Anti Influenza - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Anti Influenza

The Experts below are selected from a list of 17742 Experts worldwide ranked by ideXlab platform

Anti Influenza – Free Register to Access Experts & Abstracts

Shin-ichiro Nishimura – One of the best experts on this subject based on the ideXlab platform.

  • Novel trivalent AntiInfluenza reagent
    Bioorganic & Medicinal Chemistry Letters, 2010
    Co-Authors: Fei Feng, Nobuaki Miura, Norikazu Isoda, Yoshihiro Sakoda, Masatoshi Okamatsu, Hiroshi Kida, Shin-ichiro Nishimura

    Abstract:

    Abstract We designed and synthesized novel trivalent AntiInfluenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyses were carried out with a model which was constructed with a computer simulation. A previously reported cyclic glycopeptide blocker [Ohta, T.; Miura, N.; Fujitani, N.; Nakajima, F.; Niikura, K.; Sadamoto, R.; Guo, C.-T.; Suzuki, T.; Suzuki, Y.; Monde, K.; Nishimura, S.-I. Angew. Chem. Int. Ed. , 2003 , 42 , 5186] bound to the HA in the model. The analyses suggest that the glutamine residue in the cyclic peptide bearing Neu5Acα2,3Galβ1,4Glc trisaccharide via a linker interacts with the Gln189 in HA through hydrogen bonding. The present AntiInfluenza reagents likely interact with a glutamine residue included in the vicinity of Gln189. A plague reduction assay of the Influenza virus, A/PR/8/1934 (H1N1), was performed in MDCK cells to evaluate for the synthesized compounds to inhibit viral replication. One of the compounds showed approximately 85% inhibition at the concentration of 400 μM at 4 °C.

  • Novel trivalent AntiInfluenza reagent
    Bioorganic & Medicinal Chemistry Letters, 2010
    Co-Authors: Fei Feng, Nobuaki Miura, Norikazu Isoda, Yoshihiro Sakoda, Masatoshi Okamatsu, Hiroshi Kida, Shin-ichiro Nishimura

    Abstract:

    Abstract We designed and synthesized novel trivalent AntiInfluenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyses were carried out with a model which was constructed with a computer simulation. A previously reported cyclic glycopeptide blocker [Ohta, T.; Miura, N.; Fujitani, N.; Nakajima, F.; Niikura, K.; Sadamoto, R.; Guo, C.-T.; Suzuki, T.; Suzuki, Y.; Monde, K.; Nishimura, S.-I. Angew. Chem. Int. Ed. , 2003 , 42 , 5186] bound to the HA in the model. The analyses suggest that the glutamine residue in the cyclic peptide bearing Neu5Acα2,3Galβ1,4Glc trisaccharide via a linker interacts with the Gln189 in HA through hydrogen bonding. The present AntiInfluenza reagents likely interact with a glutamine residue included in the vicinity of Gln189. A plague reduction assay of the Influenza virus, A/PR/8/1934 (H1N1), was performed in MDCK cells to evaluate for the synthesized compounds to inhibit viral replication. One of the compounds showed approximately 85% inhibition at the concentration of 400 μM at 4 °C.

Fei Feng – One of the best experts on this subject based on the ideXlab platform.

  • Novel trivalent AntiInfluenza reagent
    Bioorganic & Medicinal Chemistry Letters, 2010
    Co-Authors: Fei Feng, Nobuaki Miura, Norikazu Isoda, Yoshihiro Sakoda, Masatoshi Okamatsu, Hiroshi Kida, Shin-ichiro Nishimura

    Abstract:

    Abstract We designed and synthesized novel trivalent AntiInfluenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyses were carried out with a model which was constructed with a computer simulation. A previously reported cyclic glycopeptide blocker [Ohta, T.; Miura, N.; Fujitani, N.; Nakajima, F.; Niikura, K.; Sadamoto, R.; Guo, C.-T.; Suzuki, T.; Suzuki, Y.; Monde, K.; Nishimura, S.-I. Angew. Chem. Int. Ed. , 2003 , 42 , 5186] bound to the HA in the model. The analyses suggest that the glutamine residue in the cyclic peptide bearing Neu5Acα2,3Galβ1,4Glc trisaccharide via a linker interacts with the Gln189 in HA through hydrogen bonding. The present AntiInfluenza reagents likely interact with a glutamine residue included in the vicinity of Gln189. A plague reduction assay of the Influenza virus, A/PR/8/1934 (H1N1), was performed in MDCK cells to evaluate for the synthesized compounds to inhibit viral replication. One of the compounds showed approximately 85% inhibition at the concentration of 400 μM at 4 °C.

  • Novel trivalent AntiInfluenza reagent
    Bioorganic & Medicinal Chemistry Letters, 2010
    Co-Authors: Fei Feng, Nobuaki Miura, Norikazu Isoda, Yoshihiro Sakoda, Masatoshi Okamatsu, Hiroshi Kida, Shin-ichiro Nishimura

    Abstract:

    Abstract We designed and synthesized novel trivalent AntiInfluenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyses were carried out with a model which was constructed with a computer simulation. A previously reported cyclic glycopeptide blocker [Ohta, T.; Miura, N.; Fujitani, N.; Nakajima, F.; Niikura, K.; Sadamoto, R.; Guo, C.-T.; Suzuki, T.; Suzuki, Y.; Monde, K.; Nishimura, S.-I. Angew. Chem. Int. Ed. , 2003 , 42 , 5186] bound to the HA in the model. The analyses suggest that the glutamine residue in the cyclic peptide bearing Neu5Acα2,3Galβ1,4Glc trisaccharide via a linker interacts with the Gln189 in HA through hydrogen bonding. The present AntiInfluenza reagents likely interact with a glutamine residue included in the vicinity of Gln189. A plague reduction assay of the Influenza virus, A/PR/8/1934 (H1N1), was performed in MDCK cells to evaluate for the synthesized compounds to inhibit viral replication. One of the compounds showed approximately 85% inhibition at the concentration of 400 μM at 4 °C.

Xiaorong Wang – One of the best experts on this subject based on the ideXlab platform.

  • AntiInfluenza agents from plants and traditional Chinese medicine.
    Phytotherapy research : PTR, 2006
    Co-Authors: Xiaoyan Wang, Wei Jia, Aihua Zhao, Xiaorong Wang

    Abstract:

    Influenza is a serious threat to health in all parts of the world. The control and treatment of Influenza depends mainly on chemical or biochemical agents and, to date, some AntiInfluenza agents have been isolated from plants as a result of chemical and pharmacological studies. These agents include a variety of polyphenols, flavonoids, saponins, glucosides and alkaloids. Traditional medicine focuses on the use of herbs and traditional Chinese medicine has performed well in clinical practice and shows a potential in the therapy of Influenza and its symptoms. The present paper reviews some constituents and extracts from plants and traditional Chinese medicine with AntiInfluenza activity.