The Experts below are selected from a list of 3933 Experts worldwide ranked by ideXlab platform
Jungwon Yoon - One of the best experts on this subject based on the ideXlab platform.
-
Electromagnetic Actuation Scheme for Swarm of Magnetic Nanoparticles Steering in Multi-bifurcation
2019 International Conference on Manipulation Automation and Robotics at Small Scales (MARSS), 2019Co-Authors: Ali Kafash Hoshiar, Jungwon YoonAbstract:Magnetic drug targeting has emerged as a promising approach for enhancing the efficiency of drug delivery. Recent developments in real-time monitoring techniques can enable the guidance of magnetic nanoparticles (MNPs) in a multi-bifurcation network. This paper introduces an electromagnetic-based steering Scheme for guiding MNPs inside a multi-bifurcation network. In the proposed Scheme, the particles are initially guided to a safe zone using an asymmetrical field function to handle aggregated MNPs. Then, a transporter field function is used to transfer the particles between safe zones, and finally a sustainer field function is used to keep the particles within the safe zone. A steering algorithm is proposed to enhance the targeting performance in a multi-bifurcation network. Utilizing the proposed concept, a high success rate for targeting is achieved in a simulation, which demonstrates the possibility of guiding MNPs in a multi-bifurcation network. This promising result has encouraged us to conduct further studies.
-
A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier
Nanomaterials (Basel Switzerland), 2017Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon YoonAbstract:The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.
-
a novel magnetic Actuation Scheme to disaggregate nanoparticles and enhance passage across the blood brain barrier
Nanomaterials, 2017Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon YoonAbstract:The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.
-
Simulation studies of a novel electromagnetic Actuation Scheme for focusing magnetic micro/nano-carriers into a deep target region
AIP Advances, 2017Co-Authors: Xingming Zhang, Ali Kafash Hoshiar, Myeong Ok Kim, Jungwon YoonAbstract:The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing Schemes. In this paper, we propose a novel electro-magnetic Actuation Scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed Actuation Scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing Scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic Actuation Scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.
-
simulation studies of a novel electromagnetic Actuation Scheme for focusing magnetic micro nano carriers into a deep target region
AIP Advances, 2017Co-Authors: Xingming Zhang, Ali Kafash Hoshiar, Myeong Ok Kim, Jungwon YoonAbstract:The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing Schemes. In this paper, we propose a novel electro-magnetic Actuation Scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed Actuation Scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing Scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic Actuation Scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.
Yung C. Liang - One of the best experts on this subject based on the ideXlab platform.
-
A new Actuation Scheme to enhance the linear momentum of MEMS inertia sensors
Sensors and Actuators A-physical, 2005Co-Authors: Tao Zhao, Yung C. LiangAbstract:The micro-electro-mechanical systems (MEMS) inertia sensors, such as silicon microgyroscopes, utilize linear momentum to detect the plane-motion information. Their sensing sensitivity is proportional to the amount of linear momentum created by the linear actuator within the sensor. In this paper, a new driving Scheme is proposed to enhance the linear momentum with a larger linear displacement during Actuation. In our implementation, the displacement can be 1.8 times or higher than that of achievable using the conventional form of Actuation for the same system voltage. Or, if for the same Actuation displacement, the proposed Scheme can reduce the system voltage by at least 25% to be suitable for low-voltage system integration.
-
new Actuation method for push pull electrostatic mems comb drive
IEEE Transactions on Industrial Electronics, 2003Co-Authors: Tao Zhao, Yung C. LiangAbstract:In this paper, a new Actuation Scheme for the push-pull electrostatic microelectromechanical systems comb drive actuators is proposed. The displacement amplitude excited by the new form of driving voltages can be more than three times as large as that which is achievable using the conventional form for the same applied system voltage.
Yong Zhang - One of the best experts on this subject based on the ideXlab platform.
-
A hybrid Actuation Scheme of trans-femoral prosthesis for motion adaptation
2009 4th IEEE Conference on Industrial Electronics and Applications, 2009Co-Authors: Fei Wang, Yong ZhangAbstract:Conventional trans-femoral (TF) prosthesis adopts body-powered Actuation manner, in which flexion and extension of knee joint rely on the movement of residual limb and body weight of amputee and is controlled by adjustable damping force output by pneumatic or hydraulic cylinder mounted on the TF prosthesis. This manner, however, suffers from the deficiency of driving torque when carrying out some special motions. On the other hand, external-powered TF prosthesis actuated mainly by eletrical motor, can obtain high performance in knee joint control, whereas high energy-consumption as well as large stiffness and inertia limite its practial applications. In our research, a hybrid Actuation Scheme combing magneto-rheological (MR) damper augmented with a DC motor, is proposed to improve the motion adaptation for TF prosthesis. Hybrid Actuation Scheme has been validated on a virtual prototype of TF prosthesis. The experimental results show the significant improvement that can be achieved with hybrid Actuation over an Actuation system with MR damper alone when carrying out the over-barrier task.
Oussama Khatib - One of the best experts on this subject based on the ideXlab platform.
-
A new hybrid Actuation Scheme with artificial pneumatic muscles and a magnetic particle brake for safe human-robot collaboration
The International Journal of Robotics Research, 2014Co-Authors: Dongjun Shin, Xiyang Yeh, Oussama KhatibAbstract:Interest in the field of human-centered robotics continues to grow, particularly in utilizing pneumatic artificial muscles (PAMs) for close human-robot collaborations. Addressing the limited control performance of PAMs, we proposed a hybrid Actuation Scheme that combines PAMs (macro) and a low-inertia DC motor (mini). While the Scheme has shown significantly improved control performance and robot safety, a small DC motor has difficulties in handling the large stored energies of the PAMs, particularly for large changes in initial load due to PAM failure. In order to further improve robot safety, we develop a new hybrid Actuation Scheme with PAMs (macro) and a particle brake (mini). This design allows for a higher torque-to-weight ratio and inherently stable energy dissipation. Addressing optimal mini Actuation selection between a motor and a brake, and a control strategy for PAMs and a brake, we conducted comparative studies of hybrid Actuations with (1) a DC motor and (2) a brake for concept validation. Experimental comparisons show that the hybrid Actuation with PAMs and a brake provides higher energy efficiency for control bandwidths under 2 Hz, and more effective reduction of large impact forces due to the brake's high torque capacity and passive energy dissipation.
Ali Kafash Hoshiar - One of the best experts on this subject based on the ideXlab platform.
-
Electromagnetic Actuation Scheme for Swarm of Magnetic Nanoparticles Steering in Multi-bifurcation
2019 International Conference on Manipulation Automation and Robotics at Small Scales (MARSS), 2019Co-Authors: Ali Kafash Hoshiar, Jungwon YoonAbstract:Magnetic drug targeting has emerged as a promising approach for enhancing the efficiency of drug delivery. Recent developments in real-time monitoring techniques can enable the guidance of magnetic nanoparticles (MNPs) in a multi-bifurcation network. This paper introduces an electromagnetic-based steering Scheme for guiding MNPs inside a multi-bifurcation network. In the proposed Scheme, the particles are initially guided to a safe zone using an asymmetrical field function to handle aggregated MNPs. Then, a transporter field function is used to transfer the particles between safe zones, and finally a sustainer field function is used to keep the particles within the safe zone. A steering algorithm is proposed to enhance the targeting performance in a multi-bifurcation network. Utilizing the proposed concept, a high success rate for targeting is achieved in a simulation, which demonstrates the possibility of guiding MNPs in a multi-bifurcation network. This promising result has encouraged us to conduct further studies.
-
A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier
Nanomaterials (Basel Switzerland), 2017Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon YoonAbstract:The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.
-
a novel magnetic Actuation Scheme to disaggregate nanoparticles and enhance passage across the blood brain barrier
Nanomaterials, 2017Co-Authors: Ali Kafash Hoshiar, Myeong Ok Kim, Faiz Ul Amin, Jungwon YoonAbstract:The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed Actuation Schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel Scheme with an aggregation model for a feed-forward magnetic Actuation design. A simulation platform for aggregated particle delivery is developed and an Actuation Scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic Actuation. The experimental results with a Y-shaped channel indicated the success of the proposed Scheme in steering and disaggregation. The delivery performance of the developed Scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed Scheme enhanced the transport and uptake of MNPs across the BBB in mice. The Scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic Actuation Scheme.
-
Simulation studies of a novel electromagnetic Actuation Scheme for focusing magnetic micro/nano-carriers into a deep target region
AIP Advances, 2017Co-Authors: Xingming Zhang, Ali Kafash Hoshiar, Myeong Ok Kim, Jungwon YoonAbstract:The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing Schemes. In this paper, we propose a novel electro-magnetic Actuation Scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed Actuation Scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing Scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic Actuation Scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.
-
simulation studies of a novel electromagnetic Actuation Scheme for focusing magnetic micro nano carriers into a deep target region
AIP Advances, 2017Co-Authors: Xingming Zhang, Ali Kafash Hoshiar, Myeong Ok Kim, Jungwon YoonAbstract:The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing Schemes. In this paper, we propose a novel electro-magnetic Actuation Scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed Actuation Scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing Scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic Actuation Scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.
