The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Ronald H A Plasterk - One of the best experts on this subject based on the ideXlab platform.
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the diverse functions of micrornas in Animal Development and disease
Developmental Cell, 2006Co-Authors: Wigard P Kloosterman, Ronald H A PlasterkAbstract:MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in Animal Development and disease.
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micro rnas in Animal Development
Cell, 2006Co-Authors: Ronald H A PlasterkAbstract:Micro RNAs (miRNAs) are ∼22 nucleotide single-stranded noncoding RNA molecules that bind to target messenger RNAs (mRNAs) and silence their expression. This Essay explores the importance of miRNAs in Animal Development and their possible roles in disease and evolution.
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microrna function in Animal Development
FEBS Letters, 2005Co-Authors: Erno Wienholds, Ronald H A PlasterkAbstract:MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease.
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MicroRNA function in Animal Development
FEBS Letters, 2005Co-Authors: Erno Wienholds, Ronald H A PlasterkAbstract:MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Eric A Miska - One of the best experts on this subject based on the ideXlab platform.
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microrna functions in Animal Development and human disease
Development, 2005Co-Authors: Ines Alvarezgarcia, Eric A MiskaAbstract:Five years into the `small RNA revolution' it is hard not to share in the excitement about the rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin-4 , in the nematode Caenorhabditis elegans , many more of these short regulatory RNA genes have been identified in flowering plants, worms, flies, fish, frogs and mammals. Currently, about 2% of the known human genes encode microRNAs. MicroRNAs are essential for Development and this review will summarise our current knowledge of Animal microRNA function. We will also discuss the emerging links of microRNA biology to stem cell research and human disease, in particular cancer.
Erno Wienholds - One of the best experts on this subject based on the ideXlab platform.
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microrna function in Animal Development
FEBS Letters, 2005Co-Authors: Erno Wienholds, Ronald H A PlasterkAbstract:MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease.
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MicroRNA function in Animal Development
FEBS Letters, 2005Co-Authors: Erno Wienholds, Ronald H A PlasterkAbstract:MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in Animals. Particularly, we focus on the roles of miRNAs in vertebrate Development and disease. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Yukiko M. Yamashita - One of the best experts on this subject based on the ideXlab platform.
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Centrosome asymmetry and inheritance during Animal Development
Current Opinion in Cell Biology, 2012Co-Authors: Laurence Pelletier, Yukiko M. YamashitaAbstract:The centrosome is a subcellular organelle that is responsible for the majority of microtubule organization. Through this ability, the centrosome is involved in cell division, migration, and polarization. Recent studies have revealed intriguing asymmetries between mother and daughter centrioles as well as between mother and daughter centrosomes, and the involvement of such asymmetries in multiple cellular and Developmental processes. This review aims to summarize recent discoveries on such asymmetries in centrioles/centrosomes and the potential implication of their inheritance patterns during cell division and Development.
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Centrosome asymmetry and inheritance during Animal Development
Current Opinion in Cell Biology, 2012Co-Authors: Laurence Pelletier, Yukiko M. YamashitaAbstract:The centrosome is a subcellular organelle that is responsible for the majority of microtubule organization. Through this ability, the centrosome is involved in cell division, migration, and polarization. Recent studies have revealed intriguing asymmetries between mother and daughter centrioles as well as between mother and daughter centrosomes, and the involvement of such asymmetries in multiple cellular and Developmental processes. This review aims to summarize recent discoveries on such asymmetries in centrioles/centrosomes and the potential implication of their inheritance patterns during cell division and Development. © 2012 Elsevier Ltd.
Ines Alvarezgarcia - One of the best experts on this subject based on the ideXlab platform.
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microrna functions in Animal Development and human disease
Development, 2005Co-Authors: Ines Alvarezgarcia, Eric A MiskaAbstract:Five years into the `small RNA revolution' it is hard not to share in the excitement about the rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin-4 , in the nematode Caenorhabditis elegans , many more of these short regulatory RNA genes have been identified in flowering plants, worms, flies, fish, frogs and mammals. Currently, about 2% of the known human genes encode microRNAs. MicroRNAs are essential for Development and this review will summarise our current knowledge of Animal microRNA function. We will also discuss the emerging links of microRNA biology to stem cell research and human disease, in particular cancer.
