The Experts below are selected from a list of 74340 Experts worldwide ranked by ideXlab platform
Yuan Xu - One of the best experts on this subject based on the ideXlab platform.
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synthesis of tert butyl peresters from Aldehydes by bu4ni catalyzed metal free oxidation and its combination with the kharasch sosnovsky reaction
ChemInform, 2012Co-Authors: Chao Zhang, Yuan XuAbstract:A new tert-butyl perester synthesis directly from Aldehydes (I) and tert-butyl hydroperoxide (II) is developed via Bu4NI-catalyzed Aldehyde C—H oxidation.
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synthesis of tert butyl peresters from Aldehydes by bu4ni catalyzed metal free oxidation and its combination with the kharasch sosnovsky reaction
Chemical Communications, 2011Co-Authors: Chao Zhang, Yuan XuAbstract:A new tert-butyl peresters synthesis directly from Aldehydes and TBHP was developed viaBu4NI-catalyzed Aldehyde C−H oxidation. Mechanistic studies suggest that the protocol proceeds via a radical process. Combining the method with the Kharasch–Sosnovsky reaction offers a practical approach for the synthesis of allylic esters from simple Aldehydes and alkenesvia a two-step one-pot procedure.
Chao Zhang - One of the best experts on this subject based on the ideXlab platform.
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synthesis of tert butyl peresters from Aldehydes by bu4ni catalyzed metal free oxidation and its combination with the kharasch sosnovsky reaction
ChemInform, 2012Co-Authors: Chao Zhang, Yuan XuAbstract:A new tert-butyl perester synthesis directly from Aldehydes (I) and tert-butyl hydroperoxide (II) is developed via Bu4NI-catalyzed Aldehyde C—H oxidation.
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synthesis of tert butyl peresters from Aldehydes by bu4ni catalyzed metal free oxidation and its combination with the kharasch sosnovsky reaction
Chemical Communications, 2011Co-Authors: Chao Zhang, Yuan XuAbstract:A new tert-butyl peresters synthesis directly from Aldehydes and TBHP was developed viaBu4NI-catalyzed Aldehyde C−H oxidation. Mechanistic studies suggest that the protocol proceeds via a radical process. Combining the method with the Kharasch–Sosnovsky reaction offers a practical approach for the synthesis of allylic esters from simple Aldehydes and alkenesvia a two-step one-pot procedure.
Christian Wolf - One of the best experts on this subject based on the ideXlab platform.
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metal free one pot oxidative amination of Aldehydes to amides
Organic Letters, 2007Co-Authors: Kekeli Ekouekovi, Christian WolfAbstract:Metal-free oxidative amination of aromatic Aldehydes in the presence of TBHP provides convenient access to amides in 85−99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates Aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.
Michael North - One of the best experts on this subject based on the ideXlab platform.
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a bimetallic aluminium salen complex for asymmetric cyanohydrin synthesis
Tetrahedron Letters, 2009Co-Authors: Michael North, Courtney WilliamsonAbstract:Abstract In the presence of a phosphine oxide cocatalyst, a bimetallic aluminium(salen) complex was found to catalyse the asymmetric addition of trimethylsilyl cyanide to Aldehydes. Under optimised conditions, enantioselectivities of 53–96% were obtained using 2 mol % of the catalyst. An analysis of the reaction kinetics showed that the reactions exhibited first-order kinetics, with the rate of reaction being independent of the Aldehyde concentration.
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synthetic and mechanistic studies on asymmetric cyanohydrin synthesis using a titanium salen bimetallic catalyst
Tetrahedron, 2004Co-Authors: Yuri N. Belokon, Lisa A Clutterbuck, John A Blacker, Paola Carta, Michael NorthAbstract:Abstract A bimetallic titanium(salen) complex 1 was found to catalyse the asymmetric addition of ethyl cyanoformate to Aldehydes. Best results were obtained using 5 mol% of the catalyst at −40 °C and under these conditions, both aromatic and aliphatic Aldehydes were converted into cyanohydrin carbonates with up to 99% enantiomeric excess. The same catalyst could also be used to catalyse the asymmetric addition of potassium cyanide to Aldehydes in the presence of propionic anhydride, leading to cyanohydrin esters. Mechanistic studies showed that the enantiomeric excess of the product increased during the early stages of this reaction. However, by adding a ‘sacrificial Aldehyde’ this effect could be eliminated. The structure of the catalyst in solution was investigated using variable concentration, variable temperature and variable solvent NMR studies. These experiments showed that the catalyst exists as a mixture of monometallic 4 and bimetallic 1 species, a result which is consistent with previous mechanistic studies on the asymmetric addition of trimethylsilyl cyanide to Aldehydes and ketones catalysed by the same catalyst. A mechanistic rationale for all of these observations is reported.
Kekeli Ekouekovi - One of the best experts on this subject based on the ideXlab platform.
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metal free one pot oxidative amination of Aldehydes to amides
Organic Letters, 2007Co-Authors: Kekeli Ekouekovi, Christian WolfAbstract:Metal-free oxidative amination of aromatic Aldehydes in the presence of TBHP provides convenient access to amides in 85−99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates Aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.