The Experts below are selected from a list of 1440 Experts worldwide ranked by ideXlab platform
Shu-li You - One of the best experts on this subject based on the ideXlab platform.
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Iridium-Catalyzed Asymmetric Allylic Amination Reactions with N-Aryl Phosphoramidite Ligands
Organometallics, 2016Co-Authors: Xiao Zhang, Qiang Cheng, Wen-bo Liu, Shu-li YouAbstract:A series of N-aryl phosphoramidite ligands were synthesized, and the iridium complexes derived from these novel ligands were proven to be efficient catalysts for asymmetric intermolecular Allylic Amination reactions. This C–N bond forming process readily accommodates a diverse range of amines and Allylic carbonates, especially for the previously challenging ortho-substituted cinnamyl substrates. Moreover, isolation and characterization of the corresponding (π-allyl)–iridium complex K1 reveal that the active iridacycle is generated through a C(sp2)–H bond insertion of tetrahydroquinoline of the ligand.
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Enantioselective Synthesis of Pyrrole-Fused Piperazine and Piperazinone Derivatives via Ir-Catalyzed Asymmetric Allylic Amination
ACS Catalysis, 2016Co-Authors: Chun-xiang Zhuo, Xiao Zhang, Shu-li YouAbstract:Ir-catalyzed intramolecular asymmetric Allylic Amination reaction of pyrrole derivatives was achieved. The pyrrole-fused piperazine and piperazinone derivatives could be easily accessed from the pyrrole-tethered Allylic carbonates in good yields and enantioselectivity (up to 98% ee).
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Highly Regio‐ and Enantioselective Synthesis of N‐Substituted 2‐Pyridones: Iridium‐Catalyzed Intermolecular Asymmetric Allylic Amination.
ChemInform, 2015Co-Authors: Xiao Zhang, Ze-peng Yang, Lin Huang, Shu-li YouAbstract:The Ir-catalyzed asymmetric Allylic Amination of 2-hydroxypyridines with allyl methyl carbonates (II) is reported for the first time.
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highly regio and enantioselective synthesis of n substituted 2 pyridones iridium catalyzed intermolecular asymmetric Allylic Amination
ChemInform, 2015Co-Authors: Xiao Zhang, Ze-peng Yang, Lin Huang, Shu-li YouAbstract:The Ir-catalyzed asymmetric Allylic Amination of 2-hydroxypyridines with allyl methyl carbonates (II) is reported for the first time.
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highly regio and enantioselective synthesis of n substituted 2 pyridones iridium catalyzed intermolecular asymmetric Allylic Amination
Angewandte Chemie, 2015Co-Authors: Xiao Zhang, Ze-peng Yang, Lin Huang, Shu-li YouAbstract:The first iridium-catalyzed intermolecular asymmetric Allylic Amination reaction with 2-hydroxypyridines has been developed, thus providing a highly efficient synthesis of enantioenriched N-substituted 2-pyridone derivatives from readily available starting materials. This protocol features a good tolerance of functional groups in both the Allylic carbonates and 2-hydroxypyridines, thereby delivering multifunctionalized heterocyclic products with up to 98 % yield and 99 % ee.
Toshiyuki Itoh - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts.
ChemInform, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:A facile protocol for the regio- and enantioselective Allylic Amination of Allylic esters to give the corresponding α-type Allylic amines is presented.
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts
Organic letters, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:The palladium-catalyzed regio- and enantioselective Allylic Amination of trifluoromethyl group substituted racemic and unsymmetrical 1,3-disubstituted Allylic esters has been accomplished. The enantioselective formation of the α-type Allylic amines was attained by the dynamic kinetic asymmetric transformation (DYKAT).
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Ruthenium-catalyzed regio- and enantioselective Allylic Amination of racemic 1-arylallyl esters.
Organic letters, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Kenta Uchida, Hiroaki Tsuji, Maki Minakawa, Toshiyuki ItohAbstract:The regio- and enantioselective Allylic Amination of racemic monosubstituted Allylic esters, such as 1-arylallyl acetates, with cyclic secondary amines has been accomplished. The RuCl3/(S,S)-ip-pybox catalyst system has effectively catalyzed the reaction to afford the enantiomerically enriched branch-type Allylic amines with perfect regioselectivity and high enantioselectivity.
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Regioselective synthesis of trifluoromethyl group substituted Allylic amines via palladium-catalyzed Allylic Amination
Tetrahedron Letters, 2008Co-Authors: Motoi Kawatsura, Takuya Hirakawa, Tomoko Tanaka, Daiji Ikeda, Shuichi Hayase, Toshiyuki ItohAbstract:The palladium-catalyzed regioselective Allylic Amination of a-trifluoromethylated allyl acetate occurred using Pd(OAc)2/DPPE and [Pd(p-allyl)(cod)]BF4/DPPF. The selective formation of the c-product was attained by Pd(OAc)2/DPPE, while the a-product was obtained using [Pd(p-allyl)(cod)]BF4/DPPF. 2008 Elsevier Ltd. All rights reserved.
Motoi Kawatsura - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of α-Tertiary Amines by the Ruthenium-catalyzed Regioselective Allylic Amination of Tertiary Allylic Esters
Chemistry Letters, 2020Co-Authors: Shota Mizuno, Hiroaki Tsuji, Yasuhiro Uozumi, Motoi KawatsuraAbstract:We demonstrated a ruthenium-catalyzed regioselective Allylic Amination of tertiary Allylic esters with various amines using [Cp*Ru(CH3CN)3][PF6]/5,5′-dimethyl-2,2′-bipyridine (5,5′-diMe-2,2′-bpy) a...
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Ruthenium-catalyzed regioselective Allylic Amination of 2,3,3-trifluoroAllylic carbonates
Organic & biomolecular chemistry, 2017Co-Authors: Shin-ichi Isobe, Shou Terasaki, Taisyun Hanakawa, Shota Mizuno, Motoi KawatsuraAbstract:We demonstrated the ruthenium-catalyzed Allylic Amination of 2,3,3-trifluoroAllylic carbonates with several types of amines. The reactions proceeded with several types of amines, and succeeded in obtaining polyfluorinated terminal alkenes possessing branched Allylic amines as a single regioisomer.
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Regioselective Construction of α,α-Disubstituted Allylic Amines by the Ruthenium-Catalyzed Allylic Amination of Tertiary Allylic Acetates
2017Co-Authors: Shota Mizuno, Shou Terasaki, Toru Shinozawa, Motoi KawatsuraAbstract:The ruthenium-catalyzed regioselective Allylic Amination of tertiary Allylic acetates with several types of amines has been accomplished. The reaction was effectively catalyzed by Cp*RuCl2/5,5′-dimethyl-2,2′-bipyridine or its related ruthenium catalyst systems, and α,α-disubstituted Allylic amines were formed as a single regioisomer in moderate to high yields
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts.
ChemInform, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:A facile protocol for the regio- and enantioselective Allylic Amination of Allylic esters to give the corresponding α-type Allylic amines is presented.
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts
Organic letters, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:The palladium-catalyzed regio- and enantioselective Allylic Amination of trifluoromethyl group substituted racemic and unsymmetrical 1,3-disubstituted Allylic esters has been accomplished. The enantioselective formation of the α-type Allylic amines was attained by the dynamic kinetic asymmetric transformation (DYKAT).
Min Shi - One of the best experts on this subject based on the ideXlab platform.
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cinchona alkaloid catalyzed regio and enantioselective Allylic Amination of morita baylis hillman carbonates with isatins
ChemInform, 2012Co-Authors: Min Shi, Meixin Zhao, Mingxiao Chen, Wenhao Tang, Dengke Wei, Tonglei DaiAbstract:The Allylic Amination products are obtained with good yields and enantioselectivities using (DHQD)2-PHAL as a catalyst.
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Cinchona Alkaloid Catalyzed Regio‐ and Enantioselective Allylic Amination of Morita—Baylis—Hillman Carbonates with Isatins.
ChemInform, 2012Co-Authors: Mei‐xin Zhao, Ming‐xiao Chen, Wen‐hao Tang, Deng‐ke Wei, Tong‐lei Dai, Min ShiAbstract:The Allylic Amination products are obtained with good yields and enantioselectivities using (DHQD)2-PHAL as a catalyst.
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cinchona alkaloid catalyzed regio and enantioselective Allylic Amination of morita baylis hillman carbonates with isatins
European Journal of Organic Chemistry, 2012Co-Authors: Min Shi, Meixin Zhao, Mingxiao Chen, Wenhao Tang, Dengke Wei, Tonglei DaiAbstract:An efficient enantioselective Allylic Amination of Morita–Baylis–Hillman (MBH) carbonates derived from methyl acrylate and aromatic aldehydes with isatins has been realized in the presence of commercially available cinchona alkaloids. The Allylic Amination products were obtained in moderate-to-good yields (46–74 %) with moderate-to-good enantioselectivities (up to 89 % ee) under mild conditions. The synthetic utility of the Amination products has been well demonstrated by the facile synthesis of methyl (3R,4R)-10-oxo-4-phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indole-3-carboxylate.
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Cinchona Alkaloid Catalyzed Regio‐ and Enantioselective Allylic Amination of Morita–Baylis–Hillman Carbonates with Isatins
European Journal of Organic Chemistry, 2012Co-Authors: Mei‐xin Zhao, Ming‐xiao Chen, Wen‐hao Tang, Deng‐ke Wei, Tong‐lei Dai, Min ShiAbstract:An efficient enantioselective Allylic Amination of Morita–Baylis–Hillman (MBH) carbonates derived from methyl acrylate and aromatic aldehydes with isatins has been realized in the presence of commercially available cinchona alkaloids. The Allylic Amination products were obtained in moderate-to-good yields (46–74 %) with moderate-to-good enantioselectivities (up to 89 % ee) under mild conditions. The synthetic utility of the Amination products has been well demonstrated by the facile synthesis of methyl (3R,4R)-10-oxo-4-phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indole-3-carboxylate.
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chiral bifunctional thiourea phosphane organocatalysts in asymmetric Allylic Amination of morita baylis hillman acetates
European Journal of Organic Chemistry, 2011Co-Authors: Hongping Deng, Yin Wei, Min ShiAbstract:A series of new chiral bifunctional thiourea-phosphane catalysts was synthesized and successfully applied in the catalytic, asymmetric Allylic Amination of Morita-Baylis-Hillman (MBH) acetates derived from the methyl vinyl ketone (MVK) or ethyl vinyl ketone (EVK) system, with phthalimide, affording the Amination products in up to over 99 % yield and 90 % ee for a wide range of substrates derived from different aromatic aldehydes.
Uttam K. Tambar - One of the best experts on this subject based on the ideXlab platform.
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Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent‐Sitagliptin.
ChemInform, 2014Co-Authors: Hongli Bao, Liela Bayeh, Uttam K. TambarAbstract:A two-step ene-reaction/[2,3]-rearrangement for the enantioselective Allylic Amination of nonactivated olefins is developed.
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Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent-Sitagliptin.
Synlett : accounts and rapid communications in synthetic organic chemistry, 2013Co-Authors: Hongli Bao, Liela Bayeh, Uttam K. TambarAbstract:The presence of nitrogen atoms in most chiral pharmaceutical drugs has motivated the development of numerous strategies for the synthesis of enantiomerically enriched amines. Current methods are based on multistep transformations of functionalized Allylic electrophiles to form chiral Allylic amines. The enantioselective Allylic Amination of nonactivated olefins would represent a more direct and more attractive strategy. We report the enantioselective synthesis of ent-sitagliptin through an Allylic Amination of a nonactivated terminal olefin.
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catalytic enantioselective Allylic Amination of unactivated terminal olefins via an ene reaction 2 3 rearrangement
ChemInform, 2013Co-Authors: Uttam K. TambarAbstract:That is the first asymmetric Allylic Amination of unfunctionalized alkenes using a nitrogen-containing reagent and a chiral Pd-catalyst.
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Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]‐Rearrangement.
ChemInform, 2013Co-Authors: Hongli Bao, Uttam K. TambarAbstract:That is the first asymmetric Allylic Amination of unfunctionalized alkenes using a nitrogen-containing reagent and a chiral Pd-catalyst.
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catalytic enantioselective Allylic Amination of unactivated terminal olefins via an ene reaction 2 3 rearrangement
Journal of the American Chemical Society, 2012Co-Authors: Uttam K. TambarAbstract:The enantioselective Allylic Amination of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen-containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched Allylic amines via an ene reaction/[2,3]-rearrangement.
