The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
Maciej Wysocki - One of the best experts on this subject based on the ideXlab platform.
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ectopic acth syndrome due to bilateral ovarian Androblastoma with double gynandroblastic differentiation in one ovary
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1993Co-Authors: A Kasperlikzaluska, Ludwika Sikorowa, Elzbieta Ploch, Piotr Soszynski, W Jeske, B Migdalska, Maciej WysockiAbstract:Abstract A case of fulminant Cushing's syndrome due to an ectopic ACTH secretion in a patient with bilateral ovarian sex-cord stromal tumour is reported. Surgical resection of the ovaries as well as the inhibitors of steroid synthesis and cytostatics caused only transient improvement because the widespread neoplastic dissemination progressed very quickly.
Yu‑lan Mu - One of the best experts on this subject based on the ideXlab platform.
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Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report.
Oncology Letters, 2015Co-Authors: Hui Zhang, Chun‑yan Li, Tao Li, Yu‑lan MuAbstract:Sertoli-Leydig cell tumor of the ovary, also known as Androblastoma, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary. The tumor accounts for
Klaus Steger - One of the best experts on this subject based on the ideXlab platform.
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Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor
Fertility and Sterility, 1999Co-Authors: Thomas Klonisch, Sabine Hombach-klonisch, J. Buchmann, Bernd Fischer, Martin Bergmann, Klaus StegerAbstract:Relaxin-like factor (RLF), a new member of the insulin-like growth factor family, is a reliable marker for normal Leydig cells in the human postpubertal testis (1). Expression of the RLF gene appears to be developmentally regulated, given that only during puberty is RLF expression up-regulated. We recently demonstrated down-regulation of the human RLF gene in testicular Leydig cell tumors indicating dedifferentiation of the Leydig cells within the tumor (2). Ovarian Sertoli-Leydig cell tumors (SLCTs), histologically typed as Androblastomas, are rare, potentially malignant sex-cord stromal tumors exhibiting testicular-like structure and differentiation of various degrees. In the present study, we investigated the expression of RLF, 17a-hydroxylase, 3b-hydroxysteroid dehydrogenase (3b-HSD), Ki-67, and cytokeratin 18 in a human ovarian SLCT of low differentiation.
A. Lewczuk - One of the best experts on this subject based on the ideXlab platform.
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Ectopic ACTH syndrome associated with ovarian steroid-cell tumor
Journal of Endocrinological Investigation, 2002Co-Authors: K. Sworczak, K. Blaut, M. Malecha, A. LewczukAbstract:Several cases of ovarian neoplasms resulting in Cushing’s syndrome due to ectopic secretion of ACTH or ectopic secretion of F have been reported. Tumors producing ACTH include adenocarcinoma, Androblastoma, Sertoli cell carcinoma, carcinoid tumor and teratoma. Cortisol secretion has been reported in ovarian steroid cell tumor (unclassified steroid cell tumor). We present a case of a 19-year-old woman with Cushing’s syndrome in course of an ovarian steroid cell tumor with ectopic ACTH production. To our knowledge, it is the first reported case of ACTH secreting ovarian steroid cell tumor causing Cushing’s syndrome.
E Azevedo - One of the best experts on this subject based on the ideXlab platform.
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364 A case of sertoli-leydig cell tumor of ovary in young woman: a rare disease
E-Poster viewings, 2019Co-Authors: G Resende, B Ruiz, V Sanz, Yl Viana, E AzevedoAbstract:Objectives We reported a Sertoli-Leydig cell tumor with symptoms of hyperandrogenism. Methods Sertoli-Leydig cell tumor (SLCT) also called Androblastoma represents less than 0,5% of all primary ovarian tumor. The majority of SLCTs are unilateral and confined to the ovaries. It’s more common in young women between the age of 25 and 35. In approximately 90% of the cases are diagnosed as Stage IA. Results We reported a case of SLCT in a 17-year-old female who was presented at emergency room with acute abdominal pain caused by an ovarian torsion. She underwent an emergency laparotomy with confirmed finding of an ovarian tumor without disease at peritoneal cavity. Histopathological examination showed a well encapsulated gray colored solid mass with smooth external surface measuring 16.0 x 14.5 x 11.0 cm. The patient did not receive any adjuvant treatment. After ten months, she presented a pelvic peritoneal recurrence associated with symptoms of hyperandrogenism including hirsutism, deepening of the voice as well amenorrhea. Optimal oncologic cytoreduction surgery was performed. Histopathological exam confirmed Sertoli- Leydig tumor. Immunohistochemical revealed positive for inhibin alpha, FOXL2 and calretinin. The patient received six cycles of carboplatin and paclitaxel chemotherapy regimen. After treatment, the symptoms of hyperandrogenism disappeared. In the moment, the patient has been in a follow-up without any evidence of disease. Conclusions There is not consensus about the best treatment options. Surgery is still the standard treatment of primary and resectable cases. After recurrence, chemotherapy with platinum and taxares agents are useful in clinical practice.
