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Antipyretic Activity

The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform

E Woode – 1st expert on this subject based on the ideXlab platform

  • Antipyretic Activity of polyalthia longifolia benth hook f var pendula annonaceae on lipopolysaccharide induced fever in rats
    Journal of Medical and Biomedical Sciences, 2013
    Co-Authors: Kofi Annan, R A Dickson, Kwame Sarpong, C Asare, K I Amponsah, E Woode

    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic Activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic Activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic Activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12

  • Antipyretic Activity of Polyalthia longifolia Benth. & Hook. F. var. pendula (Annonaceae), on lipopolysaccharide-induced fever in rats
    , 2013
    Co-Authors: Kofi Annan, R A Dickson, Kwame Sarpong, C Asare, K I Amponsah, E Woode

    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic Activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic Activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic Activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12

Erdem Yesilada – 2nd expert on this subject based on the ideXlab platform

  • Sesquiterpene lactones with antinociceptive and Antipyretic Activity from two Centaurea species.
    Journal of Ethnopharmacology, 2009
    Co-Authors: Esra Küpeli Akkol, Reyhan Arif, Fatma Ergun, Erdem Yesilada

    Abstract:

    Abstract Ethnopharmacological relevance Several Centaurea species are used to alleviate pain and inflammatory symptoms in rheumatoid arthritis, high fever, and head ache in Turkish folk medicine. Aim of the study The effectiveness of extracts, fractions and subfractions from dried Centaurea solstitialis L. subsp. solstitialis (CSS) (Asteraceae) roots and aerial parts were studied on mice. Materials and methods The antinociceptive and Antipyretic effects of Centaurea solstitialis L. subsp. solstitialis have been investigated by using p-benzoquinone-induced writhing reflex for antinociceptive Activity and Freund’s Complete Adjuvant-induced pyrexia model for Antipyretic Activity assessment in mice. Results The ethanolic extract from the aerial parts of the plant was shown to possess significant antinociceptive (p  Conclusion Results of the present study proved that aerial part of CSS possesses antinociceptive and Antipyretic activities supporting the folkloric assertion in Turkish folk medicine. However, these effects seem not limited to CSS, some other Centaurea species, in fact, having no folkloric use might be equally active.

  • sesquiterpene lactones with antinociceptive and Antipyretic Activity from two centaurea species
    Journal of Ethnopharmacology, 2009
    Co-Authors: Esra Küpeli Akkol, Reyhan Arif, Fatma Ergun, Erdem Yesilada

    Abstract:

    Abstract Ethnopharmacological relevance Several Centaurea species are used to alleviate pain and inflammatory symptoms in rheumatoid arthritis, high fever, and head ache in Turkish folk medicine. Aim of the study The effectiveness of extracts, fractions and subfractions from dried Centaurea solstitialis L. subsp. solstitialis ( CSS ) (Asteraceae) roots and aerial parts were studied on mice. Materials and methods The antinociceptive and Antipyretic effects of Centaurea solstitialis L. subsp. solstitialis have been investigated by using p-benzoquinone-induced writhing reflex for antinociceptive Activity and Freund’s Complete Adjuvant-induced pyrexia model for Antipyretic Activity assessment in mice. Results The ethanolic extract from the aerial parts of the plant was shown to possess significant antinociceptive ( p p CSS . On the other hand, a comparative study was conducted on another species, Centaurea depressa Bieb., which has no similar folkloric utilization. Following the same fractionation chart same compounds were defined as the active ingredients. Conclusion Results of the present study proved that aerial part of CSS possesses antinociceptive and Antipyretic activities supporting the folkloric assertion in Turkish folk medicine. However, these effects seem not limited to CSS , some other Centaurea species, in fact, having no folkloric use might be equally active.

Kofi Annan – 3rd expert on this subject based on the ideXlab platform

  • Antipyretic Activity of polyalthia longifolia benth hook f var pendula annonaceae on lipopolysaccharide induced fever in rats
    Journal of Medical and Biomedical Sciences, 2013
    Co-Authors: Kofi Annan, R A Dickson, Kwame Sarpong, C Asare, K I Amponsah, E Woode

    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic Activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic Activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic Activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12

  • Antipyretic Activity of Polyalthia longifolia Benth. & Hook. F. var. pendula (Annonaceae), on lipopolysaccharide-induced fever in rats
    , 2013
    Co-Authors: Kofi Annan, R A Dickson, Kwame Sarpong, C Asare, K I Amponsah, E Woode

    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic Activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic Activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic Activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12