Aglepristone - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Aglepristone

The Experts below are selected from a list of 471 Experts worldwide ranked by ideXlab platform

Aglepristone – Free Register to Access Experts & Abstracts

Axel Wehrend – One of the best experts on this subject based on the ideXlab platform.

  • parturition induction in ewes by a progesterone receptor blocker Aglepristone and subsequent neonatal survival preliminary results
    Theriogenology, 2017
    Co-Authors: R. G. Özalp, A. Yavuz, A. Orman, I. Seker, Ali Risvanli, Ö.o. Demiral, Udum D Kucuksen, Axel Wehrend

    Abstract:

    The clinical effects of Aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of Aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first Aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P < 0.05). No difference was observed in concentrations of free total estrogens and oxytocin between groups. The body temperature of lambs was significantly different between AG10 and CG groups both right after (P = 0.011) and 12 hours after parturition (P = 0.014). The lambs in CG had the highest mean birth weight (4.29 ± 0.28 kg), which was significantly different from the induced groups. No significant difference of blood pH and blood gases values between groups was identified both at birth and 12 hours after parturition for lambs. Significant differences could clearly be observed in total protein and blood urea nitrogen and total protein findings 12 hours after parturition (P < 0.05), whereas no difference was found in blood glucose, albumin, inorganic phosphor, triglyceride, or total cholesterol parameters. The results of this study show that the administration of Aglepristone to induce parturition can precisely control lambing time without any side effects in either mothers or lambs.

  • DYNAMICS OF SOME VAGINAL PARAMETERS IN NON-PREGNANT BITCHES AFTER MID-LUTEAL Aglepristone TREATMENT
    Slovenian Veterinary Research, 2016
    Co-Authors: Anton Antonov, Plamen Georgiev, Julieta Dineva Dineva, Theresa Conze, Radostina Dimitrova, Axel Wehrend

    Abstract:

    The aim of our study was to investigate the effects of the antiprogestin Aglepristone after its application in bitches with high serum progesterone concentrations on some specific vaginal parameters. Twelve non-pregnant female dogs from different breeds and ages were included in the study. The bitches were divided into two groups. Group I (n = 6) received Aglepristone (10 mg/kg, subcutaneously) injected twice, 24 h apart, on days 29 and 30 after the estimated day of ovulation, which was determined by progesterone assays. Group II (n = 6) served as a control group and received a placebo. The electrical resistance of vaginal mucus, vaginal pH and serum P4 levels were determined on days 29, 30, 33, 36, 39, 42 and 45 after ovulation. Additionally, vaginal smears were performed to evaluate the changes in vaginal cells. Partial luteolysis was detected at day 32.5 ± 2.26 (mean ± SD) and 44 ± 1.73 in treated and control bitches, respectively (p < 0.001). Complete luteolysis (P4 < 2 ng/ml) was observed on day 41.5 ± 2.26 in treated bitches. Beginning on the day after the first treatment, a decrease in electrical resistance of vaginal mucus was measured in the experimental group. A significant reduction (p < 0.05) occurred on day 41.5±2.26 compared with day 29. The pH of vaginal secretions of all bitches in Group I increased during the period starting from the day after the first treatment. A significant difference (p < 0.05) was found on day 32.5 ± 2.26. No changes were detected for either parameter in the control group. The cell populations in vaginal smears of all animals were similar. In conclusion, Aglepristone administration to dogs during the mid-luteal stage influenced vaginal pH and the electrical resistance of vaginal mucus. Key words: vagina; bitch; Aglepristone; electrical resistance; pH

  • Parturition induction in ewes by a progesterone receptor blocker, Aglepristone, and subsequent neonatal survival: Preliminary results
    Theriogenology, 2016
    Co-Authors: R. G. Özalp, A. Yavuz, A. Orman, I. Seker, D. Udum Küçükşen, Ali Risvanli, Ö.o. Demiral, Axel Wehrend

    Abstract:

    The clinical effects of Aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of Aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first Aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P 

Piotr Jurka – One of the best experts on this subject based on the ideXlab platform.

  • Changes in ovaries and uterus after Aglepristone administration in the third week of luteal phase of non-pregnant bitches.
    PloS one, 2015
    Co-Authors: Kamil Kacprzak, Piotr Jurka, Izabella Dolka, Michał Czopowicz, Anna Ruszczak, A. M. Duszewska

    Abstract:

    Objective
    The mechanism of Aglepristone action in the placentation time in the bitch remains unclear. The aim of this study was to describe the mechanism by which Aglepristone influences ovaries and uterus and to measure the levels of steroid sex hormones in non-pregnant bitches.

  • Serum estradiol concentrations in study (n = 9) and control (n = 5) bitches during the luteal phase, from days 8 to 27 after the estimated LH peak.
    , 2015
    Co-Authors: Kamil Kacprzak, Piotr Jurka, Izabella Dolka, Michał Czopowicz, Anna Ruszczak, Anna Duszewska

    Abstract:

    The AA indicates days of treatment with Aglepristone (10 mg/kg bw) or saline and O it is the day of castration. Results are expressed as means ± SD.

  • Serum progesterone concentrations in study (n = 9) and control (n = 5) bitches during the luteal phase, from days 8 to 27 after the estimated LH peak.
    , 2015
    Co-Authors: Kamil Kacprzak, Piotr Jurka, Izabella Dolka, Michał Czopowicz, Anna Ruszczak, Anna Duszewska

    Abstract:

    The AA indicates days of treatment with Aglepristone (10 mg/kg bw) or saline and O it is a day of ovariohysterectomy. Results are expressed as means ± SD. & and asterisks indicate values significantly different from controls (p

F. Fieni – One of the best experts on this subject based on the ideXlab platform.

  • Clinical evaluation of the use of Aglepristone associated with oxytocin to induce parturition in bitch.
    Reproduction in Domestic Animals, 2009
    Co-Authors: F. Fieni, Anne Gogny

    Abstract:

    Contents

    To evaluate the efficacy and safety of Aglepristone 15 mg kg−1 for induction of parturition in bitches, 22 pregnant beagle bitches were injected subcutaneously on day 60 post-estimated LH surge, and again 24 h later with Aglepristone and subsequently were given 0.15 IU kg−1 oxytocin at hourly intervals until delivery of the last puppy. Six pregnant beagle bitches were used as a non-treated control group. In the control group, parturition occurred at 63.2 ± 0.5 days, 29 pups were born and the average expulsion time per puppy was 1.0 ± 0.6 h. In the treated group, parturition was obtained on average 29.7 ± 5.6 h after Aglepristone administration, 121 pups were born and average expulsion time per pup was 1.1 ± 0.4 h. The percentage of live puppies, 7 weeks after birth, was 86.1% (25/29) and 86.8% (105/121) for the control and treated groups, respectively. No significant difference was observed between the control and treated groups for the average expulsion time per live puppy and for the percentage of live puppies at birth, 48 h, 7 days or 7 weeks after birth (p > 0.05). This study confirms previous results and demonstrates that the combination of Aglepristone and oxytocin can be safely and reliably used to induce parturition in beagle bitches, at 60 days post-estimated LH surge.

  • clinical evaluation of the use of Aglepristone with or without cloprostenol to treat cystic endometrial hyperplasia pyometra complex in bitches
    Theriogenology, 2006
    Co-Authors: F. Fieni

    Abstract:

    The aim of the study was to evaluate the efficacy of Aglepristone (10 mg/kg on days 1, 2 and 8) for the treatment of metritis or pyometra in bitches (n = 67) either alone for cases of metritis (n = 15), or in cases of pyometra (n = 52) with (n = 32) or without (n = 20) the addition of low doses (1 mg/kg) of cloprostenol for 5days (days 3‐7). Examinations performed on day 90, in addition to days 8, 14 and 28, determined that treatments had been curative in the long term in 54/67 bitches (80.6%). Bitches in whom pyometra did not resolve, were given additional Aglepristone on day 14 (n = 38) and day 28 (n = 20). Aglepristone alone was curative in 15/15 bitches with metritis. In 17/17 bitches with closed pyometra, cervical opening occurred within48 h of Aglepristone administration. Amongst the 52 bitches with open (n = 35) or closed (n = 17) pyometra, the additional treatment with cloprostenol from days 3 to 7, significantly improved the overall success rate at day 90, which was 27/32 (84.4%), compared to 12/20 (60.0%) in bitches without cloprostenol (P < 0.05). The leucocyte count and plasma progesterone concentrations significantly decreased over thecourseoftreatment.Thirteenof15bitchesinwhomplasmaprogesteroneconcentrationswereinitiallylow(<3.18 nmol/L)were cured. The recurrence rate after 12 and 24 months was 13.0% (3/23) and 19.0% (4/21), respectively.

  • Clinical, biological and hormonal study of mid-pregnancy termination in cats with Aglepristone
    Theriogenology, 2006
    Co-Authors: F. Fieni, Jacques Martal, Pierre-guy Marnet, Siliart B, Franck Guittot

    Abstract:

    Abstract In order to evaluate the efficacy, the safety and the variation in plasma concentrations of estrogens, progesterone, PGFM, oxytocin, cortisol and prolactin after mid-pregnancy termination induced by Aglepristone, 61 pregnant queens (33.3 + 4.2 days), were injected subcutaneously with 0.15 mg/kg Aglepristone, repeated once 24 h later. Five queens served as control and received a placebo. The efficacy of Aglepristone was 88.5% and termination of pregnancy was achieved in 50% of the queens within 3 days. Brief periods of depression and anorexia were noted in 9.3% of the queens before fetal expulsion (these symptoms were attributed to the phenomenon of fetal expulsions). Not one of the queens that aborted developed uterine disease. There were no changes in plasma concentrations of estrogen, prostaglandin, prolactin or oxytocin following Aglepristone administration. However, there were significant increases in plasma concentrations of progesterone and cortisol 60 and 30 h, respectively, after Aglepristone administration. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterised by an increase in estrogen, PGFM and oxytocin concentrations, whereas prolactin and cortisol levels remained at a basal level.