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Mehmet Akyüz - One of the best experts on this subject based on the ideXlab platform.

  • determination of Aromatic Amines in hair dye and henna samples by ion pair extraction and gas chromatography mass spectrometry
    Journal of Pharmaceutical and Biomedical Analysis, 2008
    Co-Authors: Mehmet Akyüz
    Abstract:

    Abstract A gas chromatography–mass spectrometry (GC–MS) method has been proposed for the determination of carcinogenic and toxic Aromatic Amines in hair dye, henna and dyed hair samples. The method includes ion-pair extraction of Aromatic Amines from aqueous samples with bis-2-ethylhexylphosphate (BEHPA) released after solving the samples in acidic solution followed by sonication, derivatisation of compounds with isobutyl chloroformate (IBCF) and their GC–MS analysis in both electron impact (EI) and positive and negative ion chemical ionisation (PNICI) mode as their isobutyloxycarbonyl ( iso BOC) derivatives. The obtained recoveries of Aromatic Amines ranged from 92.2 to 98.4% and the precision of this method, as indicated by the relative standard deviations (RSDs) was within the range of 0.7–4.2%. The detection limits obtained from calculations by using GC–MS results based on signal-to-noise ratio (S/N)= 3 were within the range from 0.02 to 0.20 ng/g. In the present study, the commercially available 54 permanent hair dye, 35 modified or natural henna and 15 dyed hair samples were analysed for the Aromatic Amines by the proposed method and the method was shown to be suitable to determine the Aromatic amine ingredients and metabolites of these commercial products.

  • simultaneous determination of aliphatic and Aromatic Amines in water and sediment samples by ion pair extraction and gas chromatography mass spectrometry
    Journal of Chromatography A, 2006
    Co-Authors: Mehmet Akyüz
    Abstract:

    Abstract A gas chromatography–mass spectrometry (GC–MS) method has been proposed for the determination of aliphatic and Aromatic Amines in a variety of environmental samples including wastewater, river water, sea water and sediment samples. The method includes ion-pair extraction with bis-2-ethylhexylphosphate (BEHPA), derivatisation of compounds with isobutyl chloroformate (IBCF) and their GC–MS analysis. Aliphatic and Aromatic Amines were isolated from aqueous samples using BEHPA as ion-pair reagent and derivatised with IBCF for their chromatographic analysis. Solid–liquid extraction of aliphatic and Aromatic Amines in sediment samples were performed in Soxhlet apparatus with acidic MeOH and ion-pair extraction with BEHPA were carried out for the isolation of Amines followed by derivatisation with IBCF. Aliphatic and Aromatic Amines were then analysed with GC–MS in both electron impact (EI) and positive and negative ion chemical ionisation (PNICI) mode as their isobutyloxycarbonyl (isoBOC) derivatives. The obtained recoveries ranged from 81.0 to 98.0% and the precision of this method, as indicated by the relative standard deviations (RSDs) was within the range of 0.5 and 4.3%. The detection limits obtained from calculations by using GC–MS results based on S/N = 3 were within the range from 0.07 to 0.50 ng/l.

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