The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform

Taizan Suchi - One of the best experts on this subject based on the ideXlab platform.

  • inconsistent association of epstein barr virus with cd56 ncam positive Angiocentric Lymphoma occuring in sites other than the upper and lower respiratory tract
    Histopathology, 1996
    Co-Authors: Yoichiro Kobashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Yuko Sasajima, Yasushi Yatabe, Shigeo Mori, Ryuzo Ueda, Hirohiko Yamabe, Taizan Suchi
    Abstract:

    Abstract We previously described nine cases of Angiocentric Lymphoma of a possible natural killer (NK)-cell lineage with a surface CD3-CD56+ phenotype occurring in sites other than the upper and lower respiratory tract. This study was performed to investigate the association of Epstein-Barr virus (EBV) with these Lymphomas, using the polymerase chain reaction (PCR) for the presence of EBV-DNA, in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs) and immunohistology for EBV-determined nuclear antigen-2 (EBNA-2) and latent membrane protein-1 (LMP-1) in paraffin sections. PCR and ISH produced almost identical results, and EBERs were identified in the nuclei of the Lymphoma cells of three cases, two of which exhibited LMP-1 in the cytoplasm of tumour cells without EBNA-2 expression. Molecular genetic analysis revealed EBV to be incorporated into these three EBER-positive cases either clonally or biclonally. It was revealed by re-evaluation of their morphology with the established EBV status on each case that, in contrast to the rather variable and irregular cellular composition of the EBV-positive tumours, the EBV-negative tumours stood out because of their remarkably uniform 'blastoid' appearance, and could be grouped as blastic NK-cell Lymphoma. The relationship of the EBV-positive cases with nasal NK-cell tumours has yet to be clarified.

  • clinicopathologic study of cd56 ncam positive Angiocentric Lymphoma occurring in sites other than the upper and lower respiratory tract
    The American Journal of Surgical Pathology, 1995
    Co-Authors: Shigeo Nakamura, Taizan Suchi, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Shinsuke Iida, Yoshitoyo Kagami, Michinori Ogura, Eriko Katoh
    Abstract:

    The expression of the neural cell adhesion molecule (NCAM) (CD56, NKH-1) is a rare phenomenon in malignant Lymphoma. Recently, several authors, including our group, described the clinicopathologic, phenotypic, and genotypic features of NCAM-positive tumors as a unique subgroup within a larger category of hematolymphoid malignancies. Ten cases of CD56+ Angiocentric Lymphoma occurring in sites other than the upper aerodigestive tract were studied for evaluating their characteristics. The disease occurred in six men and four women varying from 24 to 85 years (mean age, 53 years) who often exhibited a striking predilection for extranodal sites of involvement, such as the skin, gastrointestinal tract, and muscle, usually in the absence of peripheral lymphadenopathy. Although the cytologic appearances and immunophenotypic profile varied from case to case, these tumors often exhibited azurophilic granules, an Angiocentric growth pattern, and surface CD3-, T-cell receptor (TCR) antigens-, and CD56+ phenotype without B-cell phenotype, except for a single case of CD3+, TCR alpha/beta+, and CD56+ phenotype. Genotype investigation exhibited germline configuration of the TCR beta and gamma chain genes and the immunoglobulin heavy chain gene in all five cases of surface CD3- phenotype examined, whereas the case of CD3+ phenotype showed rearrangement of TCR beta. They seem to constitute a distinct entity of the lineage spectrum spanning from natural killer (NK) cell to NK-like T cell.

Shigeo Nakamura - One of the best experts on this subject based on the ideXlab platform.

  • inconsistent association of epstein barr virus with cd56 ncam positive Angiocentric Lymphoma occuring in sites other than the upper and lower respiratory tract
    Histopathology, 1996
    Co-Authors: Yoichiro Kobashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Yuko Sasajima, Yasushi Yatabe, Shigeo Mori, Ryuzo Ueda, Hirohiko Yamabe, Taizan Suchi
    Abstract:

    Abstract We previously described nine cases of Angiocentric Lymphoma of a possible natural killer (NK)-cell lineage with a surface CD3-CD56+ phenotype occurring in sites other than the upper and lower respiratory tract. This study was performed to investigate the association of Epstein-Barr virus (EBV) with these Lymphomas, using the polymerase chain reaction (PCR) for the presence of EBV-DNA, in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs) and immunohistology for EBV-determined nuclear antigen-2 (EBNA-2) and latent membrane protein-1 (LMP-1) in paraffin sections. PCR and ISH produced almost identical results, and EBERs were identified in the nuclei of the Lymphoma cells of three cases, two of which exhibited LMP-1 in the cytoplasm of tumour cells without EBNA-2 expression. Molecular genetic analysis revealed EBV to be incorporated into these three EBER-positive cases either clonally or biclonally. It was revealed by re-evaluation of their morphology with the established EBV status on each case that, in contrast to the rather variable and irregular cellular composition of the EBV-positive tumours, the EBV-negative tumours stood out because of their remarkably uniform 'blastoid' appearance, and could be grouped as blastic NK-cell Lymphoma. The relationship of the EBV-positive cases with nasal NK-cell tumours has yet to be clarified.

  • clinicopathologic study of cd56 ncam positive Angiocentric Lymphoma occurring in sites other than the upper and lower respiratory tract
    The American Journal of Surgical Pathology, 1995
    Co-Authors: Shigeo Nakamura, Taizan Suchi, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Shinsuke Iida, Yoshitoyo Kagami, Michinori Ogura, Eriko Katoh
    Abstract:

    The expression of the neural cell adhesion molecule (NCAM) (CD56, NKH-1) is a rare phenomenon in malignant Lymphoma. Recently, several authors, including our group, described the clinicopathologic, phenotypic, and genotypic features of NCAM-positive tumors as a unique subgroup within a larger category of hematolymphoid malignancies. Ten cases of CD56+ Angiocentric Lymphoma occurring in sites other than the upper aerodigestive tract were studied for evaluating their characteristics. The disease occurred in six men and four women varying from 24 to 85 years (mean age, 53 years) who often exhibited a striking predilection for extranodal sites of involvement, such as the skin, gastrointestinal tract, and muscle, usually in the absence of peripheral lymphadenopathy. Although the cytologic appearances and immunophenotypic profile varied from case to case, these tumors often exhibited azurophilic granules, an Angiocentric growth pattern, and surface CD3-, T-cell receptor (TCR) antigens-, and CD56+ phenotype without B-cell phenotype, except for a single case of CD3+, TCR alpha/beta+, and CD56+ phenotype. Genotype investigation exhibited germline configuration of the TCR beta and gamma chain genes and the immunoglobulin heavy chain gene in all five cases of surface CD3- phenotype examined, whereas the case of CD3+ phenotype showed rearrangement of TCR beta. They seem to constitute a distinct entity of the lineage spectrum spanning from natural killer (NK) cell to NK-like T cell.

Takashi Koshikawa - One of the best experts on this subject based on the ideXlab platform.

  • inconsistent association of epstein barr virus with cd56 ncam positive Angiocentric Lymphoma occuring in sites other than the upper and lower respiratory tract
    Histopathology, 1996
    Co-Authors: Yoichiro Kobashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Yuko Sasajima, Yasushi Yatabe, Shigeo Mori, Ryuzo Ueda, Hirohiko Yamabe, Taizan Suchi
    Abstract:

    Abstract We previously described nine cases of Angiocentric Lymphoma of a possible natural killer (NK)-cell lineage with a surface CD3-CD56+ phenotype occurring in sites other than the upper and lower respiratory tract. This study was performed to investigate the association of Epstein-Barr virus (EBV) with these Lymphomas, using the polymerase chain reaction (PCR) for the presence of EBV-DNA, in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs) and immunohistology for EBV-determined nuclear antigen-2 (EBNA-2) and latent membrane protein-1 (LMP-1) in paraffin sections. PCR and ISH produced almost identical results, and EBERs were identified in the nuclei of the Lymphoma cells of three cases, two of which exhibited LMP-1 in the cytoplasm of tumour cells without EBNA-2 expression. Molecular genetic analysis revealed EBV to be incorporated into these three EBER-positive cases either clonally or biclonally. It was revealed by re-evaluation of their morphology with the established EBV status on each case that, in contrast to the rather variable and irregular cellular composition of the EBV-positive tumours, the EBV-negative tumours stood out because of their remarkably uniform 'blastoid' appearance, and could be grouped as blastic NK-cell Lymphoma. The relationship of the EBV-positive cases with nasal NK-cell tumours has yet to be clarified.

  • clinicopathologic study of cd56 ncam positive Angiocentric Lymphoma occurring in sites other than the upper and lower respiratory tract
    The American Journal of Surgical Pathology, 1995
    Co-Authors: Shigeo Nakamura, Taizan Suchi, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Shinsuke Iida, Yoshitoyo Kagami, Michinori Ogura, Eriko Katoh
    Abstract:

    The expression of the neural cell adhesion molecule (NCAM) (CD56, NKH-1) is a rare phenomenon in malignant Lymphoma. Recently, several authors, including our group, described the clinicopathologic, phenotypic, and genotypic features of NCAM-positive tumors as a unique subgroup within a larger category of hematolymphoid malignancies. Ten cases of CD56+ Angiocentric Lymphoma occurring in sites other than the upper aerodigestive tract were studied for evaluating their characteristics. The disease occurred in six men and four women varying from 24 to 85 years (mean age, 53 years) who often exhibited a striking predilection for extranodal sites of involvement, such as the skin, gastrointestinal tract, and muscle, usually in the absence of peripheral lymphadenopathy. Although the cytologic appearances and immunophenotypic profile varied from case to case, these tumors often exhibited azurophilic granules, an Angiocentric growth pattern, and surface CD3-, T-cell receptor (TCR) antigens-, and CD56+ phenotype without B-cell phenotype, except for a single case of CD3+, TCR alpha/beta+, and CD56+ phenotype. Genotype investigation exhibited germline configuration of the TCR beta and gamma chain genes and the immunoglobulin heavy chain gene in all five cases of surface CD3- phenotype examined, whereas the case of CD3+ phenotype showed rearrangement of TCR beta. They seem to constitute a distinct entity of the lineage spectrum spanning from natural killer (NK) cell to NK-like T cell.

Kuniyoshi Kitoh - One of the best experts on this subject based on the ideXlab platform.

  • inconsistent association of epstein barr virus with cd56 ncam positive Angiocentric Lymphoma occuring in sites other than the upper and lower respiratory tract
    Histopathology, 1996
    Co-Authors: Yoichiro Kobashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Yuko Sasajima, Yasushi Yatabe, Shigeo Mori, Ryuzo Ueda, Hirohiko Yamabe, Taizan Suchi
    Abstract:

    Abstract We previously described nine cases of Angiocentric Lymphoma of a possible natural killer (NK)-cell lineage with a surface CD3-CD56+ phenotype occurring in sites other than the upper and lower respiratory tract. This study was performed to investigate the association of Epstein-Barr virus (EBV) with these Lymphomas, using the polymerase chain reaction (PCR) for the presence of EBV-DNA, in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs) and immunohistology for EBV-determined nuclear antigen-2 (EBNA-2) and latent membrane protein-1 (LMP-1) in paraffin sections. PCR and ISH produced almost identical results, and EBERs were identified in the nuclei of the Lymphoma cells of three cases, two of which exhibited LMP-1 in the cytoplasm of tumour cells without EBNA-2 expression. Molecular genetic analysis revealed EBV to be incorporated into these three EBER-positive cases either clonally or biclonally. It was revealed by re-evaluation of their morphology with the established EBV status on each case that, in contrast to the rather variable and irregular cellular composition of the EBV-positive tumours, the EBV-negative tumours stood out because of their remarkably uniform 'blastoid' appearance, and could be grouped as blastic NK-cell Lymphoma. The relationship of the EBV-positive cases with nasal NK-cell tumours has yet to be clarified.

  • clinicopathologic study of cd56 ncam positive Angiocentric Lymphoma occurring in sites other than the upper and lower respiratory tract
    The American Journal of Surgical Pathology, 1995
    Co-Authors: Shigeo Nakamura, Taizan Suchi, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Shinsuke Iida, Yoshitoyo Kagami, Michinori Ogura, Eriko Katoh
    Abstract:

    The expression of the neural cell adhesion molecule (NCAM) (CD56, NKH-1) is a rare phenomenon in malignant Lymphoma. Recently, several authors, including our group, described the clinicopathologic, phenotypic, and genotypic features of NCAM-positive tumors as a unique subgroup within a larger category of hematolymphoid malignancies. Ten cases of CD56+ Angiocentric Lymphoma occurring in sites other than the upper aerodigestive tract were studied for evaluating their characteristics. The disease occurred in six men and four women varying from 24 to 85 years (mean age, 53 years) who often exhibited a striking predilection for extranodal sites of involvement, such as the skin, gastrointestinal tract, and muscle, usually in the absence of peripheral lymphadenopathy. Although the cytologic appearances and immunophenotypic profile varied from case to case, these tumors often exhibited azurophilic granules, an Angiocentric growth pattern, and surface CD3-, T-cell receptor (TCR) antigens-, and CD56+ phenotype without B-cell phenotype, except for a single case of CD3+, TCR alpha/beta+, and CD56+ phenotype. Genotype investigation exhibited germline configuration of the TCR beta and gamma chain genes and the immunoglobulin heavy chain gene in all five cases of surface CD3- phenotype examined, whereas the case of CD3+ phenotype showed rearrangement of TCR beta. They seem to constitute a distinct entity of the lineage spectrum spanning from natural killer (NK) cell to NK-like T cell.

Eriko Katoh - One of the best experts on this subject based on the ideXlab platform.

  • clinicopathologic study of cd56 ncam positive Angiocentric Lymphoma occurring in sites other than the upper and lower respiratory tract
    The American Journal of Surgical Pathology, 1995
    Co-Authors: Shigeo Nakamura, Taizan Suchi, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Shinsuke Iida, Yoshitoyo Kagami, Michinori Ogura, Eriko Katoh
    Abstract:

    The expression of the neural cell adhesion molecule (NCAM) (CD56, NKH-1) is a rare phenomenon in malignant Lymphoma. Recently, several authors, including our group, described the clinicopathologic, phenotypic, and genotypic features of NCAM-positive tumors as a unique subgroup within a larger category of hematolymphoid malignancies. Ten cases of CD56+ Angiocentric Lymphoma occurring in sites other than the upper aerodigestive tract were studied for evaluating their characteristics. The disease occurred in six men and four women varying from 24 to 85 years (mean age, 53 years) who often exhibited a striking predilection for extranodal sites of involvement, such as the skin, gastrointestinal tract, and muscle, usually in the absence of peripheral lymphadenopathy. Although the cytologic appearances and immunophenotypic profile varied from case to case, these tumors often exhibited azurophilic granules, an Angiocentric growth pattern, and surface CD3-, T-cell receptor (TCR) antigens-, and CD56+ phenotype without B-cell phenotype, except for a single case of CD3+, TCR alpha/beta+, and CD56+ phenotype. Genotype investigation exhibited germline configuration of the TCR beta and gamma chain genes and the immunoglobulin heavy chain gene in all five cases of surface CD3- phenotype examined, whereas the case of CD3+ phenotype showed rearrangement of TCR beta. They seem to constitute a distinct entity of the lineage spectrum spanning from natural killer (NK) cell to NK-like T cell.