The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Adam B Yanke - One of the best experts on this subject based on the ideXlab platform.
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what factors influence the biomechanical properties of Allograft Tissue for acl reconstruction a systematic review
Clinical Orthopaedics and Related Research, 2017Co-Authors: Drew A Lansdown, Andrew J Riff, Molly Meadows, Adam B Yanke, Bernard R BachAbstract:Background Allograft Tissue is used in 22% to 42% of anterior cruciate ligament (ACL) reconstructions. Clinical outcomes have been inconsistent with Allograft Tissue, with some series reporting no differences in outcomes and others reporting increased risk of failure. There are numerous variations in processing and preparation that may influence the eventual performance of Allograft Tissue in ACL reconstruction. We sought to perform a systematic review to summarize the factors that affect the biomechanical properties of Allograft Tissue for use in ACL reconstruction. Many factors might impact the biomechanical properties of Allograft Tissue, and these should be understood when considering using Allograft Tissue or when reporting outcomes from Allograft reconstruction.
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concomitant arthroscopic meniscal Allograft transplantation and anterior cruciate ligament reconstruction
Arthroscopy techniques, 2016Co-Authors: Bryan M Saltzman, Brian J Cole, Justin W Griffin, Nathan G Wetters, Maximilian A Meyer, Adam B YankeAbstract:Abstract In recent decades, arthroscopic meniscal Allograft transplantation (MAT) has been refined as a robust option for the treatment of evolving unicompartmental tibiofemoral arthrosis in the setting of meniscal deficiency. It is imperative that the MAT be performed in a knee with anatomic stability and alignment to reduce aberrant biomechanical forces experienced by the Allograft Tissue to maintain its durability. Thus, in an anterior cruciate ligament (ACL)–deficient knee, ACL reconstruction (ACLR) must be performed to restore the stable knee environment for the MAT to succeed. Although these operations can be performed in staged fashion, a single-stage procedure with concomitant MAT and ACLR is an option. Its performance is technically demanding and requires careful consideration as to the intraoperative setup, incisions, graft options, surgical tools, and procedural order to properly secure the transplanted meniscal Allograft and restore a functional, anatomic ACL. We present our preferred technique for concomitant arthroscopic MAT and ACLR, as well as some potential pitfalls and pearls to avoid pitfalls.
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the biomechanical effects of 1 0 to 1 2 mrad of gamma irradiation on human bone patellar tendon bone Allografts
American Journal of Sports Medicine, 2013Co-Authors: Adam B Yanke, Rebecca Bell, Vincent M Wang, Andrew S Lee, Richard W Kang, Richard C Mather, Elizabeth Shewman, Bernard R BachAbstract:Background:Recent data suggest that anterior cruciate ligament (ACL) reconstruction with irradiated Allograft Tissue may lead to increased failure rates.Hypothesis:Low-dose (1.0-1.2 Mrad) gamma irradiation does not significantly alter the preimplantation biomechanical properties of bone–patellar tendon–bone (BTB) Allografts.Study Design:Controlled laboratory study.Methods:Cyclic and failure mechanical properties were evaluated for 20 paired central-third human BTB Allografts, with and without 1.0 to 1.2 Mrad of gamma irradiation. Testing included cyclic loading at 0.5 Hz for 100 cycles from 50 to 200 N and failure testing at a strain rate of 10% per second.Results:Cyclic elongation did not change significantly (P = .151) with irradiation, increasing from a mean ± SD of 9.4 ± 2.1 mm to 11.3 ± 3.4 mm. Cyclic creep strain approached a significant increase with irradiation (1.3% ± 0.8% to 2.6% ± 1.5%; P = .076). Failure testing was not affected with irradiation with regard to maximum load (1680 ± 417 mm to 14...
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multiple freeze thaw cycled meniscal Allograft Tissue a biomechanical biochemical and histologic analysis
Journal of Orthopaedic Research, 2008Co-Authors: Adam B Yanke, Paul B Lewis, James M Williams, Nadim J Hallab, Amarjit S Virdi, Brian J ColeAbstract:Meniscus Allografting has provided relief of meniscal injuries that were previously thought irreparable. However, meniscus Allograft Tissue remains limited and a significant problem. To improve Allograft Tissue yield, decrease processing costs, and increase graft availability, this study investigated the biomechanical changes of meniscal Allograft Tissue frozen and thawed multiple times. Specifically, our study compared the intrinsic compressive resistances of meniscus undergoing four freeze-thaw cycles versus Tissue undergoing a single freeze-thaw cycle. Seven menisci that were originally procured and processed for Allografting were donated for the study. Each meniscus was segmented and samples independently underwent novel constant slow-rate compression testing, and histological and biochemical evaluation. The menisci that underwent a single freeze-thaw cycle demonstrated a significantly higher Young's Modulus (14 megapascals) as compared to menisci undergoing multiple freeze-thaw cycles (10 megapascals, p ¼0.03). These results were maintained when medial and lateral menisci were compared independently. Histological and biochemical analyses supported, but did not provide an explanation for the change in intrinsic compressive resistance. From these results, transplantation of meniscal Allograft Tissue frozen and thawed four times may be compromised in its ability to resist compression; and thus may undermine its role in replacing native meniscal Tissue. 2007 Orthopaedic Research Society.
Nirav K Pandya - One of the best experts on this subject based on the ideXlab platform.
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clinical outcomes after medial patellofemoral ligament reconstruction utilizing Allograft Tissue in pediatric and adolescent patients minimum 2 year follow up
Orthopaedic Journal of Sports Medicine, 2021Co-Authors: Sachin Allahabadi, Nirav K PandyaAbstract:Background:Medial patellofemoral ligament (MPFL) reconstruction has gained popularity as a tool to manage recurrent patellar instability. The use of Allograft for reconstruction includes benefits o...
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does the utilization of Allograft Tissue in medial patellofemoral ligament reconstruction in pediatric and adolescent patients restore patellar stability
Clinical Orthopaedics and Related Research, 2017Co-Authors: Eric A Hohn, Nirav K PandyaAbstract:Background Medial patellofemoral ligament (MPFL) reconstruction is one of several surgical procedures used to treat patellofemoral instability. Use of Allograft Tissue can preserve autogenous Tissue and may be preferable in patients with connective Tissue disorders or ligamentous laxity. Although there are successful reports in adults, it is unclear if the use of Allograft Tissue in MPFL reconstruction can restore patellofemoral stability in children and adolescents.
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does the utilization of Allograft Tissue in medial patellofemoral ligament reconstruction in pediatric and adolescent patients restore patellar stability
Clinical Orthopaedics and Related Research, 2017Co-Authors: Eric A Hohn, Nirav K PandyaAbstract:Medial patellofemoral ligament (MPFL) reconstruction is one of several surgical procedures used to treat patellofemoral instability. Use of Allograft Tissue can preserve autogenous Tissue and may be preferable in patients with connective Tissue disorders or ligamentous laxity. Although there are successful reports in adults, it is unclear if the use of Allograft Tissue in MPFL reconstruction can restore patellofemoral stability in children and adolescents. (1) Does Allograft Tissue in MPFL reconstruction in pediatric and adolescent patients restore patellar stability? (2) What complications were associated with Allograft MPFL reconstructions in children and adolescents? Between June 2012 and August 2015, one surgeon (NKP) performed 26 MPFL reconstructions in 23 patients with gracilis Allograft for traumatic patellar instability. Of those, 25 (96%) were available for followup more than 1 year later (mean, 24 months; range, 12–44 months). During this time, the surgeon suggested reconstruction to patients who had recurrent dislocation or subluxation after 6 weeks of bracing, physical therapy, and activity modification if they were noted to have a torn or attenuated MPFL on MRI. During that period, this was the only surgical technique the surgeon used to treat traumatic patellar instability. Patients undergoing concurrent bony procedures were ineligible for inclusion. The mean age of the patients in the series was 16.0 (± 2) years. Age, sex, skeletal maturity, presence of trochlear dysplasia, and additional arthroscopic procedures at the time of reconstruction were collected. Postoperative notes and imaging were reviewed for presence of complications defined as recurrent dislocation, recurrent subluxations, fractures, infection, or arthrofibrosis. These complications were identified by chart review by the senior surgeon (NKP) and study personnel (EH) not involved in clinical care of the patients or by patient-reported complications. Recurrent subluxation or dislocation was patient-reported at the time of the clinic visit or followup phone/email contact. Fractures were defined as any cortical disruption in the femur or patella that required treatment (change in postoperative protocol), infection requiring treatment (antibiotics and/or return to the operating room), or arthrofibrosis (stiffness that necessitated a change in the postoperative protocol or manipulation under anesthesia). Ninety-two percent (23 of 25) of patients reported no further instability episodes after MPFL reconstruction. Sixteen percent (four of 25) of patients had complications: two repeat episodes of patellar instability, one patella fracture, and one symptomatic hardware requiring interference screw removal. No patients developed arthrofibrosis or infection. In this small case series, we found that MPFL reconstruction using Allograft Tissue in children and adolescents resulted in a low risk of recurrent instability, perhaps comparable to what has been published by others who have used autograft Tissue. Longer followup is needed, because in some orthopaedic applications, Allograft ligaments have been observed to attenuate over time. Future studies might compare these techniques using patient-reported outcomes scores as well as use a control group of patients with autograft Tissue. Level IV, therapeutic study.
Bernard R Bach - One of the best experts on this subject based on the ideXlab platform.
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what factors influence the biomechanical properties of Allograft Tissue for acl reconstruction a systematic review
Clinical Orthopaedics and Related Research, 2017Co-Authors: Drew A Lansdown, Andrew J Riff, Molly Meadows, Adam B Yanke, Bernard R BachAbstract:Background Allograft Tissue is used in 22% to 42% of anterior cruciate ligament (ACL) reconstructions. Clinical outcomes have been inconsistent with Allograft Tissue, with some series reporting no differences in outcomes and others reporting increased risk of failure. There are numerous variations in processing and preparation that may influence the eventual performance of Allograft Tissue in ACL reconstruction. We sought to perform a systematic review to summarize the factors that affect the biomechanical properties of Allograft Tissue for use in ACL reconstruction. Many factors might impact the biomechanical properties of Allograft Tissue, and these should be understood when considering using Allograft Tissue or when reporting outcomes from Allograft reconstruction.
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the biomechanical effects of 1 0 to 1 2 mrad of gamma irradiation on human bone patellar tendon bone Allografts
American Journal of Sports Medicine, 2013Co-Authors: Adam B Yanke, Rebecca Bell, Vincent M Wang, Andrew S Lee, Richard W Kang, Richard C Mather, Elizabeth Shewman, Bernard R BachAbstract:Background:Recent data suggest that anterior cruciate ligament (ACL) reconstruction with irradiated Allograft Tissue may lead to increased failure rates.Hypothesis:Low-dose (1.0-1.2 Mrad) gamma irradiation does not significantly alter the preimplantation biomechanical properties of bone–patellar tendon–bone (BTB) Allografts.Study Design:Controlled laboratory study.Methods:Cyclic and failure mechanical properties were evaluated for 20 paired central-third human BTB Allografts, with and without 1.0 to 1.2 Mrad of gamma irradiation. Testing included cyclic loading at 0.5 Hz for 100 cycles from 50 to 200 N and failure testing at a strain rate of 10% per second.Results:Cyclic elongation did not change significantly (P = .151) with irradiation, increasing from a mean ± SD of 9.4 ± 2.1 mm to 11.3 ± 3.4 mm. Cyclic creep strain approached a significant increase with irradiation (1.3% ± 0.8% to 2.6% ± 1.5%; P = .076). Failure testing was not affected with irradiation with regard to maximum load (1680 ± 417 mm to 14...
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bony incorporation of soft Tissue anterior cruciate ligament grafts in an animal model autograft versus Allograft with low dose gamma irradiation
American Journal of Sports Medicine, 2012Co-Authors: Sanjeev Bhatia, Rebecca Bell, Rachel M Frank, Scott A Rodeo, Bernard R Bach, Brian J Cole, S Chubinskaya, Vincent M Wang, Nikhil N VermaAbstract:Background:The effect of low-dose gamma irradiation on healing of soft Tissue Allografts remains largely unknown.Hypothesis:The authors hypothesized that soft Tissue Allograft healing to bone would be delayed compared with that of autograft Tissue and that low-dose (1.2 Mrad) gamma irradiation would not affect the healing response of Allograft Tissue after anterior cruciate ligament (ACL) reconstruction.Study Design:Controlled laboratory study.Methods:Forty-eight New Zealand White rabbits underwent bilateral ACL reconstructions with semitendinosus tendon graft. Sixteen rabbits were reconstructed with autografts and the remainder with Allografts. The 32 Allograft rabbits each received 1 irradiated Allograft (1.2 Mrad), with the contralateral leg receiving a nonirradiated Allograft. Animals were euthanized at 2 weeks or 8 weeks postoperatively. Tensile stiffness, maximum load, and displacement at maximum load were measured. Tibial and femoral segments were sectioned perpendicular to the tunnel axis allowing...
Sonia Maria Oliani - One of the best experts on this subject based on the ideXlab platform.
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annexin a12 26 treatment improves skin heterologous transplantation by modulating inflammation and angiogenesis processes
Frontiers in Pharmacology, 2018Co-Authors: Jessica Zani Lacerda, Carine Cristiane Drewes, Kallyne Kioko Oliveira Mimura, Caroline De Freitas Zanon, Tahera Ansari, Karin V Greco, Sandra Helena Poliselli Farsky, Sonia Maria OlianiAbstract:Skin graft successful depends on reduction of local inflammation evoked by the surgical lesion and efficient neovascularization to nutrition the graft. It has been shown that N-terminal portion of the Annexin A1 protein (AnxA1) with its anti-inflammatory properties induces epithelial mucosa repair and presents potential therapeutic approaches. The role of AnxA1 on wound healing has not been explored and we investigated in this study the effect of the peptide Ac2-26 (N-terminal AnxA1 peptide Ac2-26; AnxA12-26) on heterologous skin scaffolds transplantation in BALB/c mice, focusing on inflammation and angiogenesis. Treatment with AnxA12-26, once a day, from day 3-60 after scaffold implantation improved the take of the implant, induced vessels formation, enhanced gene and protein levels of the vascular growth factor-A (VEGF-A) and fibroblast influx into Allograft Tissue. It also decreased pro- while increasing anti-inflammatory cytokines. The pro-angiogenic activity of AnxA12-26 was corroborated by topical application of AnxA12-26 on the subcutaneous Tissue of mice. Moreover, treatment of human umbilical endothelial cells (HUVEC) with AnxA12-26 improved proliferation, shortened cycle, increased migration and actin polymerization similarly to those evoked by VEGF-A. The peptide treatment instead only potentiated the tube formation induced by VEGF-A. Collectively, our data showed that AnxA12-26 treatment favours the Tissue regeneration after skin grafting by avoiding exacerbated inflammation and improving the angiogenesis process.
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Table_1_Annexin A12–26 Treatment Improves Skin Heterologous Transplantation by Modulating Inflammation and Angiogenesis Processes.pdf
2018Co-Authors: Jessica Zani Lacerda, Carine Cristiane Drewes, Kallyne Kioko Oliveira Mimura, Caroline De Freitas Zanon, Tahera Ansari, Karin V Greco, Sandra Helena Poliselli Farsky, Cristiane Damas Gil, Sonia Maria OlianiAbstract:Skin graft successful depends on reduction of local inflammation evoked by the surgical lesion and efficient neovascularization to nutrition the graft. It has been shown that N-terminal portion of the Annexin A1 protein (AnxA1) with its anti-inflammatory properties induces epithelial mucosa repair and presents potential therapeutic approaches. The role of AnxA1 on wound healing has not been explored and we investigated in this study the effect of the peptide Ac2–26 (N-terminal AnxA1 peptide Ac2–26; AnxA12–26) on heterologous skin scaffolds transplantation in BALB/c mice, focusing on inflammation and angiogenesis. Treatment with AnxA12–26, once a day, from day 3–60 after scaffold implantation improved the take of the implant, induced vessels formation, enhanced gene and protein levels of the vascular growth factor-A (VEGF-A) and fibroblast influx into Allograft Tissue. It also decreased pro- while increasing anti-inflammatory cytokines. The pro-angiogenic activity of AnxA12–26 was corroborated by topical application of AnxA12–26 on the subcutaneous Tissue of mice. Moreover, treatment of human umbilical endothelial cells (HUVECs) with AnxA12–26 improved proliferation, shortened cycle, increased migration and actin polymerization similarly to those evoked by VEGF-A. The peptide treatment instead only potentiated the tube formation induced by VEGF-A. Collectively, our data showed that AnxA12–26 treatment favors the Tissue regeneration after skin grafting by avoiding exacerbated inflammation and improving the angiogenesis process.
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Annexin A12–26 Treatment Improves Skin Heterologous Transplantation by Modulating Inflammation and Angiogenesis Processes
Frontiers Media S.A., 2018Co-Authors: Jessica Zani Lacerda, Carine Cristiane Drewes, Kallyne Kioko Oliveira Mimura, Caroline De Freitas Zanon, Tahera Ansari, Karin V Greco, Sandra Helena Poliselli Farsky, Sonia Maria Oliani, Cristiane Damas GilAbstract:Skin graft successful depends on reduction of local inflammation evoked by the surgical lesion and efficient neovascularization to nutrition the graft. It has been shown that N-terminal portion of the Annexin A1 protein (AnxA1) with its anti-inflammatory properties induces epithelial mucosa repair and presents potential therapeutic approaches. The role of AnxA1 on wound healing has not been explored and we investigated in this study the effect of the peptide Ac2–26 (N-terminal AnxA1 peptide Ac2–26; AnxA12–26) on heterologous skin scaffolds transplantation in BALB/c mice, focusing on inflammation and angiogenesis. Treatment with AnxA12–26, once a day, from day 3–60 after scaffold implantation improved the take of the implant, induced vessels formation, enhanced gene and protein levels of the vascular growth factor-A (VEGF-A) and fibroblast influx into Allograft Tissue. It also decreased pro- while increasing anti-inflammatory cytokines. The pro-angiogenic activity of AnxA12–26 was corroborated by topical application of AnxA12–26 on the subcutaneous Tissue of mice. Moreover, treatment of human umbilical endothelial cells (HUVECs) with AnxA12–26 improved proliferation, shortened cycle, increased migration and actin polymerization similarly to those evoked by VEGF-A. The peptide treatment instead only potentiated the tube formation induced by VEGF-A. Collectively, our data showed that AnxA12–26 treatment favors the Tissue regeneration after skin grafting by avoiding exacerbated inflammation and improving the angiogenesis process
Kinam Park - One of the best experts on this subject based on the ideXlab platform.
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decellularized extracellular matrix derived from human adipose Tissue as a potential scaffold for Allograft Tissue engineering
Journal of Biomedical Materials Research Part A, 2011Co-Authors: Ji Suk Choi, Young Chan Choi, Hyunjin Yang, Kinam ParkAbstract:Decellularized Tissues composed of extracellular matrix (ECM) have been clinically used to support the regeneration of various human Tissues and organs. Most decellularized Tissues so far have been derived from animals or cadavers. Therefore, despite the many advantages of decellularized Tissue, there are concerns about the potential for immunogenicity and the possible presence of infectious agents. Herein, we present a biomaterial composed of ECM derived from human adipose Tissue, the most prevalent, expendable, and safely harvested Tissue in the human body. The ECM was extracted by successive physical, chemical, and enzymatic treatments of human adipose Tissue isolated by liposuction. Cellular components including nucleic acids were effectively removed without significant disruption of the morphology or structure of the ECM. Major ECM components were quantified, including acid/pepsin-soluble collagen, sulfated glycosaminoglycan (GAG), and soluble elastin. In an in vivo experiment using mice, the decellularized ECM graft exhibited good compatibility to surrounding Tissues. Overall results suggest that the decellularized ECM containing biological and chemical cues of native human ECM could be an ideal scaffold material not only for autologous but also for Allograft Tissue engineering. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2011.
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decellularized extracellular matrix derived from human adipose Tissue as a potential scaffold for Allograft Tissue engineering
Journal of Biomedical Materials Research Part A, 2011Co-Authors: Ji Suk Choi, Young Chan Choi, Hyunjin Yang, Kinam Park, Beob Soo Kim, Jun Young Kim, Jae Dong Kim, Hee Young Lee, Yong Woo ChoAbstract:Decellularized Tissues composed of extracellular matrix (ECM) have been clinically used to support the regeneration of various human Tissues and organs. Most decellularized Tissues so far have been derived from animals or cadavers. Therefore, despite the many advantages of decellularized Tissue, there are concerns about the potential for immunogenicity and the possible presence of infectious agents. Herein, we present a biomaterial composed of ECM derived from human adipose Tissue, the most prevalent, expendable, and safely harvested Tissue in the human body. The ECM was extracted by successive physical, chemical, and enzymatic treatments of human adipose Tissue isolated by liposuction. Cellular components including nucleic acids were effectively removed without significant disruption of the morphology or structure of the ECM. Major ECM components were quantified, including acid/pepsin-soluble collagen, sulfated glycosaminoglycan (GAG), and soluble elastin. In an in vivo experiment using mice, the decellularized ECM graft exhibited good compatibility to surrounding Tissues. Overall results suggest that the decellularized ECM containing biological and chemical cues of native human ECM could be an ideal scaffold material not only for autologous but also for Allograft Tissue engineering.