Animal Age - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Animal Age

The Experts below are selected from a list of 138954 Experts worldwide ranked by ideXlab platform

Animal Age – Free Register to Access Experts & Abstracts

Paolo Zatta – One of the best experts on this subject based on the ideXlab platform.

  • Effect of aluminum consumption on the vestibulo-ocular reflex
    Metabolic Brain Disease, 2006
    Co-Authors: Ombretta Mameli, M. A. Caria, Paolo Melis, Pamela Zambenedetti, M. Ramila, Paolo Zatta

    Abstract:

    The effects of chronic exposure (90 days) to Aluminum chloride (AlCl_3) were analyzed in 3, 10 and 24 month old male rats ( n =270) by investigating the function of the VOR (vestibulo-ocular reflex) in correlation with Aluminum (Al) concentrations in blood and brain. The VOR was chosen and tested in basal conditions (pre-exposure measures) and during the continuous administration of three different concentrations of AlCl_3 (0.5, 1, 2 g/l in drinking solution): the control Animals being exposed to NaCl (0.125, 0.25 and 5 g/l in drinking solution). Results showed that LOAEL (Lowest Observed Adverse Effect Level) was 43.1±11.4 mg Al/kg-day. At this concentration the Al induced significant VOR impairment in all exposed rats, regardless of Animal Age. Neuroanatomical analysis showed that VOR impairment was not dependent on astrocyte damAge nor evidences of amyloid deposits in the exposed rats was found. Significant changes of Al concentrations were observed in nervous tissue, while its concentration in whole blood was unaffected. Furthermore, results show that it is possible to identify an individual neurotoxic threshold for each Animal and therefore hypothesize the clinical use of the VOR test for the evaluation of individual risk toxicity to chronic Al exposure.

  • Effect of aluminum consumption on the vestibulo-ocular reflex
    Metabolic Brain Disease, 2006
    Co-Authors: Ombretta Mameli, M. A. Caria, Paolo Melis, Pamela Zambenedetti, M. Ramila, Paolo Zatta

    Abstract:

    The effects of chronic exposure (90 days) to Aluminum chloride (AlCl_3) were analyzed in 3, 10 and 24 month old male rats ( n =270) by investigating the function of the VOR (vestibulo-ocular reflex) in correlation with Aluminum (Al) concentrations in blood and brain. The VOR was chosen and tested in basal conditions (pre-exposure measures) and during the continuous administration of three different concentrations of AlCl_3 (0.5, 1, 2 g/l in drinking solution): the control Animals being exposed to NaCl (0.125, 0.25 and 5 g/l in drinking solution). Results showed that LOAEL (Lowest Observed Adverse Effect Level) was 43.1±11.4 mg Al/kg-day. At this concentration the Al induced significant VOR impairment in all exposed rats, regardless of Animal Age. Neuroanatomical analysis showed that VOR impairment was not dependent on astrocyte damAge nor evidences of amyloid deposits in the exposed rats was found. Significant changes of Al concentrations were observed in nervous tissue, while its concentration in whole blood was unaffected. Furthermore, results show that it is possible to identify an individual neurotoxic threshold for each Animal and therefore hypothesize the clinical use of the VOR test for the evaluation of individual risk toxicity to chronic Al exposure.

Stephen F Badylak – One of the best experts on this subject based on the ideXlab platform.

  • the effect of source Animal Age upon the in vivo remodeling characteristics of an extracellular matrix scaffold
    Biomaterials, 2012
    Co-Authors: Brian M Sicari, Scott A Johnson, Bernard F Siu, Peter M Crapo, Kerry A Daly, Hongbin Jiang, Christopher J Medberry, Stephen Tottey, Neill J Turner, Stephen F Badylak

    Abstract:

    Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the Age of the Animal from which the ECM is derived. The present study compared the in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in Age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source Animal Age. Scaffolds derived from younger Animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older Animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophAge response.

  • the effect of source Animal Age upon extracellular matrix scaffold properties
    Biomaterials, 2011
    Co-Authors: Stephen Tottey, Scott A Johnson, Peter M Crapo, Hongbin Jiang, Christopher J Medberry, Janet E Reing, Li Zhang, Brandon P Reines, Stephen F Badylak

    Abstract:

    Biologic scaffold materials composed of mammalian extracellular matrix (ECM) are commonly used for the repair and reconstruction of injured tissues. An important, but unexplored variable of biologic scaffolds is the Age of the Animal from which the ECM is prepared. The objective of the present study was to compare the structural, mechanical, and compositional properties of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in Age. Degradation product bioactivity of these ECM materials was also examined. Results showed that there are distinct differences in each of these variables among the various Age source ECM scaffolds. The strength and growth factors content of ECM from 3-week-old Animals is less than that of ECM harvested from 12, 26 or >52-week-old Animals. The elastic modulus of SIS-ECM for 3 week and >52-week-old source was less than that of the 12 and 26 week source. Degradation products from all Age source ECMs were chemotactic for perivascular stem cells, with the 12 week source the most potent, while the oldest source caused the greatest increase in proliferation. In summary, distinct differences exist in the mechanical, structural, and biologic properties of SIS-ECM harvested from different Aged Animals.

Ombretta Mameli – One of the best experts on this subject based on the ideXlab platform.

  • Effect of aluminum consumption on the vestibulo-ocular reflex
    Metabolic Brain Disease, 2006
    Co-Authors: Ombretta Mameli, M. A. Caria, Paolo Melis, Pamela Zambenedetti, M. Ramila, Paolo Zatta

    Abstract:

    The effects of chronic exposure (90 days) to Aluminum chloride (AlCl_3) were analyzed in 3, 10 and 24 month old male rats ( n =270) by investigating the function of the VOR (vestibulo-ocular reflex) in correlation with Aluminum (Al) concentrations in blood and brain. The VOR was chosen and tested in basal conditions (pre-exposure measures) and during the continuous administration of three different concentrations of AlCl_3 (0.5, 1, 2 g/l in drinking solution): the control Animals being exposed to NaCl (0.125, 0.25 and 5 g/l in drinking solution). Results showed that LOAEL (Lowest Observed Adverse Effect Level) was 43.1±11.4 mg Al/kg-day. At this concentration the Al induced significant VOR impairment in all exposed rats, regardless of Animal Age. Neuroanatomical analysis showed that VOR impairment was not dependent on astrocyte damAge nor evidences of amyloid deposits in the exposed rats was found. Significant changes of Al concentrations were observed in nervous tissue, while its concentration in whole blood was unaffected. Furthermore, results show that it is possible to identify an individual neurotoxic threshold for each Animal and therefore hypothesize the clinical use of the VOR test for the evaluation of individual risk toxicity to chronic Al exposure.

  • Effect of aluminum consumption on the vestibulo-ocular reflex
    Metabolic Brain Disease, 2006
    Co-Authors: Ombretta Mameli, M. A. Caria, Paolo Melis, Pamela Zambenedetti, M. Ramila, Paolo Zatta

    Abstract:

    The effects of chronic exposure (90 days) to Aluminum chloride (AlCl_3) were analyzed in 3, 10 and 24 month old male rats ( n =270) by investigating the function of the VOR (vestibulo-ocular reflex) in correlation with Aluminum (Al) concentrations in blood and brain. The VOR was chosen and tested in basal conditions (pre-exposure measures) and during the continuous administration of three different concentrations of AlCl_3 (0.5, 1, 2 g/l in drinking solution): the control Animals being exposed to NaCl (0.125, 0.25 and 5 g/l in drinking solution). Results showed that LOAEL (Lowest Observed Adverse Effect Level) was 43.1±11.4 mg Al/kg-day. At this concentration the Al induced significant VOR impairment in all exposed rats, regardless of Animal Age. Neuroanatomical analysis showed that VOR impairment was not dependent on astrocyte damAge nor evidences of amyloid deposits in the exposed rats was found. Significant changes of Al concentrations were observed in nervous tissue, while its concentration in whole blood was unaffected. Furthermore, results show that it is possible to identify an individual neurotoxic threshold for each Animal and therefore hypothesize the clinical use of the VOR test for the evaluation of individual risk toxicity to chronic Al exposure.