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Ming Zhong - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and characterization of core‐shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of Macleaya cordata (Willd) R. Br.
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
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synthesis and characterization of core shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of macleaya cordata willd r br
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
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Optimization of microwave-assisted extraction of protopine and Allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology.
Journal of Separation Science, 2010Co-Authors: Ming Zhong, Kelong Huang, Jian-guo Zeng, Jin-ming She, Li ZhangAbstract:The purpose of the research was to investigate the multiple response optimizations for the extraction of protopine and Allocryptopine from the stems of Macleaya cordata (Willd) R. Br. by using microwave-assisted extraction (MAE). A three-level, three-factor Box-Behnken design of response surface methodology was used to develop response model, and desirability function was employed to optimize the effects of main extraction parameters. Three variables, ethanol concentration (20-80%, v/v), extraction temperature (30-70 degrees C) and solvent/solid ratio (10:1 to 30:1, mL/g), were investigated in this study. The results showed that the optimum parameters of MAE were ethanol concentration of 45.2 % (v/v), extraction temperature of 54.7 degrees C and solvent/solid ratio of 20.4:1 (mL/g). Under these conditions, the extraction yields of protopine and Allocryptopine were 89.4 and 102.0%, respectively, and the extracta sicca yield was 12.5%. The combination use of response surface methodology, Box-Behnken design and the appropriate desirability function could provide an insight into a lab-scale MAE process, and help to develop procedures for commercial production of active ingredients from medical plants.
Lu Wang - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and characterization of core‐shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of Macleaya cordata (Willd) R. Br.
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
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synthesis and characterization of core shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of macleaya cordata willd r br
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
Yan-hong Wang - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and characterization of core‐shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of Macleaya cordata (Willd) R. Br.
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
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synthesis and characterization of core shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of macleaya cordata willd r br
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
Binbin Zhou - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and characterization of core‐shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of Macleaya cordata (Willd) R. Br.
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
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synthesis and characterization of core shell magnetic molecularly imprinted polymers for selective extraction of Allocryptopine from the wastewater of macleaya cordata willd r br
Journal of Molecular Recognition, 2020Co-Authors: Lu Wang, Yan-hong Wang, Binbin Zhou, Ming ZhongAbstract:A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the Allocryptopine from the waster of Macleaya cordata (Willd) R. Br. In this study, MMIP was synthesized by using Fe3 O4 @SiO2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and Allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and Allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was -2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm (R2 > 0.98, 298 K) and pseudo-second-order kinetics model (R2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for Allocryptopine (ALL, C21 H23 NO5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of Allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on Allocryptopine separating from the wastewater of Macleaya cordata (Willd) R. Br.
Liangwei Zhao - One of the best experts on this subject based on the ideXlab platform.
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in vivo anthelmintic activity of five alkaloids from macleaya microcarpa maxim fedde against dactylogyrus intermedius in carassius auratus
Veterinary Parasitology, 2010Co-Authors: Gao-xue Wang, Zhuang Zhou, Dongxin Jiang, Jing Han, Jianfu Wang, Liangwei ZhaoAbstract:Abstract The present study aims to evaluate the anthelmintic properties of aerial part of Macleaya microcarpa (Maxim) Fedde. Bioassay-guided fractionation and isolation of the compounds with anthelmintic activity were performed on the ethanolic extract of M. microcarpa yielding five bioactive alkaloids namely: sanguinarine, cryptopine, β-Allocryptopine, protopine and 6-methoxyl-dihydro-chelerythrine by comparing spectral data (UV, NMR, and EI-MS) with literature values. According to in vivo anthelmintic assays, they were found to be 100% effective at the concentrations of 0.7, 8.0, 8.0, 16.0 and 7.0 mg l−1, and the median effective concentration (EC50) values for the five compounds were 0.37, 3.31, 4.64, 8.13 and 3.63 mg l−1, respectively. Additionally, the acute toxicity on goldfish for the five active compounds was also investigated with median lethal concentrations (LC50) values of 1.13, 16.12, 15.88, 21.69 and 10.91 mg l−1, respectively. The resulting therapeutic indices for sanguinarine, cryptopine, β-Allocryptopine, protopine and 6-methoxyl-dihydro-chelerythrine were 3.03, 4.82, 3.40, 2.66 and 2.99 correspondingly. Correlations analysis between the log P and EC50, LC50 of the five alkaloids revealed that the activity of the five alkaloids was well correlated with their hydrophobicity and r2 = 0.45 is for anthelmintic activity while r2 = 0.47 is for acute toxicity for goldfish, respectively. These results provided evidence that the studied plant extract, as well as the isolated compounds, especially sanguinarine, might be potential plant-based medicines for the treatment of D. intermedius infection.
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In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus.
Veterinary Parasitology, 2010Co-Authors: Gao-xue Wang, Zhuang Zhou, Dongxin Jiang, Jing Han, Jianfu Wang, Liangwei ZhaoAbstract:The present study aims to evaluate the anthelmintic properties of aerial part of Macleaya microcarpa (Maxim) Fedde. Bioassay-guided fractionation and isolation of the compounds with anthelmintic activity were performed on the ethanolic extract of M. microcarpa yielding five bioactive alkaloids namely: sanguinarine, cryptopine, beta-Allocryptopine, protopine and 6-methoxyl-dihydro-chelerythrine by comparing spectral data (UV, NMR, and EI-MS) with literature values. According to in vivo anthelmintic assays, they were found to be 100% effective at the concentrations of 0.7, 8.0, 8.0, 16.0 and 7.0 mgl(-1), and the median effective concentration (EC(50)) values for the five compounds were 0.37, 3.31, 4.64, 8.13 and 3.63 mgl(-1), respectively. Additionally, the acute toxicity on goldfish for the five active compounds was also investigated with median lethal concentrations (LC(50)) values of 1.13, 16.12, 15.88, 21.69 and 10.91 mgl(-1), respectively. The resulting therapeutic indices for sanguinarine, cryptopine, beta-Allocryptopine, protopine and 6-methoxyl-dihydro-chelerythrine were 3.03, 4.82, 3.40, 2.66 and 2.99 correspondingly. Correlations analysis between the logP and EC(50), LC(50) of the five alkaloids revealed that the activity of the five alkaloids was well correlated with their hydrophobicity and r(2)=0.45 is for anthelmintic activity while r(2)=0.47 is for acute toxicity for goldfish, respectively. These results provided evidence that the studied plant extract, as well as the isolated compounds, especially sanguinarine, might be potential plant-based medicines for the treatment of D. intermedius infection.
