The Experts below are selected from a list of 2544 Experts worldwide ranked by ideXlab platform
Kwang Ho Lee - One of the best experts on this subject based on the ideXlab platform.
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Presence of anti-Ro/SSA Antibody may be associated with anti-Aquaporin-4 Antibody positivity in neuromyelitis optica spectrum disorder
Journal of the Neurological Sciences, 2014Co-Authors: Jae-hyun Park, Jaechun Hwang, Ju-hong Min, Byoung Joon Kim, Eun-suk Kang, Kwang Ho LeeAbstract:Abstract Background Neuromyelitis optica (NMO) is often associated with systemic autoimmune diseases or serological markers of non-organ-specific autoimmunity, and has been most frequently associated with Sjogren's syndrome and anti-Ro/SSA Antibody (SSA-Ab) positivity in Asian populations. Objective We evaluated the clinical significance of anti-Ro/SSA Antibody positivity in patients with NMO spectrum disorder (NMOSD). Methods We retrospectively collected data from 106 consecutive patients with NMOSD and reviewed clinical features and laboratory findings. All patients underwent tests for SSA-Ab and anti-Aquaporin-4 Antibody (AQP4-Ab) using cell-based indirect immunofluorescence assays. Results Among 106 patients, 20 (18.9%) were positive for SSA-Ab. Of 48 AQP4-Ab-positive patients, 18 (37.5%) had SSA-Ab. AQP4-Ab seropositivity was 90.0% in patients positive for SSA-Ab, and 32.6% in patients without SSA-Ab (p Conclusion We found that the presence of SSA-Ab was highly associated with seropositivity for AQP4-Ab in patients with NMOSD.
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Presence of anti-Ro/SSA Antibody may be associated with anti-Aquaporin-4 Antibody positivity in neuromyelitis optica spectrum disorder.
Journal of the neurological sciences, 2014Co-Authors: Jae-hyun Park, Jaechun Hwang, Ju-hong Min, Byoung Joon Kim, Eun-suk Kang, Kwang Ho LeeAbstract:Neuromyelitis optica (NMO) is often associated with systemic autoimmune diseases or serological markers of non-organ-specific autoimmunity, and has been most frequently associated with Sjögren's syndrome and anti-Ro/SSA Antibody (SSA-Ab) positivity in Asian populations. We evaluated the clinical significance of anti-Ro/SSA Antibody positivity in patients with NMO spectrum disorder (NMOSD). We retrospectively collected data from 106 consecutive patients with NMOSD and reviewed clinical features and laboratory findings. All patients underwent tests for SSA-Ab and anti-Aquaporin-4 Antibody (AQP4-Ab) using cell-based indirect immunofluorescence assays. Among 106 patients, 20 (18.9%) were positive for SSA-Ab. Of 48 AQP4-Ab-positive patients, 18 (37.5%) had SSA-Ab. AQP4-Ab seropositivity was 90.0% in patients positive for SSA-Ab, and 32.6% in patients without SSA-Ab (p<0.001). Presence of SSA-Ab was associated with systemic autoimmune diseases, including Sjögren's syndrome (p<0.001) and systemic lupus erythematosus (p=0.003), and with the presence of non-organ-specific autoantibodies such as anti-nuclear Antibody and anti-dsDNA Antibody in patients with NMOSD, but was not associated with annualized relapse rate or final Expanded Disability Status Scale score independent of AQP4-Ab positivity. We found that the presence of SSA-Ab was highly associated with seropositivity for AQP4-Ab in patients with NMOSD. Copyright © 2014 Elsevier B.V. All rights reserved.
Michael Scheel - One of the best experts on this subject based on the ideXlab platform.
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mri based methods for spinal cord atrophy evaluation a comparison of cervical cord cross sectional area cervical cord volume and full spinal cord volume in patients with Aquaporin 4 Antibody seropositive neuromyelitis optica spectrum disorders
American Journal of Neuroradiology, 2018Co-Authors: Claudia Chien, Alexander U Brandt, Felix Schmidt, Judith Bellmannstrobl, Klemens Ruprecht, Friedemann Paul, Michael ScheelAbstract:BACKGROUND AND PURPOSE: Measures for spinal cord atrophy have become increasingly important as imaging biomarkers in the assessment of neuroinflammatory diseases, especially in neuromyelitis optica spectrum disorders. The most commonly used method, mean upper cervical cord area, is relatively easy to measure and can be performed on brain MRIs that capture cervical myelon. Measures of spinal cord volume (eg, cervical cord volume or total cord volume) require longer scanning and more complex analysis but are potentially better suited as spinal cord atrophy measures. This study investigated spinal cord atrophy measures in a cohort of healthy subjects and patients with Aquaporin-4 Antibody seropositive neuromyelitis optica spectrum disorders and evaluated the discriminatory performance of mean upper cervical cord cross-sectional area compared with cervical cord volume and total cord volume. MATERIALS AND METHODS: Mean upper cervical cord area, cervical cord volume, and total cord volume were measured using 3T MRIs from healthy subjects (n = 19) and patients with neuromyelitis optica spectrum disorders (n = 30). Group comparison and receiver operating characteristic analyses between healthy controls and patients with neuromyelitis optica spectrum disorders were performed. RESULTS: Mean upper cervical cord area, cervical cord volume, and total cord volume measures showed similar and highly significant group differences between healthy control subjects and patients with neuromyelitis optica spectrum disorders (P CONCLUSIONS: All 3 measures showed similar discriminatory power between healthy control and neuromyelitis optica spectrum disorders groups. Mean upper cervical cord area is easier to obtain compared with cervical cord volume and total cord volume and can be regarded as an efficient representative measure of spinal cord atrophy in the neuromyelitis optica spectrum disorders context.
Scheel M. - One of the best experts on this subject based on the ideXlab platform.
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MRI-based methods for spinal cord atrophy evaluation: a comparison of cervical cord cross-sectional area, cervical cord volume, and full spinal cord volume in patients with Aquaporin-4 Antibody seropositive neuromyelitis optica spectrum disorders
American Society of Neuroradiology, 2018Co-Authors: Chien C., Brandt A.u., Schmidt F., Bellmann-strobl J., Ruprecht K., Paul F., Scheel M.Abstract:BACKGROUND AND PURPOSE: Measures for spinal cord atrophy have become increasingly important as imaging biomarkers in the assessment of neuroinflammatory diseases, especially in neuromyelitis optica spectrum disorders. The most commonly used method, mean upper cervical cord area, is relatively easy to measure and can be performed on brain MRIs that capture cervical myelon. Measures of spinal cord volume (eg, cervical cord volume or total cord volume) require longer scanning and more complex analysis but are potentially better suited as spinal cord atrophy measures. This study investigated spinal cord atrophy measures in a cohort of healthy subjects and patients with Aquaporin-4 Antibody seropositive neuromyelitis optica spectrum disorders and evaluated the discriminatory performance of mean upper cervical cord cross-sectional area compared with cervical cord volume and total cord volume. MATERIALS AND METHODS: Mean upper cervical cord area, cervical cord volume, and total cord volume were measured using 3T MRIs from healthy subjects (n = 19) and patients with neuromyelitis optica spectrum disorders (n = 30). Group comparison and receiver operating characteristic analyses between healthy controls and patients with neuromyelitis optica spectrum disorders were performed. RESULTS: Mean upper cervical cord area, cervical cord volume, and total cord volume measures showed similar and highly significant group differences between healthy control subjects and patients with neuromyelitis optica spectrum disorders (P
Jae-hyun Park - One of the best experts on this subject based on the ideXlab platform.
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Presence of anti-Ro/SSA Antibody may be associated with anti-Aquaporin-4 Antibody positivity in neuromyelitis optica spectrum disorder
Journal of the Neurological Sciences, 2014Co-Authors: Jae-hyun Park, Jaechun Hwang, Ju-hong Min, Byoung Joon Kim, Eun-suk Kang, Kwang Ho LeeAbstract:Abstract Background Neuromyelitis optica (NMO) is often associated with systemic autoimmune diseases or serological markers of non-organ-specific autoimmunity, and has been most frequently associated with Sjogren's syndrome and anti-Ro/SSA Antibody (SSA-Ab) positivity in Asian populations. Objective We evaluated the clinical significance of anti-Ro/SSA Antibody positivity in patients with NMO spectrum disorder (NMOSD). Methods We retrospectively collected data from 106 consecutive patients with NMOSD and reviewed clinical features and laboratory findings. All patients underwent tests for SSA-Ab and anti-Aquaporin-4 Antibody (AQP4-Ab) using cell-based indirect immunofluorescence assays. Results Among 106 patients, 20 (18.9%) were positive for SSA-Ab. Of 48 AQP4-Ab-positive patients, 18 (37.5%) had SSA-Ab. AQP4-Ab seropositivity was 90.0% in patients positive for SSA-Ab, and 32.6% in patients without SSA-Ab (p Conclusion We found that the presence of SSA-Ab was highly associated with seropositivity for AQP4-Ab in patients with NMOSD.
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Presence of anti-Ro/SSA Antibody may be associated with anti-Aquaporin-4 Antibody positivity in neuromyelitis optica spectrum disorder.
Journal of the neurological sciences, 2014Co-Authors: Jae-hyun Park, Jaechun Hwang, Ju-hong Min, Byoung Joon Kim, Eun-suk Kang, Kwang Ho LeeAbstract:Neuromyelitis optica (NMO) is often associated with systemic autoimmune diseases or serological markers of non-organ-specific autoimmunity, and has been most frequently associated with Sjögren's syndrome and anti-Ro/SSA Antibody (SSA-Ab) positivity in Asian populations. We evaluated the clinical significance of anti-Ro/SSA Antibody positivity in patients with NMO spectrum disorder (NMOSD). We retrospectively collected data from 106 consecutive patients with NMOSD and reviewed clinical features and laboratory findings. All patients underwent tests for SSA-Ab and anti-Aquaporin-4 Antibody (AQP4-Ab) using cell-based indirect immunofluorescence assays. Among 106 patients, 20 (18.9%) were positive for SSA-Ab. Of 48 AQP4-Ab-positive patients, 18 (37.5%) had SSA-Ab. AQP4-Ab seropositivity was 90.0% in patients positive for SSA-Ab, and 32.6% in patients without SSA-Ab (p<0.001). Presence of SSA-Ab was associated with systemic autoimmune diseases, including Sjögren's syndrome (p<0.001) and systemic lupus erythematosus (p=0.003), and with the presence of non-organ-specific autoantibodies such as anti-nuclear Antibody and anti-dsDNA Antibody in patients with NMOSD, but was not associated with annualized relapse rate or final Expanded Disability Status Scale score independent of AQP4-Ab positivity. We found that the presence of SSA-Ab was highly associated with seropositivity for AQP4-Ab in patients with NMOSD. Copyright © 2014 Elsevier B.V. All rights reserved.
Toshiyuki Takahashi - One of the best experts on this subject based on the ideXlab platform.
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Optimal management of neuromyelitis optica spectrum disorder with Aquaporin-4 Antibody by oral prednisolone maintenance therapy
Multiple sclerosis and related disorders, 2021Co-Authors: Yoshiki Takai, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Hiroshi Kuroda, Tetsuya Akaishi, Masashi AokiAbstract:Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing neuroinflammatory disease associated with Aquaporin-4 Antibody. Since disabilities in patients with NMOSD accumulate with attacks, relapse prevention is crucially important for improving long-term outcomes. Corticosteroids are inexpensive and promising drugs for relapse prevention in NMOSD, but few studies have analysed the efficacy of corticosteroids in NMOSD, especially regarding the appropriate dosing and tapering regimens. Methods A single-center, retrospective analysis of corticosteroid therapy in Aquaporin-4 Antibody-positive NMOSD patients fulfilling the 2015 international consensus diagnostic criteria was conducted. Results Medical records of a total of 89 Japanese patients with Aquaporin-4 Antibody-positive NMOSD seen at Department of Neurology, Tohoku University Hospital (2000∼2016) were reviewed. At the last follow-up, 66% of the patients were treated with prednisolone (PSL) monotherapy, and the percentage of those receiving PSL monotherapy or a combination of PSL and other immunosuppressants increased from 17.5% in 2000 to 94.1% in 2016. On the other hand, annualised relapse rate (ARR) decreased from 0.78 (13 attacks in 200 person-months) in 2000 to 0.07 (5 attacks in 819 person-months) in 2016. Under PSL treatment, the mean ARR significantly decreased, and disabilities stabilized (PSL treatment vs no-medication; ARR: 0.21 vs 0.98, P Conclusion Our study suggests that PSL monotherapy is effective to prevent relapse in about half of patients with Aquaporin-4 Antibody-positive NMOSD if the doses are gradually reduced. Although it is important to have a treatment strategy tailored to each patient, this study provides an evidence that PSL monotherapy can be an option for relapse prevention in some patients with NMOSD.
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clinical characteristics of anti Aquaporin 4 Antibody positive optic neuritis in japan
Neuro-Ophthalmology, 2018Co-Authors: Akiko Yamagami, Toshiyuki Takahashi, Masato Wakakura, Kenji Inoue, Hitoshi Ishikawa, Keiko TanakaAbstract:To investigate the clinical characteristics and the effectiveness of maintenance therapy of anti-AQP4 Antibody positive optic neuritis in Japanese patients, medical records from 69 patients (103 eyes) were retrospective reviewed. The status of relapse in patients who received maintenance therapy following acute therapy was compared with that before maintenance therapy in patients who started maintenance therapy ≥6 months after acute therapy. In Japan, anti-AQP4 Antibody positive optic neuritis was characterized by older onset age and poor visual outcome. The yearly rate and total number of relapses were lower when maintenance therapy was followed immediately after acute therapy.
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Neuromyelitis Optica Spectrum Disorders.
Neuroimaging clinics of North America, 2017Co-Authors: Tetsuya Akaishi, Douglas Kazutoshi Sato, Ichiro Nakashima, Toshiyuki Takahashi, Kazuo FujiharaAbstract:Neuromyelitis optica (NMO) is clinically characterized by severe optic neuritis and transverse myelitis, but recent studies with anti-Aquaporin-4-Antibody specific to NMO have revealed that the clinical spectrum is wider than previously thought. International consensus diagnostic criteria propose NMO spectrum disorders (NMOSD) as the term to define the entire spectrum including typical NMO, optic neuritis, acute myelitis, brain syndrome, and their combinations. NMOSD is now divided into anti-Aquaporin-4-Antibody-seropositive NMOSD and -seronegative NMOSD (or unknown serostatus). MR imaging and optical coherence tomography are indispensable in the diagnosis and evaluation of NMOSD. This article reviews the clinical and MR imaging findings of anti-Aquaporin-4-Antibody-seropositive and anti-myelin oligodendrocyte glycoprotein-Antibody-seropositive NMOSD.
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Paraneoplastic neuromyelitis optica spectrum disorder manifesting as intractable nausea and acute cerebellar ataxia associated with lung adenocarcinoma
Neurology and Clinical Neuroscience, 2015Co-Authors: Masako Kobata, Toshiyuki Takahashi, Kazumasa Okada, Tomoyo Hashimoto, Atsuji Matsuyama, Ayumi Uchibori, Hiroaki AdachiAbstract:We report a 65-year-old woman with neuromyelitis optica spectrum disorder manifesting acute cerebellar ataxia, and intractable nausea and vomiting. She tested positive for anti-Aquaporin 4 antibodies and had a lung adenocarcinoma simultaneously. She underwent partial pulmonary resection, and tumor cells of the lung adenocarcinoma were stained with an anti-Aquaporin 4 Antibody. By administering intravenous methyl prednisolone and plasma exchange, Aquaporin 4 Antibody titer was reduced, and neurological deficits and the lesion status on magnetic resonance imaging markedly improved. Paraneoplastic neuromyelitis optica spectrum disorder in conjunction with lung adenocarcinoma was a reasonable diagnosis.
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Case report Anti-Aquaporin 4 Antibody-positive acute disseminated encephalomyelitis
2015Co-Authors: Akihisa Okumura, Mika Nakazawa, Ayuko Igarashi, Shinpei Abe, Mitsuru Ikeno, Eri Nakahara, Yuichiro Yamashiro, Toshiaki Shimizu, Toshiyuki TakahashiAbstract:Objective: To describe the clinical and neuroimaging features of a young female patient with acute disseminated encephalomyelitis associated with anti-Aquaporin-4 antibodies. Methods: The patient had mild encephalopathy 14 days after influenza vaccination. Cerebrospinal fluid analysis revealed an increased cell count and a marked increase in myelin basic protein. Magnetic resonance imaging (MRI) demonstrated multiple lesions in the juxtacortical white matter. The patient was diagnosed with acute disseminated encephalomyelitis and treated with methylprednisolone pulse therapy. She recovered in 1 month. However, right retrobulbar optic neuritis appeared 2 months after discharge, and serum anti-Aquaporin 4 antibodies were measured with a cell-based assay. Results: Anti-Aquaporin 4 antibodies were present in the patient’s serum. She was treated with a prolonged course of oral prednisolone. The patient was negative for serum anti-Aquaporin 4 antibodies 8 months after the second clinical event, and prednisolone was discontinued 13 months after the second clinical event. Serum anti-Aquaporin 4 antibodies remained negative 4 months after the discontinuation of prednisolone. There was no evidence of relapse at 9 months after discontinuation of steroids. Conclusions: This case will expand the spectrum of anti-Aquaporin-4 Antibody-related central nervous system disorders. The measurement of anti-Aquaporin 4 Antibody may be considered in patients with a clinical diagnosis of acute disseminated encephalomyelitis and a second clinical event within a short interval. 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.