Antimicrobial Activity

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José Roberto Guimarães - One of the best experts on this subject based on the ideXlab platform.

  • Antimicrobial Activity and acute toxicity of ozonated lomefloxacin solution.
    Environmental Science and Pollution Research, 2017
    Co-Authors: Amanda Marchi Duarte De Oliveira, Milena Guedes Maniero, Caio Rodrigues-silva, José Roberto Guimarães
    Abstract:

    Lomefloxacin (LOM) is a synthetic Antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its Antimicrobial Activity. This study evaluated the effect of ozonation of LOM (500 μg L−1), the residual Antimicrobial Activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L−1 O3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L−1 O3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the Antimicrobial Activity of the solution dropped as ozone dose increased (Antimicrobial Activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in Antimicrobial Activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O3) that acted the most in the process.

  • degradation of flumequine by photocatalysis and evaluation of Antimicrobial Activity
    Chemical Engineering Journal, 2013
    Co-Authors: Caio Rodriguessilva, Milena Guedes Maniero, Susanne Rath, José Roberto Guimarães
    Abstract:

    This study evaluated the efficiencies of advanced oxidation processes (UV/TiO2 and UV/TiO2/H2O2) for the flumequine degradation, an Antimicrobial and emergent pollutant. The photocatalytic process was capable of degrading approximately 55% of the drug after 15 min of reaction using 0.31 mmol L−1 TiO2 in suspension; the addition of H2O2 (0.5 mmol L−1) increased flumequine degradation to 81.6%. For UV/TiO2, increasing catalyst concentration (0.08–0.62 mmol L−1) corresponded to an increase in the degradation efficiency. Using mass spectrometry, it was possible to identify five putative byproducts formed during the advanced oxidation processes. Due to the risks of bacterial resistance, the Antimicrobial Activity of the treated solutions was evaluated and compared to an untreated solution. Residual Antimicrobial Activity was detected after 15 min of reaction in all of the evaluated conditions. The Antimicrobial Activity was considerably reduced by the photocatalytic processes (UV/TiO2 and UV/TiO2/H2O2) throughout the reaction.

Satyahari Dey - One of the best experts on this subject based on the ideXlab platform.

Milena Guedes Maniero - One of the best experts on this subject based on the ideXlab platform.

  • Antimicrobial Activity and acute toxicity of ozonated lomefloxacin solution.
    Environmental Science and Pollution Research, 2017
    Co-Authors: Amanda Marchi Duarte De Oliveira, Milena Guedes Maniero, Caio Rodrigues-silva, José Roberto Guimarães
    Abstract:

    Lomefloxacin (LOM) is a synthetic Antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its Antimicrobial Activity. This study evaluated the effect of ozonation of LOM (500 μg L−1), the residual Antimicrobial Activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L−1 O3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L−1 O3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the Antimicrobial Activity of the solution dropped as ozone dose increased (Antimicrobial Activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in Antimicrobial Activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O3) that acted the most in the process.

  • degradation of flumequine by photocatalysis and evaluation of Antimicrobial Activity
    Chemical Engineering Journal, 2013
    Co-Authors: Caio Rodriguessilva, Milena Guedes Maniero, Susanne Rath, José Roberto Guimarães
    Abstract:

    This study evaluated the efficiencies of advanced oxidation processes (UV/TiO2 and UV/TiO2/H2O2) for the flumequine degradation, an Antimicrobial and emergent pollutant. The photocatalytic process was capable of degrading approximately 55% of the drug after 15 min of reaction using 0.31 mmol L−1 TiO2 in suspension; the addition of H2O2 (0.5 mmol L−1) increased flumequine degradation to 81.6%. For UV/TiO2, increasing catalyst concentration (0.08–0.62 mmol L−1) corresponded to an increase in the degradation efficiency. Using mass spectrometry, it was possible to identify five putative byproducts formed during the advanced oxidation processes. Due to the risks of bacterial resistance, the Antimicrobial Activity of the treated solutions was evaluated and compared to an untreated solution. Residual Antimicrobial Activity was detected after 15 min of reaction in all of the evaluated conditions. The Antimicrobial Activity was considerably reduced by the photocatalytic processes (UV/TiO2 and UV/TiO2/H2O2) throughout the reaction.

Amanda Marchi Duarte De Oliveira - One of the best experts on this subject based on the ideXlab platform.

  • Antimicrobial Activity and acute toxicity of ozonated lomefloxacin solution.
    Environmental Science and Pollution Research, 2017
    Co-Authors: Amanda Marchi Duarte De Oliveira, Milena Guedes Maniero, Caio Rodrigues-silva, José Roberto Guimarães
    Abstract:

    Lomefloxacin (LOM) is a synthetic Antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its Antimicrobial Activity. This study evaluated the effect of ozonation of LOM (500 μg L−1), the residual Antimicrobial Activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L−1 O3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L−1 O3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the Antimicrobial Activity of the solution dropped as ozone dose increased (Antimicrobial Activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in Antimicrobial Activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O3) that acted the most in the process.

Prajjal K. Singha - One of the best experts on this subject based on the ideXlab platform.