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Actuation Scheme

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Jungwon Yoon – One of the best experts on this subject based on the ideXlab platform.

  • Electromagnetic Actuation Scheme for Swarm of Magnetic Nanoparticles Steering in Multi-bifurcation
    2019 International Conference on Manipulation Automation and Robotics at Small Scales (MARSS), 2019
    Co-Authors: Ali Kafash Hoshiar, Jungwon Yoon
    Abstract:

    Magnetic drug targeting has emerged as a promising approach for enhancing the efficiency of drug delivery. Recent developments in real-time monitoring techniques can enable the guidance of magnetic nanoparticles (MNPs) in a multi-bifurcation network. This paper introduces an electromagnetic-based steering Scheme for guiding MNPs inside a multi-bifurcation network. In the proposed Scheme, the particles are initially guided to a safe zone using an asymmetrical field function to handle aggregated MNPs. Then, a transporter field function is used to transfer the particles between safe zones, and finally a sustainer field function is used to keep the particles within the safe zone. A steering algorithm is proposed to enhance the targeting performance in a multi-bifurcation network. Utilizing the proposed concept, a high success rate for targeting is achieved in a simulation, which demonstrates the possibility of guiding MNPs in a multi-bifurcation network. This promising result has encouraged us to conduct further studies.

  • A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier
    Nanomaterials (Basel Switzerland), 2017
    Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon Yoon
    Abstract:

    The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.

  • a novel magnetic Actuation Scheme to disaggregate nanoparticles and enhance passage across the blood brain barrier
    Nanomaterials, 2017
    Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon Yoon
    Abstract:

    The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.

Yung C. Liang – One of the best experts on this subject based on the ideXlab platform.

Yong Zhang – One of the best experts on this subject based on the ideXlab platform.

Oussama Khatib – One of the best experts on this subject based on the ideXlab platform.

  • A new hybrid Actuation Scheme with artificial pneumatic muscles and a magnetic particle brake for safe human-robot collaboration
    The International Journal of Robotics Research, 2014
    Co-Authors: Dongjun Shin, Xiyang Yeh, Oussama Khatib
    Abstract:

    Interest in the field of human-centered robotics continues to grow, particularly in utilizing pneumatic artificial muscles (PAMs) for close human-robot collaborations. Addressing the limited control performance of PAMs, we proposed a hybrid Actuation Scheme that combines PAMs (macro) and a low-inertia DC motor (mini). While the Scheme has shown significantly improved control performance and robot safety, a small DC motor has difficulties in handling the large stored energies of the PAMs, particularly for large changes in initial load due to PAM failure. In order to further improve robot safety, we develop a new hybrid Actuation Scheme with PAMs (macro) and a particle brake (mini). This design allows for a higher torque-to-weight ratio and inherently stable energy dissipation. Addressing optimal mini Actuation selection between a motor and a brake, and a control strategy for PAMs and a brake, we conducted comparative studies of hybrid Actuations with (1) a DC motor and (2) a brake for concept validation. Experimental comparisons show that the hybrid Actuation with PAMs and a brake provides higher energy efficiency for control bandwidths under 2 Hz, and more effective reduction of large impact forces due to the brake’s high torque capacity and passive energy dissipation.

Ali Kafash Hoshiar – One of the best experts on this subject based on the ideXlab platform.

  • Electromagnetic Actuation Scheme for Swarm of Magnetic Nanoparticles Steering in Multi-bifurcation
    2019 International Conference on Manipulation Automation and Robotics at Small Scales (MARSS), 2019
    Co-Authors: Ali Kafash Hoshiar, Jungwon Yoon
    Abstract:

    Magnetic drug targeting has emerged as a promising approach for enhancing the efficiency of drug delivery. Recent developments in real-time monitoring techniques can enable the guidance of magnetic nanoparticles (MNPs) in a multi-bifurcation network. This paper introduces an electromagnetic-based steering Scheme for guiding MNPs inside a multi-bifurcation network. In the proposed Scheme, the particles are initially guided to a safe zone using an asymmetrical field function to handle aggregated MNPs. Then, a transporter field function is used to transfer the particles between safe zones, and finally a sustainer field function is used to keep the particles within the safe zone. A steering algorithm is proposed to enhance the targeting performance in a multi-bifurcation network. Utilizing the proposed concept, a high success rate for targeting is achieved in a simulation, which demonstrates the possibility of guiding MNPs in a multi-bifurcation network. This promising result has encouraged us to conduct further studies.

  • A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier
    Nanomaterials (Basel Switzerland), 2017
    Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon Yoon
    Abstract:

    The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.

  • a novel magnetic Actuation Scheme to disaggregate nanoparticles and enhance passage across the blood brain barrier
    Nanomaterials, 2017
    Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon Yoon
    Abstract:

    The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.