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Alkaline Condition

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Weiqi Yan – One of the best experts on this subject based on the ideXlab platform.

  • porous β tricalcium phosphate collagen composites prepared in an Alkaline Condition
    Journal of Biomedical Materials Research Part A, 2008
    Co-Authors: Chao Zou, Wenjian Weng, Kui Cheng, Ge Shen, Gaorong Han, Binggang Guan, Weiqi Yan
    Abstract:

    Bone substitute materials with natural bone-like structure are considered to be favorable for bone regeneration. In this work, porous β-tricalcium phosphate (β-TCP)/collagen composite consisting of bone-like microstructural units was prepared using nanosized β-TCP particles and Alkaline-disassembled collagen. The resulting composite showed a good interconnecting porous structure with ∼90% porosity and 100 ∼ 300 μm pore size. The pore walls were dense, and the combination status of collagen and nanosized β-TCP particles demonstrated that nanosized β-TCP particles tightly connected collagen microfibrils as a bone-like microstructural unit. MTT and Alkaline phosphatase (ALP) assays showed that the porous composite had enhanced effects on cellular proliferation and activity of osteoblast compared with a control of pure collagen. It is suggested that the adoption of nanosized β-TCP particles is a main contribution to the formation of the composite with a bone-like microstructural unit, and the unique microstructure could be a main role for the composite to have the positive influence on osteoblast cell proliferation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

  • Porous β-tricalcium phosphate/collagen composites prepared in an Alkaline Condition
    Journal of biomedical materials research. Part A, 2008
    Co-Authors: Chao Zou, Wenjian Weng, Kui Cheng, Ge Shen, Gaorong Han, Binggang Guan, Weiqi Yan
    Abstract:

    Bone substitute materials with natural bone-like structure are considered to be favorable for bone regeneration. In this work, porous β-tricalcium phosphate (β-TCP)/collagen composite consisting of bone-like microstructural units was prepared using nanosized β-TCP particles and Alkaline-disassembled collagen. The resulting composite showed a good interconnecting porous structure with ∼90% porosity and 100 ∼ 300 μm pore size. The pore walls were dense, and the combination status of collagen and nanosized β-TCP particles demonstrated that nanosized β-TCP particles tightly connected collagen microfibrils as a bone-like microstructural unit. MTT and Alkaline phosphatase (ALP) assays showed that the porous composite had enhanced effects on cellular proliferation and activity of osteoblast compared with a control of pure collagen. It is suggested that the adoption of nanosized β-TCP particles is a main contribution to the formation of the composite with a bone-like microstructural unit, and the unique microstructure could be a main role for the composite to have the positive influence on osteoblast cell proliferation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

Chao Zou – One of the best experts on this subject based on the ideXlab platform.

  • porous β tricalcium phosphate collagen composites prepared in an Alkaline Condition
    Journal of Biomedical Materials Research Part A, 2008
    Co-Authors: Chao Zou, Wenjian Weng, Kui Cheng, Ge Shen, Gaorong Han, Binggang Guan, Weiqi Yan
    Abstract:

    Bone substitute materials with natural bone-like structure are considered to be favorable for bone regeneration. In this work, porous β-tricalcium phosphate (β-TCP)/collagen composite consisting of bone-like microstructural units was prepared using nanosized β-TCP particles and Alkaline-disassembled collagen. The resulting composite showed a good interconnecting porous structure with ∼90% porosity and 100 ∼ 300 μm pore size. The pore walls were dense, and the combination status of collagen and nanosized β-TCP particles demonstrated that nanosized β-TCP particles tightly connected collagen microfibrils as a bone-like microstructural unit. MTT and Alkaline phosphatase (ALP) assays showed that the porous composite had enhanced effects on cellular proliferation and activity of osteoblast compared with a control of pure collagen. It is suggested that the adoption of nanosized β-TCP particles is a main contribution to the formation of the composite with a bone-like microstructural unit, and the unique microstructure could be a main role for the composite to have the positive influence on osteoblast cell proliferation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

  • Porous β-tricalcium phosphate/collagen composites prepared in an Alkaline Condition
    Journal of biomedical materials research. Part A, 2008
    Co-Authors: Chao Zou, Wenjian Weng, Kui Cheng, Ge Shen, Gaorong Han, Binggang Guan, Weiqi Yan
    Abstract:

    Bone substitute materials with natural bone-like structure are considered to be favorable for bone regeneration. In this work, porous β-tricalcium phosphate (β-TCP)/collagen composite consisting of bone-like microstructural units was prepared using nanosized β-TCP particles and Alkaline-disassembled collagen. The resulting composite showed a good interconnecting porous structure with ∼90% porosity and 100 ∼ 300 μm pore size. The pore walls were dense, and the combination status of collagen and nanosized β-TCP particles demonstrated that nanosized β-TCP particles tightly connected collagen microfibrils as a bone-like microstructural unit. MTT and Alkaline phosphatase (ALP) assays showed that the porous composite had enhanced effects on cellular proliferation and activity of osteoblast compared with a control of pure collagen. It is suggested that the adoption of nanosized β-TCP particles is a main contribution to the formation of the composite with a bone-like microstructural unit, and the unique microstructure could be a main role for the composite to have the positive influence on osteoblast cell proliferation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

Jianmin Chen – One of the best experts on this subject based on the ideXlab platform.

Tae-jin Lee – One of the best experts on this subject based on the ideXlab platform.

Venkata S Mohan – One of the best experts on this subject based on the ideXlab platform.