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Purnima Adhikary - One of the best experts on this subject based on the ideXlab platform.
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the reversible Antifertility Effect of piper betle linn on swiss albino male mice
Contraception, 2000Co-Authors: Madhumita Sarkar, Paramita Gangopadhyay, Bidyut Basak, Kausiki Chakrabarty, Julie Banerji, Purnima AdhikaryAbstract:Abstract To study the Antifertility Effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days.
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the reversible Antifertility Effect of piper betle linn on swiss albino male mice
Contraception, 2000Co-Authors: Madhumita Sarkar, Paramita Gangopadhyay, Bidyut Basak, Kausiki Chakrabarty, Julie Banerji, Purnima Adhikary, A ChatterjeeAbstract:To study the Antifertility Effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p <0.05) was observed. Biochemical parameters did not show any marked alterations in testosterone content in serum nor 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in testes although fructose content in seminal vesicles was reduced as are the weights of reproductive organs. The cholesterol content in testes increased, although not appreciably. After cessation of drug (plant extract) treatment, the altered parameters recovered. Results suggest that the contraceptive Effect of the extract of leaf-stalk of Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days.
Legesse Zerihun - One of the best experts on this subject based on the ideXlab platform.
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Antifertility Effect of Jatropha Curcas L. seed in guinea pigs
Ethiopian Public Health Association, 2017Co-Authors: Eyassu Makonnen, Amr A.h.rostom, Getachew Assefa, Legesse ZerihunAbstract:Abstract: A crude seed extract of Jatropha curcas was studied for its claimed anti-fertility Effect. The extract was orally administered to matured female albino guinea pigs. It was found to reduce the number of births. This was further confirmed by the anti-implantation and abortifacient Effects of the extract observed in this study. The extract was also found to prolong the oestrus cycle of guinea pigs. The diestrus phase was significantly increased, while the oestrus phase was shortened. The weight of the uterus was shown to reduce in animals treated with the extract, while that of the ovaries did not show a significant change from that of the control. These observations suggest that the seeds of the plant possess Antifertility activity.[Ethiop. J. Health Dev. 1997;11(2):145-148
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The possible mechanisms for the Antifertility action of methanolic root extract of Rumex steudelii
Makerere University Medical School, 2005Co-Authors: Endalk Gebrie, Eyasu Makonnen, Legesse Zerihun, Asfaw DebellaAbstract:Background: The practice of traditional medicine for the control of fertility in most parts of Ethiopia is based on the uses of plant medicines for many years. Rumex steudelii Hochst (Polygonaceae) , locally known as "Tult" or "Yeberemelas" is one of the traditionally used Antifertility plants in Ethiopia. In our previous study, the methanolic extract of R. steudelii root was found to show Antifertility activity in female rats. Objectives: The present study focused further on the possible mechanisms of the Antifertility Effect of the methanolic extract of R. steudelii. Methods: The Effect of the extract on implantation, the uterus weight of immature ovariectomized rats and serum estrogenprogesterone ratio was evaluated. Its Effect on isolated guinea pig uterus in the presence and absence of uterine muscle contractions inhibitors was also assessed. Test for in vivo abortifacient Effect was also carried out. Results: It was found that the extract decreased the number of implantation sites significantly. At a contraceptive dose, it was also observed to have no estrogenic activity in immature rat bioassay. The extract did not affect the serum estrogen-progesterone ratio. It produced concentration dependent increase in uterine muscle contractions similar to those of the standard drug, oxytocin. Incubation of the tissue with three uterine muscle contractions inhibitors revealed that the extract produced uterine contractions perhaps by activating muscarinic and/or histaminic receptors. The in vivo abortifacient Effect was not seen upon administration of both lower and higher doses of the extract in pregnant rats. Conclusion: All these observations suggest that the extract produced Antifertility Effect mainly by inhibiting implantation though antiestrogen, progesterogen and uterotonic Effects could as well be possible mechanisms
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the possible mechanisms for the Antifertility action of methanolic root extract of rumex steudelii
African Health Sciences, 2005Co-Authors: Endalk Gebrie, Eyasu Makonnen, Legesse Zerihun, Asfaw DebellaAbstract:Back ground: The practice of traditional medicine for the control of fertility in most parts of Ethiopia is based on the uses of plant medicines for many years. Rumex steudelii Hochst (Polygonaceae), locally known as “Tult” or “Yeberemelas” is one of the traditionally used Antifertility plants in Ethiopia. In our previous study, the methanolic extract of R. steudelii root was found to show Antifertility activity in female rats. Objectives: The present study focused further on the possible mechanisms of the Antifertility Effect of the methanolic extract of R. steudelii. Methods: The Effect of the extract on implantation, the uterus weight of immature ovariectomized rats and serum estrogenprogesterone ratio was evaluated. Its Effect on isolated guinea pig uterus in the presence and absence of uterine muscle contractions inhibitors was also assessed. Test for in vivo abortifacient Effect was also carried out. Results: It was found that the extract decreased the number of implantation sites significantly. At a contraceptive dose, it was also observed to have no estrogenic activity in immature rat bioassay. The extract did not affect the serum estrogen-progesterone ratio. It produced concentration dependent increase in uterine muscle contractions similar to those of the standard drug, oxytocin. Incubation of the tissue with three uterine muscle contractions inhibitors revealed that the extract produced uterine contractions perhaps by activating muscarinic and/or histaminic receptors. The in vivo abortifacient Effect was not seen upon administration of both lower and higher doses of the extract in pregnant rats. Conclusion: All these observations suggest that the extract produced Antifertility Effect mainly by inhibiting implantation though antiestrogen, progesterogen and uterotonic Effects could as well be possible mechanisms. African Health Sciences 2005; 5(2): 119 -125
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Phytochemical screening and pharmacological evaluations for the Antifertility Effect of the methanolic root extract of Rumex steudelii.
Journal of ethnopharmacology, 2005Co-Authors: Endalk Gebrie, Eyasu Makonnen, Asfaw Debella, Legesse ZerihunAbstract:The practice of traditional medicine for the control of fertility in most parts of Ethiopia is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally used Antifertility plants: Rumex steudelii. The secondary metabolites of the root of this plant were determined. The methanolic extract of the roots of this plant were investigated for their Antifertility activity in female rats and oral LD50 was determined in mice. The identification of the secondary metabolites showed that the roots of the plant contained phytosterols and polyphenols. It was found that the extract reduced significantly (p
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phytochemical screening and pharmacological evaluations for the Antifertility Effect of the methanolic root extract of rumex steudelii
Journal of Ethnopharmacology, 2005Co-Authors: Endalk Gebrie, Eyasu Makonnen, Asfaw Debella, Legesse ZerihunAbstract:The practice of traditional medicine for the control of fertility in most parts of Ethiopia is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally used Antifertility plants: Rumex steudelii. The secondary metabolites of the root of this plant were determined. The methanolic extract of the roots of this plant were investigated for their Antifertility activity in female rats and oral LD50 was determined in mice. The identification of the secondary metabolites showed that the roots of the plant contained phytosterols and polyphenols. It was found that the extract reduced significantly (p < 0.01) the number of litters. It also produced Antifertility Effect in a dose dependent manner and the contraceptive Effect was manifested for a definite period of time. Furthermore, the extract prolonged significantly the estrus cycle (p < 0.05) and the diestrous phase (p < 0.01) of the rats. The wet weights of the ovaries and uterus were shown to be reduced significantly (p < 0.01) and (p < 0.05), respectively. The oral LD50 of the extract was found to be 5 g/kg in mice. All these observations suggest that the extract has Antifertility Effect and is safe at the Effective Antifertility doses employed in this study.
Madhumita Sarkar - One of the best experts on this subject based on the ideXlab platform.
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the reversible Antifertility Effect of piper betle linn on swiss albino male mice
Contraception, 2000Co-Authors: Madhumita Sarkar, Paramita Gangopadhyay, Bidyut Basak, Kausiki Chakrabarty, Julie Banerji, Purnima AdhikaryAbstract:Abstract To study the Antifertility Effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days.
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the reversible Antifertility Effect of piper betle linn on swiss albino male mice
Contraception, 2000Co-Authors: Madhumita Sarkar, Paramita Gangopadhyay, Bidyut Basak, Kausiki Chakrabarty, Julie Banerji, Purnima Adhikary, A ChatterjeeAbstract:To study the Antifertility Effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p <0.05) was observed. Biochemical parameters did not show any marked alterations in testosterone content in serum nor 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in testes although fructose content in seminal vesicles was reduced as are the weights of reproductive organs. The cholesterol content in testes increased, although not appreciably. After cessation of drug (plant extract) treatment, the altered parameters recovered. Results suggest that the contraceptive Effect of the extract of leaf-stalk of Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days.
Rita Mahanta - One of the best experts on this subject based on the ideXlab platform.
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Effect of mimosa pudica root extract on vaginal estrous and serum hormones for screening of Antifertility activity in albino mice
Contraception, 2007Co-Authors: Mausumi Ganguly, Nirada Devi, Rita Mahanta, Mridul Kr BorthakurAbstract:Abstract Background Several plants are traditionally used as birth control agents by the rural people in India. Mimosa pudica is one of the folk medicinal plants commonly used as Antifertility agent in some places in India. The present work was carried out to evaluate the claimed Antifertility Effect of the plant by carrying out pharmacological studies with the root extract of the plant. Study Design Air-dried roots of M. pudica were extracted using methanol. Dried methanol extract of the root was administered orally to Swiss albino mice for 21 consecutive days. Estrous cycle, reproductive hormones (LH, FSH, prolactin, estradiol and progesterone) and number of litters produced were studied in both control and extract-administered groups by using standard methods. Phytochemical studies of the methanolic root extract were carried out using qualitative and thin-layer chromatography methods. Results M. pudica root extract, when administered orally at a dose of 300 mg/kg body weight/day, prolonged the length of the estrous cycle with significant increase in the duration of the diestrous phase and reduced the number of litters in albino mice. The number of litters was increased in the posttreatment period. The analysis of the principal hormones (LH, FSH, prolactin, estradiol and progesterone) involved in the regulation of the estrous cycle showed that the root extract altered gonadotropin release and estradiol secretion. Conclusions The root extract of M. pudica has Antifertility Effect as it prolongs the estrous cycle and disturbs the secretion of gonadotropin hormones in albino mice. The decrease in FSH level in the proestrus and estrus stages in the extract-administered group compared with those of control animals indicates the disturbance of estrous cycle and ovulation through suppression of FSH.
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Antifertility activity of the methanolic leaf extract of cissampelos pareira in female albino mice
Journal of Ethnopharmacology, 2007Co-Authors: Mausumi Ganguly, Mridul Kr Borthakur, Nirada Devi, Rita MahantaAbstract:meenakshi Cissampelos pareira Linn. is one of the folk medicinal plants commonly used as Antifertility agent in some places of India. The aim of the present study was to evaluate the validity of the Antifertility Effect of the leaf extract. Cissampelos pareira leaf extract, when administered orally, altered the estrous cycle pattern in female mice, prolonged the length of estrous cycle with significant increase in the duration of diestrus stage and reduced significantly the number of litters in albino mice. The analysis of the principal hormones involved in estrous cycle regulation showed that the plant extract altered gonadotropin release (LH, FSH and prolactin) and estradiol secretion. The results indicated the Antifertility Effect of Cissampelos pareira leaf extract in female albino mice. The oral LD50 of the extract was found to be 7.3 g/kg in mice.
A Chatterjee - One of the best experts on this subject based on the ideXlab platform.
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the reversible Antifertility Effect of piper betle linn on swiss albino male mice
Contraception, 2000Co-Authors: Madhumita Sarkar, Paramita Gangopadhyay, Bidyut Basak, Kausiki Chakrabarty, Julie Banerji, Purnima Adhikary, A ChatterjeeAbstract:To study the Antifertility Effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p <0.05) was observed. Biochemical parameters did not show any marked alterations in testosterone content in serum nor 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in testes although fructose content in seminal vesicles was reduced as are the weights of reproductive organs. The cholesterol content in testes increased, although not appreciably. After cessation of drug (plant extract) treatment, the altered parameters recovered. Results suggest that the contraceptive Effect of the extract of leaf-stalk of Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days.