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Piccinini Silva - One of the best experts on this subject based on the ideXlab platform.
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Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis * Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla
2011Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini SilvaAbstract:Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica
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acute Acneiform Eruption induced by interferon beta 1b during treatment for multiple sclerosis erupcao Acneiforme aguda induzida por interferon beta 1b durante tratamento para esclerose multipla
2011Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini SilvaAbstract:Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica
Ronaldo Figueiredo Machado - One of the best experts on this subject based on the ideXlab platform.
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Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis
Sociedade Brasileira de Dermatologia, 2011Co-Authors: Dário Júnior De Freitas Rosa, Fernanda De Abreu Toledo Matias, Sâmya Diégues Cedrim, Ronaldo Figueiredo Machado, Vânia Carolina Piccinini SilvaAbstract:Esclerose múltipla é uma doença inflamatória desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapêutica é baseada no uso de imunomoduladores, como o interferon beta, que são geralmente bem tolerados. As manifestações cutâneas secundárias ao interferon beta-1b são representadas, na maioria das vezes, por reações no local de sua aplicação subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupção Acneiforme pelo interferon beta-1b.Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomodulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b
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Acute Acneiform Eruption induced by interferon beta-1b during treatment for multiple sclerosis * Erupção Acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla
2011Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini SilvaAbstract:Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica
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acute Acneiform Eruption induced by interferon beta 1b during treatment for multiple sclerosis erupcao Acneiforme aguda induzida por interferon beta 1b durante tratamento para esclerose multipla
2011Co-Authors: Ronaldo Figueiredo Machado, Vânia Carolina, Piccinini SilvaAbstract:Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomod- ulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an Acneiform Eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform Eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose multipla e uma doenca inflamatoria desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapeutica e baseada no uso de imunomoduladores, como o interferon beta, que sao geralmente bem tolerados. As manifestacoes cutâneas secundarias ao interferon beta-1b sao representadas, na maioria das vezes, por reacoes no local de sua aplicacao subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupcao Acneiforme pelo interferon beta-1b. Palavras-chave: Erupcoes Acneiformes; Esclerose multipla; Interferon beta; Terapeutica
Pablo Fernandezpenas - One of the best experts on this subject based on the ideXlab platform.
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Acneiform Eruption in a patient with metastatic melanoma after ceasing combination dabrafenib trametinib therapy
Melanoma Research, 2014Co-Authors: Pablo Uribe, Rachael Anforth, Richard F. Kefford, Pablo FernandezpenasAbstract:BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) increase survival in BRAF mutant metastatic melanoma patients; however, they induce a well-known spectrum of cutaneous side effects during treatment. Whereas the BRAFi dabrafenib induces cutaneous squamous cell carcinomas and verrucal keratosis, the MEKi trametinib frequently induces Acneiform Eruptions that are reversible after drug discontinuation. Furthermore, when dabrafenib and trametinib are used in combination, there are fewer cutaneous toxicities. We report a patient with BRAF mutant metastatic melanoma treated with the BRAFi/MEKi combination therapy who developed an Acneiform Eruption after treatment discontinuation rather than during active therapy. Moreover, the Eruption resolved when the combination treatment was reintroduced and recurred after increasing the dose of trametinib. The Eruption may be explained by the longer half-life of trametinib (4.5 days) compared with dabrafenib (5.2 h). This is the first case reported with this particular side effect induced after stopping the treatment and could become more frequent as the BRAFi/MEKi combination of drugs is more frequently prescribed.
E. Van Cutsem - One of the best experts on this subject based on the ideXlab platform.
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clinical signs pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
Annals of Oncology, 2005Co-Authors: Siegfried Segae, E. Van CutsemAbstract:The last few years, new therapies targeting the epidermal growth factor receptor (EGFR) have shown their efficacy in the treatment of several types of cancer. Monoclonal antibodies against the EGFR (e.g. cetuximab, panitumumab) or EGFR tyrosine kinase inhibitors (e.g. gefitinib, erlotinib) are generally well tolerated and do not have the severe systemic side-effects usually seen with cytotoxic drugs. A considerable number of patients treated with these EGFR inhibitors, however, develop dermatological side-effects, most frequently an Acneiform Eruption but also xerosis, eczema, fissures, telangiectasia, hyperpigmentation, hair changes and paronychia with pyogenic granuloma. These skin effects appear to be mechanism-based linked to the inhibition of EGFR action but the exact pathophysiology remains elusive. Left untreated these dermatological side-effects could represent a threat to patient compliance. Therefore effective management is mandatory. Mild cases of Acneiform Eruption respond well to topical anti-inflammatory acne therapy, whereas tetracyclines are needed to treat moderate to severe cases. This review outlines the broad spectrum of cutaneous side-effects of EGFR inhibitors, discusses possible underlying mechanisms and provides practical guidelines for the management based on literature data and on personal experience.
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Review Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
2005Co-Authors: Siegfried Segaert, E. Van CutsemAbstract:The last few years, new therapies targeting the epidermal growth factor receptor (EGFR) have shown their efficacy in the treatment of several types of cancer. Monoclonal antibodies against the EGFR (e.g. cetuximab, panitumumab) or EGFR tyrosine kinase inhibitors (e.g. gefitinib, erlotinib) are generally well tolerated and do not have the severe systemic side-effects usually seen with cyto-toxic drugs. A considerable number of patients treated with these EGFR inhibitors, however, develop dermatological side-effects, most frequently an Acneiform Eruption but also xerosis, eczema, fissures, telangiectasia, hyperpigmentation, hair changes and paronychia with pyogenic granuloma. These skin effects appear to be mechanism-based linked to the inhibition of EGFR action but the exact pathophysiology remains elusive. Left untreated these dermatological side-effects could rep-resent a threat to patient compliance. Therefore effective management is mandatory. Mild cases of Acneiform Eruption respond well to topical anti-inflammatory acne therapy, whereas tetracyclines are needed to treat moderate to severe cases. This review outlines the broad spectrum of cutaneous side-effects of EGFR inhibitors, discusses possible underlying mechanisms and provides practical guide-lines for the management based on literature data and on personal experience. Key words: Acneiform Eruption, cetuximab, epidermal growth factor receptor, erlotinib, gefitini
Juliana Hein - One of the best experts on this subject based on the ideXlab platform.
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Vellus hair cysts presenting as an atypical Acneiform Eruption
Anais Brasileiros de Dermatologia, 2011Co-Authors: Hiram Larangeira De Almeida, Lisia Nudelmann, Joice Göebel, Nathália Janovik, Juliana HeinAbstract:A 32-year-old male patient presented for 8 months an asymptomatic therapy-resistant Acneiform Eruption on his back and buttocks. Skin examination showed several inflammatory papules, which evolved to hyperpigmentation. At the same distribution non inflammatory papules, which resembled rice grains, were also observed. Light microscopy showed small keratin-filled cysts, with an epithelial multilayered wall, without granular layer. Keratin and some vellus hairs were identified inside the cyst, confirming the diagnosis of vellus hair cysts. Diagnosis of vellus hair cysts should be suspected in cases of multiple papules or therapy-resistant cases of Acneiform Eruptions
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Vellus hair cysts presenting as an atypical Acneiform Eruption Cisto de pelo velos apresentando-se como erupção Acneiforme atípica
Sociedade Brasileira de Dermatologia, 2011Co-Authors: Hiram Larangeira De Almeida, Lisia Nudelmann, Joice Göebel, Nathália Janovik, Juliana HeinAbstract:A 32-year-old male patient presented for 8 months an asymptomatic therapy-resistant Acneiform Eruption on his back and buttocks. Skin examination showed several inflammatory papules, which evolved to hyperpigmentation. At the same distribution non inflammatory papules, which resembled rice grains, were also observed. Light microscopy showed small keratin-filled cysts, with an epithelial multilayered wall, without granular layer. Keratin and some vellus hairs were identified inside the cyst, confirming the diagnosis of vellus hair cysts. Diagnosis of vellus hair cysts should be suspected in cases of multiple papules or therapy-resistant cases of Acneiform EruptionsUm paciente de 32 anos apresentou há 8 meses uma erupção Acneiforme resistente à terapêutica, localizada no dorso e nádegas. Ao exame apresentava inúmeras pápulas inflamatórias, que evoluiam para hiperpigmentação. Na mesma distribuição havia lesões não inflamatórias, lembrando grão de arroz. A microscopia óptica demonstrou cisto dérmico cuja parede era de epitélio estratificado, sem camada granular, preenchido de queratina e com pelos no interior, confirmando o diagnóstico de cisto de pelo veloso. Essa entidade deve ser suspeitada em casos de múltiplas pápulas ou erupções Acneiformes resistentes à terapi
