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Adjuvant

The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform

Yehuda Shoenfeld – 1st expert on this subject based on the ideXlab platform

  • autoimmune inflammatory syndrome induced by Adjuvants asia 2013 unveiling the pathogenic clinical and diagnostic aspects
    Journal of Autoimmunity, 2013
    Co-Authors: Carlo Perricone, Yehuda Shoenfeld, Serena Colafrancesco, Roei David Mazor, Alessandra Soriano, Nancy Agmonlevin

    Abstract:

    In 2011 a new syndrome termed ‘ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants’ was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an Adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other Adjuvants, as well as infectious components, that also may have an Adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with postvaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of Adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different Adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the

  • Autoimmune/inflammatory syndrome induced by Adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
    Journal of Autoimmunity, 2013
    Co-Authors: Carlo Perricone, Serena Colafrancesco, Roei David Mazor, Alessandra Soriano, Nancy Agmon-levin, Yehuda Shoenfeld

    Abstract:

    In 2011 a new syndrome termed ‘ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants’ was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an Adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other Adjuvants, as well as infectious components, that also may have an Adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with postvaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of Adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different Adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the

  • Adjuvants and autoimmunity
    Lupus, 2009
    Co-Authors: Eitan Israeli, Nancy Agmonlevin, M. Blank, Yehuda Shoenfeld

    Abstract:

    Some Adjuvants may exert adverse effects upon injection or, on the other hand, may not trigger a full immunological reaction. The mechanisms underlying Adjuvant adverse effects are under renewed scrutiny because of the enormous implications for vaccine development. In the search for new and safer Adjuvants, several new Adjuvants were developed by pharmaceutical companies utilizing new immunological and chemical innovations. The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of special immune receptors called toll-like receptors (TLRs) that are expressed on leukocyte membranes. The very fact that TLR activation leads to adaptive immune responses to foreign entities explains why so many Adjuvants used today in vaccinations are developed to mimic TLR ligands. Alongside their supportive role, Adjuvants were found to inflict by themselves an illness of autoimmune nature, defined as ‘the Adjuvant diseases’. The debatable question of sili…

Carlo Perricone – 2nd expert on this subject based on the ideXlab platform

  • autoimmune inflammatory syndrome induced by Adjuvants asia 2013 unveiling the pathogenic clinical and diagnostic aspects
    Journal of Autoimmunity, 2013
    Co-Authors: Carlo Perricone, Yehuda Shoenfeld, Serena Colafrancesco, Roei David Mazor, Alessandra Soriano, Nancy Agmonlevin

    Abstract:

    In 2011 a new syndrome termed ‘ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants’ was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an Adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other Adjuvants, as well as infectious components, that also may have an Adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with postvaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of Adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different Adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the

  • Autoimmune/inflammatory syndrome induced by Adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
    Journal of Autoimmunity, 2013
    Co-Authors: Carlo Perricone, Serena Colafrancesco, Roei David Mazor, Alessandra Soriano, Nancy Agmon-levin, Yehuda Shoenfeld

    Abstract:

    In 2011 a new syndrome termed ‘ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants’ was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an Adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other Adjuvants, as well as infectious components, that also may have an Adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with postvaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of Adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different Adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the

Nancy Agmonlevin – 3rd expert on this subject based on the ideXlab platform

  • autoimmune inflammatory syndrome induced by Adjuvants asia 2013 unveiling the pathogenic clinical and diagnostic aspects
    Journal of Autoimmunity, 2013
    Co-Authors: Carlo Perricone, Yehuda Shoenfeld, Serena Colafrancesco, Roei David Mazor, Alessandra Soriano, Nancy Agmonlevin

    Abstract:

    In 2011 a new syndrome termed ‘ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants’ was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an Adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other Adjuvants, as well as infectious components, that also may have an Adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with postvaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of Adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different Adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the

  • Adjuvants and autoimmunity
    Lupus, 2009
    Co-Authors: Eitan Israeli, Nancy Agmonlevin, M. Blank, Yehuda Shoenfeld

    Abstract:

    Some Adjuvants may exert adverse effects upon injection or, on the other hand, may not trigger a full immunological reaction. The mechanisms underlying Adjuvant adverse effects are under renewed scrutiny because of the enormous implications for vaccine development. In the search for new and safer Adjuvants, several new Adjuvants were developed by pharmaceutical companies utilizing new immunological and chemical innovations. The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of special immune receptors called toll-like receptors (TLRs) that are expressed on leukocyte membranes. The very fact that TLR activation leads to adaptive immune responses to foreign entities explains why so many Adjuvants used today in vaccinations are developed to mimic TLR ligands. Alongside their supportive role, Adjuvants were found to inflict by themselves an illness of autoimmune nature, defined as ‘the Adjuvant diseases’. The debatable question of sili…