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Chengxiao Zhang – One of the best experts on this subject based on the ideXlab platform.

  • nanomaterial Amplified Signal off on electrogenerated chemiluminescence aptasensors for the detection of thrombin
    Biosensors and Bioelectronics, 2010
    Co-Authors: Qiang Gao, Jia Yang, Chengxiao Zhang

    Abstract:

    Abstract Two electrogenerated chemiluminescence (ECL) aptasensors for the detection of thrombin were developed using the thrombin binding aptamer (TBA) taken as a molecular recognition element and nanomaterial as a carrier of the ECL capture/Signal probe. In the “Signal off” aptasensor, the thiolated capture probe (ss-DNA, 12-mer) was self-assembled on the gold nanoparticles (GNPs) which were self-assembled on the surface of gold electrode, and hybridized with six-base segment of the ss-DNA sequence (Tgt-aptamer, 21-mer) containing TBA-I (ss-DNA, 15-mer) tagged with ruthenium complex, producing a high ECL intensity. Introduction of the analyte thrombin triggered the dissociation of the Tgt-aptamer tagged with ruthenium complex from the aptasensors, led to significantly decrease in ECL intensity. The decreased ECL intensity was in proportion to the concentration of thrombin in a range from 2.7 × 10 −12 to 2.7 × 10 −9  M with a detection limit of 8 × 10 −13  M. In the “Signal on” aptasensor, the thiolated TBA-I was self-assembled on the gold electrode for capturing thrombin onto the electrode and then the TBA-II (ss-DNA, 29-mer) labeled with single-walled carbon-nanotubes (SWNT)-ECL tag was bound with epitope of thrombin, producing a high ECL intensity. The increased ECL intensity was linearly with the concentration of thrombin from 1.0 × 10 −14  M to 1.0 × 10 −11  M with a detection limit of 3 × 10 −15  M. The present work demonstrates that using nanomaterial as a carrier for capture probe and Signal probe is a promising way to amplify the ECL Signal and to improve the sensitivity of the aptasensors.

  • Nanomaterial-Amplified “Signal off/on” electrogenerated chemiluminescence aptasensors for the detection of thrombin.
    Biosensors & bioelectronics, 2010
    Co-Authors: Qiang Gao, Jia Yang, Chengxiao Zhang

    Abstract:

    Abstract Two electrogenerated chemiluminescence (ECL) aptasensors for the detection of thrombin were developed using the thrombin binding aptamer (TBA) taken as a molecular recognition element and nanomaterial as a carrier of the ECL capture/Signal probe. In the “Signal off” aptasensor, the thiolated capture probe (ss-DNA, 12-mer) was self-assembled on the gold nanoparticles (GNPs) which were self-assembled on the surface of gold electrode, and hybridized with six-base segment of the ss-DNA sequence (Tgt-aptamer, 21-mer) containing TBA-I (ss-DNA, 15-mer) tagged with ruthenium complex, producing a high ECL intensity. Introduction of the analyte thrombin triggered the dissociation of the Tgt-aptamer tagged with ruthenium complex from the aptasensors, led to significantly decrease in ECL intensity. The decreased ECL intensity was in proportion to the concentration of thrombin in a range from 2.7 × 10 −12 to 2.7 × 10 −9  M with a detection limit of 8 × 10 −13  M. In the “Signal on” aptasensor, the thiolated TBA-I was self-assembled on the gold electrode for capturing thrombin onto the electrode and then the TBA-II (ss-DNA, 29-mer) labeled with single-walled carbon-nanotubes (SWNT)-ECL tag was bound with epitope of thrombin, producing a high ECL intensity. The increased ECL intensity was linearly with the concentration of thrombin from 1.0 × 10 −14  M to 1.0 × 10 −11  M with a detection limit of 3 × 10 −15  M. The present work demonstrates that using nanomaterial as a carrier for capture probe and Signal probe is a promising way to amplify the ECL Signal and to improve the sensitivity of the aptasensors.

Mark Shtaif – One of the best experts on this subject based on the ideXlab platform.

  • Noiseless amplification and Signal-to-noise ratio in single-sideband transmission.
    Optics Letters, 2003
    Co-Authors: Antonio Mecozzi, Mark Shtaif

    Abstract:

    We study the properties of optical single-sideband (SSB) modulation with respect to Signal-to-noise ratio and limits to spectral efficiency. We show that SSB Signals undergo truly noiseless amplification, which can be understood in view of Heisenberg’s uncertainty principle. Yet, contrary to previously published results, this phenomenon offers no advantages in terms of the Signal-to-noise ratio of the Amplified Signal. We show that, when an intensity receiver is used, single-sideband modulation can improve spectral efficiency in the limit of a high optical Signal-to-noise ratio and in the presence of a strong carrier Signal.

  • Experimental study of the statistical properties of nonlinearly Amplified Signals in semiconductor optical amplifiers
    IEEE Photonics Technology Letters, 1997
    Co-Authors: Mark Shtaif, Gadi Eisenstein

    Abstract:

    We examine the effect of nonlinear amplification on the noise properties of an Amplified Signal. We show that the output noise statistics can be approximated as Gaussian over a wide range of practical parameters. In addition, we show that nonlinear amplification of noise carrying Signals may result in an enhancement of the Signal-to-noise ratio (SNR). Basic principles dictate that this can not improve the bit error rate performance of a communication link, as long as an optimal detection scheme is used. Hence, we conclude that for communication systems that exploit nonlinear amplification in semiconductor optical amplifiers, evaluation of performance on the basis of the SNR can be misleading and should be made with great care.

Yan He – One of the best experts on this subject based on the ideXlab platform.

  • electrochemical sensor based on electrodeposited graphene au modified electrode and nanoau carrier Amplified Signal strategy for attomolar mercury detection
    Analytical Chemistry, 2015
    Co-Authors: Yi Zhang, Guang Ming Zeng, Lin Tang, Jun Chen, Xiao Xiao He, Yan He

    Abstract:

    An electrochemical sensor was developed for attomolar Hg2+ detection. Three single-stranded DNA probes were rationally designed for selective and sensitive detection of the target, which combined T…

  • electrochemical sensor based on electrodeposited graphene au modified electrode and nanoau carrier Amplified Signal strategy for attomolar mercury detection
    Analytical Chemistry, 2015
    Co-Authors: Yi Zhang, Guang Ming Zeng, Lin Tang, Jun Chen, Xiao Xiao He, Yan He

    Abstract:

    An electrochemical sensor was developed for attomolar Hg2+ detection. Three single-stranded DNA probes were rationally designed for selective and sensitive detection of the target, which combined T-Hg2+-T coordination chemistry and the characteristic of convenient modification of electrochemical Signal indicator. Graphene and nanoAu were successively electrodeposited on a glass carbon electrode surface to improve the electrode conductivity and functionalize with the 10-mer thymine-rich DNA probe (P1). NanoAu carriers functionalized with 29-mer guanine-rich DNA probe (P3) labeled methyl blue (MB-nanoAu-P 3s) were used to further strengthen Signal response. In the presence of Hg2+, a T-T mismatched dsDNA would occur between P1 and a 22-mer thymine-rich DNA probe (P2) on the electrode surface due to T-Hg2+-T coordination chemistry. Followed by adding the MB-nanoAu-P 3s for hybridization with P2, square wave voltammetry was executed. Under optimal conditions, Hg2+ could be detected in the range from 1.0 aM to…