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Peter Stenvinkel - One of the best experts on this subject based on the ideXlab platform.

  • hand grip muscle strength lean body mass and plasma proteins as markers of nutritional status in patients with chronic renal failure close to start of dialysis therapy
    American Journal of Kidney Diseases, 2000
    Co-Authors: Olof Heimburger, Abdul Rashid Qureshi, William S Blaner, Lars Berglund, Peter Stenvinkel
    Abstract:

    Abstract We studied 115 patients (69 men, 46 women) with chronic renal failure (CRF) aged younger than 70 years close to the start of dialysis therapy to assess the prevalence of malnutrition and study the relationship between various nutritional parameters in these patients. Nutritional status was classified by means of subjective global assessment. Anthropometric measurements (AMs) were performed, and hand-grip strength (HGS) was measured using the Harpenden dynamometer. Body composition, including lean body mass (LBM), was evaluated by dual-energy x-ray absorptiometry (DXA), and LBM was also estimated by means of AMs and creatinine kinetics (CK). The mean age of the patients was 52 ± 12 years, and creatinine clearance was 9 ± 3 mL/min. Malnutrition was seen in 53 patients (48%). As expected, malnourished patients differed in several aspects from well-nourished patients. LBM (estimated by all methods), fat mass (FM), HGS, creatinine clearance, and transthyretin and vitamin A Levels were less in malnourished patients, whereas serum Albumin Levels did not differ. Estimates of LBM by means of DXA, AMs, and CK correlated well with each other. Although DXA and AMs gave similar mean values, LBM was an average of 8 kg less estimated by means of CK, and Bland-Altman plots showed the best agreement between AMs and DXA. HGS showed a strong correlation to LBM (regardless of method) in both men and women. Serum Albumin Level was not related to HGS or LBM, whereas significant correlations were found between serum Albumin Level and Albumin losses in urine, C-reactive protein (CRP) Level, and creatinine clearance. Multiple logistic regression showed that low HGS, low percentage of FM, female sex, and high serum CRP Levels were independent factors associated with malnutrition, whereas serum Albumin Level and percentage of LBM did not reach statistical significance. In conclusion, the present study shows a high prevalence of malnutrition in predialysis patients with CRF and suggests that HGS is a reliable, inexpensive, and easy-to-perform nutritional parameter in patients with CRF. Conversely, serum Albumin Level seems to be a poor nutritional marker in patients with advanced CRF.

Jungol Song - One of the best experts on this subject based on the ideXlab platform.

  • association of preoperative hypoAlbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery a retrospective study
    Journal of Neurosurgery, 2017
    Co-Authors: Kyungmi Kim, Jiyeon Bang, Seonok Kim, Saegyeol Kim, Joung Uk Kim, Jungol Song
    Abstract:

    OBJECTIVE HypoAlbuminemia is known to be independently associated with postoperative acute kidney injury (AKI). However, little is known about the association between the preoperative serum Albumin Level and postoperative AKI in patients undergoing brain tumor surgery. The authors investigated the incidence of AKI, impact of preoperative serum Albumin Level on postoperative AKI, and death in patients undergoing brain tumor surgery. METHODS The authors retrospectively reviewed the electronic medical records and laboratory results of 2363 patients who underwent brain tumor surgery between January 2008 and December 2014. Postoperative AKI was defined according to Kidney Disease: Improving Global Outcomes Definition and Staging (KDIGO). Multivariate logistic regression analysis was used to identify demographic, preoperative laboratory, and intraoperative factors associated with AKI development. Cox proportional hazards models were used to investigate the adjusted odds ratio and hazard ratio for the association between preoperative serum Albumin Level and outcome variables. RESULTS The incidence of AKI was 1.8% (n = 43) using KDIGO criteria. The incidence of AKI was higher in patients with a preoperative serum Albumin Level < 3.8 g/dl (3.5%) than in those with a preoperative serum Albumin Level ≥ 3.8 g/dl (1.2%, p < 0.001). The overall mortality was also higher in the former than in the latter group (5.0% vs 1.8%, p < 0.001). After inverse probability of treatment-weighting adjustment, a preoperative serum Albumin Level < 3.8 g/dl was also found to be associated with postoperative AKI (OR 1.981, 95% CI 1.022-3.841; p = 0.043) and death (HR 2.726, 95% CI 1.522-4.880; p = 0.001). CONCLUSIONS The authors' results demonstrated that a preoperative serum Albumin Level of < 3.8 g/dl was independently associated with AKI and mortality in patients undergoing brain tumor surgery.

  • hypoAlbuminemia within two postoperative days is an independent risk factor for acute kidney injury following living donor liver transplantation a propensity score analysis of 998 consecutive patients
    Critical Care Medicine, 2015
    Co-Authors: Bohyun Sang, Jiyeon Bang, Jungol Song, Gyusam Hwang
    Abstract:

    Objective:Acute kidney injury is a known major complication of liver transplantation. Previous reports have shown that hypoAlbuminemia is associated with an increased risk of acute kidney injury. However, little is known about the relationship between the early postoperative Albumin Level and acute

Ozgur Tanriverdi - One of the best experts on this subject based on the ideXlab platform.

  • a discussion of serum Albumin Level in advanced stage hepatocellular carcinoma a medical oncologist s perspective
    Medical Oncology, 2014
    Co-Authors: Ozgur Tanriverdi
    Abstract:

    Hepatocellular carcinoma is the most common primary malignant tumor of the liver, and it is particularly prevalent in East and Southeast Asia. With surgical and/or local interventional treatment methods, survival rates for early-stage hepatocellular cancers have increased. However, it is not yet clear which staging systems are more applicable in hepatocellular carcinoma. Serum Albumin Level is already being used as a criterion in most staging systems. Albumin is an important serum protein in human bodily functions, but only 5 % of the daily amount needed is synthesized by the liver. The serum Albumin Level is affected by multifactorial situations, including capillary permeability, drugs, liver insufficiency, inflammation and/or infections, dehydration or overhydration, protein loosing disorders, and decreased nutrition intake in anorexia-malnutrition syndrome and cancer cachexia. Because of this complex situation, serum Albumin Level may affect many staging systems for hepatocellular carcinoma by leading to false-negative results. In this paper, the statuses of current staging systems are reviewed, and possible negative events regarding the serum Albumin Levels found in these staging systems are discussed.

Incheol Choi - One of the best experts on this subject based on the ideXlab platform.

Takanari Kitazono - One of the best experts on this subject based on the ideXlab platform.

  • lower serum Albumin Level is associated with an increased risk for loss of residual kidney function in patients receiving peritoneal dialysis
    Therapeutic Apheresis and Dialysis, 2020
    Co-Authors: Shunsuke Yamada, Yasuhiro Kawai, Kazuhiko Tsuruya, Shoji Tsuneyoshi, Hiroaki Tsujikawa, Hokuto Arase, Hisako Yoshida, Toshiaki Nakano, Takanari Kitazono
    Abstract:

    Preserving residual kidney function (RKF) is important in the management of patients on peritoneal dialysis. However, few studies have examined the association between serum Albumin Level and the risk of RKF loss. We prospectively recruited 104 patients who began peritoneal dialysis treatment at our hospital between 2006 and 2016. The primary outcome was complete RKF loss, defined as urine volume < 100 mL/day. Serum Albumin Level at baseline was the main exposure. During a median observation period of 24 months, 33 patients developed RKF loss. A Cox proportional hazards model showed that hypoAlbuminemia was associated with an increased risk of RKF, even after adjustments for potential confounding factors. Multivariable-adjusted linear regression analysis also showed that hypoAlbuminemia was associated with greater rates of decline in 24-h urine volume and in renal Kt/V urea. Our findings suggest that hypoAlbuminemia is associated with an increased risk of RKF loss in patients with peritoneal dialysis.

  • association between serum Albumin Level and incidence of end stage renal disease in patients with immunoglobulin a nephropathy a possible role of Albumin as an antioxidant agent
    PLOS ONE, 2018
    Co-Authors: Yasuhiro Kawai, Shigeru Tanaka, Ritsuko Katafuchi, Kosuke Masutani, Akihiro Tsuchimoto, Kumiko Torisu, Koji Mitsuiki, Kazuhiko Tsuruya, Takanari Kitazono
    Abstract:

    Serum Albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum Albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum Albumin Level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum Albumin Level: Low, Middle, and High group (≤3.9 g/dL, 4.0–4.3 g/dL, ≥4.4 g/dL, respectively). During the median 5.1-year follow-up period, 152 patients (11.2%) developed ESRD. Participants in the Low group had a 1.88-fold increased risk for ESRD compared with those in the High group after adjustment for clinical parameters, including urinary protein excretion, and pathological parameters (Oxford classification). We also experimentally proved the antioxidant capacity of Albumin on mesangial cells. The intracellular reactive oxygen species and mitochondrial injury, induced by hydrogen peroxide were significantly attenuated in Albumin-pretreated mouse mesangial cells and human kidney cells compared with γ-globulin-pretreated cells. Low serum Albumin Level is an independent risk factor for ESRD in patients with IgAN. The mechanism could be explained by the antioxidant capacity of serum Albumin.