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Acetylation
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Prostakov N.s. – One of the best experts on this subject based on the ideXlab platform.
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SYNTHESIS AND FUNGICIDAL ACTIVITY OF SUBSTITUTED TETRAHYDROPYRIDO[3,4-C]COUMARINS AND BENZO[H]TETRAHYDROPYRIDO[3,4-C]COUMARINS
, 2020Co-Authors: Mandal T.k., Soldatenkov A.t., Ageev E.a., Stashenko E.v., Denisov E.n., Andreeva E.i., Prostakov N.s.Abstract:Condensation of aromatic aldehydes with 2,6-diphenyl-3-carboethoxy-4-piperidone and ammonium acetate gave rise to a number of substituted tetrahydropyrido [3,4-c] coumarines. Their methylation and Acetylation were investigated. The way hydrazine hydrate affected the compounds in question was also reported. The resultants were tested for fungicidal properties
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Transformations of 2,6-dimethyl- and 2,3-dimethyl-6-ethyl-4-(2′-furyl)pyridines involving the furan and pyridine rings
Латвийский институт органического синтеза Латвийской академии наук Springer New York Consultants Bureau, 2020Co-Authors: Prostakov N.s., Soldatenkov A.t., Radzha P.k., Khil'be T.e.Abstract:Alkyl-substituted 4-(2′-furyl)pyridines are brominated and nitrated in the C5′ position of the furan ring; however, they do not undergo electrophilic substitution reactions such as Acetylation, formylation, and chloro- and aminomethylation. Furyl-substituted indolizines and tetrahydropyridines were obtained from quaternary salts of 2,6-dimethyl-4-(2′-furyl)pyridine. © 1983 Plenum Publishing Corporation
Fusco Giuliana – One of the best experts on this subject based on the ideXlab platform.
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The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Runfola Matteo, De Simone Alfonso, Vendruscolo Michele, Dobson, Christophe M, Fusco GiulianaAbstract:The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Emerging evidence indicates that the interaction of αS with lipid membranes defines both its physiological function and pathological effects. The characterisation of the modes of membrane binding by αS is therefore crucial to clarify the balance between normal and aberrant behaviour of this protein. Here we used solid-state nuclear magnetic resonance (ssNMR) spectroscopy to probe the nature of the N-terminally acetylated form of αS (NTAc-αS) bound to synaptic-like lipid vesicles. This post-translational modification is prevalent for the physiological form of αS and modulates the binding to lipid bilayers. By probing the structure, dynamics and membrane topology of NTAc- αS, we found that N-terminal Acetylation does not alter significantly the conformational properties of the membrane-bound state of αS, despite increasing its propensity for binding. Taken together, our data and previous characterisations of the cytosolic state of NTAc-αS clarify that the role of N-terminal Acetylation is to regulate the binding affinity of αS for synaptic vesicles without altering the structural properties of the bound state.This research is supported by Parkinson’s UK (G-1508, A.D., M.V., C.M.D and
G.F.), the UK Medical Research Council (MR/N000676/1, A.D., M.V. and C.M.D.), the European
Research Council (ERC) Consolidator Grant (CoG) ‘BioDisOrder” (819644, A.D.), The Centre for
Misfolding Diseases of the University of Cambridge (C.M.D. and M.V.) and the St John’s College
Fellowship (G.F.) -
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Runfola Matteo, De Simone Alfonso, Vendruscolo Michele, Dobson, Christophe M, Fusco GiulianaAbstract:The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Emerging evidence indicates that the interaction of αS with lipid membranes defines both its physiological function and pathological effects. The characterisation of the modes of membrane binding by αS is therefore crucial to clarify the balance between normal and aberrant behaviour of this protein. Here we used solid-state nuclear magnetic resonance (ssNMR) spectroscopy to probe the nature of the N-terminally acetylated form of αS (NTAc-αS) bound to synaptic-like lipid vesicles. This post-translational modification is prevalent for the physiological form of αS and modulates the binding to lipid bilayers. By probing the structure, dynamics and membrane topology of NTAc-αS, we found that N-terminal Acetylation does not alter significantly the conformational and topological properties of the membrane-bound state of αS, despite increasing its propensity for binding. Taken together, our data and previous characterisations of the cytosolic state of NTAc-αS clarify that the role of the N-terminal Acetylation is to regulate the binding affinity of αS for synaptic vesicles without altering the structural properties of the bound state
Soldatenkov A.t. – One of the best experts on this subject based on the ideXlab platform.
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SYNTHESIS AND FUNGICIDAL ACTIVITY OF SUBSTITUTED TETRAHYDROPYRIDO[3,4-C]COUMARINS AND BENZO[H]TETRAHYDROPYRIDO[3,4-C]COUMARINS
, 2020Co-Authors: Mandal T.k., Soldatenkov A.t., Ageev E.a., Stashenko E.v., Denisov E.n., Andreeva E.i., Prostakov N.s.Abstract:Condensation of aromatic aldehydes with 2,6-diphenyl-3-carboethoxy-4-piperidone and ammonium acetate gave rise to a number of substituted tetrahydropyrido [3,4-c] coumarines. Their methylation and Acetylation were investigated. The way hydrazine hydrate affected the compounds in question was also reported. The resultants were tested for fungicidal properties
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Transformations of 2,6-dimethyl- and 2,3-dimethyl-6-ethyl-4-(2′-furyl)pyridines involving the furan and pyridine rings
Латвийский институт органического синтеза Латвийской академии наук Springer New York Consultants Bureau, 2020Co-Authors: Prostakov N.s., Soldatenkov A.t., Radzha P.k., Khil'be T.e.Abstract:Alkyl-substituted 4-(2′-furyl)pyridines are brominated and nitrated in the C5′ position of the furan ring; however, they do not undergo electrophilic substitution reactions such as Acetylation, formylation, and chloro- and aminomethylation. Furyl-substituted indolizines and tetrahydropyridines were obtained from quaternary salts of 2,6-dimethyl-4-(2′-furyl)pyridine. © 1983 Plenum Publishing Corporation