The Experts below are selected from a list of 243042 Experts worldwide ranked by ideXlab platform
Thomas M File - One of the best experts on this subject based on the ideXlab platform.
-
distribution of 13 valent pneumococcal conjugate vaccine streptococcus Pneumoniae serotypes in us adults aged 50 years with community acquired Pneumonia
The Journal of Infectious Diseases, 2013Co-Authors: Robert Sherwin, Peter Paradiso, Sharon Gray, Ronika Alexander, Paul C Mcgovern, Jay Graepel, Michael W Pride, Jay Purdy, Thomas M FileAbstract:Background. Streptococcus Pneumoniae causes a substantial proportion of community-acquired Pneumonia (CAP) and healthcare-associated Pneumonia (HCAP) in the United States. Limited data are available regarding the pneumococcal serotypes causing CAP and HCAP. Methods. Adults aged ≥50 years presenting to participating US hospitals with radiographically confirmed Pneumonia between February 2010 and September 2011 were screened for inclusion. S. Pneumoniae was identified using microbiological cultures, BinaxNOW® S. Pneumoniae assay, or urine antigen detection (UAD) assay capable of detecting 13-valent pneumococcal conjugate vaccine (PCV13)–associated serotypes. Results. Among 710 subjects enrolled, the median age was 65.4 years; 54.2% of subjects were male, 22.4% of radiographically confirmed Pneumonia cases were considered HCAP, and 96.6% of subjects were hospitalized. S. Pneumoniae was detected in 98 subjects (13.8%) by any test, and PCV13-associated serotype(s) were identified by UAD in 78 (11.0%). Serotype 19A was most prevalent, followed by 7F/A, 3, and 5. Serotypes associated with 7valent pneumococcal conjugate vaccine (PCV7) accounted for 25% of UAD-positive isolates. Conclusions. Pneumococcal serotypes causing noninvasive Pneumonia in adults may differ significantly from those causing invasive disease, with PCV7-associated serotypes overrepresented. Serotype 5, rarely seen in contemporary surveillance of invasive disease in the United States, substantially contributed to the observed cases of S. Pneumoniae–positive CAP or HCAP.
Naoyuki Miyashita - One of the best experts on this subject based on the ideXlab platform.
-
setting a standard for the initiation of steroid therapy in refractory or severe mycoplasma Pneumoniae Pneumonia in adolescents and adults
Journal of Infection and Chemotherapy, 2015Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Hiroto Akaike, Hideto Teranishi, Norikazu Inamura, Takaaki Tanaka, Tokio Wakabayashi, Takashi Nakano, Niro OkimotoAbstract:Abstract Serum interleukin (IL)-18 level was thought to be a useful as a predictor of refractory or severe Mycoplasma Pneumoniae Pneumonia, and steroid administration is reported to be effective in this situation. The serum levels of IL-18 correlated significantly with those of lactate dehydrogenase (LDH). The purpose of this study was to set a standard for the initiation of steroid therapy in M. Pneumoniae Pneumonia using a simple serum marker. We analyzed 41 adolescent and adult patients with refractory or severe M. Pneumoniae Pneumonia who received steroid therapy, and compared them with 108 patients with M. Pneumoniae Pneumonia who responded to treatment promptly (control group). Serum LDH levels were significantly higher in the refractory and severe group than in the control group at the initiation of steroid therapy (723 vs 210 IU/L, respectively; p
-
macrolide resistant mycoplasma Pneumoniae Pneumonia in adolescents and adults clinical findings drug susceptibility and therapeutic efficacy
Antimicrobial Agents and Chemotherapy, 2013Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Hiroto Akaike, Hideto Teranishi, Niro OkimotoAbstract:We investigated differences in the clinical findings between 30 patients with macrolide-resistant Mycoplasma Pneumoniae Pneumonia and 43 patients with macrolide-sensitive M. Pneumoniae Pneumonia in adolescents and adults. No differences in clinical presentation were observed between the two groups. Among patients with macrolide-resistant Mycoplasma Pneumoniae Pneumonia, treatment was more effective in the groups that received quinolones and minocycline than in the group that received macrolides (P = 0.0361 and P = 0.0237, respectively).
-
Chlamydophila Pneumoniae serology: cross-reaction with Mycoplasma Pneumoniae infection
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2012Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Hiroto Akaike, Hideto Teranishi, Tadashi Kato, Toshikiyo Hayashi, Niro OkimotoAbstract:Atypical pathogens Mycoplasma Pneumoniae and Chlamydophila Pneumoniae play an important role in community-acquired Pneumonia. However, it has been pointed out that positive enzyme-linked immunosorbent assay (ELISA, Hitazyme C. Pneumoniae) IgM reactivity is frequent among M. Pneumoniae Pneumonia patients. To clarify the reactivity of ELISA IgM in M. Pneumoniae Pneumonia, findings were compared with immunoblotting, ELNAS Plate C. Pneumoniae (ELNAS) and the micro-immunofluorescence (MIF) test. Ninety-eight serologically confirmed cases with M. Pneumoniae Pneumonia and 10 cases with C. Pneumoniae Pneumonia were enrolled in this study. C. Pneumoniae IgM-positive cases measured by the ELISA were observed in 30 (30 %) patients with M. Pneumoniae Pneumonia. However, there were no positive cases by immunoblotting, ELNAS, or MIF test. These cases determined to be IgM positive only in the ELISA were all negative by another serological test, recombinant enzyme immunoassay (rEIA), and these positive results in the ELISA were considered to be false-positive reactions. In contrast, IgM-positive findings in patients with C. Pneumoniae Pneumonia did not show any positive reaction in M. Pneumoniae antibody titer. ELISA showed a high frequency of false-positive findings in patients with M. Pneumoniae Pneumonia, which included false-positive cases with a high titer for IgM. To accurately diagnose C. Pneumoniae infection in various studies, including respiratory infections, researchers should consider the IgM false-positive reaction with ELISA in patients with suspected atypical Pneumonia.
-
clinical potential of diagnostic methods for the rapid diagnosis of mycoplasma Pneumoniae Pneumonia in adults
European Journal of Clinical Microbiology & Infectious Diseases, 2011Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Tetsuya Yamaguchi, Mikio OkaAbstract:The purpose of the present study was to evaluate the accuracy and usefulness of three rapid diagnostic methods, ImmunoCard Mycoplasma kit, chest high-resolution computed tomography (HRCT) findings, and the Japanese Respiratory Society (JRS) scoring system (including six parameters), for the early presumptive diagnosis of Mycoplasma Pneumoniae Pneumonia in adults. We performed three rapid diagnostic methods at the same time in four Pneumonia groups: 68 cases with M. Pneumoniae Pneumonia, 133 cases with Streptococcus Pneumoniae Pneumonia, 30 cases with Haemophilus influenzae Pneumonia, and 20 cases with Legionella Pneumonia. The sensitivity and specificity were 35% and 68% for ImmunoCard, 73% and 85% with HRCT, and 83% and 90% with the JRS scoring system, respectively. Among the three rapid diagnostic methods, the JRS scoring system was the most useful tool for initiating the administration of adequate antibiotic therapy for probable M. Pneumoniae Pneumonia. We suggest that M. Pneumoniae Pneumonia should be suspected when there is a correlation of more than five parameters in the JRS scoring system (99% specificity). If there is a correlation of three or four parameters in the JRS scoring system, chest computed tomography (CT) findings are helpful for the presumptive diagnosis of M. Pneumoniae Pneumonia.
-
radiographic features of mycoplasma Pneumoniae Pneumonia differential diagnosis and performance timing
BMC Medical Imaging, 2009Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Tadaaki Sugiu, Keiko Oda, Tetsuya Yamaguchi, Yoshihiro Kobashi, Mikio OkaAbstract:The Japanese Respiratory Society guidelines propose a differential diagnosis for atypical Pneumonia and bacterial Pneumonia using a scoring system for the selection of appropriate antibiotic. In order to improve this scoring system, the guidelines are seeking new specific parameter. The purpose of this study was to clarify the pattern of abnormalities with Mycoplasma Pneumoniae Pneumonia on chest computed tomography (CT) and whether the radiographic findings could distinguish M. Pneumoniae Pneumonia from Streptococcus Pneumoniae Pneumonia. A retrospective review was performed of the CT findings of 64 cases and 68 cases where M. Pneumoniae and S. Pneumoniae, respectively, were the only pathogen identified by the panel of diagnostic tests used. Of the 64 patients with M. Pneumoniae Pneumonia, bronchial wall thickening was observed most frequently (81%), followed by centrilobular nodules (78%), ground-glass attenuation (78%), and consolidation (61%). Bronchial wall thickening and centrilobular nodules were observed more often in M. Pneumoniae patients than in S. Pneumoniae patients (p < 0.0001). The presence of bilateral bronchial wall thickening or centrilobular nodules was only seen in patients with M. Pneumoniae Pneumonia. Using the scoring system of the Japanese Respiratory Society guidelines and chest CT findings, 97% of M. Pneumoniae patients were suspected to be M. Pneumoniae Pneumonia without serology. When comparing the CT findings between early stage and progressed stage in the same patients with severe Pneumonia, the radiographic features of early stage M. Pneumoniae Pneumonia were not observed clearly in the progressed stage. The present results indicate that the diagnosis of M. Pneumoniae Pneumonia would appear to be reliable when found with a combination of bronchial wall thickening and centrilobular nodules in the CT findings. However, these CT findings are not observed in progressed severe M. Pneumoniae Pneumonia patients.
Hiromu Mori - One of the best experts on this subject based on the ideXlab platform.
-
thin section ct findings of patients with acute streptococcus Pneumoniae Pneumonia with and without concurrent infection
British Journal of Radiology, 2012Co-Authors: Fumito Okada, Yumiko Ando, Tomoko Nakayama, Keiko Morikawa, R Ishii, S. Matsushita, T. Maeda, Hiromu MoriAbstract:Objectives: The aim of this study was to compare the pulmonary thin-section CT findings of patients with acute Streptococcus Pneumoniae Pneumonia with and without concurrent infection. Methods: The study group comprised 86 patients with acute S. Pneumoniae Pneumonia, 36 patients with S. Pneumoniae Pneumonia combined with Haemophilus influenzae infection, 26 patients with S. Pneumoniae Pneumonia combined with Pseudomonas aeruginosa infection and 22 patients with S. Pneumoniae Pneumonia combined with methicillin-susceptible Staphylococcus aureus (MSSA) infection. We compared the thin-section CT findings among the groups. Results: Centrilobular nodules and bronchial wall thickening were significantly more frequent in patients with Pneumonia caused by concurrent infection (H. influenzae: p<0.001 and p<0.001, P. aeruginosa: p<0.001 and p<0.001, MSSA: p<0.001 and p<0.001, respectively) than in those infected with S. Pneumoniae alone. Cavity and bilateral pleural effusions were significantly more frequent in cas...
-
Clinical and pulmonary thin-section CT findings in acute Klebsiella Pneumoniae Pneumonia
European Radiology, 2008Co-Authors: Fumito Okada, Yumiko Ando, Tomoko Nakayama, Koichi Honda, Maki Kiyonaga, Shuichi Tanoue, Toru Maeda, Hiromu MoriAbstract:The aim of this study was to assess the clinical and pulmonary thin-section CT findings in patients with acute Klebsiella Pneumoniae Pneumonia. We retrospectively evaluated thin-section CT examinations performed between January 1991 and December 2007 from 962 patients with acute Klebsiella Pneumoniae Pneumonia. Seven hundred and sixty-four cases with concurrent infectious diseases were excluded. Thus, our study group comprised 198 patients (118 male, 80 female; age range 18–97 years, mean age 61.5). Underlying diseases and clinical findings were assessed. Parenchymal abnormalities were evaluated along with the presence of enlarged lymph nodes and pleural effusion. CT findings in patients with acute Klebsiella Pneumoniae Pneumonia consisted mainly of ground-glass attenuation (100%), consolidation (91.4%), and intralobular reticular opacity (85.9%), which were found in the periphery (96%) of both sides of the lungs (72.2%) and were often associated with pleural effusion (53%). The underlying conditions in patients with Klebsiella Pneumoniae Pneumonia were alcoholism or smoking habit.
Jae Ho Lee - One of the best experts on this subject based on the ideXlab platform.
-
effects of methylprednisolone pulse therapy on refractory mycoplasma Pneumoniae Pneumonia in children
Allergy Asthma and Immunology Research, 2014Co-Authors: Sun Young You, Eun Ae Yang, Hye Jeong Jwa, Hong Ryang Kil, Jae Ho LeeAbstract:Purpose Mycoplasma Pneumoniae (M. Pneumoniae) is one of the most common causes of community-acquired Pneumonia in children. The clinical course is typically self-limited and benign; however, rare cases of severe Pneumonia can develop despite appropriate antibiotic therapy. We studied the effects of methylprednisolone pulse therapy on severe refractory M. Pneumoniae Pneumonia in children.
-
environmental and occupational respiratory diseases 1060 clinical responses to methylprednisolone pulse therapy in children with severe refractory mycoplasma Pneumoniae Pneumonia
World Allergy Organization Journal, 2013Co-Authors: Jae Ho Lee, Sun Young You, Eun Ae Yang, You Sook Youn, Hong Ryang GilAbstract:Background Mycoplasma Pneumoniae (M. Pneumoniae) Pneumonia is one of the most common causes of community acquired Pneumonia in children. The clinical course is usually self limited and benign. But rarely severe Pneumonia could be complicated despite appropriate antibiotic therapy. We determine the impact of methylprednisolone pulse therapy on the severe refractory M. Pneumoniae Pneumonia in children.
Kazunobu Ouchi - One of the best experts on this subject based on the ideXlab platform.
-
setting a standard for the initiation of steroid therapy in refractory or severe mycoplasma Pneumoniae Pneumonia in adolescents and adults
Journal of Infection and Chemotherapy, 2015Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Hiroto Akaike, Hideto Teranishi, Norikazu Inamura, Takaaki Tanaka, Tokio Wakabayashi, Takashi Nakano, Niro OkimotoAbstract:Abstract Serum interleukin (IL)-18 level was thought to be a useful as a predictor of refractory or severe Mycoplasma Pneumoniae Pneumonia, and steroid administration is reported to be effective in this situation. The serum levels of IL-18 correlated significantly with those of lactate dehydrogenase (LDH). The purpose of this study was to set a standard for the initiation of steroid therapy in M. Pneumoniae Pneumonia using a simple serum marker. We analyzed 41 adolescent and adult patients with refractory or severe M. Pneumoniae Pneumonia who received steroid therapy, and compared them with 108 patients with M. Pneumoniae Pneumonia who responded to treatment promptly (control group). Serum LDH levels were significantly higher in the refractory and severe group than in the control group at the initiation of steroid therapy (723 vs 210 IU/L, respectively; p
-
macrolide resistant mycoplasma Pneumoniae Pneumonia in adolescents and adults clinical findings drug susceptibility and therapeutic efficacy
Antimicrobial Agents and Chemotherapy, 2013Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Hiroto Akaike, Hideto Teranishi, Niro OkimotoAbstract:We investigated differences in the clinical findings between 30 patients with macrolide-resistant Mycoplasma Pneumoniae Pneumonia and 43 patients with macrolide-sensitive M. Pneumoniae Pneumonia in adolescents and adults. No differences in clinical presentation were observed between the two groups. Among patients with macrolide-resistant Mycoplasma Pneumoniae Pneumonia, treatment was more effective in the groups that received quinolones and minocycline than in the group that received macrolides (P = 0.0361 and P = 0.0237, respectively).
-
Chlamydophila Pneumoniae serology: cross-reaction with Mycoplasma Pneumoniae infection
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2012Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Hiroto Akaike, Hideto Teranishi, Tadashi Kato, Toshikiyo Hayashi, Niro OkimotoAbstract:Atypical pathogens Mycoplasma Pneumoniae and Chlamydophila Pneumoniae play an important role in community-acquired Pneumonia. However, it has been pointed out that positive enzyme-linked immunosorbent assay (ELISA, Hitazyme C. Pneumoniae) IgM reactivity is frequent among M. Pneumoniae Pneumonia patients. To clarify the reactivity of ELISA IgM in M. Pneumoniae Pneumonia, findings were compared with immunoblotting, ELNAS Plate C. Pneumoniae (ELNAS) and the micro-immunofluorescence (MIF) test. Ninety-eight serologically confirmed cases with M. Pneumoniae Pneumonia and 10 cases with C. Pneumoniae Pneumonia were enrolled in this study. C. Pneumoniae IgM-positive cases measured by the ELISA were observed in 30 (30 %) patients with M. Pneumoniae Pneumonia. However, there were no positive cases by immunoblotting, ELNAS, or MIF test. These cases determined to be IgM positive only in the ELISA were all negative by another serological test, recombinant enzyme immunoassay (rEIA), and these positive results in the ELISA were considered to be false-positive reactions. In contrast, IgM-positive findings in patients with C. Pneumoniae Pneumonia did not show any positive reaction in M. Pneumoniae antibody titer. ELISA showed a high frequency of false-positive findings in patients with M. Pneumoniae Pneumonia, which included false-positive cases with a high titer for IgM. To accurately diagnose C. Pneumoniae infection in various studies, including respiratory infections, researchers should consider the IgM false-positive reaction with ELISA in patients with suspected atypical Pneumonia.
-
clinical potential of diagnostic methods for the rapid diagnosis of mycoplasma Pneumoniae Pneumonia in adults
European Journal of Clinical Microbiology & Infectious Diseases, 2011Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Tetsuya Yamaguchi, Mikio OkaAbstract:The purpose of the present study was to evaluate the accuracy and usefulness of three rapid diagnostic methods, ImmunoCard Mycoplasma kit, chest high-resolution computed tomography (HRCT) findings, and the Japanese Respiratory Society (JRS) scoring system (including six parameters), for the early presumptive diagnosis of Mycoplasma Pneumoniae Pneumonia in adults. We performed three rapid diagnostic methods at the same time in four Pneumonia groups: 68 cases with M. Pneumoniae Pneumonia, 133 cases with Streptococcus Pneumoniae Pneumonia, 30 cases with Haemophilus influenzae Pneumonia, and 20 cases with Legionella Pneumonia. The sensitivity and specificity were 35% and 68% for ImmunoCard, 73% and 85% with HRCT, and 83% and 90% with the JRS scoring system, respectively. Among the three rapid diagnostic methods, the JRS scoring system was the most useful tool for initiating the administration of adequate antibiotic therapy for probable M. Pneumoniae Pneumonia. We suggest that M. Pneumoniae Pneumonia should be suspected when there is a correlation of more than five parameters in the JRS scoring system (99% specificity). If there is a correlation of three or four parameters in the JRS scoring system, chest computed tomography (CT) findings are helpful for the presumptive diagnosis of M. Pneumoniae Pneumonia.
-
radiographic features of mycoplasma Pneumoniae Pneumonia differential diagnosis and performance timing
BMC Medical Imaging, 2009Co-Authors: Naoyuki Miyashita, Kazunobu Ouchi, Yasuhiro Kawai, Tadaaki Sugiu, Keiko Oda, Tetsuya Yamaguchi, Yoshihiro Kobashi, Mikio OkaAbstract:The Japanese Respiratory Society guidelines propose a differential diagnosis for atypical Pneumonia and bacterial Pneumonia using a scoring system for the selection of appropriate antibiotic. In order to improve this scoring system, the guidelines are seeking new specific parameter. The purpose of this study was to clarify the pattern of abnormalities with Mycoplasma Pneumoniae Pneumonia on chest computed tomography (CT) and whether the radiographic findings could distinguish M. Pneumoniae Pneumonia from Streptococcus Pneumoniae Pneumonia. A retrospective review was performed of the CT findings of 64 cases and 68 cases where M. Pneumoniae and S. Pneumoniae, respectively, were the only pathogen identified by the panel of diagnostic tests used. Of the 64 patients with M. Pneumoniae Pneumonia, bronchial wall thickening was observed most frequently (81%), followed by centrilobular nodules (78%), ground-glass attenuation (78%), and consolidation (61%). Bronchial wall thickening and centrilobular nodules were observed more often in M. Pneumoniae patients than in S. Pneumoniae patients (p < 0.0001). The presence of bilateral bronchial wall thickening or centrilobular nodules was only seen in patients with M. Pneumoniae Pneumonia. Using the scoring system of the Japanese Respiratory Society guidelines and chest CT findings, 97% of M. Pneumoniae patients were suspected to be M. Pneumoniae Pneumonia without serology. When comparing the CT findings between early stage and progressed stage in the same patients with severe Pneumonia, the radiographic features of early stage M. Pneumoniae Pneumonia were not observed clearly in the progressed stage. The present results indicate that the diagnosis of M. Pneumoniae Pneumonia would appear to be reliable when found with a combination of bronchial wall thickening and centrilobular nodules in the CT findings. However, these CT findings are not observed in progressed severe M. Pneumoniae Pneumonia patients.
