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Shaojiang Song – One of the best experts on this subject based on the ideXlab platform.

  • Timosaponin AIII: A novel potential anti-tumor compound from Anemarrhena asphodeloides.
    Steroids, 2018
    Co-Authors: Feng-ying Han, Xiao-yu Song, Jing-jie Chen, Guo-dong Yao, Shaojiang Song
    Abstract:

    Timosaponin AIII, a major steroidal saponin found in Anemarrhena asphodeloides Bge., which has been widely used as anti-pyretic, anti-diabetic, anti-inflammatory, anti-platelet aggregator and anti-depressant agents in traditional Chinese medicine. Recent pharmacological study showed that timosaponin AIII had potent cytotoxicity, which was potential to be developed as an anticancer agent, however the molecular mechanism underlying the anticancer activity has not been fully elucidated. This review aims to give a systematic summary of the study of timosaponin AIII to reveal its anti-tumor activities by investigating invasion and migration, apoptosis, autophagy and reversing multi-drug resistance. Furthermore, we also make an overview of the mechanisms identified till now. These meaningful findings may provide novel insights on exploiting timosaponin AIII as a new anti-tumor agent.

  • two new components from the rhizome of Anemarrhena asphodeloides bge and their antiplatelet aggregative activity
    Phytochemistry Letters, 2014
    Co-Authors: Yu Sun, Ying Peng, Chunting Liu, Qingbo Liu, Shaojiang Song
    Abstract:

    Two new components, Anemarrhena A (1) and Anemarrhena B (2), together with five known ones (3–7), were isolated from the rhizome of Anemarrhena asphodeloides Bge. Their structures were established by detailed spectral studies, including 1D-NMR (1H NMR, 13C NMR and DEPT), 2D-NMR (HSQC, HMBC and NOESY), HR-ESI-MS and by the comparison with literature data. The absolute configuration of 2 was further determined by CD analysis. The isolated compounds were evaluated for their antiplatelet aggregative activity. Compounds 1, 2, 3, 5, 6 and 7 exhibited moderate activity of antiplatelet aggregation in vitro, compound 4 showed potential antiplatelet aggregation activity.

  • Steroidal saponins from Anemarrhena asphodeloides.
    Journal of Asian natural products research, 2013
    Co-Authors: Qingbo Liu, Ying Peng, Yu Sun, Pin-yi Gao, Shaojiang Song
    Abstract:

    Two new steroidal saponins, named anemarnoside A and anemarnoside B, along with three known compounds, timosaponin J, timosaponin B II, and timosaponin B, have been isolated from Anemarrhena asphodeloides. Their structures were established by spectroscopic techniques (IR, MS, 1D NMR, and 2D NMR) and by comparison with published data.

Hai-xue Kuang – One of the best experts on this subject based on the ideXlab platform.

  • The water-eluting component of Anemarrhena asphodeloides Bge. laxative effects on loperamide-induced constipation rats
    , 2020
    Co-Authors: Yan Liu, Yong-gang Xia, Bing-you Yang, Yanping Sun, Hai-xue Kuang
    Abstract:

    Abstract Background Slow transit functional constipation (STC) is the most common type of chronic constipation,with seriously affecting people’s survival and quality of life in the recent years. Based on the safety and small side effects of traditional Chinese medicine, it is urgent to research and develop new medicine for the treatment of constipation. As a traditional Chinese medicine, Anemarrhena asphodeloides Bge. has been reported treat constipation in a long time, and carbohydrate is its active ingredient. Methods ELISA used for detection of serum gastrointestinal hormones and neurotransmitters levels. HE stain was analyzed to evaluate the colon injury. Western blot and RT-PCR detected interstitial cells of Cajal markers (SCF/c-Kit) and aquaporins (AQPs). Results The mainly compositions of oligosaccharide and amino acid from AABW was determined by HPLC. Based on the laxative activities of AABW in the study, AABW obviously enhanced the contents of VIP, Gas, MTL, SP and 5-HT and decreased the levels of NO from loperamide-induced rats by Elisa kits. Additionally, AABW could up-regulate the expressions of SCF, c-Kit, AQP3, VIP and down-regulate AQP8 to repair the damage of colon. Conclusion These findings suggested that AABW, which could treat constipation through mediating intestinal motility and water metabolism, were laxative active constituents from Anemarrhena asphodeloides Bge..

  • Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats.
    Journal of ethnopharmacology, 2019
    Co-Authors: Yan Liu, Wei Guan, Yong-gang Xia, Yuan-yuan Zhou, Bing-you Yang, Hai-xue Kuang
    Abstract:

    Abstract Ethnopharmacological relevance As a traditional Chinese herbal medicine, Anemarrhena asphodeloides Bge. possesses the effects of nourishing yin, moistening dryness, clearing lungs and relieving fire. Simultaneously, it has been used to treat constipation for more than one thousand years in China. However, modern medical studies are limited and lacking on its therapeutic mechanism. Aim of the study: This current study was aimed to investigate the laxative activities and explore the potential mechanism of Anemarrhena asphodeloides Bge. polysaccharides (AABP) in loperamide-induced constipation rats. Materials and methods The structure of AABP was determined by using infrared spectrum, high performance gel permpermeationochromatography (HPGPC), and high performance liquid chrochromatography (HPLC). Real-time quantitative polymerase chain reaction (PCR), multitudinous methods were adopted to explore the underlining therapeutic mechanism of AABP in treating constipation, including enzyme-linked immunosorbent assay (ELISA), histopathological, immunohistochemistry and western blotting. Results In the present study, the average molemolecular weight of AABP was determined as 1.11 × 103 kDa. The primary monosaccharide compositions were analyzed including D-mannose, L-rhamnose, D-galacturonic acid, D-glucose, D-galagalactose and L-arabinose (1, 0.04, 0.53, 0.11, 0.33, 0.25, respectively) by high-performance liquid chrochromatography (HPLC). AABP significantly increased the levels of gastrin (Gas), motilin (MTL), substance P (SP), 5-hydroxytryptamine (5-HT) and vasoactive intestinal peptpeptide (VIP), and decreased the NO content of loperamide-induced rats to ameliorate constipation in the rats. Whilst, AABP repaired the damaged colons by regulating PCNA and ICAM-1 protein expressions. Additionally, AABP up-regulated the levels of SCF, c-Kit, AQP3 and VIP as well as down-regulated the expressions of AQP8, AQP4 and PGE2. Conclusion The present findings suggested that AABP were the laxative active ingredients isolated from Anemarrhena asphodeloides Bge., which could treat constipation through regulating the gastrointestinal hormones and neurotransmitters to improve the intestinal motility and water metabolism.

  • Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides.
    Molecules (Basel Switzerland), 2017
    Co-Authors: Bing-you Yang, Yan Liu, Xin Yin, Hai-xue Kuang
    Abstract:

    Four new compounds, aneglycoside A–C (1–3) and timosaponin U (4), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were determined through extensive spectroscopic analysis, chemical characteristics, and high-resolution mass spectrometry (HRMS). All the isolations were evaluated for cytotoxicity against HepG2, Hela, and SGC7901 human cancer lines. Compounds 1, 2, and 4 showed weak antiproliferative activities on HepG2, Hela, and SGC7901 cells.

Xue-feng Huang – One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxic steroidal saponins from the rhizome of Anemarrhena asphodeloides.
    Steroids, 2019
    Co-Authors: Yunfang Zhao, Jing Zhou, Min-jie Zhang, Min Zhang, Xue-feng Huang
    Abstract:

    Two novel steroidal saponins, timosaponin V and W (1 and 2), together with seven known steroidal saponins (3-9), were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, 1H-1H COSY, and NOESY), and MS analyses. The cytotoxic activities of the isolates were evaluated. Compound 1 showed a significant cytotoxic activity against MCF-7 and HepG2 cell lines with IC50 values of 2.16 ± 0.19 μM and 2.01 ± 0.19 μM, respectively.

  • New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III
    , 2018
    Co-Authors: Yunfang Zhao, Yu-wei Zhang, Yinru Wang, Tingting Shang, Susan L. Morris-natschke, Wei Liu, Hong Yin, Kuo-hsiung Lee, Xue-feng Huang
    Abstract:

    Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge. To potentially discover derivatives with better biological activity, timosaponin B III was structurally modified via acid hydrolysis to yield one new (2, timopregnane A I) C21 steroidal glycoside and seven known compounds. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry. All eight compounds were evaluated for cytotoxic activity against MCF7, SW480, HepG2, and SGC7901 cell lines in vitro. As a result, compounds 6 and 7 showed significant activity (IC50 2.94–12.2 μM) against all tested cell lines. Structure–activity relationships of these compounds were investigated and the preliminary conclusions were provided. Moreover, a new transformation pathway was discovered in the acid hydrolysis of timosaponin B III for the first time.

  • steroidal saponins with cytotoxic activities from the rhizomes of Anemarrhena asphodeloids bge
    Phytochemistry Letters, 2017
    Co-Authors: Yu-wei Zhang, Yunfang Zhao, Yinru Wang, Tingting Shang, Leimin Yang, Xue-feng Huang
    Abstract:

    Abstract Two new steroidal saponins, named timosaponin R (1) and S (2), together with seven known compounds (3-9) were isolated from the rhizomes of Anemarrhena asphodeloides Bge. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry. All the compounds were evaluated for cytotoxic activities against the four human cancer cell lines MCF7, SW480, HepG2 and SGC7901 in vitro. Compounds 7-9 showed moderate activities against all the cell lines.

Jun Chang – One of the best experts on this subject based on the ideXlab platform.

  • anti respiratory syncytial virus rsv activity of timosaponin a iii from the rhizomes of Anemarrhena asphodeloides
    Journal of Medicinal Plants Research, 2011
    Co-Authors: U J Youn, Jang J E, Nam J W, Y J Lee, Y M Son, H J Shin, Han A R, Jun Chang, Seo E K
    Abstract:

    Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.   Key words: LiliaceaeAnemarrhena asphodeloides, timosaponin A-III, respiratory syncytial virus (RSV).

  • Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV).
    Chemistry & biodiversity, 2007
    Co-Authors: Green Bae, Jun Chang, Jun Lee, Eun-kyoung Seo
    Abstract:

    Three known phenolic compounds, (-)-(R)-nyasol (= 4,4′-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3)–isolated from the rhizomes of Anemarrhena asphodeloides–were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 = 1.15 microM). In addition, the known, but inactive, compound ‘trans-N-(para-coumaroyl)tyramine’ (= (2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; 4) was isolated from this plant for the first time.

Seo E K – One of the best experts on this subject based on the ideXlab platform.

  • anti respiratory syncytial virus rsv activity of timosaponin a iii from the rhizomes of Anemarrhena asphodeloides
    Journal of Medicinal Plants Research, 2011
    Co-Authors: U J Youn, Jang J E, Nam J W, Y J Lee, Y M Son, H J Shin, Han A R, Jun Chang, Seo E K
    Abstract:

    Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.   Key words: Liliaceae, Anemarrhena asphodeloides, timosaponin A-III, respiratory syncytial virus (RSV).