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Achilles Tendinitis

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Fengsheng Wang – One of the best experts on this subject based on the ideXlab platform.

Yeungjen Chen – One of the best experts on this subject based on the ideXlab platform.

  • extracorporeal shock waves promote healing of collagenase induced Achilles Tendinitis and increase tgf β1 and igf i expression
    Journal of Orthopaedic Research, 2004
    Co-Authors: Yeungjen Chen, Chingjen Wang, Kuender D Yang, Huichen Huang, Yuting Huang, Fengsheng Wang
    Abstract:

    Extracorporeal shock waves (ESW) have recently been used in resolving Tendinitis. However, mechanisms by which ESW promote tendon repair is not fully understood. In this study, we reported that an optimal ESW treatment promoted healing of Achilles tendintis by inducing TGF-b1 and IGF-I. Rats with the collagenease-induced Achilles Tendinitis were given a single ESW treatment (0.16 mJ/mm 2 energy flux density) with 0, 200, 500 and 1000 impulses. Achilles tendons were subjected to biomechanical (load to failure and stiffness), biochemical properties (DNA, glycosaminoglycan and hydroxyproline content) and histological assessment. ESW with 200 impulses restored biomechanical and biochemical characteristics of healing tendons 12 weeks after treatment. However, ESW treatments with 500 and 1000 impulses elicited inhibitory effects on Tendinitis repair. Histological observation demonstrated that ESW treatment resolved edema, swelling, and inflammatory cell infiltration in injured tendons. Lesion site underwent intensive tenocyte proliferation, neovascularization and progressive tendon tissue regeneration. Tenocytes at the hypertrophied cellular tissue and newly developed tendon tissue expressed strong proliferating cell nuclear antigen (PCNA) after ESW treatment, suggesting that physical ESW could increase the mitogenic responses of tendons. Moreover, the proliferation of tenocytes adjunct to hypertrophied cell aggregate and newly formed tendon tissue coincided with intensive TGF-b1 and IGF-I expression. Increasing TGF-b1 expression was noted in the early stage of tendon repair, and elevated IGF-I expression was persisted throughout the healing period. Together, low-energy shock wave effectively promoted tendon healing. TGF-b1 and IGF-I played important roles in mediating ESW-stimulated cell proliferation and tissue regeneration of tendon.

  • Extracorporeal shock waves promote healing of collagenase‐induced Achilles Tendinitis and increase TGF‐β1 and IGF‐I expression
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2004
    Co-Authors: Yeungjen Chen, Chingjen Wang, Kuender D Yang, Huichen Huang, Yuting Huang, Yur-ren Kuo, Yi-chih Sun, Fengsheng Wang
    Abstract:

    Extracorporeal shock waves (ESW) have recently been used in resolving Tendinitis. However, mechanisms by which ESW promote tendon repair is not fully understood. In this study, we reported that an optimal ESW treatment promoted healing of Achilles tendintis by inducing TGF-b1 and IGF-I. Rats with the collagenease-induced Achilles Tendinitis were given a single ESW treatment (0.16 mJ/mm 2 energy flux density) with 0, 200, 500 and 1000 impulses. Achilles tendons were subjected to biomechanical (load to failure and stiffness), biochemical properties (DNA, glycosaminoglycan and hydroxyproline content) and histological assessment. ESW with 200 impulses restored biomechanical and biochemical characteristics of healing tendons 12 weeks after treatment. However, ESW treatments with 500 and 1000 impulses elicited inhibitory effects on Tendinitis repair. Histological observation demonstrated that ESW treatment resolved edema, swelling, and inflammatory cell infiltration in injured tendons. Lesion site underwent intensive tenocyte proliferation, neovascularization and progressive tendon tissue regeneration. Tenocytes at the hypertrophied cellular tissue and newly developed tendon tissue expressed strong proliferating cell nuclear antigen (PCNA) after ESW treatment, suggesting that physical ESW could increase the mitogenic responses of tendons. Moreover, the proliferation of tenocytes adjunct to hypertrophied cell aggregate and newly formed tendon tissue coincided with intensive TGF-b1 and IGF-I expression. Increasing TGF-b1 expression was noted in the early stage of tendon repair, and elevated IGF-I expression was persisted throughout the healing period. Together, low-energy shock wave effectively promoted tendon healing. TGF-b1 and IGF-I played important roles in mediating ESW-stimulated cell proliferation and tissue regeneration of tendon.

J J Biundo – One of the best experts on this subject based on the ideXlab platform.

Hak Jun Kim – One of the best experts on this subject based on the ideXlab platform.

Sung Eun Kim – One of the best experts on this subject based on the ideXlab platform.

  • Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles Tendinitis rat model.
    Carbohydrate polymers, 2020
    Co-Authors: Hong Joon Choi, S.j. Choi, Mi Hyun Song, Kyu Sik Shim, Hak Jun Kim, Youn Mook Lim, Kyeongsoon Park, Jae Gyoon Kim, Sung Eun Kim
    Abstract:

    Gradual wear and tear can cause a local inflammatory response in tendons. The trauma and inflammatory reaction eventually impair the biomechanical properties of the tendon. In this study, we prepared lactoferrin-immobilized, heparin-anchored, poly(lactic-co-glycolic acid) nanoparticles (LF/Hep-PLGA NPs) and evaluated their in vitro anti-inflammatory effects on interleukin-1β (IL-1β)-treated tenocytes and in vivo tendon healing effects in a rat model of Achilles Tendinitis. Long-term LF-deliverable NPs (LF/Hep-PLGA NPs) remarkably decreased mRNA levels of pro-inflammatory factors [cyclooxygenase-2 (COX-2), IL-1β, matrix metalloproteinase-3 (MMP-3), MMP-13, IL-6, and tumor necrosis factor-α (TNF-α)] and increased mRNA levels of anti-inflammatory cytokines (IL-4 and IL-10) in both IL-1β-treated tenocytes and the Achilles tendons of a collagenase-induced Achilles Tendinitis rat model. Interestingly, anti-inflammatory LF/Hep-PLGA NPs greatly enhanced collagen content, mRNA levels of tenogenic markers [collagen type I (COL1A1), decorin (DCN), tenascin-C (TNC)], and biomechanical properties such as tendon stiffness and tensile strength. These results suggest that anti-inflammatory LF/Hep-PLGA NPs are effective at restoring tendons in Achilles Tendinitis.

  • Therapeutic Efficacy of Intratendinous Delivery of Dexamethasone Using Porous Microspheres for Amelioration of Inflammation and Tendon Degeneration on Achilles Tendinitis in Rats
    BioMed research international, 2020
    Co-Authors: S.j. Choi, Mi Hyun Song, Kyu Sik Shim, Hak Jun Kim, Youn Mook Lim, Hae Ryong Song, Kyeongsoon Park, Sung Eun Kim
    Abstract:

    Achilles Tendinitis caused by overuse, aging, or gradual wear induces pain, swelling, and stiffness of Achilles tendon and leads to tendon rupture. This study was performed to investigate the suppression of inflammation responses in interleukin-1β- (IL-1β-) stimulated tenocytes in vitro and the suppression of the progression of Achilles Tendinitis-induced rat models in vivo using dexamethasone-containing porous microspheres (DEX/PMSs) for a sustained intratendinous DEX delivery. DEX from DEX/PMSs showed the sustained release of DEX. Treatment of IL-1β-stimulated tenocytes with DEX/PMSs suppressed the mRNA levels for COX-2, IL-1β, IL-6, and TNF-α. The intratendinous injection of DEX/PMSs into Achilles Tendinitis rats both decreased the mRNA levels for these cytokines and increased mRNA levels for anti-inflammatory cytokines IL-4 and IL-10 in tendon tissues. Furthermore, DEX/PMSs effectively prevented tendon degeneration by enhancing the collagen content and biomechanical properties. Our findings suggest that DEX/PMSs show great potential as a sustained intratendinous delivery system for ameliorating inflammation responses as well as tendon degeneration in Achilles Tendinitis.

  • Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles Tendinitis
    Journal of Industrial and Engineering Chemistry, 2019
    Co-Authors: Tae Hoon Lee, Sung Eun Kim, Kyeongsoon Park, Jae Yong Lee, Jae Gyoon Kim, Hak Jun Kim
    Abstract:

    Abstract We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles Tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α, and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles Tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles Tendinitis.