Aglepristone

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  • parturition induction in ewes by a progesterone receptor blocker Aglepristone and subsequent neonatal survival preliminary results
    Theriogenology, 2017
    Co-Authors: R. G. Özalp, A. Yavuz, A. Orman, I. Seker, Ali Risvanli, Ö.o. Demiral, Udum D Kucuksen, Axel Wehrend
    Abstract:

    The clinical effects of Aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of Aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first Aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P < 0.05). No difference was observed in concentrations of free total estrogens and oxytocin between groups. The body temperature of lambs was significantly different between AG10 and CG groups both right after (P = 0.011) and 12 hours after parturition (P = 0.014). The lambs in CG had the highest mean birth weight (4.29 ± 0.28 kg), which was significantly different from the induced groups. No significant difference of blood pH and blood gases values between groups was identified both at birth and 12 hours after parturition for lambs. Significant differences could clearly be observed in total protein and blood urea nitrogen and total protein findings 12 hours after parturition (P < 0.05), whereas no difference was found in blood glucose, albumin, inorganic phosphor, triglyceride, or total cholesterol parameters. The results of this study show that the administration of Aglepristone to induce parturition can precisely control lambing time without any side effects in either mothers or lambs.

  • DYNAMICS OF SOME VAGINAL PARAMETERS IN NON-PREGNANT BITCHES AFTER MID-LUTEAL Aglepristone TREATMENT
    Slovenian Veterinary Research, 2016
    Co-Authors: Anton Antonov, Plamen Georgiev, Julieta Dineva Dineva, Theresa Conze, Radostina Dimitrova, Axel Wehrend
    Abstract:

    The aim of our study was to investigate the effects of the antiprogestin Aglepristone after its application in bitches with high serum progesterone concentrations on some specific vaginal parameters. Twelve non-pregnant female dogs from different breeds and ages were included in the study. The bitches were divided into two groups. Group I (n = 6) received Aglepristone (10 mg/kg, subcutaneously) injected twice, 24 h apart, on days 29 and 30 after the estimated day of ovulation, which was determined by progesterone assays. Group II (n = 6) served as a control group and received a placebo. The electrical resistance of vaginal mucus, vaginal pH and serum P4 levels were determined on days 29, 30, 33, 36, 39, 42 and 45 after ovulation. Additionally, vaginal smears were performed to evaluate the changes in vaginal cells. Partial luteolysis was detected at day 32.5 ± 2.26 (mean ± SD) and 44 ± 1.73 in treated and control bitches, respectively (p < 0.001). Complete luteolysis (P4 < 2 ng/ml) was observed on day 41.5 ± 2.26 in treated bitches. Beginning on the day after the first treatment, a decrease in electrical resistance of vaginal mucus was measured in the experimental group. A significant reduction (p < 0.05) occurred on day 41.5±2.26 compared with day 29. The pH of vaginal secretions of all bitches in Group I increased during the period starting from the day after the first treatment. A significant difference (p < 0.05) was found on day 32.5 ± 2.26. No changes were detected for either parameter in the control group. The cell populations in vaginal smears of all animals were similar. In conclusion, Aglepristone administration to dogs during the mid-luteal stage influenced vaginal pH and the electrical resistance of vaginal mucus. Key words: vagina; bitch; Aglepristone; electrical resistance; pH

  • Parturition induction in ewes by a progesterone receptor blocker, Aglepristone, and subsequent neonatal survival: Preliminary results
    Theriogenology, 2016
    Co-Authors: R. G. Özalp, A. Yavuz, A. Orman, I. Seker, D. Udum Küçükşen, Ali Risvanli, Ö.o. Demiral, Axel Wehrend
    Abstract:

    The clinical effects of Aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of Aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first Aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P 

  • Prevention of pregnancy in cats using Aglepristone on days 5 and 6 after mating
    Theriogenology, 2010
    Co-Authors: Sandra Goericke-pesch, Plamen Georgiev, Axel Wehrend
    Abstract:

    The aim of this study was to test for the efficacy of Aglepristone treatment for prevention of early pregnancy in the cat. Eleven cats (Gr. 1) were treated with 10 mg/kg Aglepristone on days 5 and 6 after mating, 17 cats (Gr. 2) were used as untreated controls. Blood samples for progesterone (P4) determination were collected from 6 cats of Gr. 1 and 9 cats of Gr. 2, respectively. Ultrasound examination on day 25 revealed no pregnancy in any of the treated cats. In both groups, P4 concentrations increased from day 5 (before treatment) to day 20 (P < 0.01). In Gr. 1, the interval between Aglepristone treatment and the subsequent estrus ranged from 5–299 d [18.5 (5.2) d]. Mean interestrus interval was 205 ± 72 d in Gr. 2. Mean duration of subsequent estrus was not different to duration of estrus before treatment in Gr. 1 and in Gr. 2, respectively. Mean time between treatment and next pregnancy was 56.4 (4.7) d, ranging from 5–325 d. Pregnancy rates after the next estrus following treatment were 64 and 82% after the first and second estrus, respectively. No major treatment-related side effects were observed. In conclusion, treatment was found to be highly effective for prevention of early pregnancy.

  • Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating
    Reproduction in domestic animals = Zuchthygiene, 2010
    Co-Authors: Plamen Georgiev, H. Bostedt, Sandra Goericke-pesch, M Dimitrov, P Petkov, K Stojanthev, V Tsoneva, Axel Wehrend
    Abstract:

    Contents The aim of this study was to test for the efficacy and safety of the use of Aglepristone for pregnancy termination on day 45 in cats. Six healthy cats were treated with 10 mg/kg Aglepristone sc on day 45 and 46 after mating; six other cats served as untreated controls. The effect of treatment was monitored by general examination, vaginal cytology, ultrasonography and blood sampling for haematology and progesterone determination. Besides, interoestrus interval and next pregnancy including litter size were recorded. The efficacy of treatment was approximately 67% (4/6) with abortion occurring 4–7 days after the first injection and a sanguineous discharge and erythrocytes in vaginal smears for at least 6 days afterwards. The two treated cats that did not abort gave birth to two kittens on day 67 and had a stillbirth of a single kitten on day 71, respectively. As expected enlargement of the mammary glands and lactation were observed in all treated cats. No other treatment-induced side effects were observed. Progesterone levels at abortion were high (30–140 nmol/l), but were decreased on day 55. Aglepristone treatment did not affect fertility in following cycles. Finally, it can be concluded that late-term pregnancy termination with Aglepristone is possible but due to a success rate of 67% an ultrasonographical examination 7 days after treatment is an inherent necessity to control the effect of treatment.

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F. Fieni - One of the best experts on this subject based on the ideXlab platform.

  • Clinical evaluation of the use of Aglepristone associated with oxytocin to induce parturition in bitch.
    Reproduction in Domestic Animals, 2009
    Co-Authors: F. Fieni, Anne Gogny
    Abstract:

    Contents To evaluate the efficacy and safety of Aglepristone 15 mg kg−1 for induction of parturition in bitches, 22 pregnant beagle bitches were injected subcutaneously on day 60 post-estimated LH surge, and again 24 h later with Aglepristone and subsequently were given 0.15 IU kg−1 oxytocin at hourly intervals until delivery of the last puppy. Six pregnant beagle bitches were used as a non-treated control group. In the control group, parturition occurred at 63.2 ± 0.5 days, 29 pups were born and the average expulsion time per puppy was 1.0 ± 0.6 h. In the treated group, parturition was obtained on average 29.7 ± 5.6 h after Aglepristone administration, 121 pups were born and average expulsion time per pup was 1.1 ± 0.4 h. The percentage of live puppies, 7 weeks after birth, was 86.1% (25/29) and 86.8% (105/121) for the control and treated groups, respectively. No significant difference was observed between the control and treated groups for the average expulsion time per live puppy and for the percentage of live puppies at birth, 48 h, 7 days or 7 weeks after birth (p > 0.05). This study confirms previous results and demonstrates that the combination of Aglepristone and oxytocin can be safely and reliably used to induce parturition in beagle bitches, at 60 days post-estimated LH surge.

  • clinical evaluation of the use of Aglepristone with or without cloprostenol to treat cystic endometrial hyperplasia pyometra complex in bitches
    Theriogenology, 2006
    Co-Authors: F. Fieni
    Abstract:

    The aim of the study was to evaluate the efficacy of Aglepristone (10 mg/kg on days 1, 2 and 8) for the treatment of metritis or pyometra in bitches (n = 67) either alone for cases of metritis (n = 15), or in cases of pyometra (n = 52) with (n = 32) or without (n = 20) the addition of low doses (1 mg/kg) of cloprostenol for 5days (days 3‐7). Examinations performed on day 90, in addition to days 8, 14 and 28, determined that treatments had been curative in the long term in 54/67 bitches (80.6%). Bitches in whom pyometra did not resolve, were given additional Aglepristone on day 14 (n = 38) and day 28 (n = 20). Aglepristone alone was curative in 15/15 bitches with metritis. In 17/17 bitches with closed pyometra, cervical opening occurred within48 h of Aglepristone administration. Amongst the 52 bitches with open (n = 35) or closed (n = 17) pyometra, the additional treatment with cloprostenol from days 3 to 7, significantly improved the overall success rate at day 90, which was 27/32 (84.4%), compared to 12/20 (60.0%) in bitches without cloprostenol (P < 0.05). The leucocyte count and plasma progesterone concentrations significantly decreased over thecourseoftreatment.Thirteenof15bitchesinwhomplasmaprogesteroneconcentrationswereinitiallylow(<3.18 nmol/L)were cured. The recurrence rate after 12 and 24 months was 13.0% (3/23) and 19.0% (4/21), respectively.

  • Clinical, biological and hormonal study of mid-pregnancy termination in cats with Aglepristone
    Theriogenology, 2006
    Co-Authors: F. Fieni, Jacques Martal, Pierre-guy Marnet, Siliart B, Franck Guittot
    Abstract:

    Abstract In order to evaluate the efficacy, the safety and the variation in plasma concentrations of estrogens, progesterone, PGFM, oxytocin, cortisol and prolactin after mid-pregnancy termination induced by Aglepristone, 61 pregnant queens (33.3 + 4.2 days), were injected subcutaneously with 0.15 mg/kg Aglepristone, repeated once 24 h later. Five queens served as control and received a placebo. The efficacy of Aglepristone was 88.5% and termination of pregnancy was achieved in 50% of the queens within 3 days. Brief periods of depression and anorexia were noted in 9.3% of the queens before fetal expulsion (these symptoms were attributed to the phenomenon of fetal expulsions). Not one of the queens that aborted developed uterine disease. There were no changes in plasma concentrations of estrogen, prostaglandin, prolactin or oxytocin following Aglepristone administration. However, there were significant increases in plasma concentrations of progesterone and cortisol 60 and 30 h, respectively, after Aglepristone administration. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterised by an increase in estrogen, PGFM and oxytocin concentrations, whereas prolactin and cortisol levels remained at a basal level.

  • Clinical evaluation of the use of Aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches
    Theriogenology, 2006
    Co-Authors: F. Fieni
    Abstract:

    The aim of the study was to evaluate the efficacy of Aglepristone (10 mg/kg on days 1, 2 and 8) for the treatment of metritis or pyometra in bitches (n = 67) either alone for cases of metritis (n = 15), or in cases of pyometra (n = 52) with (n = 32) or without (n = 20) the addition of low doses (1 mg/kg) of cloprostenol for 5days (days 3‐7). Examinations performed on day 90, in addition to days 8, 14 and 28, determined that treatments had been curative in the long term in 54/67 bitches (80.6%). Bitches in whom pyometra did not resolve, were given additional Aglepristone on day 14 (n = 38) and day 28 (n = 20). Aglepristone alone was curative in 15/15 bitches with metritis. In 17/17 bitches with closed pyometra, cervical opening occurred within48 h of Aglepristone administration. Amongst the 52 bitches with open (n = 35) or closed (n = 17) pyometra, the additional treatment with cloprostenol from days 3 to 7, significantly improved the overall success rate at day 90, which was 27/32 (84.4%), compared to 12/20 (60.0%) in bitches without cloprostenol (P < 0.05). The leucocyte count and plasma progesterone concentrations significantly decreased over thecourseoftreatment.Thirteenof15bitchesinwhomplasmaprogesteroneconcentrationswereinitiallylow(

  • Hormonal variation in bitches after early or mid-pregnancy termination with Aglepristone (RU534).
    Journal of reproduction and fertility. Supplement, 2001
    Co-Authors: F. Fieni, Jacques Martal, Pierre-guy Marnet, Siliart B, Bernard F, Riou M, J.f. Bruyas, Tainturier D
    Abstract:

    Seven bitches in early pregnancy (12.8 +/- 3.8 days after ovulation; group 1) and seven bitches in mid-pregnancy (32.0 +/- 1.53 days after ovulation; group 2) were used in this study. For each group, five bitches were treated with 0.10 mg Aglepristone (Alizine) kg-1 and this dose was repeated 24 h later. Two control bitches received a placebo. Blood samples were collected at 6 h intervals to determine plasma concentrations of progesterone, dihydro-keto prostaglandin F2 alpha (PGFM), oxytocin, prolactin and cortisol. Parturition occurred in the four control bitches. All bitches treated with Aglepristone aborted. In group 1, embryonic death occurred; in group 2, fetal expulsion occurred 60-132 h after administration of Aglepristone. After pregnancy termination, the interoestrous interval of Aglepristone-treated bitches was significantly shorter than that before treatment. Treatment with Aglepristone did not modify plasma concentrations of progesterone, prostaglandin, oxytocin or cortisol within 24 h after its administration, but it induced, in mid-pregnancy (group 2) a discharge of prolactin within 12 h after its administration. As an abortifacient, Aglepristone acted on the uterus and, therefore, did not have direct or immediate luteolytic properties. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterized by an increase in the concentration of PGFM, but oxytocin and cortisol remained at basal concentrations.

A. M. Duszewska - One of the best experts on this subject based on the ideXlab platform.

E. Bigliardi - One of the best experts on this subject based on the ideXlab platform.

  • The use of Aglepristone in the treatment of pregnancy related diabetic ketoacidosis: description of a case in a bitch
    JOURNAL OF ADVANCES IN AGRICULTURE, 2015
    Co-Authors: Daniela Callegari, Carla Bresciani, Enrico Parmigiani, Ezio Bianchi, Valeria De Cesaris, Virginia Bigaran, E. Bigliardi
    Abstract:

    Gestational diabetes mellitus (GDM) is a rare disease in dogs that depends from an endogenous insulin supply that is insufficient to meet the tissues demands for the action of diabetogenic molecules like progesterone (P4), estradiol, growth hormone (GH), placental lactogen and placental cytokines. This report describes for the first time a case of GDM complicated by ketoacidosis treated with the P 4 receptor blocker Aglepristone. In our case Aglepristone seemed to increase insulin sensitivity, helping in the resolution of ketoacidosis and of diabetes mellitus. Aglepristone may represent an effective and well tolerated therapeutic option in case of GDM.

  • Use of Aglepristone for the treatment of P4 induced insulin resistance in dogs
    Journal of Veterinary Science, 2014
    Co-Authors: E. Bigliardi, Carla Bresciani, Daniela Callegari, Francesco Di Ianni, G. Morini, Enrico Parmigiani, Ezio Bianchi
    Abstract:

    Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of Aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine insulin zinc suspension (Caninsulin) and Aglepristone (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 and 17 from diagnosis. At day 5, no significant variation in glycemia was shown. At day 12 and 20, serum glucose concentrations were significant lower (p < 0.05). From day 12 the insulin dose was reduced to 0.8 IU BID. Insulin was reduced in the following weeks and glycemia was controlled.