The Experts below are selected from a list of 9480 Experts worldwide ranked by ideXlab platform
G T Tucker - One of the best experts on this subject based on the ideXlab platform.
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application of the Analogue Computer to pharmacokinetic and biopharmaceutical studies with amphetamine type compounds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, G T TuckerAbstract:The kinetics of absorption, metabolism, and excretion of (+)-amphetamine and (+)-methylamphetamine, after oral administration of “free” dosage forms to man, under controlled acidic urine conditions, have been examined using an electronic Analogue Computer. This device has also been used to determine the in vivo rate of release of the drugs from hard gelatin capsule dosage forms and prolonged-release preparations. In vivo drug release from the prolonged-release preparations was correlated with in vitro drug release data.
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use of the Analogue Computer to predict the distribution and excretion of drugs under conditions of fluctuating urinary ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:An Analogue Computer program, incorporating a previously established relation between urinary pH and amphetamine excretion, has been used to predict the quantitative excretion of the drug under normal conditions of fluctuating urinary pH. Under the same conditions, a comparison has been made of Computer predicted body levels of amphetamine after administration of the drug in a single solution dose, three divided solution doses, and in various prolonged-release formulations. Advantages of sustained-release preparations are indicated and specifications for a theoretically ideal sustained-release formulation are suggested.
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use of the Analogue Computer to examine the quantitative relation between urinary ph and kidney reabsorption of drugs partially ionized at physiological ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:A method, involving the use of an Analogue Computer, is described for determining a quantitative relation between measured urinary pH and the kidney tubular reabsorption of certain drugs under normal conditions of fluctuating urinary pH. The method is based on the use of drug excretion versus time profiles under normal conditions and of absorption, metabolism and excretion rate constants, determined under conditions of controlled urinary pH, e.g. constant acidic pH (<5) in the case of basic drugs. In support of the theoretical treatment, experimental results, using amphetamine as a model drug, are presented. The implications of the method are discussed with respect to the evaluation of drug formulations under normal urinary pH conditions.
A. H. Beckett - One of the best experts on this subject based on the ideXlab platform.
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application of the Analogue Computer to pharmacokinetic and biopharmaceutical studies with amphetamine type compounds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, G T TuckerAbstract:The kinetics of absorption, metabolism, and excretion of (+)-amphetamine and (+)-methylamphetamine, after oral administration of “free” dosage forms to man, under controlled acidic urine conditions, have been examined using an electronic Analogue Computer. This device has also been used to determine the in vivo rate of release of the drugs from hard gelatin capsule dosage forms and prolonged-release preparations. In vivo drug release from the prolonged-release preparations was correlated with in vitro drug release data.
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use of the Analogue Computer to predict the distribution and excretion of drugs under conditions of fluctuating urinary ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:An Analogue Computer program, incorporating a previously established relation between urinary pH and amphetamine excretion, has been used to predict the quantitative excretion of the drug under normal conditions of fluctuating urinary pH. Under the same conditions, a comparison has been made of Computer predicted body levels of amphetamine after administration of the drug in a single solution dose, three divided solution doses, and in various prolonged-release formulations. Advantages of sustained-release preparations are indicated and specifications for a theoretically ideal sustained-release formulation are suggested.
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use of the Analogue Computer to examine the quantitative relation between urinary ph and kidney reabsorption of drugs partially ionized at physiological ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:A method, involving the use of an Analogue Computer, is described for determining a quantitative relation between measured urinary pH and the kidney tubular reabsorption of certain drugs under normal conditions of fluctuating urinary pH. The method is based on the use of drug excretion versus time profiles under normal conditions and of absorption, metabolism and excretion rate constants, determined under conditions of controlled urinary pH, e.g. constant acidic pH (<5) in the case of basic drugs. In support of the theoretical treatment, experimental results, using amphetamine as a model drug, are presented. The implications of the method are discussed with respect to the evaluation of drug formulations under normal urinary pH conditions.
R. N. Boyes - One of the best experts on this subject based on the ideXlab platform.
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use of the Analogue Computer to predict the distribution and excretion of drugs under conditions of fluctuating urinary ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:An Analogue Computer program, incorporating a previously established relation between urinary pH and amphetamine excretion, has been used to predict the quantitative excretion of the drug under normal conditions of fluctuating urinary pH. Under the same conditions, a comparison has been made of Computer predicted body levels of amphetamine after administration of the drug in a single solution dose, three divided solution doses, and in various prolonged-release formulations. Advantages of sustained-release preparations are indicated and specifications for a theoretically ideal sustained-release formulation are suggested.
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use of the Analogue Computer to examine the quantitative relation between urinary ph and kidney reabsorption of drugs partially ionized at physiological ph
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A. H. Beckett, R. N. Boyes, G T TuckerAbstract:A method, involving the use of an Analogue Computer, is described for determining a quantitative relation between measured urinary pH and the kidney tubular reabsorption of certain drugs under normal conditions of fluctuating urinary pH. The method is based on the use of drug excretion versus time profiles under normal conditions and of absorption, metabolism and excretion rate constants, determined under conditions of controlled urinary pH, e.g. constant acidic pH (<5) in the case of basic drugs. In support of the theoretical treatment, experimental results, using amphetamine as a model drug, are presented. The implications of the method are discussed with respect to the evaluation of drug formulations under normal urinary pH conditions.
Judith A Rees - One of the best experts on this subject based on the ideXlab platform.
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an Analogue Computer simulation of drug dissolution
Journal of Pharmacy and Pharmacology, 2011Co-Authors: J H Collett, Judith A ReesAbstract:The dissolution rate of salicylic acid from non-disintegrating discs at controlled pH has been determined. A theoretical model of dissolution has been developed in terms of the diffusion layer theory. This model has been programmed on an Analogue Computer and theoretical dissolution curves have been obtained. Experimental dissolution curves have been compared with simulated curves and the fit of the data has allowed the estimation of drug concentration in the diffusion layer.
James S Small - One of the best experts on this subject based on the ideXlab platform.
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the Analogue alternative the electronic Analogue Computer in britain and the usa 1930 1975
2001Co-Authors: James S SmallAbstract:Introduction 1. Analogue Computing Devices in the 19th and Early 20th Centuries 2. The Origins, Form and Function of Electronic Analogue Devices and Computers, 1937-1950 3. Electronic Analogue Computer Development, 1945-1955: Military Programmes, Aeronautics and Electronics 4. Commercialisation, Hybridisation and Competition: the Electronic and Hybrid Computer Industry in the USA, 1945-1975 5. The Origins, Commericialisation and Decline of Electronic Analogue and Hybrid Computing in Britain, 1945-1975 6. Electronic Analogue Computers and Engineering Culture 7. Negotiating a Place for Electronic Analogue Computers: the Analogue Versus Digital Debate. Conclusion.