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Anna Lee - One of the best experts on this subject based on the ideXlab platform.

  • multivariate analysis of factors associated with umbilical Arterial pH and standard base excess after caesarean section under spinal anaesthesia
    Anaesthesia, 2003
    Co-Authors: W Ngan D Kee, Anna Lee
    Abstract:

    Summary We have investigated the factors predicting umbilical Arterial pH (UA pH) and standard base excess (UA BE) in 337 consecutive elective Caesarean sections performed under spinal anaesthesia. Multiple linear regression analysis was performed with UA pH and UA BE as the dependent factors. We found that the significant factors predicting UA pH were: use of epHedrine, uterine incision-to-delivery time, maximum decrease in systolic Arterial pressure and the interaction between epHedrine use and duration of hypotension (adjusted R2 = 0.39, F15,321 = 15.4, p < 0.0001). The significant factors predicting UA BE were: use of epHedrine and the interaction between epHedrine use and duration of hypotension (adjusted R2 = 0.52, F15,321 = 25.0, p < 0.0001). We conclude that, in order to minimise the risk of fetal acidosis, epHedrine should not be used before delivery, uterine incision-to-delivery time should be as short as possible, and alpHa-agonists such as metaraminol or pHenylepHrine should be used to minimise both the magnitude and duration of hypotension.

  • Multivariate analysis of factors associated with umbilical Arterial pH and standard base excess after Caesarean section under spinal anaesthesia.
    Anaesthesia, 2003
    Co-Authors: W.d. Ngan Kee, Anna Lee
    Abstract:

    Summary We have investigated the factors predicting umbilical Arterial pH (UA pH) and standard base excess (UA BE) in 337 consecutive elective Caesarean sections performed under spinal anaesthesia. Multiple linear regression analysis was performed with UA pH and UA BE as the dependent factors. We found that the significant factors predicting UA pH were: use of epHedrine, uterine incision-to-delivery time, maximum decrease in systolic Arterial pressure and the interaction between epHedrine use and duration of hypotension (adjusted R2 = 0.39, F15,321 = 15.4, p

Marcos I Restrepo - One of the best experts on this subject based on the ideXlab platform.

Oriol Sibila - One of the best experts on this subject based on the ideXlab platform.

James E Leasure - One of the best experts on this subject based on the ideXlab platform.

  • Arterial pH and carbon dioxide tension as indicators of tissue perfusion during cardiac arrest in a canine model
    Critical care medicine, 1992
    Co-Authors: Mark G. Angelos, Daniel J. Debehnke, James E Leasure
    Abstract:

    Background and Methods Previous studies have shown that Paco2 and end-tidal CO2 reflect coronary artery perfusion pressures during cardiac arrest. We investigated the relationship of coronary artery perfusion pressure to central Arterial pH and Paco2 values during resuscitation from cardiac arrest in a canine model. Twenty-four mongrel dogs were block randomized to three different resuscitation groups after induction of ventricular fibrillation and cardiac arrest: a) standard cardiopulmonary resuscitation (CPR) and advanced life support (n = 8); b) cardiopulmonary bypass (n = 8); or c) open-chest CPR (n = 8). Central Arterial blood gases and perfusion pressures were monitored during cardiac arrest and during resuscitation. Results Prearrest blood gases and hemodynamic values were similar between groups. Sixteen dogs from all three groups were successfully resuscitated. Survivors had significantly higher coronary artery perfusion pressure (p =.03), Paco2(p =.015), and lower pH (p =.01) values than nonsurvivors. There was no correlation of pH and Paco2 during mechanical external CPR. However, after institution of the different resuscitation techniques, pH and Paco2 each showed a statistically significant correlation (r2 =.50 and .33, respectively) with coronary artery perfusion pressure. Conclusions Central Arterial pH and Paco2 monitoring during cardiac arrest may reflect the adequacy of tissue perfusion during resuscitation and may predict resuscitation outcome from ventricular fibrillation. (Crit Care Med 1992; 20:1302–1308)

W.d. Ngan Kee - One of the best experts on this subject based on the ideXlab platform.