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Michael Wink - One of the best experts on this subject based on the ideXlab platform.

  • piquia shells caryocar villosum a fruit by product with antioxidant and Antiaging properties in caenorhabditis elegans
    Oxidative Medicine and Cellular Longevity, 2020
    Co-Authors: Mariana Roxo, Herbenya Peixoto, Pille Wetterauer, Emerson Silva Lima, Michael Wink
    Abstract:

    In a context of rising demand for sustainable Antiaging interventions, fruit processing by-products are a promising source of bioactive compounds for the production of Antiaging dietary supplements. Piquia (Caryocar villosum) is a native Amazonian fruit consisting of 65% nonedible shells. In the present study, the phytochemical profile of a hydroalcoholic extract of piquia shells (CV) was characterized by LC-MS/MS analysis. Its antioxidant and Antiaging activities were investigated using the nematode Caenorhabditis elegans as an in vivo model. CV is mainly composed by hydrolysable tannins and triterpenoid saponins. The extract enhanced stress resistance of wild-type and mutant worms by reducing the intracellular levels of reactive oxygen species (ROS) and by increasing their survival against a lethal dose of the prooxidant juglone. These effects involved the upregulation of sod-3 and downregulation of gst-4 and hsp-16.2, studied through the GFP fluorescent reporter intensity and at the transcriptional level by qRT-PCR analysis. CV extended the lifespan of wild-type worms in a DAF-16/FoxO- and SKN-1/Nrf-dependent manner. Taken together, our findings indicate piquia shells as potential candidates for nutraceutical applications. Further studies are needed to validate the relevance of our findings to Antiaging interventions in humans.

  • lifespan extending and oxidative stress resistance properties of a leaf extracts from anacardium occidentale l in caenorhabditis elegans
    Oxidative Medicine and Cellular Longevity, 2019
    Co-Authors: Chatrawee Duangjan, Panthakarn Rangsinth, Michael Wink, Tewin Tencomnao
    Abstract:

    Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity. The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C. elegans) model. AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4. Moreover, AO extracts exhibited Antiaging activities and enhanced longevity. We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms. Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and Antiaging properties in the C. elegans model and may lead to new agents to benefit humans in the near future.

  • natural lignans from arctium lappa as Antiaging agents in caenorhabditis elegans
    Phytochemistry, 2015
    Co-Authors: Michael Wink
    Abstract:

    Abstract Arctium lappa is a well-known traditional medicinal plant in China (TCM) and Europe that has been used for thousands of years to treat arthritis, baldness or cancer. The plant produces lignans as secondary metabolites, which have a wide range of bioactivities. Yet, their Antiaging potential has not been explored. In this study, we isolated six lignans from A. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol A, lappaol C, and lappaol F. The antioxidant and Antiaging properties of the isolated lignans were studied using Caenorhabditis elegans as a relevant animal model. All lignans at concentrations of 10 and 100 μM significantly extended the mean life span of C. elegans . The strongest effect was observed with matairesinol, which at a concentration of 100 μM extended the life span of worms by 25%. Additionally, we observed that five lignans are strong free radical-scavengers in vitro and in vivo and all lignans can improve survival of C. elegans under oxidative stress. Furthermore, the lignans can induce the nuclear translocation of the transcription factor DAF-16 and up-regulate its expression, suggesting that a possible underlying mechanism of the observed longevity-promoting activity of lignans depends on DAF-16 mediated signaling pathway. All lignans up-regulated the expression of jnk-1 , indicating that lignans may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Our study reports new Antiaging activities of lignans, which might be candidates for developing Antiaging agents.

Fang Chen - One of the best experts on this subject based on the ideXlab platform.

  • Research Article In Vivo Antioxidant and Anti-Skin-Aging Activities of Ethyl Acetate Extraction from Idesia polycarpa Defatted Fruit Residue in Aging Mice Induced by D-Galactose
    2016
    Co-Authors: Ran-ran Jia, Lin Tang, Fang Chen
    Abstract:

    permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and Antiaging activities of ethyl acetate extraction (EAE) from Idesia polycarpa defatted fruit residue for the first time.The oxygen radical absorbance capacity (ORAC) of EAEwas 13.09 ± 0.1

  • in vivo antioxidant and anti skin aging activities of ethyl acetate extraction from idesia polycarpa defatted fruit residue in aging mice induced by d galactose
    Evidence-based Complementary and Alternative Medicine, 2014
    Co-Authors: Ran-ran Jia, Lin Tang, Fang Chen
    Abstract:

    Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and Antiaging activities of ethyl acetate extraction (EAE) from Idesia polycarpa defatted fruit residue for the first time. The oxygen radical absorbance capacity (ORAC) of EAE was 13.09 ± 0.11 μmol Trolox equivalents (TE)/mg, which showed EAE had great in vitro free radical scavenging and antioxidant activity. Biochemical indexes and morphological analysis of all tested tissues showed that EAE could effectively improve the total antioxidant capacity (T-AOC) of the antioxidant defense system of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of tissues and serum, increase glutathione (GSH) content and decrease the malondialdehyde (MDA) content, and maintain the skin collagen, elastin, and moisture content. Meanwhile, EAE could effectively attenuate the morphological damage in brain, liver, kidney, and skin induced by D-gal and its effect was not less than that of the well-known L-ascorbic acid (VC) and α-tocopherol (VE). Overall, EAE is a potent natural Antiaging agent with great antioxidant activity, which can be developed as a new medicine and cosmetic for the treatment of age-related conditions.

Kyung Chan Park - One of the best experts on this subject based on the ideXlab platform.

  • molecular mechanisms of dermal aging and Antiaging approaches
    International Journal of Molecular Sciences, 2019
    Co-Authors: Jung Won Shin, Soon Hyo Kwon, Ji Young Choi, Chang Hun Huh, Hye Ryung Choi, Kyung Chan Park
    Abstract:

    The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging process, the dermis undergoes significant changes. Collagen, which is a major component of ECM, becomes fragmented and coarsely distributed, and its total amount decreases. This is mainly due to increased activity of matrix metalloproteinases, and impaired transforming growth factor-β signaling induced by reactive oxygen species generated during aging. The reduction in the amount of collagen hinders the mechanical interaction between fibroblasts and the ECM, and consequently leads to the deterioration of fibroblast function and further decrease in the amount of dermal collagen. Other ECM components, including elastic fibers, glycosaminglycans (GAGs), and proteoglycans (PGs), also change during aging, ultimately leading to a reduction in the amount of functional components. Elastic fibers decrease in intrinsically aged skin, but accumulate abnormally in photoaged skin. The changes in the levels of GAGs and PGs are highly diverse, and previous studies have reported conflicting results. A reduction in the levels of functional dermal components results in the emergence of clinical aging features, such as wrinkles and reduced elasticity. Various Antiaging approaches, including topicals, energy-based procedures, and dermal fillers, can restore the molecular features of dermal aging with clinical efficacy. This review summarizes the current understanding of skin aging at the molecular level, and associated treatments, to put some of the new Antiaging technology that has emerged in this rapidly expanding field into molecular context.

Edward J. Masoro - One of the best experts on this subject based on the ideXlab platform.

  • caloric restriction and aging an update
    Experimental Gerontology, 2000
    Co-Authors: Edward J. Masoro
    Abstract:

    Restricting food intake to 50 to 70% of that eaten by ad lib-fed rats and mice markedly increases longevity, retards age-associated physiological deterioration, and delays and, in some cases, prevents age-associated diseases. These actions are due to the reduced intake of calories, and thus the phenomenon has been called the Antiaging action of caloric restriction (CR). This article focuses on the possible biological mechanisms underlying the Antiaging action. The following three proposed mechanisms are considered in depth: 1) attenuation of oxidative damage; 2) modulation of glycemia and insulinemia; 3) hormesis. The evolution of the Antiaging action of CR is also considered. Based on this consideration, a scenario unifying the above mechanisms is presented.

  • Hormesis and the Antiaging Action of Dietary Restriction
    Experimental Gerontology, 1998
    Co-Authors: Edward J. Masoro
    Abstract:

    Hormesis refers to the often encountered phenomenon of a beneficial biological action from a factor or agent that is generally viewed as detrimental. Beneficial actions that have been observed include life span extension. It is proposed that life span extension in rodents by dietary restriction is an example of hormesis and that sustained moderate hyperadrenocorticism underlies this life prolongation. Evidence supporting this concept is presented. The possibility is also suggested that whenever hormesis leads to an extension of mammalian life span, it is likely that moderate hyperadrenocorticism plays a major role.

Yuichi Uchino - One of the best experts on this subject based on the ideXlab platform.

  • the Antiaging approach for the treatment of dry eye
    Cornea, 2012
    Co-Authors: Kazuo Tsubota, Motoko Kawashima, Takaaki Inaba, Murat Dogru, Yukihiro Matsumoto, Reiko Ishida, Minako Kaido, Takashi Kojima, Miki Uchino, Yuichi Uchino
    Abstract:

    Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision, causing a dramatic deterioration in the quality of life. Although new treatments such as the P2Y2 agonist or cyclosporine eye drops have been developed and a certain level of patient satisfaction can now be obtained, no fundamental treatment has been developed. Currently, there is no therapy available to recover lacrimal function to its normal status. Recent progress in the understanding of aging has laid the foundations for a new way of thinking about intervention of the aging process. Because dry eye is accelerated by aging, a useful approach for the prevention or treatment of dry eye may be to interfere with the aging process. In the scientific community, there is a global consensus that calorie restriction can extend the life span of various kinds of animals, establishing an intervention to aging. Another important hypothesis believed to be involved in aging is the free radical theory. According to these theories, the aging process may be managed by controlling levels of calories or reactive oxygen species. In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye.