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Annona Cherimola

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Rana Khalife – One of the best experts on this subject based on the ideXlab platform.

  • The pro-apoptotic effect of a Terpene-rich Annona Cherimola leaf extract on leukemic cell lines.
    BMC complementary and alternative medicine, 2019
    Co-Authors: Carl Ammoury, Tony Haykal, Peter Nasr, Mohammad Hassan Hodroj, Robin I. Taleb, Rita Sarkis, Maria Younes, Marianne El Khoury, Marilyne Sily, Rana Khalife

    Abstract:

    The edible fruit Annona Cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona Cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1). The anti-proliferative effect of A. Cherimola ethanolic leaf extract was evaluated via cell viability assay. Its pro-apoptotic effect was assessed through Cell Death ELISA and dual Annexin V/PI staining. To further investigate the molecular mechanism by which the extract promoted apoptosis and inhibited the proliferation of the AML cells used, apoptotic protein expression was determined through western blots. Extract composition was elucidated by Gas Chromatography-Mass Spectrometry (GC-MS). Our results showed that the treatment with A. Cherimola ethanolic leaf extract exhibited an inhibitory effect on the proliferation of both cancer cell lines used in a dose- and time-dependent manner, with no toxic effects on normal mononuclear cells (MNCs) isolated from human bone marrow. This effect was mediated by DNA fragmentation and apoptosis, as revealed by Cell Death ELISA and dual Annexin V/PI staining. Western blot analysis revealed a Bax/Bcl2 dependent mechanism of apoptosis, as well as PARP cleavage, confirming the apoptotic results observed previously. These effects may be attributed to the presence of terpenes which constitute a large component of the leafy extract, as revealed via GC-MS. All the data presented in our study show that the terpene-rich A. Cherimola ethanolic leaf extract exhibits an anti-proliferative and pro-apoptotic effect on the AML cell lines used.

Fang Rong Chang – One of the best experts on this subject based on the ideXlab platform.

  • Four alkaloids from Annona Cherimola.
    Phytochemistry, 2001
    Co-Authors: Chung-yi Chen, Fang Rong Chang, Wen Bin Pan

    Abstract:

    Four alkaloids, annocherine A, annocherine B, cherianoine, and romucosine H, along with one known alkaloid, artabonatine B, were isolated from the MeOH extract of the stems of Annona Cherimola. Their structures were identified on the basis of both analysis of their spectral data and from chemical evidence.

  • Aromin-A, an Annonaceous acetogenin from Annona Cherimola.
    Phytochemistry, 1999
    Co-Authors: Chung-yi Chen, Fang Rong Chang, Hui Fen Chiu

    Abstract:

    Chromatographic fractionation of a MeOH extract from the stems of Annona Cherimola led to the isolation of a new non-adjacent, bis-THF ring acetogenin (one THF ring being at C-4 and the other at C-16), aromin-A (1) along with the known cytotoxic acetogenin squamocin (2). The structures of these isolates were established by means of mass spectrometry and spectroscopic techniques.

  • Amides from stems of Annona Cherimola
    Phytochemistry, 1998
    Co-Authors: Chung-yi Chen, Fang Rong Chang, Hsin Fu Yen

    Abstract:

    Abstract Four new amides, N – cis -caffeoyltyramine, dihydro-feruloyltyramine, N – trans -feruloylmethoxytyramine and N – cis -feruloylmethoxytyramine, along with two known amides, N – p -coumaroyltyramine and N – cis -feruloyltyramine, were isolated from the fresh stem parts of Annona Cherimola . Their structures were characterized and identified by spectral analysis.

Chung-yi Chen – One of the best experts on this subject based on the ideXlab platform.

  • annocherine c a new c α hydroxy benzylisoquinoline and other constituents from the leaves of Annona Cherimola
    Journal of The Chinese Chemical Society, 2001
    Co-Authors: Chung-yi Chen

    Abstract:

    A new C-α hydroxy benzylisoquinoline, annocherine C (1), along with nine teen compounds including six alkaloids, liriodenine (2), oxoxylopine (3), oxonantenine (4), (-)-asimilobine (5), (-)-xylopine (6) and (-)-anolobine (7); four steroids, β-sitosterol, stigmasterol, β-sitosteryl-D-glucoside and stigmasteryl-D-glucoside and nine benzenoids, methylparabene, vanillin, trans-methyl p-coumarate, cis -methyl p-coumarate, p-hydroxybenzadehyde, p-hydroxybenzoic acid, 4-methoxybenzoic acid methylester, methyl vanillate and p-dihydrocoumaric acid, were isolated from the leaves of Annona Cherimola. These compounds were identified by spectral analysis.

  • Annocherine C, A New C‐α Hydroxy Benzylisoquinoline and Other Constituents from the Leaves of Annona Cherimola
    Journal of the Chinese Chemical Society, 2001
    Co-Authors: Chung-yi Chen

    Abstract:

    A new C-α hydroxy benzylisoquinoline, annocherine C (1), along with nine teen compounds including six alkaloids, liriodenine (2), oxoxylopine (3), oxonantenine (4), (-)-asimilobine (5), (-)-xylopine (6) and (-)-anolobine (7); four steroids, β-sitosterol, stigmasterol, β-sitosteryl-D-glucoside and stigmasteryl-D-glucoside and nine benzenoids, methylparabene, vanillin, trans-methyl p-coumarate, cis -methyl p-coumarate, p-hydroxybenzadehyde, p-hydroxybenzoic acid, 4-methoxybenzoic acid methylester, methyl vanillate and p-dihydrocoumaric acid, were isolated from the leaves of Annona Cherimola. These compounds were identified by spectral analysis.

  • Four alkaloids from Annona Cherimola.
    Phytochemistry, 2001
    Co-Authors: Chung-yi Chen, Fang Rong Chang, Wen Bin Pan

    Abstract:

    Four alkaloids, annocherine A, annocherine B, cherianoine, and romucosine H, along with one known alkaloid, artabonatine B, were isolated from the MeOH extract of the stems of Annona Cherimola. Their structures were identified on the basis of both analysis of their spectral data and from chemical evidence.