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Antiparasitic Therapy
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Mahendra Bhandari – One of the best experts on this subject based on the ideXlab platform.
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Visceral Leishmaniasis in a Renal Transplant Recipient: Diagnostic and Therapeutic Problems
American journal of nephrology, 1996Co-Authors: Raj K. Sharma, Ratan Jha, Pradeep Kumar, Vijay Kher, Amit Gupta, Anant Kumar, Sanjeev Gulati, Pradeep Arora, Manjula Murari, Mahendra BhandariAbstract:Visceral leishmaniasis is infrequently reported in renal transplant recipients. A 40-year-old renal transplant recipient developed hepatosplenomegaly and pyrexia of unknown origin 5 months after transplantation. Visceral leishmaniasis was confirmed on bone marrow examination. The usual dose of Antiparasitic Therapy with stibogluconate sodium failed to eradicate Leishmania donovani. High-dose conventional Therapy with stibogluconate sodium for an extended period of time was successful in the treatment of a relapse of leishmaniasis.
Brian G. Blackburn – One of the best experts on this subject based on the ideXlab platform.
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SYMPOSIUM ON ANTIMICROBIAL TherapyAntiparasitic Therapy
Mayo Clinic proceedings, 2011Co-Authors: Shanthi Kappagoda, Upinder Singh, Brian G. BlackburnAbstract:Parasitic diseases affect more than 2 billion people globally and cause substantial morbidity and mortality, particularly among the world’s poorest people. This overview focuses on the treatment of the major protozoan and helminth infections in humans. Recent developments in Antiparasitic Therapy include the expansion of artemisinin-based therapies for malaria, new drugs for soil-transmitted helminths and intestinal protozoa, expansion of the indications for Antiparasitic drug treatment in patients with Chagas disease, and the use of combination Therapy for leishmaniasis and human African trypanosomiasis.
Tomasz Kula – One of the best experts on this subject based on the ideXlab platform.
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Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy
PloS one, 2012Co-Authors: Raina N. Fichorova, Yujin Lee, Hidemi S. Yamamoto, Yuko Takagi, Gary R. Hayes, Russell P. Goodman, Xenia Chepa-lotrea, Olivia R. Buck, Richard Murray, Tomasz KulaAbstract:Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 million each year rendering them more susceptible to devastating pregnancy complications (especially preterm birth), HIV infection and HPV-related cancer. While first-line antibiotic treatment (metronidazole) commonly kills the protozoan pathogen, it fails to improve reproductive outcome. We show that endosymbiotic Trichomonasvirus, highly prevalent in T. vaginalis clinical isolates, is sensed by the human epithelial cells via Toll-like receptor 3, triggering Interferon Regulating Factor -3, interferon type I and proinflammatory cascades previously implicated in preterm birth and HIV-1 susceptibility. Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae.
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endobiont viruses sensed by the human host beyond conventional Antiparasitic Therapy
PLOS ONE, 2012Co-Authors: Raina N. Fichorova, Yujin Lee, Hidemi S. Yamamoto, Yuko Takagi, Gary R. Hayes, Russell P. Goodman, Olivia R. Buck, Xenia Chepalotrea, Ryan Murray, Tomasz KulaAbstract:Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 million each year rendering them more susceptible to devastating pregnancy complications (especially preterm birth), HIV infection and HPV-related cancer. While first-line antibiotic treatment (metronidazole) commonly kills the protozoan pathogen, it fails to improve reproductive outcome. We show that endosymbiotic Trichomonasvirus, highly prevalent in T. vaginalis clinical isolates, is sensed by the human epithelial cells via Toll-like receptor 3, triggering Interferon Regulating Factor -3, interferon type I and proinflammatory cascades previously implicated in preterm birth and HIV-1 susceptibility. Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae.