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Androblastoma

The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform

Maciej Wysocki – 1st expert on this subject based on the ideXlab platform

  • ectopic acth syndrome due to bilateral ovarian Androblastoma with double gynandroblastic differentiation in one ovary
    European Journal of Obstetrics & Gynecology and Reproductive Biology, 1993
    Co-Authors: A Kasperlikzaluska, Ludwika Sikorowa, Elzbieta Ploch, Piotr Soszynski, W Jeske, B Migdalska, Maciej Wysocki

    Abstract:

    Abstract A case of fulminant Cushing’s syndrome due to an ectopic ACTH secretion in a patient with bilateral ovarian sex-cord stromal tumour is reported. Surgical resection of the ovaries as well as the inhibitors of steroid synthesis and cytostatics caused only transient improvement because the widespread neoplastic dissemination progressed very quickly.

Yu‑lan Mu – 2nd expert on this subject based on the ideXlab platform

  • Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report.
    Oncology Letters, 2015
    Co-Authors: Hui Zhang, Chun‑yan Li, Tao Li, Yu‑lan Mu

    Abstract:

    Sertoli-Leydig cell tumor of the ovary, also known as Androblastoma, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary. The tumor accounts for

Klaus Steger – 3rd expert on this subject based on the ideXlab platform

  • Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor
    Fertility and Sterility, 1999
    Co-Authors: Thomas Klonisch, Sabine Hombach-klonisch, J. Buchmann, Bernd Fischer, Martin Bergmann, Klaus Steger

    Abstract:

    Relaxin-like factor (RLF), a new member of the insulin-like growth factor family, is a reliable marker for normal Leydig cells in the human postpubertal testis (1). Expression of the RLF gene appears to be developmentally regulated, given that only during puberty is RLF expression up-regulated. We recently demonstrated down-regulation of the human RLF gene in testicular Leydig cell tumors indicating dedifferentiation of the Leydig cells within the tumor (2). Ovarian Sertoli-Leydig cell tumors (SLCTs), histologically typed as Androblastomas, are rare, potentially malignant sex-cord stromal tumors exhibiting testicular-like structure and differentiation of various degrees. In the present study, we investigated the expression of RLF, 17a-hydroxylase, 3b-hydroxysteroid dehydrogenase (3b-HSD), Ki-67, and cytokeratin 18 in a human ovarian SLCT of low differentiation.