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Piccinini Silva – One of the best experts on this subject based on the ideXlab platform.

  • Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis * Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla
    , 2011
    Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini Silva

    Abstract:

    Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica

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  • acute Acneiform Eruption induced by interferon beta 1b during treatment for multiple sclerosis erupcao Acneiforme aguda induzida por interferon beta 1b durante tratamento para esclerose multipla
    , 2011
    Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini Silva

    Abstract:

    Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica

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Ronaldo Figueiredo Machado – One of the best experts on this subject based on the ideXlab platform.

  • Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis
    Sociedade Brasileira de Dermatologia, 2011
    Co-Authors: Dário Júnior De Freitas Rosa, Fernanda De Abreu Toledo Matias, Sâmya Diégues Cedrim, Ronaldo Figueiredo Machado, Vânia Carolina Piccinini Silva

    Abstract:

    Esclerose múltipla é uma doença inflamatória desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapêutica é baseada no uso de imunomoduladores, como o interferon beta, que são geralmente bem tolerados. As manifestações cutâneas secundárias ao interferon beta-1b são representadas, na maioria das vezes, por reações no local de sua aplicação subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupção Acneiforme pelo interferon beta-1b.Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomodulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b

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  • Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis * Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla
    , 2011
    Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini Silva

    Abstract:

    Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica

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  • acute Acneiform Eruption induced by interferon beta 1b during treatment for multiple sclerosis erupcao Acneiforme aguda induzida por interferon beta 1b durante tratamento para esclerose multipla
    , 2011
    Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini Silva

    Abstract:

    Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica

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Pablo Fernandezpenas – One of the best experts on this subject based on the ideXlab platform.

  • Acneiform Eruption in a patient with metastatic melanoma after ceasing combination dabrafenib trametinib therapy
    Melanoma Research, 2014
    Co-Authors: Pablo Uribe, Rachael Anforth, Richard F. Kefford, Pablo Fernandezpenas

    Abstract:

    BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) increase survival in BRAF mutant metastatic melanoma patients; however, they induce a well-known spectrum of cutaneous side effects during treatment. Whereas the BRAFi dabrafenib induces cutaneous squamous cell carcinomas and verrucal keratosis, the MEKi trametinib frequently induces Acneiform Eruptions that are reversible after drug discontinuation. Furthermore, when dabrafenib and trametinib are used in combination, there are fewer cutaneous toxicities. We report a patient with BRAF mutant metastatic melanoma treated with the BRAFi/MEKi combination therapy who developed an Acneiform Eruption after treatment discontinuation rather than during active therapy. Moreover, the Eruption resolved when the combination treatment was reintroduced and recurred after increasing the dose of trametinib. The Eruption may be explained by the longer half-life of trametinib (4.5 days) compared with dabrafenib (5.2 h). This is the first case reported with this particular side effect induced after stopping the treatment and could become more frequent as the BRAFi/MEKi combination of drugs is more frequently prescribed.

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