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Shaojiang Song – One of the best experts on this subject based on the ideXlab platform.

  • Timosaponin AIII: A novel potential anti-tumor compound from Anemarrhena asphodeloides.
    Steroids, 2018
    Co-Authors: Feng-ying Han, Xiao-yu Song, Jing-jie Chen, Guo-dong Yao, Shaojiang Song
    Abstract:

    Timosaponin AIII, a major steroidal saponin found in Anemarrhena asphodeloides Bge., which has been widely used as anti-pyretic, anti-diabetic, anti-inflammatory, anti-platelet aggregator and anti-depressant agents in traditional Chinese medicine. Recent pharmacological study showed that timosaponin AIII had potent cytotoxicity, which was potential to be developed as an anticancer agent, however the molecular mechanism underlying the anticancer activity has not been fully elucidated. This review aims to give a systematic summary of the study of timosaponin AIII to reveal its anti-tumor activities by investigating invasion and migration, apoptosis, autophagy and reversing multi-drug resistance. Furthermore, we also make an overview of the mechanisms identified till now. These meaningful findings may provide novel insights on exploiting timosaponin AIII as a new anti-tumor agent.

  • two new components from the rhizome of Anemarrhena asphodeloides bge and their antiplatelet aggregative activity
    Phytochemistry Letters, 2014
    Co-Authors: Yu Sun, Ying Peng, Chunting Liu, Qingbo Liu, Shaojiang Song
    Abstract:

    Two new components, Anemarrhena A (1) and Anemarrhena B (2), together with five known ones (3–7), were isolated from the rhizome of Anemarrhena asphodeloides Bge. Their structures were established by detailed spectral studies, including 1D-NMR (1H NMR, 13C NMR and DEPT), 2D-NMR (HSQC, HMBC and NOESY), HR-ESI-MS and by the comparison with literature data. The absolute configuration of 2 was further determined by CD analysis. The isolated compounds were evaluated for their antiplatelet aggregative activity. Compounds 1, 2, 3, 5, 6 and 7 exhibited moderate activity of antiplatelet aggregation in vitro, compound 4 showed potential antiplatelet aggregation activity.

  • Steroidal saponins from Anemarrhena asphodeloides.
    Journal of Asian natural products research, 2013
    Co-Authors: Qingbo Liu, Ying Peng, Yu Sun, Pin-yi Gao, Shaojiang Song
    Abstract:

    Two new steroidal saponins, named anemarnoside A and anemarnoside B, along with three known compounds, timosaponin J, timosaponin B II, and timosaponin B, have been isolated from Anemarrhena asphodeloides. Their structures were established by spectroscopic techniques (IR, MS, 1D NMR, and 2D NMR) and by comparison with published data.

Hai-xue Kuang – One of the best experts on this subject based on the ideXlab platform.

Xue-feng Huang – One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxic steroidal saponins from the rhizome of Anemarrhena asphodeloides.
    Steroids, 2019
    Co-Authors: Yunfang Zhao, Jing Zhou, Min-jie Zhang, Min Zhang, Xue-feng Huang
    Abstract:

    Two novel steroidal saponins, timosaponin V and W (1 and 2), together with seven known steroidal saponins (3-9), were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, 1H-1H COSY, and NOESY), and MS analyses. The cytotoxic activities of the isolates were evaluated. Compound 1 showed a significant cytotoxic activity against MCF-7 and HepG2 cell lines with IC50 values of 2.16 ± 0.19 μM and 2.01 ± 0.19 μM, respectively.

  • New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III
    , 2018
    Co-Authors: Yunfang Zhao, Yu-wei Zhang, Yinru Wang, Tingting Shang, Susan L. Morris-natschke, Wei Liu, Hong Yin, Kuo-hsiung Lee, Xue-feng Huang
    Abstract:

    Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge. To potentially discover derivatives with better biological activity, timosaponin B III was structurally modified via acid hydrolysis to yield one new (2, timopregnane A I) C21 steroidal glycoside and seven known compounds. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry. All eight compounds were evaluated for cytotoxic activity against MCF7, SW480, HepG2, and SGC7901 cell lines in vitro. As a result, compounds 6 and 7 showed significant activity (IC50 2.94–12.2 μM) against all tested cell lines. Structure–activity relationships of these compounds were investigated and the preliminary conclusions were provided. Moreover, a new transformation pathway was discovered in the acid hydrolysis of timosaponin B III for the first time.

  • steroidal saponins with cytotoxic activities from the rhizomes of Anemarrhena asphodeloids bge
    Phytochemistry Letters, 2017
    Co-Authors: Yu-wei Zhang, Yunfang Zhao, Yinru Wang, Tingting Shang, Leimin Yang, Xue-feng Huang
    Abstract:

    Abstract Two new steroidal saponins, named timosaponin R (1) and S (2), together with seven known compounds (3-9) were isolated from the rhizomes of Anemarrhena asphodeloides Bge. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry. All the compounds were evaluated for cytotoxic activities against the four human cancer cell lines MCF7, SW480, HepG2 and SGC7901 in vitro. Compounds 7-9 showed moderate activities against all the cell lines.

Jun Chang – One of the best experts on this subject based on the ideXlab platform.

Seo E K – One of the best experts on this subject based on the ideXlab platform.

  • anti respiratory syncytial virus rsv activity of timosaponin a iii from the rhizomes of Anemarrhena asphodeloides
    Journal of Medicinal Plants Research, 2011
    Co-Authors: U J Youn, Jang J E, Nam J W, Y J Lee, Y M Son, H J Shin, Han A R, Jun Chang, Seo E K
    Abstract:

    Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.   Key words: Liliaceae, Anemarrhena asphodeloides, timosaponin A-III, respiratory syncytial virus (RSV).