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Anacardiaceae

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Isao Kubo – 1st expert on this subject based on the ideXlab platform

  • multifunctional cytotoxic agents from anacardium occidentale
    Phytotherapy Research, 2011
    Co-Authors: Isao Kubo, Teruhiko Nitoda, Felismino E. Tocoli, Ivan R. Green

    Abstract:

    The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity. Copyright © 2010 John Wiley & Sons, Ltd.

  • 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.
    Planta medica, 1999
    Co-Authors: Isao Kubo, Ikuyo Kinst-hori

    Abstract:

    By bioassay-guided fractionation using mushroom tyrosinase (EC 1.14.18.1), 2-hydroxy-4-methoxybenzaldehyde was characterized as the principal tyrosinase inhibitor from three East African medicinal plants, the root of Mondia whitei (Hook) Skeels (Asclepiaceae), the root of Rhus vulgaris Meikle (Anacardiaceae), and the bark of Sclerocarya caffra Sond (Anacardiaceae). It inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with an ID50 of 4.3 micrograms/ml (0.03 mM). The inhibition kinetics analyzed by a Lineweaver-Burk plot found this simple benzaldehyde derivative to be a mixed type inhibitor for this oxidation and affects on the enzyme in several ways. Based on finding this potent tyrosinase inhibitor, various related analogues were also tested in order to gain new insights into their inhibitory functions on a molecular basis.

  • tyrosinase inhibitors from anacardium occidentale fruits
    Journal of Natural Products, 1994
    Co-Authors: Isao Kubo, Ikuyo Kinsthori, Yoshihiro Yokokawa

    Abstract:

    : Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew [Anacardium occidentale] (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid and 5-[8(Z),11(Z),14-pentadecatrienyl]resorcinol, have indicated that both of these phenolic compounds exhibit characteristic competitive inhibition of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase.

Martinez J Quesada – 2nd expert on this subject based on the ideXlab platform

  • allergy to pistachio crossreactivity between pistachio nut and other Anacardiaceae
    Clinical & Experimental Allergy, 1995
    Co-Authors: Concepcion De Linares Fernandez, A Fiandor, A Martinezgarate, Martinez J Quesada

    Abstract:

    BACKGROUND: Anaphylaxis against Anacardiaceae nuts is uncommon and the allergens involved still poorly characterized. For this reason two patients with allergy towards pistachio nut (a member of the Anacardiaceae family) have been studied. OBJECTIVE: Identification of immunoallergens present in pistachio nut and analysis of crossreactive antigens in other members of the same plant family, specifically cashew and mango. METHODS: Presence of specific IgE for pistachio and cashew nut and for mango seed and pulp was determined by skin tests and radioallergosorbent assay (RAST). The allergenic profile of pistachio and cashew was analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) followed by immunoblotting. Crossreactivity between pistachio and the other Anacardiaceae was studied by RAST inhibition. RESULTS: Skin tests were positive for pistachio and cashew in the two children and for mango seed in one. RAST was positive for pistachio and cashew in both patients. On immunoblotting, serum from both patients recognized several pistachio and cashew allergens with a molecular weight ranging from < 14.2-70 kDa. RAST inhibition demonstrated common antigenic determinants between pistachio and cashew nut. Crossreactivity was also found between pistachio nut and mango seed but not with mango pulp. CONCLUSION: Pistachio nut contains several protein allergens able to trigger type I hypersensitivity reactions. These allergens can be found also in cashew nut and mango seed but not in mango pulp.

Oton Meira Marques – 3rd expert on this subject based on the ideXlab platform

  • registro de neosilba zadolicha mcalpine steyskal diptera lonchaeidae em umbu caja Anacardiaceae
    Neotropical Entomology, 2004
    Co-Authors: Wyratan Da Silva Santos, Carlos Alfredo Lopes De Carvalho, Oton Meira Marques

    Abstract:

    Neosilba zadolicha McAlpine & Steyskal is reported for the first time in “umbu-cajazeira” fruits (Spondias sp.), in Cruz das Almas, State of Bahia, Brazil. A total of 51 specimens were obtained from 4,100 fruits between March and July 2002. This is the first record of N. zadolicha in an Anacardiaceae species.

  • Registro de Neosilba zadolicha McAlpine & Steyskal (Diptera: Lonchaeidae) em Umbu-cajá (Anacardiaceae)
    Neotropical Entomology, 2004
    Co-Authors: Wyratan Da Silva Santos, Carlos Alfredo Lopes De Carvalho, Oton Meira Marques

    Abstract:

    Neosilba zadolicha McAlpine & Steyskal is reported for the first time in “umbu-cajazeira” fruits (Spondias sp.), in Cruz das Almas, State of Bahia, Brazil. A total of 51 specimens were obtained from 4,100 fruits between March and July 2002. This is the first record of N. zadolicha in an Anacardiaceae species.