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Sean R Cutler – One of the best experts on this subject based on the ideXlab platform.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.

Assaf Mosquna – One of the best experts on this subject based on the ideXlab platform.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.

Sangyoul Park – One of the best experts on this subject based on the ideXlab platform.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.

  • Agrochemical control of plant water use using engineered abscisic acid receptors
    Nature, 2015
    Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R Cutler

    Abstract:

    In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this ‘off the shelf’ chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.