Animal Development - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Animal Development

The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform

Ronald H A Plasterk – 1st expert on this subject based on the ideXlab platform

  • the diverse functions of micrornas in Animal Development and disease
    Developmental Cell, 2006
    Co-Authors: Wigard P Kloosterman, Ronald H A Plasterk

    Abstract:

    MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in Animal Development and disease.

  • micro rnas in Animal Development
    Cell, 2006
    Co-Authors: Ronald H A Plasterk

    Abstract:

    Micro RNAs (miRNAs) are ∼22 nucleotide single-stranded noncoding RNA molecules that bind to target messenger RNAs (mRNAs) and silence their expression. This Essay explores the importance of miRNAs in Animal Development and their possible roles in disease and evolution.

  • microrna function in Animal Development
    FEBS Letters, 2005
    Co-Authors: Erno Wienholds, Ronald H A Plasterk

    Abstract:

    MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease.

Eric A Miska – 2nd expert on this subject based on the ideXlab platform

  • microrna functions in Animal Development and human disease
    Development, 2005
    Co-Authors: Ines Alvarezgarcia, Eric A Miska

    Abstract:

    Five years into the `small RNA revolution’ it is hard not to share in the excitement about the rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin-4 , in the nematode Caenorhabditis elegans , many more of these short regulatory RNA genes have been identified in flowering plants, worms, flies, fish, frogs and mammals. Currently, about 2% of the known human genes encode microRNAs. MicroRNAs are essential for Development and this review will summarise our current knowledge of Animal microRNA function. We will also discuss the emerging links of microRNA biology to stem cell research and human disease, in particular cancer.

Erno Wienholds – 3rd expert on this subject based on the ideXlab platform

  • microrna function in Animal Development
    FEBS Letters, 2005
    Co-Authors: Erno Wienholds, Ronald H A Plasterk

    Abstract:

    MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease.

  • MicroRNA function in Animal Development
    FEBS Letters, 2005
    Co-Authors: Erno Wienholds, Ronald H A Plasterk

    Abstract:

    MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.