The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform

Wanigasekara Daya Ratnasooriya - One of the best experts on this subject based on the ideXlab platform.

  • alpinia calcarata roscoe a potent Antiinflammatory agent
    Journal of Ethnopharmacology, 2012
    Co-Authors: L.d.a.menuka Arawwawala, L S R Arambewela, Wanigasekara Daya Ratnasooriya
    Abstract:

    Abstract Aim of the study Alpinia calcarata Roscoe (Family: Zingiberaceae) rhizomes are often used in Sri Lankan traditional systems of medicine as a remedy for bronchitis, cough, respiratory ailments, diabetics, asthma and arthritis. Generally drugs that are used for arthritis have antinociceptive and Antiinflammatory properties. However, validity of the Antiinflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the Antiinflammatory potential of Alpinia calcarata rhizomes using hot water extract (AWE) and hot ethanolic extract (AEE). Materials and Methods The Antiinflammatory activity of Alpinia calcarata was evaluated by use of the carrageenan-induced paw oedema model in rats. In addition, the mechanism/s by which Alpinia calcarata is mediated the antinflammatory activity was assessed by determining its effects on (a) membrane stabilizing, (b) antihistamine and (c) prostaglandin synthesis inhibition activity. Results All the tested doses of AWE and AEE (250, 500, 750, and 1000 mg/kg) produced a significant (P ≤ 0.05) inhibition of the inflammation, most pronounced at 4 h after the injection of carrageenan. The Antiinflammatory effect induced by 500 mg/kg of AEE was superior than the reference drug, indomethacin at 4 h. Inhibition of histamine and prostaglandin synthesis production is probable mechanisms by which Alpinia calcarata mediates its Antiinflammatory action. Conclusion These findings rationalize the traditional usage of Alpinia calcarata as an Antiinflammatory agent for the first time.

Z X Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Phytochemical and Antiinflammatory studies on Terminalia catappa.
    Fitoterapia, 2004
    Co-Authors: Y M Fan, Jie Gao, Yanping Wang, X H Tang, X N Zhao, Z X Zhang
    Abstract:

    The Antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong Antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the Antiinflammatory activity of T. catappa leaves.

Zhiliang Zhang - One of the best experts on this subject based on the ideXlab platform.

  • phytochemical and Antiinflammatory studies on terminalia catappa
    Fitoterapia, 2004
    Co-Authors: Yimei Fan, Jie Gao, Yanping Wang, Xinhui Tang, Xiaozhi Zhao, Zhiliang Zhang
    Abstract:

    The Antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong Antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the Antiinflammatory activity of T. catappa leaves.

R. M. Rabanal - One of the best experts on this subject based on the ideXlab platform.

Yanping Wang - One of the best experts on this subject based on the ideXlab platform.

  • phytochemical and Antiinflammatory studies on terminalia catappa
    Fitoterapia, 2004
    Co-Authors: Yimei Fan, Jie Gao, Yanping Wang, Xinhui Tang, Xiaozhi Zhao, Zhiliang Zhang
    Abstract:

    The Antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong Antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the Antiinflammatory activity of T. catappa leaves.

  • Phytochemical and Antiinflammatory studies on Terminalia catappa.
    Fitoterapia, 2004
    Co-Authors: Y M Fan, Jie Gao, Yanping Wang, X H Tang, X N Zhao, Z X Zhang
    Abstract:

    The Antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong Antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the Antiinflammatory activity of T. catappa leaves.