The Experts below are selected from a list of 31266 Experts worldwide ranked by ideXlab platform
Sean R Cutler - One of the best experts on this subject based on the ideXlab platform.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
Assaf Mosquna - One of the best experts on this subject based on the ideXlab platform.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
Sangyoul Park - One of the best experts on this subject based on the ideXlab platform.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
Peter Havard - One of the best experts on this subject based on the ideXlab platform.
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Economic analysis for smart sprayer application in wild blueberry fields
Precision Agriculture, 2016Co-Authors: Travis Esau, Qamar Zaman, Kenny Corscadden, Arnold Schumann, Young Chang, Dominic Groulx, Peter HavardAbstract:The wild blueberry industry is spending over $80 million CAD per year on Agrochemicals for 93 000 ha under production in North America. A pressing need to reduce agro-chemical usage and production cost has resulted in the development of a smart sprayer for spot-application of Agrochemicals in wild blueberry fields. This paper encompasses the economic analysis to determine the potential savings for spot-applications of Agrochemicals using a smart sprayer. The economic analysis compared the smart sprayer with two other commercially available sprayers (basic and swath control). The swath control sprayer and smart sprayer both featured GPS auto-steer and boom section control to reduce over-spray in already applied areas based on GPS position. The basic sprayer used a foam marker for guidance with no swath control management. The smart sprayer featured a machine vision system that automatically detected target areas in the field further reducing Agrochemical input by shutting individual nozzles off in non-target areas in the field. The cost analysis was performed to compare the different features of the sprayer technologies, i.e., base sprayer, additional technology, training, usage, repair and maintenance. The additional components installed on the smart sprayer were justified in terms of Agrochemicals/water savings via spot-applications, tractor fuel and operator’s time. The application total cost was $2052 ha^−1 using the basic sprayer, $1799 ha^−1 using the swath control sprayer, and $1138 ha^−1 using the smart sprayer over a 2 year production cycle of the selected fields that were used in this study. The payback period ranged from 2.0 years (60 ha field size) to 9.8 years (20 ha field size) using the swath control sprayer. The payback period ranged from 11 months (60 ha field size) to 3.5 years (20 ha field size) when using the smart sprayer. Results revealed that the smart sprayer had significant advantage from both an environmental and economic perspective over the other two sprayers.
Brian F Volkman - One of the best experts on this subject based on the ideXlab platform.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
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Agrochemical control of plant water use using engineered abscisic acid receptors
Nature, 2015Co-Authors: Sangyoul Park, Francis C Peterson, Assaf Mosquna, Brian F Volkman, Jin Yao, Sean R CutlerAbstract:In response to water shortage, plants produce abscisic acid (ABA), which improves water consumption and stress tolerance; now, a strategy for controlling water use by activating engineered ABA receptors using an existing Agrochemical, mandipropamid, is described. In response to water shortage, plants produce elevated levels of the phytohormone abscisic acid (ABA), which improves water consumption and stress tolerance. Sean Cutler and colleagues describe a strategy for controlling water use in plants by incorporating ABA receptors engineered (by targeted mutagenesis) to be activated by an existing agrichemical — the fungicide mandipropamid. They then use this 'off the shelf' chemical to control ABA responses and drought tolerance in transgenic Arabidopsis and tomato seedlings and obtain mechanistic insights into the basis for its activity. This strategy may be applicable to other plant receptors and opens new avenues for crop improvement. Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses1,2. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing Agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the Agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an Agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
