The Experts below are selected from a list of 13533 Experts worldwide ranked by ideXlab platform
Marc L. Snapper - One of the best experts on this subject based on the ideXlab platform.
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Preparation of aliphatic ketones through a ruthenium-catalyzed tandem cross-metathesis/Allylic Alcohol isomerization.
Organic letters, 2006Co-Authors: David F. Finnegan, And Benjamin A. Seigal, Marc L. SnapperAbstract:Grubbs' 2nd generation and Hoveyda−Grubbs' ruthenium alkylidenes are shown to be effective catalysts for cross-metatheses of Allylic Alcohols with cyclic and acyclic olefins, as well as isomerization of the resulting Allylic Alcohols to alkyl ketones. The net result of this new tandem methodology is a single-flask process that provides highly functionalized, ketone-containing products from simple Allylic Alcohol precursors.
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preparation of aliphatic ketones through a ruthenium catalyzed tandem cross metathesis Allylic Alcohol isomerization
Organic Letters, 2006Co-Authors: David F. Finnegan, And Benjamin A. Seigal, Marc L. SnapperAbstract:Grubbs' 2nd generation and Hoveyda−Grubbs' ruthenium alkylidenes are shown to be effective catalysts for cross-metatheses of Allylic Alcohols with cyclic and acyclic olefins, as well as isomerization of the resulting Allylic Alcohols to alkyl ketones. The net result of this new tandem methodology is a single-flask process that provides highly functionalized, ketone-containing products from simple Allylic Alcohol precursors.
Weiqing Xie - One of the best experts on this subject based on the ideXlab platform.
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tandem Allylic Alcohol isomerization oxo michael addition reaction promoted by re2o7
RSC Advances, 2016Co-Authors: Qiang Zhang, Yang Shang, Mumin Shi, Yucui Huangfu, Leilei Liu, Rong Liang, Yisheng Lai, Jinming Gao, Weiqing XieAbstract:Re2O7 catalyzed tandem Allylic Alcohol isomerization/oxa-Michael addition reaction of cyclohexadienone was developed. The reaction features a regioselective and stereoselective isomerization of Allylic Alcohol and diastereoselective ring closure via oxa-Michael addition. This method also enabled construction of enantiopure bicyclic enones from substrates incorporated with chiral Allylic Alcohol via efficient chirality transfer.
Steven D. Burke - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of thromboxane B2 via ketalization/ring-closing metathesis.
Organic letters, 2007Co-Authors: Christopher C. Marvin, And Alexander J. L. Clemens, Steven D. BurkeAbstract:Total synthesis of thromboxane B2 using intermolecular ketalization followed by ring-closing metathesis is reported. Other key steps include a Sharpless asymmetric epoxidation to form an oxirane on the endo face of the bicyclic acetal, epoxide opening using lithioacetonitrile, an Allylic Alcohol 1,3-transposition, and Mitsunobu lactonization.
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synthesis of thromboxane b2 via ketalization ring closing metathesis
Organic Letters, 2007Co-Authors: Christopher C. Marvin, And Alexander J. L. Clemens, Steven D. BurkeAbstract:Total synthesis of thromboxane B2 using intermolecular ketalization followed by ring-closing metathesis is reported. Other key steps include a Sharpless asymmetric epoxidation to form an oxirane on the endo face of the bicyclic acetal, epoxide opening using lithioacetonitrile, an Allylic Alcohol 1,3-transposition, and Mitsunobu lactonization.
Yisheng Lai - One of the best experts on this subject based on the ideXlab platform.
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tandem Allylic Alcohol isomerization oxo michael addition reaction promoted by re2o7
RSC Advances, 2016Co-Authors: Qiang Zhang, Yang Shang, Mumin Shi, Yucui Huangfu, Leilei Liu, Rong Liang, Yisheng Lai, Jinming Gao, Weiqing XieAbstract:Re2O7 catalyzed tandem Allylic Alcohol isomerization/oxa-Michael addition reaction of cyclohexadienone was developed. The reaction features a regioselective and stereoselective isomerization of Allylic Alcohol and diastereoselective ring closure via oxa-Michael addition. This method also enabled construction of enantiopure bicyclic enones from substrates incorporated with chiral Allylic Alcohol via efficient chirality transfer.
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Tandem Allylic Alcohol isomerization/oxo-Michael addition reaction promoted by Re2O7
RSC Advances, 2016Co-Authors: Qiang Zhang, Yang Shang, Mumin Shi, Yucui Huangfu, Leilei Liu, Rong Liang, Yisheng LaiAbstract:Re2O7 catalyzed tandem Allylic Alcohol isomerization/oxa-Michael addition reaction of cyclohexadienone was developed. The reaction features a regioselective and stereoselective isomerization of Allylic Alcohol and diastereoselective ring closure via oxa-Michael addition. This method also enabled construction of enantiopure bicyclic enones from substrates incorporated with chiral Allylic Alcohol via efficient chirality transfer.
Janine Cossy - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 1 2 amino Alcohols by sigmatropic rearrangements of 3 n tosylamino Allylic Alcohol derivatives
Chemistry: A European Journal, 2011Co-Authors: Marion Barbazanges, Janine Cossy, Christophe Meyer, Peter TurnerAbstract:Sigmatropic rearrangements of 3-(N-tosylamino)Allylic Alcohol derivatives, a particular subclass of functionalized enamides, have been investigated. Whereas the presence of the nitrogen atom alters the stereochemical outcome of Ireland-Claisen rearrangements of glycolates derived from such substrates, [2,3]-Wittig rearrangements of α-allyloxy acetamides or propargylic ethers derivatives provide access to a wide variety of functionalized 1,2-amino Alcohols usually with high levels of stereocontrol, as well as to heterocyclic compounds. The stereoselectivity issues of these rearrangements (1,2-diastereoselectivity, auxiliary-induced diastereoselection, chirality transfer, and double stereodifferentiation) were thoroughly investigated.
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synthesis of optically enriched 1 2 aminoAlcohols by 2 3 wittig rearrangements of 3 aza Allylic Alcohol derivatives
Tetrahedron Letters, 2008Co-Authors: Marion Barbazanges, Christophe Meyer, Janine CossyAbstract:[2,3]-Wittig rearrangements of (E)-3-aza-Allylic Alcohol derivatives can provide access to syn or anti optically enriched 1,2-aminoAlcohols by using a chirality transfer or a chiral auxiliary.
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Stereoselective Synthesis of 1,2-AminoAlcohols by [2,3]-Wittig Rearrangements
Organic Letters, 2007Co-Authors: Marion Barbazanges, And Christophe Meyer, Janine CossyAbstract:[2,3]-Wittig rearrangements of (E)-3-aza-Allylic Alcohol derivatives can provide access to functionalized 1,2-aminoAlcohols with high syn or anti diastereoselectivity depending on the anionic stabilizing group (amide or alkyne).
