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Adenomatous Polyp

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Frank Iber – One of the best experts on this subject based on the ideXlab platform.

  • Carotenoids, vitamin A and risk of Adenomatous Polyp recurrence in the Polyp prevention trial.
    International Journal of Cancer, 2004
    Co-Authors: Susan Steck-scott, Michelle R. Forman, Anne L Sowell, Craig B. Borkowf, Paul S Albert, Martha L Slattery, Brenda K. Brewer, Bette J Caan, Electra D Paskett, Frank Iber
    Abstract:

    One trial reported beta-carocarotene supplementation was protective of Adenomatous Polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to Adenomatous Polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of Polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha-carocarotene concentrations, the OR of multiple Polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30–0.99) and the OR of right-sided recurrence was 0.60 (95% CI = 0.37–0.95). Baseline dietary intakes of alpha-carocarotene and vitamin A from food with/without supplements were inversely associated with any recurrence (pfor linear trend = 0.03- alpha-carocarotene; p = 0.004 and p = 0.007 -intakes of vitamin A). Compared to the lowest quartile of averaged beta-carocarotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22–0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha-carocarotene concentrations and right-sided Polyps; alpha-carocarotene intake and recurrence of any, multiple and right-sided Polyps; beta-carocarotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha-carocarotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. © 2004 Wiley-Liss, Inc.

  • Adenomatous Polyp recurrence and physical activity in the Polyp prevention trial united states
    Cancer Causes & Control, 2002
    Co-Authors: Lisa H Colbert, Frank Iber, Martha L Slattery, Bette J Caan, Electra D Paskett, Elaine Lanza, Rachael Ballardbarbash, Joseph A Tangrea, Walt Kikendall, Peter Lance
    Abstract:

    Objective: To examine prospectively the association between physical activity and Adenomatous Polyp recurrence. Methods: Information on past year total physical activity was collected annually through an interview-administered questionnaire from the 1905 men and women enrolled in a randomized dietary intervention study, the Polyp Prevention Trial. Multiple logistic regression analysis was used to examine the association between physical activity and Polyp recurrence in up to three years of follow-up from baseline colonoscopy. Results: There were no significant associations between moderate, vigorous, or total physical activity at the start of the trial and overall Polyp recurrence in either men or women. Participants who reported consistent vigorous activity throughout the trial period had no significantly reduced risk of Polyp recurrence compared to those who reported consistent sedentary activity (OR = 0.8, CI = 0.5–1.1). Consistent vigorous activity was also not significantly associated with either advanced or multiple Polyps, nor with Polyp recurrence at any specific anatomical location in the large bowel. Conclusions: These prospective data suggest that recent physical activity is not associated with Polyp recurrence in a three-year period.

Elaine Lanza – One of the best experts on this subject based on the ideXlab platform.

  • no association between fatty acid intake and Adenomatous Polyp recurrence in the Polyp prevention trial
    Cancer Epidemiology Biomarkers & Prevention, 2005
    Co-Authors: Marie M Cantwell, Michelle R. Forman, Paul S Albert, Arthur Schatzkin, Kirk Snyder, Elaine Lanza
    Abstract:

    Dietary fat intake and cancer riskrisk have been investigated in detail in many populations, although the results have been inconsistent for colorectal cancer. Several molecular mechanisms have been proposed to explain how specific dietary fatty acids could alter colorectal canccancer riskrisk due to their

  • Relationship of visceral adipose tissue to recurrence of Adenomatous Polyps.
    The American journal of gastroenterology, 2004
    Co-Authors: David A. Sass, Elaine Lanza, Robert E. Schoen, Joel L. Weissfeld, Lisa A. Weissfeld, F. Leland Thaete, Lewis H. Kuller, Mary Mcadams, Arthur Schatzkin
    Abstract:

    OBJECTIVES: Insulin is a growth factor for colorectal cancer. Visceral adipose tissue (VAT) is strongly associated with insulin levels, and insulin and visceral obesity have been associated in cohort studies with colorectal cancer. The aim of this investigation was to determine whether VAT is associated with recurrence of Adenomatous Polyps, the precursor to colorectal cancer. METHODS: As an ancillary study to the Polyp Prevention Trial, a randomized clinical trial that evaluated the effect of a low-fat, high-fiber, high vegetable and fruit diet on Adenomatous Polyp recurrence, subjects at one clinical center underwent measurement of VAT with a single-slice CT scan through the L4-L5 interspace. The scan was performed around the time of the subject’s year 4 colonoscopy that determined adenoma recurrence. RESULTS: Of 119 subjects, 44 of 84 men (52%) and 16 of 35 women (46%) had a recurrent adenoma (p= 0.51). Body mass index (BMI) and weight at baseline and at year 4 colonoscopy were unrelated to adenoma recurrence. In a multivariate model including visceral fat quartile, remote history of Polyps, gender, age, and randomization group, only remote history of Polyps was statistically significantly associated with recurrent adenoma with a relative risk of 4.6 (95% CI 1.7, 12.4, p= 0.001). There was no consistent monotonic trend of increased or decreased risk of recurrence as one ascended quartiles of adipose tissue for visceral, subcutaneous, or total abdominal fat. CONCLUSION: In this study, no association between visceral adipose tissue and Adenomatous Polyp recurrence was observed. Further study and exploration of the role of VAT in adenoma progression is required.

  • Adenomatous Polyp recurrence and physical activity in the Polyp prevention trial united states
    Cancer Causes & Control, 2002
    Co-Authors: Lisa H Colbert, Frank Iber, Martha L Slattery, Bette J Caan, Electra D Paskett, Elaine Lanza, Rachael Ballardbarbash, Joseph A Tangrea, Walt Kikendall, Peter Lance
    Abstract:

    Objective: To examine prospectively the association between physical activity and Adenomatous Polyp recurrence. Methods: Information on past year total physical activity was collected annually through an interview-administered questionnaire from the 1905 men and women enrolled in a randomized dietary intervention study, the Polyp Prevention Trial. Multiple logistic regression analysis was used to examine the association between physical activity and Polyp recurrence in up to three years of follow-up from baseline colonoscopy. Results: There were no significant associations between moderate, vigorous, or total physical activity at the start of the trial and overall Polyp recurrence in either men or women. Participants who reported consistent vigorous activity throughout the trial period had no significantly reduced risk of Polyp recurrence compared to those who reported consistent sedentary activity (OR = 0.8, CI = 0.5–1.1). Consistent vigorous activity was also not significantly associated with either advanced or multiple Polyps, nor with Polyp recurrence at any specific anatomical location in the large bowel. Conclusions: These prospective data suggest that recent physical activity is not associated with Polyp recurrence in a three-year period.

Arthur Schatzkin – One of the best experts on this subject based on the ideXlab platform.

  • no association between fatty acid intake and Adenomatous Polyp recurrence in the Polyp prevention trial
    Cancer Epidemiology Biomarkers & Prevention, 2005
    Co-Authors: Marie M Cantwell, Michelle R. Forman, Paul S Albert, Arthur Schatzkin, Kirk Snyder, Elaine Lanza
    Abstract:

    Dietary fat intake and cancer risk have been investigated in detail in many populations, although the results have been inconsistent for colorectal cancer. Several molecular mechanisms have been proposed to explain how specific dietary fatty acids could alter colorectal cancer risk due to their

  • Relationship of visceral adipose tissue to recurrence of Adenomatous Polyps.
    The American journal of gastroenterology, 2004
    Co-Authors: David A. Sass, Elaine Lanza, Robert E. Schoen, Joel L. Weissfeld, Lisa A. Weissfeld, F. Leland Thaete, Lewis H. Kuller, Mary Mcadams, Arthur Schatzkin
    Abstract:

    OBJECTIVES: Insulin is a growth factor for colorectal cancer. Visceral adipose tissue (VAT) is strongly associated with insulin levels, and insulin and visceral obesity have been associated in cohort studies with colorectal cancer. The aim of this investigation was to determine whether VAT is associated with recurrence of Adenomatous Polyps, the precursor to colorectal cancer. METHODS: As an ancillary study to the Polyp Prevention Trial, a randomized clinical trial that evaluated the effect of a low-fat, high-fiber, high vegetable and fruit diet on Adenomatous Polyp recurrence, subjects at one clinical center underwent measurement of VAT with a single-slice CT scan through the L4-L5 interspace. The scan was performed around the time of the subject’s year 4 colonoscopy that determined adenoma recurrence. RESULTS: Of 119 subjects, 44 of 84 men (52%) and 16 of 35 women (46%) had a recurrent adenoma (p= 0.51). Body mass index (BMI) and weight at baseline and at year 4 colonoscopy were unrelated to adenoma recurrence. In a multivariate model including visceral fat quartile, remote history of Polyps, gender, age, and randomization group, only remote history of Polyps was statistically significantly associated with recurrent adenoma with a relative risk of 4.6 (95% CI 1.7, 12.4, p= 0.001). There was no consistent monotonic trend of increased or decreased risk of recurrence as one ascended quartiles of adipose tissue for visceral, subcutaneous, or total abdominal fat. CONCLUSION: In this study, no association between visceral adipose tissue and Adenomatous Polyp recurrence was observed. Further study and exploration of the role of VAT in adenoma progression is required.

Bette J Caan – One of the best experts on this subject based on the ideXlab platform.

  • Carotenoids, vitamin A and risk of Adenomatous Polyp recurrence in the Polyp prevention trial.
    International Journal of Cancer, 2004
    Co-Authors: Susan Steck-scott, Michelle R. Forman, Anne L Sowell, Craig B. Borkowf, Paul S Albert, Martha L Slattery, Brenda K. Brewer, Bette J Caan, Electra D Paskett, Frank Iber
    Abstract:

    One trial reported beta-carotene supplementation was protective of Adenomatous Polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to Adenomatous Polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of Polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha-carotene concentrations, the OR of multiple Polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30–0.99) and the OR of right-sided recurrence was 0.60 (95% CI = 0.37–0.95). Baseline dietary intakes of alpha-carotene and vitamin A from food with/without supplements were inversely associated with any recurrence (pfor linear trend = 0.03- alpha-carotene; p = 0.004 and p = 0.007 -intakes of vitamin A). Compared to the lowest quartile of averaged beta-carotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22–0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha-carotene concentrations and right-sided Polyps; alpha-carotene intake and recurrence of any, multiple and right-sided Polyps; beta-carotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. © 2004 Wiley-Liss, Inc.

  • Adenomatous Polyp recurrence and physical activity in the Polyp prevention trial united states
    Cancer Causes & Control, 2002
    Co-Authors: Lisa H Colbert, Frank Iber, Martha L Slattery, Bette J Caan, Electra D Paskett, Elaine Lanza, Rachael Ballardbarbash, Joseph A Tangrea, Walt Kikendall, Peter Lance
    Abstract:

    Objective: To examine prospectively the association between physical activity and Adenomatous Polyp recurrence. Methods: Information on past year total physical activity was collected annually through an interview-administered questionnaire from the 1905 men and women enrolled in a randomized dietary intervention study, the Polyp Prevention Trial. Multiple logistic regression analysis was used to examine the association between physical activity and Polyp recurrence in up to three years of follow-up from baseline colonoscopy. Results: There were no significant associations between moderate, vigorous, or total physical activity at the start of the trial and overall Polyp recurrence in either men or women. Participants who reported consistent vigorous activity throughout the trial period had no significantly reduced risk of Polyp recurrence compared to those who reported consistent sedentary activity (OR = 0.8, CI = 0.5–1.1). Consistent vigorous activity was also not significantly associated with either advanced or multiple Polyps, nor with Polyp recurrence at any specific anatomical location in the large bowel. Conclusions: These prospective data suggest that recent physical activity is not associated with Polyp recurrence in a three-year period.

Martha L Slattery – One of the best experts on this subject based on the ideXlab platform.

  • Carotenoids, vitamin A and risk of Adenomatous Polyp recurrence in the Polyp prevention trial.
    International Journal of Cancer, 2004
    Co-Authors: Susan Steck-scott, Michelle R. Forman, Anne L Sowell, Craig B. Borkowf, Paul S Albert, Martha L Slattery, Brenda K. Brewer, Bette J Caan, Electra D Paskett, Frank Iber
    Abstract:

    One trial reported beta-carotene supplementation was protective of Adenomatous Polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to Adenomatous Polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of Polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha-carotene concentrations, the OR of multiple Polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30–0.99) and the OR of right-sided recurrence was 0.60 (95% CI = 0.37–0.95). Baseline dietary intakes of alpha-carotene and vitamin A from food with/without supplements were inversely associated with any recurrence (pfor linear trend = 0.03- alpha-carotene; p = 0.004 and p = 0.007 -intakes of vitamin A). Compared to the lowest quartile of averaged beta-carotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22–0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha-carotene concentrations and right-sided Polyps; alpha-carotene intake and recurrence of any, multiple and right-sided Polyps; beta-carotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. © 2004 Wiley-Liss, Inc.

  • Adenomatous Polyp recurrence and physical activity in the Polyp prevention trial united states
    Cancer Causes & Control, 2002
    Co-Authors: Lisa H Colbert, Frank Iber, Martha L Slattery, Bette J Caan, Electra D Paskett, Elaine Lanza, Rachael Ballardbarbash, Joseph A Tangrea, Walt Kikendall, Peter Lance
    Abstract:

    Objective: To examine prospectively the association between physical activity and Adenomatous Polyp recurrence. Methods: Information on past year total physical activity was collected annually through an interview-administered questionnaire from the 1905 men and women enrolled in a randomized dietary intervention study, the Polyp Prevention Trial. Multiple logistic regression analysis was used to examine the association between physical activity and Polyp recurrence in up to three years of follow-up from baseline colonoscopy. Results: There were no significant associations between moderate, vigorous, or total physical activity at the start of the trial and overall Polyp recurrence in either men or women. Participants who reported consistent vigorous activity throughout the trial period had no significantly reduced risk of Polyp recurrence compared to those who reported consistent sedentary activity (OR = 0.8, CI = 0.5–1.1). Consistent vigorous activity was also not significantly associated with either advanced or multiple Polyps, nor with Polyp recurrence at any specific anatomical location in the large bowel. Conclusions: These prospective data suggest that recent physical activity is not associated with Polyp recurrence in a three-year period.