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Richard Casaburi - One of the best experts on this subject based on the ideXlab platform.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.

Sergio Faloni De Andrade - One of the best experts on this subject based on the ideXlab platform.

  • reproductive toxicology and clastogenic evaluation in mice of a phytotherapeutic formulation obtained from cinchona calisaya weddel rubiaceae used in brazilian folk medicine as female fertility Stimulant
    Journal of Ethnopharmacology, 2014
    Co-Authors: Vera Lucia Langaro Do Amaral, Marcel Frajbat, Marcel Petreanu, Tailyn Zermiani, Rilton Alves De Freitas, Edson Luis Maistro, Rivaldo Niero, Tania Mari Belle Bresolin, Valdir Cechinel Filho, Sergio Faloni De Andrade
    Abstract:

    Abstract Ethnopharmacological relevance In Brazil, a phytotherapeutic preparation produced from a standardized tincture of Cinchona calisaya Weddel such that each mL of product contains 400 µg of quinine, known in Portuguese as Agua Inglesa ® (English water), is indicated by the manufacturer as a tonic, Appetite Stimulant, and digestive. However, this preparation has long been used in folk medicine as a female fertility Stimulant. Despite its widespread use in folk medicine to stimulate female fertility, no study has been undertaken to assess the potential teratogenic and genotoxic effects of this phytotherapeutic preparation. The aim of the present study was to investigate possible toxic reproductive effects in mice caused by exposure to Agua Inglesa ® , either before mating or during the pre- and post-embryo implantation periods. The genotoxic potential was evaluated using the micronucleus assay. Material, Methods, and Results Virgin female mice, with at least one estrous cycle evidenced by vaginal cytology, were divided into five groups of 15 individuals each (Group I – control, Group II – treated with ethanol solution at 16%, Groups III, IV and V treated with phytotherapeutic preparation at 1.5 mL/kg/day, 3.0 mL/kg/day and 4.5 mL/kg/day, respectively). After the first 28 days of treatment, females were caged individually with adult fertile males. Pregnant females continued to receive treatment for seven days (preimplantation period). Body weight was recorded weekly during treatment. Signs of toxicity (weight loss, food intake, piloerection, apathy, prostration, diarrhea, seizures, behavioral changes, and locomotion) were also observed. The females were sacrificed on the 15th day of pregnancy, uterine horns were evaluated for implantation, and the placental index was recorded. In the micronucleus test, 2000 polychromatic erythrocytes (PCE) per animal, obtained from bone marrow, were scored. Results The results showed that exposure of the females during the pre- and post-implantation periods did not significantly alter the reproductive capacity ( p p >0.05) in terms of the average number of micronucleated polychromatic erythrocytes. Conclusions Although folk medicine suggests that the Agua Inglesa ® preparation is useful as a female fertility Stimulant, no such effect was confirmed in mice.

  • Reproductive toxicology and clastogenic evaluation in mice of a phytotherapeutic formulation obtained from Cinchona calisaya Weddel (Rubiaceae) used in Brazilian folk medicine as female fertility Stimulant
    Elsevier B.V., 2014
    Co-Authors: Langaro Do Amaral, Vera Lucia, Rilton Alves De Freitas, Frajbat Marcel, Petreanu Marcel, Zermiani Tailyn, Maistro, Edson Luis, Niero Rivaldo, Belle Bresolin, Tania Mari, Cechinel Filho Valdir, Sergio Faloni De Andrade
    Abstract:

    Ethnopharmacological relevance: In Brazil, a phytotherapeutic preparation produced from a standardized tincture of Cinchona calisaya Weddel such that each mL of product contains 400 mu g of quinine, known in Portuguese as Agua Inglesa (R) (English water), is indicated by the manufacturer as a tonic, Appetite Stimulant, and digestive. However, this preparation has long been used in folk medicine as a female fertility Stimulant. Despite its widespread use in folk medicine to stimulate female fertility, no study has been undertaken to assess the potential teratogenic and genotoxic effects of this phytotherapeutic preparation. The aim of the present study was to investigate possible toxic reproductive effects in mice caused by exposure to Agua Inglesa (R), either before mating or during the pre- and post-embryo implantation periods. The genotoxic potential was evaluated using the micronucleus assay.Material, Methods, and Results: Virgin female mice, with at least one estrous cycle evidenced by vaginal cytology, were divided into five groups of 15 individuals each (Group I - control, Group II - treated with ethanol solution at 16%, Groups III, IV and V treated with phytotherapeutic preparation at 1.5 mL/kg/day, 3.0 mL/kg/day and 4.5 mL/kg/day, respectively). After the first 28 days of treatment, females were caged individually with adult fertile males. Pregnant females continued to receive treatment for seven days (preimplantation period). Body weight was recorded weekly during treatment. Signs of toxicity (weight loss, food intake, piloerection, apathy, prostration, diarrhea, seizures, behavioral changes, and locomotion) were also observed. The females were sacrificed on the 15th day of pregnancy, uterine horns were evaluated for implantation, and the placental index was recorded. In the micronucleus test, 2000 polychromatic erythrocytes (PCE) per animal, obtained from bone marrow, were scored. Results The results showed that exposure of the females during the pre- and post-implantation periods did not significantly alter the reproductive capacity (p 0.05) in terms of the average number of micronucleated polychromatic erythrocytes.Conclusions: Although folk medicine suggests that the Agua Inglesa (R) preparation is useful as a female fertility Stimulant, no such effect was confirmed in mice. (C) 2014 Elsevier Ireland Ltd. All rights reserved

Jeffrey Weisberg - One of the best experts on this subject based on the ideXlab platform.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.

S. Bilal - One of the best experts on this subject based on the ideXlab platform.

  • A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)
    The Scientific World Journal, 2015
    Co-Authors: Bilal Ahmad, Muneeb U. Rehman, Insha Amin, Ishraq Hussain, Ahmad Arif, Saiema Rasool, Showkat Ahmad Bhat, Insha Afzal, S. Bilal, Manzoor R. Mir
    Abstract:

    Humans have been using natural products for medicinal use for ages. Natural products of therapeutic importance are compounds derived from plants, animals, or any microorganism. Ginger is also one of the most commonly used condiments and a natural drug in vogue. It is a traditional medicine, having some active ingredients used for the treatment of numerous diseases. During recent research on ginger, various ingredients like zingerone, shogaol, and paradol have been obtained from it. Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is a nontoxic and inexpensive compound with varied pharmacological activities. It is the least pungent component of Zingiber officinale. Zingerone is absent in fresh ginger but cooking or heating transforms gingerol to zingerone. Zingerone closely related to vanillin from vanilla and eugenol from clove. Zingerone has potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic, and so forth properties. Besides, it displays the property of enhancing growth and immune stimulation. It behaves as Appetite Stimulant, anxiolytic, antithrombotic, radiation protective, and antimicrobial. Also, it inhibits the reactive nitrogen species which are important in causing Alzheimer's disease and many other disorders. This review is written to shed light on the various pharmacological properties of zingerone and its role in alleviating numerous human and animal diseases.

  • Review Article A Review on Pharmacological Properties of Zingerone
    2015
    Co-Authors: S. Bilal, Manzoor Ur Rahman Mir
    Abstract:

    which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Humans have been using natural products for medicinal use for ages. Natural products of therapeutic importance are compounds derived from plants, animals, or any microorganism. Ginger is also one of the most commonly used condiments and a natural drug in vogue. It is a traditional medicine, having some active ingredients used for the treatment of numerous diseases. During recent research on ginger, various ingredients like zingerone, shogaol, and paradol have been obtained from it. Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is a nontoxic and inexpensive compound with varied pharmacological activities. It is the least pungent component of Zingiber officinale. Zingerone is absent in fresh ginger but cooking or heating transforms gingerol to zingerone. Zingerone closely related to vanillin from vanilla and eugenol from clove. Zingerone has potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic, and so forth properties. Besides, it displays the property of enhancing growth and immune stimulation. It behaves as Appetite Stimulant, anxiolytic, antithrombotic, radiation protective, an

  • A review on pharmacological properties of zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone),”
    2015
    Co-Authors: Bilal Ahmad, Muneeb U. Rehman, Insha Amin, Ishraq Hussain, Ahmad Arif, Saiema Rasool, Showkat Ahmad Bhat, Insha Afzal, S. Bilal
    Abstract:

    Humans have been using natural products for medicinal use for ages. Natural products of therapeutic importance are compounds derived from plants, animals, or any microorganism. Ginger is also one of the most commonly used condiments and a natural drug in vogue. It is a traditional medicine, having some active ingredients used for the treatment of numerous diseases. During recent research on ginger, various ingredients like zingerone, shogaol, and paradol have been obtained from it. Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is a nontoxic and inexpensive compound with varied pharmacological activities. It is the least pungent component of Zingiber officinale. Zingerone is absent in fresh ginger but cooking or heating transforms gingerol to zingerone. Zingerone closely related to vanillin from vanilla and eugenol from clove. Zingerone has potent antiinflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic, and so forth properties. Besides, it displays the property of enhancing growth and immune stimulation. It behaves as Appetite Stimulant, anxiolytic, antithrombotic, radiation protective, and antimicrobial. Also, it inhibits the reactive nitrogen species which are important in causing Alzheimer's disease and many other disorders. This review is written to shed light on the various pharmacological properties of zingerone and its role in alleviating numerous human and animal diseases

J Wanger - One of the best experts on this subject based on the ideXlab platform.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.

  • megestrol acetate stimulates weight gain and ventilation in underweight copd patients
    Chest, 2002
    Co-Authors: Jeffrey Weisberg, J Wanger, Jeffery S Olson, Barry Streit, Charles Fogarty, Thomas R Martin, Richard Casaburi
    Abstract:

    Study objectives To assess the effect of megestrol acetate (MA), a progestational Appetite Stimulant commonly used in patients with AIDS and cancer, on body weight and composition, respiratory muscle strength, arterial blood gas levels, and subjective perceptions in COPD patients. Design and setting Prospective, double-blind, randomized, placebo-controlled trial conducted on an outpatient basis at 18 sites. Patients Underweight ( Interventions Either MA, 800 mg/d oral suspension, or placebo at a 1:1 ratio for 8 weeks. Results Of 145 randomized patients (63% men), 128 patients completed the trial. Body weight increased by 3.2 kg in the MA group and 0.7 kg in the placebo group (p co 2 decreased (4.6 mm Hg, p o 2 increased (2.8 mm Hg, p Conclusions We conclude that MA safely increased Appetite and body weight, stimulated ventilation, and improved body image in underweight COPD patients, but did not improve respiratory muscle function or exercise tolerance.