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Kyoko Ishiguro - One of the best experts on this subject based on the ideXlab platform.

  • Antianaphylactic and antipruritic effects of the flowers of impatiens textori miq
    Biological & Pharmaceutical Bulletin, 2005
    Co-Authors: Yoshimi Ueda, Hisae Oku, Munekazu Iinuma, Kyoko Ishiguro
    Abstract:

    The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1-3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.

  • Antianaphylactic and antipruritic effects of the flowers of impatiens textori m iq
    Biological & Pharmaceutical Bulletin, 2005
    Co-Authors: Yoshimi Ueda, Munekazu Iinuma, Kyoko Ishiguro
    Abstract:

    The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1—3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.

  • a practical and speedy screening method for murine anaphylaxis on the Antianaphylactic effect of impatiens balsamina l
    Phytotherapy Research, 1997
    Co-Authors: Kyoko Ishiguro, Hisae Fukumoto
    Abstract:

    An effective screening method for antianaphylaxis was established using blood pressure (BP) monitoring in unanesthetized mice with an immediate hypersensitivity reaction system induced by hen egg-white lysozyme (HEL). This method allows speedy and reproducible screening of Antianaphylactic substances. Using this system, the Antianaphylactic effect was estimated for the 35% ethanol extract (IB) of petals of Impatiens balsamina L. and the compounds isolated from Impatiens balsamina L.

  • Antianaphylactic effects of the principal compounds from the white petals of impatiens balsamina l
    Phytotherapy Research, 1996
    Co-Authors: Hisae Fukumoto, Koichiro Isoi, Masae Yamaki, Kyoko Ishiguro
    Abstract:

    Several flavonols and naphthoquinones have been isolated from a 35% ethanol extract (IB) of the white petals of Impatiens balsamina L. The Antianaphylactic effects of the principal compounds were investigated using a murine immediately hypersensitivity reaction system induced by hen egg-white lysozyme (HEL). The active extracts and phenolic compounds in IB were shown to inhibit significantly both the fatal anaphylactic shock and heterologous PCA reaction.

  • Antianaphylactic effects of the ethanolic extract from the petals of impatiens balsamina l in mice
    Phytotherapy Research, 1992
    Co-Authors: Kyoko Ishiguro, Hisae Fukumoto, Tokiko Murashima, Masayuki Kuriyama, Masanori Semma, Koichiro Isoi
    Abstract:

    The Antianaphylactic activity of 35% EtOH extract (IB) from the white petals of Impatiens balsamina L. was investigated using murine immediate hypersensitivity reaction system induced by hen egg-white lysozyme (HEL). IB has a significant Antianaphylactic activity.

Hisae Fukumoto - One of the best experts on this subject based on the ideXlab platform.

Hyungmin Kim - One of the best experts on this subject based on the ideXlab platform.

  • paeonol inhibits anaphylactic reaction by regulating histamine and tnf α
    International Immunopharmacology, 2004
    Co-Authors: Sung Hoon Kim, Seungae Kim, Mikyung Park, Seunghyung Kim, Youngdoo Park, Hyungmin Kim, Minkyu Shin, Kyooseok Ahn
    Abstract:

    Paeonol, a major phenolic component of Moutan Cortex, was known to have antiaggregatory, antioxidant and antiinflammatory activities. In the present study, we tried to elucidate the effects of paeonol on anaphylactic reaction and its mode of action. Paeonol significantly inhibited histamine release from the rat peritoneal mast cells (RPMCs) treated with compound 48/80, a mast cell degranulator. The release of tumor necrosis factor (TNF)-alpha mast cell activating cytokine was significantly suppressed in RBL-2H3 mast cells pretreated with anti-dinitrophenyl (DNP) immunoglobulin E (IgE) in a dose-dependent manner. Paeonol significantly inhibited IgE production in B cells activated by anti-CD40 mAb, recombinant interleukin-4 (rIL-4) and recombinant histamine releasing factor (rHRF). Paeonol effectively downregulated the expression of IL-4 in the activated B cells by reverse transcription-polymerase chain reaction (RT-PCR). We also confirmed that paeonol effectively inhibited anaphylactic shock in mice by 90% at a dose of 0.5 mg/mouse versus PBS treated control 2 h after the i.p. injection of compound 48/80. These results suggest that paeonol has antianaphylatic activity by regulating histamine and TNF-alpha.

  • action of rubus coreanus extract on systemic and local anaphylaxis
    Phytotherapy Research, 2002
    Co-Authors: Taeyong Shin, Sanghyun Kim, Eunsoon Lee, Dongok Eom, Hyungmin Kim
    Abstract:

    The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01-1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose-dependent manner. RCAE (0.001-1 mg/mL) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE (0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-alpha production from RPMC. These results indicate that RCAE may possess Antianaphylactic action.

  • the evaluation of the Antianaphylactic effect of oryza sativa l subsp hsien ting in rats
    Pharmacological Research, 1999
    Co-Authors: Hyungmin Kim, Eunhee Lee, Changsoon Kang, Taeyong Shin
    Abstract:

    Abstract We studied the effect of the methanol extract of Oryza sativa L. subsp. hsien Ting (OSHT) on anaphylaxis. OSHT (0.001–1.0 mg g −1 body weight (BW)) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in rats. When OSHT was pretreated at concentrations ranging from 0.001 to 1.0 mg g −1 BW, the serum histamine levels were reduced in a dose-dependent manner. OSHT (0.001–1.0 mg g −1 BW) also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, OSHT dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when OSHT was added, significantly increased approx. 20-fold compared with that of basal cells. These results indicate that OSHT possesses strong Antianaphylactic activity by inhibition of histamine release from mast cells in vivo and in vitro .

  • the evaluation of Antianaphylactic effect of oryza sativa l in rats
    The American Journal of Chinese Medicine, 1999
    Co-Authors: Hyungmin Kim, Hye Young Shin
    Abstract:

    This study was carried out to examine the effect of methanol extract of Oryza sativa L. (Dong-Jin in Korean, abbreviate as Os-DJ hereafter) on anaphylaxis. Os-DJ (10-5 to 1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in rats. When Os-DJ was pretreated at concentration ranging from 10-5 to 1 g/kg, the serum histamine levels were reduced in a dose-dependent manner. Os-DJ (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, Os-DJ dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. These results indicate that Os-DJ possess anti anaphylactic activity by inhibition of histamine release from mast cells in vivo and in vitro.

  • Antianaphylactic properties of eugenol
    Pharmacological Research, 1997
    Co-Authors: Hyungmin Kim, Eunhee Lee, Changyoung Kim, Jonggab Chung, Sanghyun Kim L, Jongpil Lim L, Taeyong Shin L
    Abstract:

    Abstract The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 μg g −1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml −1 ) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has Antianaphylactic properties by preventing mast cell degranulation

S Leistner - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of 4 methyl 6 phenyl thieno 2 3 d pyrimidines with a formamidino or oxalamidocarbonic acid residue with Antianaphylactic activity
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, S Leistner
    Abstract:

    3-Amino-4-methyl-6-phenyl-thieno[2,3-d]pyrimidine-2-carbonic acid alkylesters 1a, b were hydrolyzed to the potassium salt of the carbonic acid 2. Cyclization of 2 with acetanhydride yielded the tricyclic 1,3-oxazinone derivative 4. This compound reacted with pyrrolidine by different conditions of reaction to give the bisamide 7, the acetamidino carbonic acid 5 and their decarboxylated product 6. Compound 1a yielded with Vilsmeier reagents the formamidino compound 3. 3-Amino-thieno[2,3-d]pyrimidin-2-carbonitrile gave under different conditions of reaction with oxalic acid diethylester or with oxalic acid ethylester chloride the tetracyclic 4-methoxy-9-methyl-7-phenyl-thieno[2,3-d:4,5-d']dipyrimidine-2-car bonic acid methylester 10 or the N-(2-cyano-4-methyl-6-phenyl-thieno[2,3-d]pyrimid-3-yl)oxalamid ic ethylester 12. These compounds were hydrolyzed to give the carbonic acids 11 and 13. Some of the synthesized substances showed an Antianaphylactic activity.

  • synthesis of 11 aryl 7 8 9 10 tetrahydro 1 2 3 triazino 4 5 4 5 thienol 2 3 b quinolines with Antianaphylactic action
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, S Leistner
    Abstract:

    Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an Antianaphylactic activity.

  • synthesis of n 2 carboxy thieno 2 3 b pyridin 3 yl formamidines corresponding alkyl esters with Antianaphylactic activity
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, J Prantz, S Leistner
    Abstract:

    A lot of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)formamidines especially in form of their amine salts--were synthesized by reaction of 3-amino-thieno[2,3-b]pyridine-2-carboxylic acids with dimethylformamide/phosphoroxide chloride or by reaction of 4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3- oxazines with amines. Carboxylic acid alkylesters of this structure were yielded from 3-amino-thieno[2,3-b]pyridine-2-carbonic acid alkylesters by reaction with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The compounds showed Antianaphylactic activity.

G Wagner - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of 4 methyl 6 phenyl thieno 2 3 d pyrimidines with a formamidino or oxalamidocarbonic acid residue with Antianaphylactic activity
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, S Leistner
    Abstract:

    3-Amino-4-methyl-6-phenyl-thieno[2,3-d]pyrimidine-2-carbonic acid alkylesters 1a, b were hydrolyzed to the potassium salt of the carbonic acid 2. Cyclization of 2 with acetanhydride yielded the tricyclic 1,3-oxazinone derivative 4. This compound reacted with pyrrolidine by different conditions of reaction to give the bisamide 7, the acetamidino carbonic acid 5 and their decarboxylated product 6. Compound 1a yielded with Vilsmeier reagents the formamidino compound 3. 3-Amino-thieno[2,3-d]pyrimidin-2-carbonitrile gave under different conditions of reaction with oxalic acid diethylester or with oxalic acid ethylester chloride the tetracyclic 4-methoxy-9-methyl-7-phenyl-thieno[2,3-d:4,5-d']dipyrimidine-2-car bonic acid methylester 10 or the N-(2-cyano-4-methyl-6-phenyl-thieno[2,3-d]pyrimid-3-yl)oxalamid ic ethylester 12. These compounds were hydrolyzed to give the carbonic acids 11 and 13. Some of the synthesized substances showed an Antianaphylactic activity.

  • synthesis of 11 aryl 7 8 9 10 tetrahydro 1 2 3 triazino 4 5 4 5 thienol 2 3 b quinolines with Antianaphylactic action
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, S Leistner
    Abstract:

    Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an Antianaphylactic activity.

  • synthesis of furo 2 3 b pyridine amidines with Antianaphylactic activity
    Die Pharmazie, 1993
    Co-Authors: G Wagner, J Prantz
    Abstract:

    The synthesis of furo[2,3-b]pyridine formamidines (D/1-D/11, F) was realized by the reaction of the 3-amino-furo[2,3-b]pyridines C/1-C/11 and E, substituted in position 2 with a carbonyl moiety with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The acetamidines H were yielded from 4-oxo-4H-3-methyl-pyrido[3',2':4,5]furo[3,2-d]1,3-oxazines with aminoethanol. The 4-oxo-4H-3-amino-3,4-dihydro-pyrido[3',2':4,5]furo[3,2-d]pyrimidines K and M reacted with dimethylformamide/phosphoroxide chloride to give the tricyclic formamidines L and K. The described amidines showed Antianaphylactic activity.

  • synthesis of n 2 carboxy thieno 2 3 b pyridin 3 yl formamidines corresponding alkyl esters with Antianaphylactic activity
    Die Pharmazie, 1993
    Co-Authors: G Wagner, H Vieweg, J Prantz, S Leistner
    Abstract:

    A lot of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)formamidines especially in form of their amine salts--were synthesized by reaction of 3-amino-thieno[2,3-b]pyridine-2-carboxylic acids with dimethylformamide/phosphoroxide chloride or by reaction of 4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3- oxazines with amines. Carboxylic acid alkylesters of this structure were yielded from 3-amino-thieno[2,3-b]pyridine-2-carbonic acid alkylesters by reaction with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The compounds showed Antianaphylactic activity.