract:

    Acanthamoeba Keratitis is a potentially blinding microbial disease that has been increasing in incidence during the past two decades. Prognosis of this serious disease had been dismal, but improvement in diagnosis, a better understanding of the natural course of the disease, and recent introduction of multiple and effective therapeutic agents have resulted in improvement of visual outcomes. A review of literature pertaining to Acanthamoeba Keratitis. Contact lens wear and exposure to contaminated water sources remain the most important risk factors; however, in vivo confocal microscopy and improved biomicroscopic screening have proven instrumental in accurate early diagnosis. Complications of Acanthamoeba Keratitis include dacryoadenitis, corneal melting and scarring, severe secondary glaucoma, cataract, and chronic anterior segment inflammation that can rarely lead to reactive blinding retinal ischemia. Combination chemotherapeutic agents have been shown to be more effective than monotherapy, whereas rehabilitative surgery such as penetrating keratoplasty is best performed on a quiet eye free of ocular inflammation and with no residual amoebae. Increased suspicion by clinicians for Acanthamoeba and confocal microscopy have allowed more rapid and accurate diagnosis; treatment with multiple antiamoeba drugs is essential to disease resolution. Provided there are no residual amoebae after treatment, penetrating keratoplasty has been successful in visual rehabilitation. Secondary glaucoma occurs frequently and may require drainage procedures for control of intraocular pressure. Posterior complications are rare but may lead to ischemic retinitis.

  • updates in Acanthamoeba Keratitis
    Eye & Contact Lens-science and Clinical Practice, 2007
    Co-Authors: J P Mcculley, Shady T. Awwad, Walter M Petroll, Harrison D Cavanagh
    Abstract:

    Purpose. Acanthamoeba Keratitis is a potentially blinding microbial disease that has been increasing in incidence during the past two decades. Prognosis of this serious disease had been dismal, but improvement in diagnosis, a better understanding of the natural course of the disease, and recent introduction of multiple and effective therapeutic agents have resulted in improvement of visual outcomes. Methods. A review of literature pertaining to Acanthamoeba Keratitis. Results. Contact lens wear and exposure to contaminated water sources remain the most important risk factors; however, in vivo confocal microscopy and improved biomicroscopic screening have proven instrumental in accurate early diagnosis. Complications of Acanthamoeba Keratitis include dacryoadenitis, corneal melting and scarring, severe secondary glaucoma, cataract, and chronic anterior segment inflammation that can rarely lead to reactive blinding retinal ischemia. Combination chemotherapeutic agents have been shown to be more effective than monotherapy, whereas rehabilitative surgery such as penetrating keratoplasty is best performed on a quiet eye free of ocular inflammation and with no residual amoebae. Conclusions. Increased suspicion by clinicians for Acanthamoeba and confocal microscopy have allowed more rapid and accurate diagnosis; treatment with multiple antiamoeba drugs is essential to disease resolution. Provided there are no residual amoebae after treatment, penetrating keratoplasty has been successful in visual rehabilitation. Secondary glaucoma occurs frequently and may require drainage procedures for control of intraocular pressure. Posterior complications are rare but may lead to ischemic retinitis.

  • Role of tear anti-Acanthamoeba IgA in Acanthamoeba Keratitis.
    Advances in experimental medicine and biology, 2002
    Co-Authors: J Y Niederkorn, H Alizadeh, Harrison D Cavanagh, Henry Leher, Sherine Apte, S. El Agha, L. Ling, Michael Hurt, Kevin Howard, J P Mcculley
    Abstract:

    Acanthamoeba Keratitis is a sight-threatening corneal disease caused by pathogenic free-living amoebae.1The organisms have been isolated from a wide variety of environments and from nasopharyngeal washes of asymptomatic individuals. 1Contact lens wear, practiced by over 25 million individuals in the United States, is the leading risk factor. Over 85% of the cases of Acanthamoeba Keratitis occurred in contact lens wearers.2 Antibodies against Acanthamoeba spp. were detected in 52-100% of normal subjects tested in two serological surveys.3,4 In spite of the ubiquity of Acanthamoeba spp., the large number of contact lens wearers, and the apparent frequency of exposure to Acanthamoeba antigens, Acanthamoeba Keratitis is rare. We hypothesized that frequent environmental exposure to Acanthamoeba antigens induces an immunity that protects against corneal infection in most contact lens wearers.

  • The diagnosis and management of Acanthamoeba Keratitis.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists Inc, 2000
    Co-Authors: J P Mcculley, H Alizadeh, J Y Niederkorn
    Abstract:

    Purpose: The purpose of this study was to evaluate the immunology, pathogenesis and therapy of Acanthamoeba Keratitis. Methods: The recent development of an animal model of Acanthamoeba Keratitis and its impact on the medical treatment and immunology of Acanthamoeba Keratitis was reviewed. Results: After initial reports, Acanthamoeba infection of the cornea remained a rare disease until an association with contact lens wear was first recognized. Although the disease is closely associated with contact lens wear, it appeared that the contaminated solutions that were coming into contact with the lenses caused the disease. All types of contact lenses can be associated with development of Acanthamoeba Keratitis. Therefore, the contact lens serves as a carrier of Acanthamoeba to the surface of the eye. The typical patient with Acanthamoeba Keratitis is a young healthy individual who is either a contact lens wearer or has had significant exposure to water contaminated with Acanthamoeba. There are several risk factors such as corneal trauma, contaminated solution and contact lenses that have been reported to be associated with Acanthamoeba Keratitis. In spite of significant improvement in the diagnosis of Acanthamoeba Keratitis, progress in developing and utilizing effective antimicrobial agents for treating this disease have been disappointing. A growing body of evidence suggests that the mammalian immune system, if properly activated, is capable of preventing and controlling ocular infections. Conclusions: In order to develop effective immunotherapeutic modalities, and to better understand the immune effector mechanisms that protect the cornea against Acanthamoeba infection, it is necessary to fully characterize and evaluate the immunobiology of Acanthamoeba Keratitis.

  • Acanthamoeba Keratitis.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists Inc, 1995
    Co-Authors: J P Mcculley, H Alizadeh, J Y Niederkorn
    Abstract:

    The incidence of Acanthamoeba Keratitis has decreased significantly, and it is no longer a reportable condition in the United States. Corneal abrasion and contact lenses play an important role in the development of Acanthamoeba Keratitis. One of the most important features of the disease is severe pain, which is atypical for herpes simplex. The pathognomonic sign for Acanthamoeba is radial neuritis or inflammation around the corneal nerve caused by the parasites. The most important step in prevention of Acanthamoeba Keratitis is effective education of patients about the care of contact lenses. A combination of Brolene and Neomycin is the best approach in treating Acanthamoeba Keratitis. However, if treatment with these drugs fails, clotrimazole is recommended.

Harrison D Cavanagh - One of the best experts on this subject based on the ideXlab platform.

  • updates in Acanthamoeba Keratitis
    Eye & Contact Lens-science and Clinical Practice, 2007
    Co-Authors: J P Mcculley, Shady T. Awwad, Walter M Petroll, Harrison D Cavanagh
    Abstract:

    Purpose. Acanthamoeba Keratitis is a potentially blinding microbial disease that has been increasing in incidence during the past two decades. Prognosis of this serious disease had been dismal, but improvement in diagnosis, a better understanding of the natural course of the disease, and recent introduction of multiple and effective therapeutic agents have resulted in improvement of visual outcomes. Methods. A review of literature pertaining to Acanthamoeba Keratitis. Results. Contact lens wear and exposure to contaminated water sources remain the most important risk factors; however, in vivo confocal microscopy and improved biomicroscopic screening have proven instrumental in accurate early diagnosis. Complications of Acanthamoeba Keratitis include dacryoadenitis, corneal melting and scarring, severe secondary glaucoma, cataract, and chronic anterior segment inflammation that can rarely lead to reactive blinding retinal ischemia. Combination chemotherapeutic agents have been shown to be more effective than monotherapy, whereas rehabilitative surgery such as penetrating keratoplasty is best performed on a quiet eye free of ocular inflammation and with no residual amoebae. Conclusions. Increased suspicion by clinicians for Acanthamoeba and confocal microscopy have allowed more rapid and accurate diagnosis; treatment with multiple antiamoeba drugs is essential to disease resolution. Provided there are no residual amoebae after treatment, penetrating keratoplasty has been successful in visual rehabilitation. Secondary glaucoma occurs frequently and may require drainage procedures for control of intraocular pressure. Posterior complications are rare but may lead to ischemic retinitis.

  • Updates in Acanthamoeba Keratitis
    Eye & contact lens, 2007
    Co-Authors: Shady T. Awwad, J P Mcculley, Walter M Petroll, Harrison D Cavanagh
    Abstract:

    Acanthamoeba Keratitis is a potentially blinding microbial disease that has been increasing in incidence during the past two decades. Prognosis of this serious disease had been dismal, but improvement in diagnosis, a better understanding of the natural course of the disease, and recent introduction of multiple and effective therapeutic agents have resulted in improvement of visual outcomes. A review of literature pertaining to Acanthamoeba Keratitis. Contact lens wear and exposure to contaminated water sources remain the most important risk factors; however, in vivo confocal microscopy and improved biomicroscopic screening have proven instrumental in accurate early diagnosis. Complications of Acanthamoeba Keratitis include dacryoadenitis, corneal melting and scarring, severe secondary glaucoma, cataract, and chronic anterior segment inflammation that can rarely lead to reactive blinding retinal ischemia. Combination chemotherapeutic agents have been shown to be more effective than monotherapy, whereas rehabilitative surgery such as penetrating keratoplasty is best performed on a quiet eye free of ocular inflammation and with no residual amoebae. Increased suspicion by clinicians for Acanthamoeba and confocal microscopy have allowed more rapid and accurate diagnosis; treatment with multiple antiamoeba drugs is essential to disease resolution. Provided there are no residual amoebae after treatment, penetrating keratoplasty has been successful in visual rehabilitation. Secondary glaucoma occurs frequently and may require drainage procedures for control of intraocular pressure. Posterior complications are rare but may lead to ischemic retinitis.

  • Secondary glaucoma associated with advanced Acanthamoeba Keratitis.
    Eye & contact lens, 2006
    Co-Authors: Patrick S. Kelley, Adam P. Dossey, David Patel, Jess T. Whitson, Robert N Hogan, Harrison D Cavanagh
    Abstract:

    PURPOSE To describe the association of Acanthamoeba Keratitis and glaucoma, to establish an incidence of glaucoma in patients with Acanthamoeba Keratitis, to discuss treatment options and outcomes in these patients, and to describe the histopathologic findings and pathogenesis of glaucoma secondary to Acanthamoeba Keratitis. METHODS After Institutional Review Board approval, the charts of all patients suspected of having Acanthamoeba Keratitis at Aston Ambulatory Center at The University of Texas Southwestern Medical Center were reviewed. Inclusion criteria were as follows: diagnosis of Acanthamoeba Keratitis by positive confocal microscopy or culture, diagnosis of glaucoma or ocular hypertension secondary to Acanthamoeba Keratitis, and at least 6 months of follow-up. Exclusion criteria included a previous diagnosis of glaucoma or ocular hypertension and any history of intraocular surgery before the development of glaucoma. The date of Keratitis development, pneumotonometry on initial and follow-up examinations, glaucoma medications used, and surgical procedures performed were tabulated. RESULTS Twenty patients (20 eyes) were included. Six (30%) eyes developed secondary glaucoma during the review period. Of the patients treated for glaucoma with medication alone, the visual acuity of three (75%) of four became light perception or no light perception. Three of six patients required glaucoma drainage device implantation for intraocular pressure control. Of these, the vision of one eye became no light perception, and the other two eyes maintained better than 20/100 vision. Histopathologic examination showed chronic inflammation of the trabecular meshwork and angle closure. No Acanthamoeba organisms were found in the angle structures. CONCLUSIONS The development of secondary glaucoma is not uncommon in Acanthamoeba Keratitis and is a poor prognostic sign in patients with Acanthamoeba Keratitis, because most progress to light perception or no light perception vision. Histopathologic findings suggest an inflammatory angle-closure mechanism, apparently without direct infiltration of the organism. The glaucoma associated with Acanthamoeba Keratitis is often severe and frequently requires surgical intervention for intraocular pressure control and vision preservation.

  • Role of tear anti-Acanthamoeba IgA in Acanthamoeba Keratitis.
    Advances in experimental medicine and biology, 2002
    Co-Authors: J Y Niederkorn, H Alizadeh, Harrison D Cavanagh, Henry Leher, Sherine Apte, S. El Agha, L. Ling, Michael Hurt, Kevin Howard, J P Mcculley
    Abstract:

    Acanthamoeba Keratitis is a sight-threatening corneal disease caused by pathogenic free-living amoebae.1The organisms have been isolated from a wide variety of environments and from nasopharyngeal washes of asymptomatic individuals. 1Contact lens wear, practiced by over 25 million individuals in the United States, is the leading risk factor. Over 85% of the cases of Acanthamoeba Keratitis occurred in contact lens wearers.2 Antibodies against Acanthamoeba spp. were detected in 52-100% of normal subjects tested in two serological surveys.3,4 In spite of the ubiquity of Acanthamoeba spp., the large number of contact lens wearers, and the apparent frequency of exposure to Acanthamoeba antigens, Acanthamoeba Keratitis is rare. We hypothesized that frequent environmental exposure to Acanthamoeba antigens induces an immunity that protects against corneal infection in most contact lens wearers.

Berthold Seitz - One of the best experts on this subject based on the ideXlab platform.

  • Acanthamoeba Keratitis - Clinical signs, differential diagnosis and treatment.
    Journal of Current Ophthalmology, 2019
    Co-Authors: Nóra Szentmáry, Loay Daas, Lei Shi, Kornelia Lenke Laurik, Sabine Lepper, Georgia Milioti, Berthold Seitz
    Abstract:

    Abstract Purpose To summarize actual literature data on clinical signs, differential diagnosis, and treatment of Acanthamoeba Keratitis. Methods Review of literature. Results Clinical signs of Acanthamoeba Keratitis are in early stages grey-dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis. As conservative treatment, we use up to one year triple-topical therapy (polyhexamethylene-biguanide, propamidine-isethionate, neomycin). In therapy resistant cases, surgical treatment options such as corneal cryotherapy, amniotic membrane transplantation, riboflavin-UVA cross-linking, and penetrating keratoplasty are applied. Conclusion With early diagnosis and conservative or surgical treatment, Acanthamoeba Keratitis heals in most cases.

  • Acanthamoeba Keratitis – Clinical signs, differential diagnosis and treatment
    Elsevier, 2019
    Co-Authors: Nóra Szentmáry, Loay Daas, Lei Shi, Kornelia Lenke Laurik, Sabine Lepper, Georgia Milioti, Berthold Seitz
    Abstract:

    Purpose: To summarize actual literature data on clinical signs, differential diagnosis, and treatment of Acanthamoeba Keratitis. Methods: Review of literature. Results: Clinical signs of Acanthamoeba Keratitis are in early stages grey-dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis. As conservative treatment, we use up to one year triple-topical therapy (polyhexamethylene-biguanide, propamidine-isethionate, neomycin). In therapy resistant cases, surgical treatment options such as corneal cryotherapy, amniotic membrane transplantation, riboflavin-UVA cross-linking, and penetrating keratoplasty are applied. Conclusion: With early diagnosis and conservative or surgical treatment, Acanthamoeba Keratitis heals in most cases. Keywords: Acanthamoeba, Keratitis, Cornea, Contact len

  • Acanthamoeba Keratitis - Clinical signs, differential diagnosis and treatment.
    Journal of current ophthalmology, 2018
    Co-Authors: Nóra Szentmáry, Loay Daas, Lei Shi, Kornelia Lenke Laurik, Sabine Lepper, Georgia Milioti, Berthold Seitz
    Abstract:

    To summarize actual literature data on clinical signs, differential diagnosis, and treatment of Acanthamoeba Keratitis. Review of literature. Clinical signs of Acanthamoeba Keratitis are in early stages grey-dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis. As conservative treatment, we use up to one year triple-topical therapy (polyhexamethylene-biguanide, propamidine-isethionate, neomycin). In therapy resistant cases, surgical treatment options such as corneal cryotherapy, amniotic membrane transplantation, riboflavin-UVA cross-linking, and penetrating keratoplasty are applied. With early diagnosis and conservative or surgical treatment, Acanthamoeba Keratitis heals in most cases.

  • Acanthamoeba Keratitis--a rare and often late diagnosed disease
    Klinische Monatsblatter fur Augenheilkunde, 2012
    Co-Authors: Nóra Szentmáry, S Goebels, P Matoula, F Schirra, Berthold Seitz
    Abstract:

    In 83-93% of the cases of Acanthamoeba Keratitis the patients are contact lens wearers. Acanthamoeba Keratitis is diagnosed--with descending order of sensitivity and specificity--through polymerase chain reaction (PCR), confocal biomicroscopy, in-vitro cultivation and histopathological examination. The typical clinical appearance of Acanthamoeba Keratitis includes pseudodendritic epitheliopathy, perineuritis, ring infiltrate or multifocal stromal infiltrates and in some cases limbitis with infiltration of the conjunctiva and/or sterile anterior uveitis. Information on reliability and efficacy of the medical/surgical therapy for Acanthamoeba Keratitis has only been published for case series and It has not been verified through randomised controlled clinical studies so far. By early diagnosis, using triple-topical therapy (polyhexamid, propamidinisoethionat, neomycin) Acanthamoeba Keratitis often heals appropriately. However, even if diagnosed early, topical therapy should be continued for 1 year. In therapy-resistant cases cryotherapy, amniotic membrane transplantation, cross-linking therapy, and therapeutic keratoplasty are performed. The prognosis of keratoplasty following Acanthamoeba Keratitis is more favourable when there were no signs of infection at least during the preceding 3 months.

Rui Hua Wei - One of the best experts on this subject based on the ideXlab platform.

  • Laser in situ keratomileusis treatment for myopia after Acanthamoeba Keratitis.
    Eye & contact lens, 2004
    Co-Authors: Li Lim, Rui Hua Wei
    Abstract:

    PURPOSE We report a case of a patient with a history of Acanthamoeba Keratitis in the right eye who was successfully treated with Laser in situ keratomileusis (LASIK) for myopia correction. METHODS A 39-year-old woman with a history of wearing daily soft contact lens had early (epithelial phase) Acanthamoeba Keratitis in the right eye. The corneal infection resolved with 5 months of topical polyhexamethylene biguanide and propamidine treatment. Recurrence of Acanthamoeba Keratitis did not occur after the first episode, and no scarring of the cornea was noted. Laser in situ keratomileusis was performed in both eyes 2 years later. RESULTS The patient successfully underwent LASIK procedures in both eyes. No complications were observed intraoperatively and postoperatively in the right eye. The cornea remained clear 3 months postoperatively, and she achieved 6/6 uncorrected visual acuity. CONCLUSIONS Following successful treatment of Acanthamoeba Keratitis, the LASIK procedure can be performed on previously infected cornea with successful results. There is no recurrence of Acanthamoeba Keratitis at 3-month follow-up.